CN104606245A - Freeze-drying method for leeches without peculiar smell - Google Patents
Freeze-drying method for leeches without peculiar smell Download PDFInfo
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- CN104606245A CN104606245A CN201510096364.9A CN201510096364A CN104606245A CN 104606245 A CN104606245 A CN 104606245A CN 201510096364 A CN201510096364 A CN 201510096364A CN 104606245 A CN104606245 A CN 104606245A
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- hirudo
- lyophilizing
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Abstract
The invention relates to a freeze-drying method for leeches without a peculiar smell. The freeze-drying method comprises the following steps: freeze-drying leeches together with milk, wherein in terms of weight, the using amount of the milk is 1-5 times that of the leeches. The prepared medicinal leeches are high in therapeutic effect, small in peculiar smell during oral administration and high in patient compliance.
Description
Invention field
The present invention relates to medicine method for making, particularly the freeze drying process of a kind of free from extraneous odour Hirudo, belong to medical art.
Background technology
Hirudo is conventional Chinese medicine.Version " Chinese Pharmacopoeia " in 2010 record the Hirudo of hyoscine be Hirudinidae animal whitmania, Hirudo and Folium Salicis Babylonicae Hirudo drying all.Hirudo tool closed by the stagnant blood blood stasis moon, effect that removing blood stasis abdominal mass is gathered, and can be used for cerebrovascular disease clinically, seminal fluid is not changed, prostate hyperplasia, the treatment of the various diseases such as uterine apoplexy syndrome.
The drying means that " Chinese Pharmacopoeia " 2010 version () records Hirudo is the summer, Qiu Erji catches, and scalds dead, dry or cold drying with boiling water.The Hirudo method of prior art drying, abnormal flavour is extra heavy, and mouthfeel is very poor, directly affects the compliance of patient." Shandong Province's prepared slices of Chinese crude drugs concocted specification " records " Hirudo powder should encapsulatedly be swallowed " under usage and dosage item, but " encapsulated " is both inconvenient in family's operation, cannot ensure the quality of products again, and also increase patient economy burden further.
Vacuum lyophilization, also known as lyophilizing, can be preserved the activity of effective medicinal components to greatest extent, keep the exterior quality of medical material, color, abnormal smells from the patient preferably, and thoroughly, keeping quality is good in dehydration.But lyophilizing Hirudo abnormal flavour is still extra heavy, and mouthfeel is still very poor, direct oral patient is still difficult to accept.Study a kind of drying means improving Hirudo curative effect, improve mouthfeel, very necessary.
Summary of the invention
The object of this invention is to provide the freeze drying process of a kind of free from extraneous odour Hirudo, make the Hirudo curative effect of lyophilizing high, oral abnormal flavour is little, and clinical effectiveness is good.
The present invention is achieved in that
A freeze drying process for free from extraneous odour Hirudo, is characterized in that: in milk, together lyophilizing.
The freeze drying process of a kind of free from extraneous odour Hirudo of the present invention, is characterized in that: milk consumption is 1-5 times of Hirudo by weight.
The freeze drying process of a kind of free from extraneous odour Hirudo of the present invention, is characterized in that: running water trematodiasis puts into milk, together lyophilizing.
The freeze drying process of a kind of free from extraneous odour Hirudo of the present invention, is characterized in that: running water trematodiasis is put into the milk that boils and scalds dead, together lyophilizing.
The freeze drying process of a kind of free from extraneous odour Hirudo of the present invention, is characterized in that: lyophilizing is refrigerated to less than-10 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation should control below 45 DEG C, and the temperature of resolution phase controls below 50 DEG C, to dry.
Hirudo provincialis curative effect prepared by the present invention is high, and oral abnormal flavour is little, and the compliance of patient is high.
Hirudo of the present invention refer to Hirudinidae animal whitmania, Hirudo and Folium Salicis Babylonicae Hirudo drying all.
Test example is intended to further illustrate usefulness of the present invention below, but not limitation of the present invention.
The Hirudo mouthfeel of test example one, distinct methods lyophilizing compares
1, by same mass products Hirudo, lyophilizing by the following method respectively.
1) lyophilizing: put in freeze dryer, be refrigerated to-20 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and the temperature of distillation should control at 40 DEG C, and the temperature of resolution phase controls at 45 DEG C, to dry;
2) lyophilizing with milk: the milk putting into 1 times by weight, together puts in freeze dryer, is refrigerated to-20 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and the temperature of distillation should control at 40 DEG C, and the temperature of resolution phase controls at 45 DEG C, to dry.
2, mouthfeel evaluation
1) be made up of 10 people and appraise group through discussion, everyone boiling water that warm water for oral use is mixed well respectively scalds the Leech that dead lyophilizing and the milk that boils scald dead lyophilizing, evaluates the mouthfeel mouthfeel concept such as " very well ", " better ", " can accept ", " poor ", " very poor ".
2) evaluation result evaluation result is in table 1
The Hirudo mouthfeel of table 1 distinct methods lyophilizing compares
| Very well | Better | Can accept | Poor | Very poor | |
| Lyophilizing with milk | 1 people | 3 people | 6 people | 0 people | 0 people |
| Lyophilizing | 0 people | 0 people | 0 people | 0 people | 10 people |
Result shows, and the Hirudo of lyophilizing with milk, oral abnormal flavour is little, and mouthfeel is good.
The Hirudo of test example two, distinct methods lyophilizing is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
1, by same mass products Hirudo, lyophilizing by the following method respectively.
1) boiling water scalds dead lyophilizing: boiling water scalds dead, and put in freeze dryer, be refrigerated to-10 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation should control at 45 DEG C, and the temperature of resolution phase controls at 50 DEG C, to dry;
2) lyophilizing in milk: the milk that boils putting into 2 times by weight scalds dead, cools, together puts in freeze dryer, be refrigerated to-10 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation should control at 45 DEG C, and the temperature of resolution phase controls at 50 DEG C, to dry.
2, the hirudo provincialis of distinct methods lyophilizing is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
She draws meat rabbit 120 to select physical health, be divided into 4 groups at random, often organize 30, namely matched group (normal feedstuff of feeding), high fat group (high lipid food of feeding), boiling water scald lyophilizing group in dead lyophilizing group (add boiling water in 100g high lipid food and scald dead lyophilizing Hirudo powder 0.5g), milk (solid contents are 12% after testing milk lyophilizing, in sterling, in 100g high lipid food, add lyophilizing Hirudo powder 0.5g in milk).The each group of all single cage of rabbit is raised, limit appetite, and every rabbit 100g every day feedstuff, freely drinks water, and tests 30d blood sampling, measures T-CHOL, triglyceride, HDL-C (high density), low-density lipoprotein cholesterol content (low-density) in serum.
The results are shown in Table 2
The hirudo provincialis powder of table 2 distinct methods lyophilizing is on the impact of high fat diet Sanguis Leporis seu oryctolagi lipid level
| To group | High fat group | The dead lyophilizing group of having one's hair waved | Lyophilizing group in milk | |
| T-CHOL | 2.082±0.176 | 3.892±0.369 | 2.243±0.235 | 2.125±0.182 |
| Triglyceride | 0.767±0.245 | 1.914±0.047 | 0.817±0.107 | 0.778±0.136 |
| High density | 1.038±0.096 | 1.320±0.253 | 1.086±0.064 | 1.054±0.063 |
| Low-density | 0.635±0.236 | 1.745±0.103 | 0.716±0.108 | 0.656±0.097 |
Result shows, high lipid food can make Sanguis Leporis seu oryctolagi lipid level get muddled, add the blood lipid level that Hirudo powder can improve high lipid food rabbit feeding in high lipid food, the hirudo provincialis curative effect of lyophilizing in milk is better than the hirudo provincialis that boiling water scalds dead lyophilizing, and then known curative effect is high.
The Hirudo antithrombin activity (U) that test example three, distinct methods are concocted compares
1, by same mass products Folium Salicis Babylonicae Hirudo, lyophilizing by the following method respectively.
1) boiling water scalds dead lyophilizing: boiling water scalds dead, and put in freeze dryer, be refrigerated to-28 DEG C, be evacuated to drying chamber pressure 40Pa, subliming by heating, the temperature of distillation should control at 45 DEG C, and the temperature of resolution phase controls at 45 DEG C, to dry;
2) lyophilizing in milk: the milk that boils putting into 3 times by weight scalds dead, and cool, put in freeze dryer, be refrigerated to-28 DEG C, be evacuated to drying chamber pressure 40Pa, subliming by heating, the temperature of distillation should control at 45 DEG C, and the temperature of resolution phase controls at 45 DEG C, to dry.
2, the hirudo provincialis antithrombin activity (U) of distinct methods drying compares.
Measure according to determination under " Chinese Pharmacopoeia " version (one) Hirudo item in 2010, the results are shown in Table the Hirudo of lyophilizing in 3(milk in sterling).
The Hirudo antithrombin activity that table 3 distinct methods is concocted compares
| Processing method | Antithrombin activity (U) |
| Boiling water scalds dead lyophilizing | 13.5 |
| Lyophilizing in milk | 15.8 |
Result shows, the hirudo provincialis antithrombase content (activity) of lyophilizing in milk scalds dead lyophilizing hirudo provincialis powder higher than boiling water, and then known curative effect is high.
Detailed description of the invention
embodiment 1
Running water trematodiasis 5kg, put into the 5kg milk that boils and scald dead, cool, together put in freeze dryer, be refrigerated to-10 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls at 45 DEG C, and the temperature of resolution phase controls at 50 DEG C, to dry.Obtain the Hirudo of free from extraneous odour.
embodiment 2
Live Folium Salicis Babylonicae Hirudo 5kg, and put into 25kg milk, together put in freeze dryer, be refrigerated to-28 DEG C, be evacuated to drying chamber pressure 40Pa, subliming by heating, the temperature of distillation controls at 40 DEG C, and the temperature of resolution phase controls at 45 DEG C, to dry.Obtain the Hirudo of free from extraneous odour.
embodiment 3
Live Hirudo 5kg, and put into the 15kg milk that boils and scald dead, cool, together put in freeze dryer, put in freeze dryer, be refrigerated to-32 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls at 30 DEG C, and the temperature of resolution phase controls at 30 DEG C, to dry.Obtain the Hirudo of free from extraneous odour.
embodiment 4
Running water trematodiasis 5kg, puts into 7kg milk, together puts in freeze dryer, is refrigerated to-20 DEG C, is evacuated to drying chamber pressure 50Pa, subliming by heating, and the temperature of distillation controls at 25 DEG C, and the temperature of resolution phase controls at 45 DEG C, to dry.Obtain the Hirudo of free from extraneous odour.
Claims (4)
1. a freeze drying process for free from extraneous odour Hirudo, is characterized in that: in milk, together lyophilizing.
2. the freeze drying process of a kind of free from extraneous odour Hirudo according to claim 1, is characterized in that: milk consumption is 1-5 times of Hirudo by weight.
3. the freeze drying process of a kind of free from extraneous odour Hirudo according to claim 1, is characterized in that: running water trematodiasis puts into milk, together lyophilizing.
4. the freeze drying process of a kind of free from extraneous odour Hirudo according to claim 1, is characterized in that: running water trematodiasis is put into the milk that boils and scalds dead, together lyophilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510096364.9A CN104606245A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method for leeches without peculiar smell |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510096364.9A CN104606245A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method for leeches without peculiar smell |
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| CN104606245A true CN104606245A (en) | 2015-05-13 |
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| CN201510096364.9A Pending CN104606245A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method for leeches without peculiar smell |
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Application publication date: 20150513 |
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