CN104189200B - A kind of emulsifiable paste for the treatment of eczema and preparation method thereof - Google Patents
A kind of emulsifiable paste for the treatment of eczema and preparation method thereof Download PDFInfo
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- CN104189200B CN104189200B CN201410501172.7A CN201410501172A CN104189200B CN 104189200 B CN104189200 B CN 104189200B CN 201410501172 A CN201410501172 A CN 201410501172A CN 104189200 B CN104189200 B CN 104189200B
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Abstract
The invention provides a kind of emulsifiable paste for the treatment of eczema and preparation method thereof, formed by the component of following mass parts: 5～15 parts of the root barks of tree peony, 5～15 parts of golden cypresses, 5～15 parts of Asian puccoons, 3～12 parts of balloonflower roots, 3～12 parts of the radix paeoniae rubrathe, 30～50 parts of glycerine, 500～1000 parts of oil-in-water type emulsifiable paste matrixes. The emulsifiable paste for the treatment of eczema provided by the invention has clearing heat and detoxicating, and effect that eliminating dampness is antipruritic can effectively be treated acute and chronic eczema, neurodermatitis, contact dermatitis, allergic dermatitis, folliculitis by affected part of exterior coating. And the present invention can be applicable to infant and sensitiveness skin quality crowd, without any side effects, evident in efficacy, no sequel is easy to use, safety.
Description
Technical field
The present invention relates to a kind of medicinal cream, be specifically related to a kind of emulsifiable paste for the treatment of eczema and preparation method thereof, belong to biological medicine technology field.
Background technology
Eczema is the inflammatory skin disease of a kind of common epidermis being caused by multiple internal and external factor and high dermis. There is the features such as symmetry, exudative, pruritus dermatopathy, polymorphy and recurrent. Clinical manifestation is that skin damages as polymorphy, and taking erythema, papule, papulo-vesicle as main, fash central authorities obviously, scatter gradually towards periphery, indefinite border, and diffusivity, has the tendency of oozing out.
Infantile eczema is called tire leprosy, infantile eczema, tire wind, tire red etc., a multitude of names on traditional Chinese medical science ancient literature. In " doctor ancestor takes mirror surgery heart method gist ", describe comparatively definitely: an impetigo glabella that starts, in tire, blood-head wind-engaging twines, the wet excessive water of the dry white bits of itching, thermoae blush class erysipelas. Add: the raw baby of this card crown, or raw tip of the brow, have another name called infantile eczema. Itched and considered to be worth doing in vain, shape is as tinea scabies, by blood-head in tire. The wind-engaging of taking to the greenwood is touching, and this is dry abnormal pigmentary deposit on the skin. Have misuse to scald, skin plays grain, and itch is immoderate. yellow water contamination, prolong and all over, wet Chi. Infantile eczema is one of paediatrics common disease frequently-occurring disease. With local erythema, papule, blister, have that juice oozes out, rotten to the corn, itch and repeatedly outbreak be its main feature. This sick origin cause of formation is many by the pungent scorching thing of wet nurse's overfeeding, by the transmission of breast milk, causes baby to be stranded by damp and hot, transformation failure of spleen. More double baby is the body of young sun, deiciency of primordial QI, and damp and hot heresy is attacked in space between skin and muscles, the inside and outside damp and hot knot of fighting mutually, i.e. cost disease. If hold concurrently mutually with ailment said due to cold or exposure damp and hot, benefaction number becomes, and itch is obvious, rises one after another; If damp and hotization is fiery, rising body fluid, shows as again the flowing water that festers, and affected part skin and flesh is scarlet.
At present, if the drug main for the treatment of acute eczema is selected appropriate dosage forms and medicine according to skin damage situation, as tacrolimus ointment, pimecrolimus ointment etc., there is the deficiencies such as not obvious, the easy recurrence of curative effect, toxic and side effect are large. But eczema ointment on the market seldom can be used for baby, or the curative effect again that baby can be suitable for is bad, causes the illness time long, also can cause that baby loses the appetite, the problem such as do not have enough sleep.
Summary of the invention
Can not be suitable for the problem such as baby or weak curative effect for solving eczema ointment of the prior art, the invention provides a kind of emulsifiable paste for the treatment of eczema and preparation method thereof.
The present invention realizes by following technical proposal: a kind of emulsifiable paste for the treatment of eczema, is made up of the component of following mass parts:
5～15 parts of the root barks of tree peony,
5～15 parts of golden cypresses,
5～15 parts of Asian puccoons,
3～12 parts of balloonflower roots,
3～12 parts of the radix paeoniae rubrathe,
30～50 parts of glycerine,
500～1000 parts of oil-in-water type emulsifiable paste matrixes.
Wherein, the root bark of tree peony: have another name called moutan bark, nature and flavor: cold, hardship, cool, be slightly cold; Return: the heart, liver, kidney, lung channel; Effect: clearing heat and cooling blood; Promoting blood circulation to remove blood stasis. Golden cypress: nature and flavor: bitter, cold; Gui Jing: kidney, bladder, large intestine channel; Effect: clearing heat and detoxicating; Heat-clearing and damp-drying drug. Asian puccoon: nature and flavor: cold, sweet, salty; Gui Jing: the heart, Liver Channel; Effect: cool blood, invigorate blood circulation, removing toxic substances promoting eruption. Balloonflower root: nature and flavor: bitter, pungent, slightly warm in nature; Gui Jing: lung channel; Effect:A surname's lung, eliminate the phlegm, relieve sore throat, apocenosis, sharp the five internal organs, fill blood, mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility. The radix paeoniae rubrathe: nature and flavor: hardship, is slightly cold; Gui Jing: Liver Channel; Effect: clearing heat and cooling blood, blood stasis removing analgesic. Each composition of the present invention is national corporation of medical herbs commercially available prod.
The invention provides the pharmacological action of medicine: the root bark of tree peony has effect of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, for sending out spot, carbuncle sore tumefacting virus. Golden cypress tool is clearing heat and detoxicating; The effect of heat-clearing and damp-drying drug, for skin sore; Skin eczema. Asian puccoon has cool blood, invigorates blood circulation, and the effect of removing toxic substances promoting eruption,, measles without adequate eruption black for macula purple, sore, eczema, burn. Balloonflower root has a surname's lung, eliminates the phlegm, relieve sore throat, apocenosis, sharp the five internal organs, fill blood, mend the exhaustion or lesion of the five internal organs, the effect such as foster the spirit of nobility, for anti-inflammatory, calmness, analgesia and antipyretic. The radix paeoniae rubrathe has effect of clearing heat and cooling blood, blood stasis removing analgesic, for carbuncle sore tumefacting virus. Each composition of the present invention is national corporation of medical herbs commercially available prod.
The emulsifiable paste for the treatment of eczema provided by the invention, makes through the following step:
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
5～15 parts of the root barks of tree peony,
5～15 parts of golden cypresses,
5～15 parts of Asian puccoons,
3～12 parts of balloonflower roots,
3～12 parts of the radix paeoniae rubrathe,
30～50 parts of glycerine,
500～1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
The present invention possesses following advantages and effect: the emulsifiable paste for the treatment of eczema provided by the invention has clearing heat and detoxicating, and effect that eliminating dampness is antipruritic can effectively be treated acute and chronic eczema, neurodermatitis, contact dermatitis, allergic dermatitis, folliculitis by affected part of exterior coating. And the present invention can be applicable to infant and sensitiveness skin quality crowd, without any side effects, evident in efficacy, no sequel is easy to use, safety.
Detailed description of the invention
Below by embodiment, the present invention will be further described.
Embodiment 1
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
10 parts of the root barks of tree peony,
5 parts of golden cypresses,
5 parts of Asian puccoons,
6 parts of balloonflower roots,
6 parts of the radix paeoniae rubrathe,
50 parts of glycerine,
1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 2
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
15 parts of the root barks of tree peony,
8 parts of golden cypresses,
10 parts of Asian puccoons,
12 parts of balloonflower roots,
3 parts of the radix paeoniae rubrathe,
30 parts of glycerine,
800 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 3
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
5 parts of the root barks of tree peony,
15 parts of golden cypresses,
12 parts of Asian puccoons,
3 parts of balloonflower roots,
12 parts of the radix paeoniae rubrathe,
40 parts of glycerine,
500 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 4
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
12 parts of the root barks of tree peony,
12 parts of golden cypresses,
15 parts of Asian puccoons,
9 parts of balloonflower roots,
6 parts of the radix paeoniae rubrathe,
50 parts of glycerine,
1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 5
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
11 parts of the root barks of tree peony,
9 parts of golden cypresses,
13 parts of Asian puccoons,
10 parts of balloonflower roots,
11 parts of the radix paeoniae rubrathe,
40 parts of glycerine,
1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
Embodiment 6
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
7 parts of the root barks of tree peony,
6 parts of golden cypresses,
14 parts of Asian puccoons,
5 parts of balloonflower roots,
5 parts of the radix paeoniae rubrathe,
30 parts of glycerine,
500 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
The emulsifiable paste of described embodiment gained treatment eczema is lividus emulsifiable paste. Differentiate through following method:
(1) get the about 10g of this product, add ethanol 30mL, ultrasonic processing 30 minutes, lets cool, and puts in ice bath approximately 30 minutes, filter, and filtrate evaporate to dryness, residue lets cool, and dissolves with 1mL ethanol, as need testing solution. Separately get Shikonin reference substance, add ethanol and make the solution of every 1mL containing 1mg. Test according to thin-layered chromatography (annex VIB of Chinese pharmacopoeia), draw the each 10 μ L of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, taking the solution of toluene-ethyl acetate-formic acid (15:1:0.1) as solvent, launch, take out, dry, in test sample chromatogram, with reference substance chromatogram relevant position on the spot of aobvious same color.
(2) get the about 10g of this product, add absolute ethyl alcohol 30mL, in water-bath, heating makes to dissolve, and lets cool, and puts in ice bath approximately 30 minutes, filters, and gets filtrate and is concentrated into 5mL, adds 2g active carbon fully to stir, and filters, and gets filtrate as need testing solution. Separately get Paeonol reference substance, add acetone and make the solution of every 1ml containing 1mg, product solution in contrast. Test according to thin-layered chromatography (two annex VB of Chinese pharmacopoeia), draw the each 10 μ L of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, taking the solution of cyclohexane-ethyl acetate-glacial acetic acid (4:1:0.1) as solvent, launch, take out, dry, spray is with 2% vanillic aldehyde ethanol solution of sulfuric acid (1 → 10) solution, and 105 DEG C to be heated to spot colour developing clear, in test sample chromatogram, then with reference substance chromatogram relevant position on the spot of aobvious same color.
The emulsifiable paste of gained treatment eczema meets the relevant every regulation (annex IR of Chinese pharmacopoeia version in 2010) under ointment item.
Get the emulsifiable paste of above-described embodiment gained treatment eczema, for following clinical treatment:
One, treatment target
Two lower limb papules, companion itches, and is diagnosed as 20 examples (age: 16～40 years old) of eczema; Waist and belly erythema, papule, is diagnosed as 20 examples (age: 16～50 years old) of urticaria; Face red spot, papule, the whole body is dispersed in erythema, is diagnosed as 30 examples (age: 1 monthly age～8 year old) of eczema; Neck side, napex, forehead itch, be liver mossization, is diagnosed as 20 examples (age: 18～30 years old) of neurodermatitis; Acneform eruptions, furfur erythema, be diagnosed as 10 examples (age: 13～20 years old) of contact dermatitis; Pruitus, little red pimple, erythema that a little is scattered, allergic constitution, is diagnosed as 30 examples (age: 10～40 years old) of allergic dermatitis; Red papule, its center hairiness is sent out and is run through, and is diagnosed as 10 examples (age: 20～30 years old) of folliculitis.
Above-mentioned all kinds of cases are divided equally at random for treatment group and each 70 examples of control group.
Two, usage
Treatment group is coated with the emulsifiable paste of above-described embodiment gained treatment eczema outside affected part, and one for several times, is even coated with 5 and observes.
In control group, adult and old man are coated with commercial PINGYANPING RUANGAO outside affected part, and infant uses the rhizoma atractylodis of equal portions and golden cypress to dry levigation and join vegetable oil and is coated with outside affected part, and one for several times, connect to be coated with 5 and to observe.
Three, result
The emulsifiable paste clinical therapeutic efficacy for the treatment of eczema provided by the invention: obvious effective rate reaches 100%, reaches 96% to two lower limb papules, the companion's person of itching eczema cure rate, and 85% above patient's first day erythema weakens, and within the 3rd day, fully recovers; Waist and belly erythema, papule person's urticaria cure rate reach 92%, and 75% above patient's first day erythema weakens, and within second day, fully recover; Face red spot, papule, the whole body are dispersed in erythema person's eczema cure rate and reach 99%, and 80% above patient's first day erythema disappear, and within second day, fully recover, and have 15% patient to smear and fully recover for one day; Neurodermatitis person's cure rate reaches 86%; Contact dermatitis person's cure rate reaches 93%; Allergic dermatitis person's cure rate reaches 98%; Folliculitis person's cure rate reaches 83%.
And control group to two lower limb papules, the companion's person of itching eczema is efficient is 68%; Waist and belly erythema, papule person's urticaria is efficient is 79%; It is 70% that face red spot, papule, the whole body are dispersed in erythema person's eczema efficient; Neurodermatitis person is efficient is 81%; Contact dermatitis person is efficient is 77%; Allergic dermatitis person is efficient is 65%; Folliculitis is efficient is 20%.
Four, conclusion
The compound preparation that the emulsifiable paste for the treatment of eczema provided by the invention is made up of the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe etc., has significant curative effect to acute and chronic eczema, neurodermatitis, contact dermatitis, allergic dermatitis, folliculitis, and its effect is better than control group.
The advantage such as effective in cure good, the application safety of the emulsifiable paste of this treatment eczema, toxic and side effect are little, prepared constant product quality, easy to use, be more suitable in clinical application, and can be applicable to infant and sensitiveness skin quality crowd, without any side effects, evident in efficacy, no sequel, safety.
Claims (2)
1. treat an emulsifiable paste for eczema, it is characterized in that being formed by the component of following mass parts:
5～15 parts of the root barks of tree peony,
5～15 parts of golden cypresses,
5～15 parts of Asian puccoons,
3～12 parts of balloonflower roots,
3～12 parts of the radix paeoniae rubrathe,
30～50 parts of glycerine,
500～1000 parts of oil-in-water type emulsifiable paste matrixes.
2. treat a preparation method for the emulsifiable paste of eczema, it is characterized in that through following each step:
(1) dry after the root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe are cleaned, then to be crushed to granularity be 200 object fine powders;
(2) get the raw materials ready by the component of following mass parts:
5～15 parts of the root barks of tree peony,
5～15 parts of golden cypresses,
5～15 parts of Asian puccoons,
3～12 parts of balloonflower roots,
3～12 parts of the radix paeoniae rubrathe,
30～50 parts of glycerine,
500～1000 parts of oil-in-water type emulsifiable paste matrixes;
(3) by the fine powder of the above-mentioned root bark of tree peony, golden cypress, Asian puccoon, balloonflower root, the radix paeoniae rubrathe, add glycerine to be ground into fine and smooth pasty state, then divide and add oil-in-water type emulsifiable paste matrix for several times, through fully grinding well and obtain the emulsifiable paste for the treatment of eczema.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991686A (en) * | 2009-08-13 | 2011-03-30 | 蔡保君 | Oral Chinese medicine formula for treating eczema |
| CN102178874A (en) * | 2010-12-14 | 2011-09-14 | 史志辉 | Preparation method of Chinese medicinal tablet for treating skin diseases |
| CN103830639A (en) * | 2014-02-28 | 2014-06-04 | 牛良信 | Medicament for treating eczema and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991686A (en) * | 2009-08-13 | 2011-03-30 | 蔡保君 | Oral Chinese medicine formula for treating eczema |
| CN102178874A (en) * | 2010-12-14 | 2011-09-14 | 史志辉 | Preparation method of Chinese medicinal tablet for treating skin diseases |
| CN103830639A (en) * | 2014-02-28 | 2014-06-04 | 牛良信 | Medicament for treating eczema and preparation method thereof |
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| 中医药治疗湿疹的临床进展;潘树伟等;《中医药信息》;19991231(第02期);12-13 * |
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