CN104606243A - Preparation method of leech powder without peculiar smell - Google Patents
Preparation method of leech powder without peculiar smell Download PDFInfo
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- CN104606243A CN104606243A CN201510096343.7A CN201510096343A CN104606243A CN 104606243 A CN104606243 A CN 104606243A CN 201510096343 A CN201510096343 A CN 201510096343A CN 104606243 A CN104606243 A CN 104606243A
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- hirudo
- powder
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- milk powder
- extraneous odour
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Abstract
The invention provides a preparation method of leech powder without a peculiar smell. The preparation method comprises the following steps: adding milk powder, and crushing together. The prepared leech powder is small in peculiar smell during oral administration, good in mouthfeel and high in patient compliance.
Description
Invention field
The present invention relates to medicine, particularly a kind of preparation method of free from extraneous odour Hirudo powder, belong to medical art.
Background technology
Hirudo begins to be loaded in Shennong's Herbal, and the drying for Hirudinidae animal whitmania, Hirudo or Folium Salicis Babylonicae Hirudo that the version Pharmacopoeia of the People's Republic of China one in 2010 records hyoscine is all.Hirudo tool closed by the stagnant blood blood stasis moon, effect that removing blood stasis abdominal mass is gathered, and can be used for cerebrovascular disease clinically, seminal fluid is not changed, prostate hyperplasia, the treatment of the various diseases such as uterine apoplexy syndrome.
The processing method that " Chinese Pharmacopoeia " 2010 version () records Hirudo is the summer, Qiu Erji catches, and scalds dead, dry or cold drying with boiling water.The Hirudo powder mixing in water for oral taking of prior art processing preparation, the abnormal flavour of Hirudo is extra heavy, and mouthfeel is very poor, directly affects the compliance of patient." Shandong Province's prepared slices of Chinese crude drugs concocted specification " records " Hirudo powder should encapsulatedly be swallowed " under usage and dosage item, but " encapsulated " is both inconvenient in family's operation, cannot ensure the quality of products again.The Hirudo powder preparation method provide a kind of and improve curative effect, improved mouthfeel is very necessary.
Summary of the invention
The object of this invention is to provide a kind of preparation method of free from extraneous odour Hirudo powder.
The object of the present invention is achieved like this:
A preparation method for free from extraneous odour Hirudo powder, is characterized in that: add milk powder and together pulverize.
The preparation method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: the amount adding milk powder is more than 0.1 times by weight.
The preparation method of a kind of free from extraneous odour Hirudo powder of the present invention, is characterized in that: the amount entering powder with milk is more than 0.5-3 times by weight.
The preparation method of a kind of free from extraneous odour Hirudo of the present invention, is characterized in that: the amount adding milk powder is 1 times by weight.
The preparation method of a kind of free from extraneous odour Hirudo of the present invention, is characterized in that: replace with and add milk powder in Hirudo powder.
Hirudo of the present invention comprises Hirudinidae animal whitmania, Hirudo and Folium Salicis Babylonicae Hirudo.
So far the present invention is completed.The preparation method of a kind of free from extraneous odour Hirudo powder of the present invention, under the medicable prerequisite of maintenance hirugen, oral abnormal flavour is little, and mouthfeel is good, and the compliance of patient is high.
Below by test example, usefulness of the present invention is described.Test example is intended to further illustrate beneficial effect of the present invention, but not restriction of the present invention.
Hirudo powder mouthfeel prepared by test example one, distinct methods compares
1, with a collection of solid carbon dioxide trematodiasis, will prepare by the following method respectively.
1) directly pulverize;
2) add milk powder to pulverize: add 0.1 times of milk powder, pulverize.
2, mouthfeel compares
Be made up of 10 people and appraise group through discussion, everyone warm water for oral use direct pulverizing of mixing well and add the Hirudo powder that milk powder pulverizes respectively, evaluates the mouthfeel mouthfeel such as " very well ", " better ", " can accept ", " poor ", " very poor ".Evaluation result is in table 1
Hirudo powder mouthfeel powder mouthfeel prepared by table 1 distinct methods compares
| Very well | Better | Can accept | Poor | Very poor | |
| Add milk powder to pulverize | 0 people | 4 people | 6 people | 0 people | 0 people |
| Direct pulverizing | 0 people | 0 people | 0 people | 4 people | 6 people |
Result shows, and Hirudo adds milk powder and pulverizes, and oral abnormal flavour is little, and mouthfeel is good.
Hirudo powder prepared by test example two, distinct methods is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
1, with a collection of dry Hirudo, Hirudo powder will be prepared by the following method.
1) directly pulverize;
2) add milk powder to pulverize: add 0.5 times of milk powder, pulverize.
2, the Hirudo powder prepared of distinct methods is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
She draws meat rabbit 120 to select physical health, be divided into 4 groups at random, often organize 30, namely matched group (normal feedstuff of feeding), high fat group (high lipid food of feeding), directly pulverizing group (adding Hirudo powder 0.5g in 100g high lipid food), add milk powder pulverizing group (add in 100g high lipid food containing clean Hirudo powder 0.5g add milk powder pulverize Hirudo).The each group of all single cage of rabbit is raised, limit appetite, and every rabbit 100g every day feedstuff, freely drinks water, and tests 30d blood sampling, measures T-CHOL, triglyceride, HDL-C (high density), low-density lipoprotein cholesterol content (low-density) in serum.The results are shown in Table 2
Hirudo powder prepared by table 2 distinct methods is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
| To group | High fat group | Direct pulverizing group | Add milk powder pulverizing group | |
| T-CHOL | 2.082±0.176 | 3.892±0.369 | 2.635±0.328 | 2.635±0.329 |
| Triglyceride | 0.767±0.245 | 1.914±0.047 | 1.032±0.117 | 1.032±0.115 |
| High density | 1.038±0.096 | 1.320±0.253 | 1.215±0.072 | 1.215±0.076 |
| Low-density | 0.635±0.236 | 1.745±0.103 | 0.864±0.031 | 0.864±0.033 |
Result shows, high lipid food can make Sanguis Leporis seu oryctolagi lipid level get muddled, add the blood lipid level that Hirudo powder can improve high lipid food rabbit feeding in high lipid food, and Hirudo powder effect prepared by distinct methods is suitable, illustrates and adds the curative effect that milk powder does not affect Hirudo.
Hirudo antithrombin activity (U) prepared by test example three, distinct methods compares
1, will with a collection of dry Folium Salicis Babylonicae Hirudo, drying by the following method.
1) directly pulverize;
2) add milk powder to pulverize: add 1 times of milk powder, pulverize.
2, the Hirudo antithrombin activity (U) that prepared by distinct methods compares.
Measure (Hirudo adding milk powder pulverizing calculates by water purification trematodiasis) according to determination under " Chinese Pharmacopoeia " version (one) Hirudo item in 2010, the results are shown in Table 3.
Hirudo antithrombin activity prepared by table 3 distinct methods compares
| Concocting method | Antithrombin activity (U) |
| Direct pulverizing | 12.6 |
| Add milk powder to pulverize | 12.6 |
As a result, calculate Hirudo antithrombin activity prepared by two kinds of methods by water purification trematodiasis suitable, illustrate and add the curative effect that milk powder does not affect Hirudo.
Detailed description of the invention
embodiment 1
Solid carbon dioxide trematodiasis 2kg, adds milk powder 0.2kg, mixing, pulverizes, obtains free from extraneous odour Hirudo powder.
embodiment 2
Dry Folium Salicis Babylonicae Hirudo 2kg, adds milk powder 2kg, mixing, pulverizes, obtains free from extraneous odour Hirudo powder.
embodiment 3
Dry Hirudo 2kg, adds milk powder 1kg, mixing, pulverizes, obtains free from extraneous odour Hirudo powder.
embodiment 4
Solid carbon dioxide trematodiasis 2kg, adds milk powder 6kg, mixing, pulverizes, obtains free from extraneous odour Hirudo powder.
embodiment 5
Solid carbon dioxide trematodiasis 2kg, adds milk powder 0.5kg, mixing, pulverizes, obtains free from extraneous odour Hirudo powder.
embodiment 6
Solid carbon dioxide trematodiasis 2kg, adds milk powder 15kg, mixing, pulverizes, obtains free from extraneous odour Hirudo powder.
embodiment 7
Solid carbon dioxide trematodiasis 2kg, adds milk powder 20kg, mixing, pulverizes, obtains free from extraneous odour Hirudo powder.
Claims (5)
1. a preparation method for free from extraneous odour Hirudo powder, is characterized in that: add milk powder and together pulverize.
2. the preparation method of a kind of free from extraneous odour Hirudo powder according to claim 1, is characterized in that: the amount adding milk powder is more than 0.1 times by weight.
3. according to the preparation method of a kind of free from extraneous odour Hirudo powder of claim 1 or claim 2, it is characterized in that: the amount entering powder with milk is more than 0.5-3 times by weight.
4., according to the preparation method of a kind of free from extraneous odour Hirudo of claim 1 or claim 2 or claim 3, it is characterized in that: the amount adding milk powder is 1 times by weight.
5., according to the preparation method of a kind of free from extraneous odour Hirudo of claim 1 or claim 2 or claim 3 or claim 4, it is characterized in that: replace with and add milk powder in Hirudo powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510096343.7A CN104606243A (en) | 2015-03-05 | 2015-03-05 | Preparation method of leech powder without peculiar smell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510096343.7A CN104606243A (en) | 2015-03-05 | 2015-03-05 | Preparation method of leech powder without peculiar smell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104606243A true CN104606243A (en) | 2015-05-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510096343.7A Pending CN104606243A (en) | 2015-03-05 | 2015-03-05 | Preparation method of leech powder without peculiar smell |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104606243A (en) |
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2015
- 2015-03-05 CN CN201510096343.7A patent/CN104606243A/en active Pending
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| PB01 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150513 |
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| WD01 | Invention patent application deemed withdrawn after publication |