CN104622909A - Method for processing high-activity and no-smell leeches - Google Patents
Method for processing high-activity and no-smell leeches Download PDFInfo
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- CN104622909A CN104622909A CN201510096344.1A CN201510096344A CN104622909A CN 104622909 A CN104622909 A CN 104622909A CN 201510096344 A CN201510096344 A CN 201510096344A CN 104622909 A CN104622909 A CN 104622909A
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- hirudo
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Abstract
The invention provides a method for processing high-activity and no-smell leeches. The method is characterized in that milk is added in a processing process, and the leech processed by the method provided by the invention is high in activity, small in oral peculiar smell, good in taste and high in patient adaptability.
Description
Invention field
The present invention relates to medicine, particularly the processing method of a kind of free from extraneous odour Hirudo, belong to medical art.
Background technology
Hirudo begins to be loaded in Shennong's Herbal, and the drying for Hirudinidae animal whitmania, Hirudo or Folium Salicis Babylonicae Hirudo that the version Pharmacopoeia of the People's Republic of China one in 2010 records hyoscine is all.Hirudo tool closed by the stagnant blood blood stasis moon, effect that removing blood stasis abdominal mass is gathered, and can be used for cerebrovascular disease clinically, seminal fluid is not changed, prostate hyperplasia, the treatment of the various diseases such as uterine apoplexy syndrome.
The chemical composition that Hirudo plays pharmacological action is mainly hirudin, heparin, enzyme and enzyme inhibitor, aminoacid, protein etc., and traditional processing method is convenient to Hirudo preservation, and along with medical skill development, modern processing request preserves the active ingredient of Hirudo as far as possible.The processing method that " Chinese Pharmacopoeia " 2010 version () records Hirudo is the summer, Qiu Erji catches, and scalds dead, dry or cold drying with boiling water.
The Hirudo powder warm water of prior art processing preparation is taken after mixing it with water, and abnormal flavour is extra heavy, and mouthfeel is very poor, directly affects the compliance of patient." Shandong Province's prepared slices of Chinese crude drugs concocted specification " records " Hirudo powder should encapsulatedly be swallowed " under usage and dosage item, but " encapsulated " is both inconvenient in family's operation, cannot ensure the quality of products again.Under the prerequisite ensureing Hirudo curative effect, provide a kind of processing method improving Hirudo powder mouthfeel, very necessary.
Summary of the invention
The object of this invention is to provide a kind of processing method of free from extraneous odour Hirudo powder.
The object of the present invention is achieved like this:
A processing method for free from extraneous odour Hirudo powder, is characterized in that: the course of processing adds milk.
The processing method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: the amount adding milk is fresh Hirudo by weight: milk=1:0.5-10.
The processing method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: the running water trematodiasis boiling water of seizure scalds dead, dry after adding milk.
The processing method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: the running water trematodiasis of seizure puts into the 1-10 milk that boils doubly by weight, dry.
The processing method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: solid carbon dioxide trematodiasis is dry after adding milk.
The processing method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: solid carbon dioxide trematodiasis is dry after adding milk, and the amount adding milk is solid carbon dioxide trematodiasis by weight: milk=1:1-30.
The processing method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: solid carbon dioxide trematodiasis adds milk powder, mixing, and pulverize, the amount adding milk powder is solid carbon dioxide trematodiasis by weight: milk powder=1:0.1-3.
Hirudo of the present invention refers to the Hirudo of Pharmacopoeia of the People's Republic of China version in 2010 hyoscine recorded, and is Hirudinidae animal whitmania, Hirudo and Folium Salicis Babylonicae Hirudo.
So far the present invention is completed.The Hirudo powder of the present invention's processing, active high, oral abnormal flavour is little, and mouthfeel is good, and the compliance of patient is high.
Below by test example, usefulness of the present invention is described.Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.
Test example one, different processing methods mouthfeel compare
1, by same mass products Hirudo, process by the following method.
1) dry: scald with boiling water dead, less than 60 DEG C oven dry, pulverize;
2) milk post-drying is added: scald with boiling water dead, add the milk of 1:1 by weight, less than 60 DEG C oven dry, pulverize.
2, mouthfeel evaluation is made up of 10 people and appraises group through discussion, everyone is the warm water for oral use oven dry of mixing well and the Hirudo powder that adds milk post-drying respectively, evaluates the mouthfeel misty idea such as " very well ", " better ", " can accept ", " poor ", " very poor ".The results are shown in Table 1
The Hirudo powder mouthfeel of table 1 different processing methods compares
| Very well | Better | Can accept | Poor | Very poor | |
| Add milk post-drying | 0 people | 1 people | 9 people | 0 people | 0 people |
| Dry | 0 people | 0 people | 0 people | 3 people | 7 people |
Result shows, and the Hirudo course of processing adds milk, and oral abnormal flavour is little, and mouthfeel is good.
The dry impact on high fat diet Sanguis Leporis seu oryctolagi lipid level of test example two, Hirudo powder distinct methods
1, by same mass products Hirudo, process by the following method.
1) dry: scald with boiling water dead, less than 60 DEG C oven dry, pulverize;
2) milk scalds dead oven dry: the milk that boils putting into 5 times by weight, and less than 60 DEG C oven dry are pulverized.
2, Hirudo powder different processing methods is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
She draws meat rabbit 120 to select physical health, be divided into 4 groups at random, often organize 30, namely blank group (normal feedstuff of feeding), high fat group (high lipid food of feeding), oven dry group (add in 100g high lipid food and dry Hirudo powder 1g), milk scald dead oven dry group (add milk in 100g high lipid food and scald dead oven dry Hirudo powder 1g).The each group of all single cage of rabbit is raised, limit appetite, and every rabbit 100g every day feedstuff, freely drinks water, and tests 30d blood sampling, measures T-CHOL, triglyceride, HDL-C (high density), low-density lipoprotein cholesterol content (low-density) in serum.The results are shown in Table 2
The Hirudo powder of table 2 distinct methods processing is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
| Blank group | High fat group | Oven dry group | Milk scalds dead oven dry group | |
| T-CHOL | 2.082±0.176 | 3.892±0.369 | 2.538±0.219 | 2.136±0.143 |
| Triglyceride | 0.767±0.245 | 1.914±0.047 | 0.780±0.167 | 0.752±0.164 |
| High density | 1.038±0.096 | 1.320±0.253 | 1.181±0.082 | 1.101±0.075 |
| Low-density | 0.635±0.236 | 1.745±0.103 | 0.751±0.073 | 0.694±0.052 |
Result shows, high lipid food can make Sanguis Leporis seu oryctolagi lipid level get muddled, and adds the blood lipid level that Hirudo powder can improve high lipid food rabbit feeding in high lipid food, and milk scalds dead oven dry group curative effect and is better than and scalds dead oven dry group with boiling water.
Test example three, different processing methods antithrombin activity (U) compare
1, by same mass products Folium Salicis Babylonicae Hirudo, process by the following method.
1) dry: scald dead with boiling water, less than 60 DEG C oven dry;
2) milk post-drying is added: scald with boiling water dead, add the milk of 1:0.5 by weight, less than 60 DEG C oven dry.
2, antithrombin activity (U) compares.
Under " Chinese Pharmacopoeia " version (one) Hirudo item in 2010, determination measures, and the results are shown in Table 3.
The Hirudo antithrombin activity of table 3 distinct methods processing compares
| Processing method | Antithrombin activity (U) |
| Dry | 7.6 |
| Add milk post-drying | 13.2 |
Result shows, the obtained Hirudo antithrombase content (activity) of two kinds of processing methods all meets States Pharmacopoeia specifications, adds the Hirudo of Hirudo antithrombase content (activity) apparently higher than oven dry of milk post-drying.
Detailed description of the invention
A processing method for free from extraneous odour Hirudo powder, is characterized in that: the course of processing adds milk.
A processing method for free from extraneous odour Hirudo powder, is characterized in that: the amount adding milk is fresh Hirudo by weight: milk=1:0.5-10.
A processing method for free from extraneous odour Hirudo powder, is characterized in that: the running water trematodiasis of seizure is scalded dead with boiling water, dry after adding milk.
A processing method for free from extraneous odour Hirudo powder, is characterized in that: the running water trematodiasis of seizure puts into the 1-10 milk that boils doubly by weight, dry.
A processing method for free from extraneous odour Hirudo powder, is characterized in that: solid carbon dioxide trematodiasis is dry after adding milk.
A processing method for free from extraneous odour Hirudo powder, is characterized in that: solid carbon dioxide trematodiasis is dry after adding milk, and the amount adding milk is solid carbon dioxide trematodiasis by weight: milk=1 ︰ 1-30.
A processing method for free from extraneous odour Hirudo powder, is characterized in that: dry periplaneta americana adds milk powder, mixing, and pulverize, the amount adding milk powder is solid carbon dioxide trematodiasis by weight: milk powder=1:0.1-3.
embodiment 1
Running water trematodiasis 5kg, scalds with boiling water dead, adds milk 2.5kg, less than 60 DEG C oven dry.Make powder, oral free from extraneous odour.
embodiment 2
Live Hirudo 5kg, scalds dead, add milk 50kg, less than 60 DEG C oven dry with boiling water.Make powder, oral free from extraneous odour.
embodiment 3
Live Folium Salicis Babylonicae Hirudo 5kg, puts into the 5kg milk that boils and scald dead, together put in freeze dryer, be refrigerated to less than-10 DEG C, be evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation should control below 40 DEG C, and the temperature of resolution phase controls below 45 DEG C, to dry.Make powder, oral free from extraneous odour.
embodiment 4
Running water trematodiasis 5kg, scalds with boiling water dead, adds milk 5kg, dry.Make powder, oral free from extraneous odour.
embodiment 5
Live Folium Salicis Babylonicae Hirudo 5kg, scalds dead, add milk 20kg, less than 60 DEG C drying under reduced pressure with boiling water.Make powder, oral free from extraneous odour.
embodiment 6
Live Hirudo 5kg, scalds dead, add milk 15kg, put in freeze dryer, be refrigerated to less than-10 DEG C, be evacuated to below drying chamber pressure 30Pa, subliming by heating with boiling water; The temperature of distillation should control below 30 DEG C, and the temperature of resolution phase controls below 40 DEG C, to dry.Make powder, oral free from extraneous odour.
embodiment 7
Running water trematodiasis 5kg, puts into the 50kg milk that boils and scalds dead, together lyophilizing.Make powder, oral free from extraneous odour.
embodiment 8
Live Folium Salicis Babylonicae Hirudo 5kg, puts into the 25kg milk that boils and scald dead, together less than 80 DEG C oven dry.Make powder, oral free from extraneous odour.
embodiment 9
Live Hirudo 5kg, puts into the 15kg milk that boils and scald dead, together dry.Make powder, oral free from extraneous odour.
embodiment 10
Solid carbon dioxide trematodiasis 5kg, adds milk 5kg, and less than 60 DEG C dry.Make powder, oral free from extraneous odour.
embodiment 11
Solid carbon dioxide trematodiasis 5kg, adds milk 150kg, together lyophilizing.Make powder, oral free from extraneous odour.
embodiment 12
Dry Hirudo 5kg, adds milk 50kg, less than 60 DEG C, drying under reduced pressure.Make powder, oral free from extraneous odour.
embodiment 13
Dry Folium Salicis Babylonicae Hirudo 5kg, adds milk powder 0.5kg, mixing, pulverizes.Make powder, oral free from extraneous odour.
embodiment 14
Solid carbon dioxide trematodiasis 5kg, adds milk powder 15kg, mixing, pulverizes.Make powder, oral free from extraneous odour.
embodiment 15
Solid carbon dioxide trematodiasis 5kg, adds milk powder 5kg, mixing, pulverizes.Make powder, oral free from extraneous odour.
embodiment 16
Solid carbon dioxide trematodiasis 5kg, adds milk powder 4kg, mixing, pulverizes.Make powder, oral free from extraneous odour.
Claims (7)
1. a processing method for free from extraneous odour Hirudo powder, is characterized in that: the course of processing adds milk.
2. the processing method of a kind of free from extraneous odour Hirudo powder according to claim 1, is characterized in that: the amount adding milk is fresh Hirudo by weight: milk=1:0.5-10.
3. the processing method of a kind of free from extraneous odour Hirudo powder according to claim 1, is characterized in that: the running water trematodiasis boiling water of seizure scalds dead, dry after adding milk.
4. the processing method of a kind of free from extraneous odour Hirudo powder according to claim 1, is characterized in that: the running water trematodiasis of seizure puts into the 1-10 milk that boils doubly by weight, dry.
5. the processing method of a kind of free from extraneous odour Hirudo powder according to claim 1, is characterized in that: solid carbon dioxide trematodiasis is dry after adding milk.
6. according to the processing method of a kind of free from extraneous odour Hirudo powder of claim 1 or claim 2, it is characterized in that: solid carbon dioxide trematodiasis is dry after adding milk, and the amount adding milk is solid carbon dioxide trematodiasis by weight: milk=1:1-30.
7. the processing method of a kind of free from extraneous odour Hirudo powder according to claim 1, is characterized in that: solid carbon dioxide trematodiasis adds milk powder, mixing, and pulverize, the amount adding milk powder is solid carbon dioxide trematodiasis by weight: milk powder=1:0.1-3.
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| CN201510096344.1A CN104622909A (en) | 2015-03-05 | 2015-03-05 | Method for processing high-activity and no-smell leeches |
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| CN201510096344.1A CN104622909A (en) | 2015-03-05 | 2015-03-05 | Method for processing high-activity and no-smell leeches |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802649A (en) * | 2017-11-21 | 2018-03-16 | 广西远程水蛭养殖有限公司 | The preparation method of the full powder of leech |
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- 2015-03-05 CN CN201510096344.1A patent/CN104622909A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802649A (en) * | 2017-11-21 | 2018-03-16 | 广西远程水蛭养殖有限公司 | The preparation method of the full powder of leech |
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