CN104640986B - 用于改变活细胞中存在的目标rna分子的序列的寡核苷酸 - Google Patents

用于改变活细胞中存在的目标rna分子的序列的寡核苷酸 Download PDF

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CN104640986B
CN104640986B CN201380047636.5A CN201380047636A CN104640986B CN 104640986 B CN104640986 B CN 104640986B CN 201380047636 A CN201380047636 A CN 201380047636A CN 104640986 B CN104640986 B CN 104640986B
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oligonucleotide
sequence
target rna
saline
rna
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CN104640986A (zh
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D·A·德布尔
T·里策马
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ProQR Therapeutics II BV
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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CN201380047636.5A 2012-07-12 2013-07-12 用于改变活细胞中存在的目标rna分子的序列的寡核苷酸 Expired - Fee Related CN104640986B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261670681P 2012-07-12 2012-07-12
US61/670,681 2012-07-12
US201261718801P 2012-10-26 2012-10-26
US61/718,801 2012-10-26
EP13166465.8 2013-05-03
EP13166465 2013-05-03
EP13172515 2013-06-18
EP13172515.2 2013-06-18
EP13173818 2013-06-26
EP13173818.9 2013-06-26
PCT/NL2013/050534 WO2014011053A1 (en) 2012-07-12 2013-07-12 Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell

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CN104640986A CN104640986A (zh) 2015-05-20
CN104640986B true CN104640986B (zh) 2018-08-28

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US (2) US9605255B2 (https=)
EP (2) EP2852668B1 (https=)
JP (1) JP6373833B2 (https=)
KR (1) KR20150037968A (https=)
CN (1) CN104640986B (https=)
AU (1) AU2013287353B2 (https=)
BR (1) BR112015000710A8 (https=)
CA (1) CA2878934A1 (https=)
CY (1) CY1117858T1 (https=)
DK (2) DK2852668T3 (https=)
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HR (1) HRP20160854T1 (https=)
HU (1) HUE029977T2 (https=)
IL (1) IL236654B (https=)
MX (1) MX356625B (https=)
NZ (1) NZ703824A (https=)
PL (1) PL2852668T3 (https=)
PT (1) PT2852668T (https=)
RS (1) RS54944B1 (https=)
RU (1) RU2663110C2 (https=)
SI (1) SI2852668T1 (https=)
SM (1) SMT201600234B (https=)
WO (1) WO2014011053A1 (https=)

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EP2852668B1 (en) 2012-07-12 2016-04-27 ProQR Therapeutics II B.V. Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell
RU2744460C2 (ru) 2014-04-15 2021-03-09 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости
KR102589295B1 (ko) 2014-05-14 2023-10-13 타르그이뮨 테라퓨틱스 아게 개선된 폴리에틸렌이민 폴리에틸렌글리콜 벡터
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
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JP6872560B2 (ja) * 2016-05-06 2021-05-19 エム． ウルフ、トッド プログラム可能ヌクレアーゼのあるゲノム編集及びプログラム可能ヌクレアーゼのないゲノム編集のための改善された方法
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CN107267516B (zh) * 2017-07-28 2020-09-29 佛山科学技术学院 双sgRNA介导的基因精确修饰方法及应用
WO2019076919A1 (en) * 2017-10-17 2019-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) COMBINED TREATMENT OF CYSTIC FIBROSIS
EP3615085A4 (en) * 2018-02-09 2021-01-13 Ohio State Innovation Foundation RNA NANOSTRUCTURES, METHOD OF MANUFACTURING AND USES THEREOF
US11866702B2 (en) 2018-03-27 2024-01-09 University Of Rochester Nucleic acid molecules for pseudouridylation
GB201808146D0 (en) 2018-05-18 2018-07-11 Proqr Therapeutics Ii Bv Stereospecific Linkages in RNA Editing Oligonucleotides
KR20210129646A (ko) 2019-01-22 2021-10-28 코로 바이오, 인크. Rna-편집 올리고뉴클레오타이드 및 그의 용도
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IL236654A0 (en) 2015-02-26
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US9994856B2 (en) 2018-06-12
MX2015000506A (es) 2015-06-03
RU2015104763A (ru) 2016-08-27
PL2852668T3 (pl) 2016-11-30
KR20150037968A (ko) 2015-04-08
SMT201600234B (it) 2016-08-31
CY1117858T1 (el) 2017-05-17
US9605255B2 (en) 2017-03-28
JP2015523082A (ja) 2015-08-13
DK2852668T3 (en) 2016-05-30
SI2852668T1 (sl) 2016-09-30
CA2878934A1 (en) 2014-01-16
AU2013287353A1 (en) 2015-02-26
EP2852668A1 (en) 2015-04-01
PT2852668T (pt) 2016-07-13
EP3103872B1 (en) 2018-08-29
ES2584856T3 (es) 2016-09-29
NZ703824A (en) 2018-06-29
US20170152518A1 (en) 2017-06-01
HRP20160854T1 (hr) 2016-09-23
IL236654B (en) 2018-02-28
RS54944B1 (sr) 2016-11-30
ES2698522T3 (es) 2019-02-05
AU2013287353B2 (en) 2018-11-08
JP6373833B2 (ja) 2018-08-15
EP3103872A1 (en) 2016-12-14
MX356625B (es) 2018-06-06
DK3103872T3 (en) 2018-10-22
CN104640986A (zh) 2015-05-20
BR112015000710A2 (https=) 2017-08-15
WO2014011053A1 (en) 2014-01-16
RU2663110C2 (ru) 2018-08-01
US20150197744A1 (en) 2015-07-16
EP2852668B1 (en) 2016-04-27
HK1208491A1 (zh) 2016-03-04

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