CN104739875A

CN104739875A - Processing method of leeches

Info

Publication number: CN104739875A
Application number: CN201510096362.XA
Authority: CN
Inventors: 方方; 张晶; 马玉奎; 刘金磊; 石红艳
Original assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Current assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Priority date: 2015-03-05
Filing date: 2015-03-05
Publication date: 2015-07-01

Abstract

The invention provides a processing method of leeches. The method comprises the following steps: putting live leeches into 1-10 folds of boiling milk, scalding to death, and then drying. The prepared leeches are high in biological activity, free of odor when taken orally, and high in compliance of patients.

Description

The processing method of a kind of Hirudo

Invention field

The present invention relates to medicine, particularly the processing method of a kind of Hirudo, belong to medical art.

Background technology

Hirudo begins to be loaded in Shennong's Herbal, the version Pharmacopoeia of the People's Republic of China one in 2010 record the Hirudo of hyoscine be Hirudinidae animal whitmania, Hirudo and Folium Salicis Babylonicae Hirudo drying all.Hirudo tool closed by the stagnant blood blood stasis moon, effect that removing blood stasis abdominal mass is gathered, and can be used for cerebrovascular disease clinically, seminal fluid is not changed, prostate hyperplasia, the treatment of the various diseases such as uterine apoplexy syndrome.

The drying means that " Chinese Pharmacopoeia " 2010 version () records Hirudo is the summer, Qiu Erji catches, and scalds dead, dry or cold drying with boiling water.The Hirudo powder warm water of prior art processing is taken after mixing it with water, and abnormal flavour is extra heavy, and mouthfeel is very poor, directly affects the compliance of patient." Shandong Province's prepared slices of Chinese crude drugs concocted specification " records " Hirudo powder should encapsulatedly be swallowed " under usage and dosage item, but " encapsulated " is both inconvenient in family's operation, cannot ensure the quality of products again.The Hirudo concocting method provide a kind of and improve curative effect, improved mouthfeel is very necessary.

Summary of the invention

The object of this invention is to provide the concocting method of a kind of new Hirudo.

Technical scheme of the present invention is as follows:

A processing method for Hirudo, is characterized in that: running water trematodiasis is put into the 1-10 milk that boils doubly by weight and scalds dead, together dry.

Hirudo of the present invention comprises Hirudinidae animal whitmania, Hirudo and Folium Salicis Babylonicae Hirudo.

So far the present invention is completed.The Hirudo biological activity that the present invention obtains is high, oral free from extraneous odour, and the compliance of patient is high.

Below by test example, usefulness of the present invention is described.Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.

The Hirudo mouthfeel of test example one, distinct methods processing compares

1, by same mass products Hirudo, process by the following method.

1) boiling water scalds dead oven dry: scald with boiling water dead, less than 60 DEG C oven dry, pulverize;

2) milk that boils scalds dead oven dry: use the milk that boils of 2 times by weight to scald dead, together dry for less than 60 DEG C, pulverize.

2, mouthfeel evaluation is made up of 10 people and appraises group through discussion, everyone boiling water that warm water for oral use is mixed well respectively scalds in milk of extremely drying and boil and scalds dead Hirudo powder of drying, and evaluates the mouthfeel mouthfeel such as " very well ", " better ", " can accept ", " poor ", " very poor ".The results are shown in Table 1

The Hirudo powder mouthfeel of table 1 distinct methods processing compares

	Very well	Better	Can accept	Poor	Very poor
						The milk that boils scalds dead oven dry	0 people	2 people	8 people	0 people	0 people
Boiling water scalds dead oven dry	0 people	0 people	0 people	1 people	9 people

Result shows, and the Hirudo scalded in the milk that boils and extremely together dry is described, oral abnormal flavour is little, and mouthfeel is good, and the compliance of patient is good.

The Hirudo of test example two, distinct methods processing is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level

1, by same mass products Hirudo, process by the following method.

1) boiling water scalds dead: scald with boiling water dead, less than 60 DEG C drying under reduced pressure, pulverize;

2) milk that boils scalds dead: scald dead with the milk that boils of 5 times by weight, 60 DEG C below together drying under reduced pressure, pulverizing.

2, the Hirudo powder of distinct methods processing is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level

She draws meat rabbit 120 to select physical health, be divided into 4 groups at random, often organize 30, namely matched group (normal feedstuff of feeding), high fat group (high lipid food of feeding), boiling water scald dead dry group (add boiling water in 100g high lipid food and scald dead dry Hirudo powder 0.5g), the milk that boils scalds dead dry group and (add the milk that boils in 100g high lipid food and scald dead dry Hirudo powder 0.5g, after testing milk lyophilizing, solid contents is 12%, and addition is in sterling).The each group of all single cage of rabbit is raised, limit appetite, and every rabbit 100g every day feedstuff, freely drinks water, and tests 30d blood sampling, measures T-CHOL, triglyceride, HDL-C (high density), low-density lipoprotein cholesterol content (low-density) in serum.The results are shown in Table 2

The Hirudo powder of table 2 distinct methods processing is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level

	To group	High fat group	Boiling water scalds dead group	The milk that boils scalds dead group
					T-CHOL	2.082±0.176	3.892±0.369	2.624±0.325	2.124±0.092
Triglyceride	0.767±0.245	1.914±0.047	1.028±0.143	0.769±0.138
					High density	1.038±0.096	1.320±0.253	1.210±0.069	1.115±0.054
Low-density	0.635±0.236	1.745±0.103	0.842±0.052	0.673±0.105

Result shows, high lipid food can make Sanguis Leporis seu oryctolagi lipid level get muddled, and adds the blood lipid level that Hirudo powder can improve high lipid food rabbit feeding in high lipid food, and the milk that boils scalds dead together dry curative effect and is better than boiling water and scalds dead dry.

The Hirudo antithrombin activity (U) of test example three, distinct methods processing compares

1, by same mass products Folium Salicis Babylonicae Hirudo, dry by the following method.

1) boiling water scalds dead dry: scald dead with boiling water, less than 60 DEG C drying under reduced pressure;

2) milk that boils scalds dead dry: scald dead with the milk that boils of 10 times by weight, less than 60 DEG C together drying under reduced pressure.

2, the Hirudo antithrombin activity (U) that distinct methods is concocted compares.

Measure according to determination under " Chinese Pharmacopoeia " version (one) Hirudo item in 2010, the results are shown in Table 3.

The Hirudo antithrombin activity of table 3 distinct methods processing compares

Concocting method	Antithrombin activity (U)
		Boiling water scalds dead dry	9.3
The milk that boils scalds dead dry	16.2

Result shows, the Hirudo antithrombase content (activity) of two kinds of method dryings all meets States Pharmacopoeia specifications, and the milk that boils scalds dead together dry Hirudo antithrombase content (activity) and scalds dead dry Hirudo apparently higher than boiling water.

Detailed description of the invention

embodiment 1

Running water trematodiasis 5kg, the milk that boils putting into 5kg scalds dead, together dries.

embodiment 2

Live Folium Salicis Babylonicae Hirudo 5kg, and the milk that boils putting into 10kg scalds dead, together dries for less than 60 DEG C.

embodiment 3

Live Hirudo 5kg, puts into the 50kg milk that boils and scald dead, cool, together put in freeze dryer, be refrigerated to less than-10 DEG C, be evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation should control below 40 DEG C, and the temperature of resolution phase controls below 45 DEG C, to dry.

embodiment 4

Live Folium Salicis Babylonicae Hirudo 5kg, puts into the 20kg milk that boils and scald dead, less than 60 DEG C, together vacuum drying.

embodiment 5

Running water trematodiasis 5kg, puts into the 15kg milk that boils and scalds dead, less than 60 DEG C, together vacuum drying.

embodiment 6

Running water trematodiasis 5kg, puts into the 8kg milk that boils and scalds dead, together microwave drying.

Claims

1. a processing method for Hirudo, is characterized in that: running water trematodiasis is put into the 1-10 milk that boils doubly by weight and scalds dead, together dry.