CN104640449A - 用于剧烈头痛的普拉克索经皮递送 - Google Patents
用于剧烈头痛的普拉克索经皮递送 Download PDFInfo
- Publication number
- CN104640449A CN104640449A CN201380048419.8A CN201380048419A CN104640449A CN 104640449 A CN104640449 A CN 104640449A CN 201380048419 A CN201380048419 A CN 201380048419A CN 104640449 A CN104640449 A CN 104640449A
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- CN
- China
- Prior art keywords
- pramipexole
- patch
- alternatively
- drug
- methods according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/570,593 US20140045801A1 (en) | 2012-08-09 | 2012-08-09 | Pramipexole transdermal delivery for severe headaches |
| US13/570,593 | 2012-08-09 | ||
| PCT/US2013/053400 WO2014025638A1 (en) | 2012-08-09 | 2013-08-02 | Pramipexole transdermal delivery for severe headaches |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104640449A true CN104640449A (zh) | 2015-05-20 |
Family
ID=50066647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380048419.8A Pending CN104640449A (zh) | 2012-08-09 | 2013-08-02 | 用于剧烈头痛的普拉克索经皮递送 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20140045801A1 (https=) |
| EP (1) | EP2884843A4 (https=) |
| JP (1) | JP2015524470A (https=) |
| CN (1) | CN104640449A (https=) |
| AU (2) | AU2013299885A1 (https=) |
| CA (1) | CA2881355A1 (https=) |
| IN (1) | IN2015DN00912A (https=) |
| TW (1) | TW201420133A (https=) |
| WO (1) | WO2014025638A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022242766A1 (zh) * | 2021-05-21 | 2022-11-24 | 成都文鼎科技发展有限公司 | 一种调节神经病变的方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| EP2946776A1 (de) * | 2014-05-20 | 2015-11-25 | LTS LOHMANN Therapie-Systeme AG | Transdermales therapeutisches System zur Abgabe von Amitriptylin |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| WO2016064873A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| CN104523709A (zh) * | 2014-12-22 | 2015-04-22 | 青岛正大海尔制药有限公司 | 一种含有琥珀酸夫罗曲坦的复方缓释制剂 |
| CA3139559A1 (en) * | 2019-05-09 | 2020-11-12 | Apkarian Technologies Llc | Methods and compositions for treating pain |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1826113A (zh) * | 2003-07-23 | 2006-08-30 | Lts勒曼治疗系统股份公司 | 含有普拉克索活性剂的透皮治疗系统 |
| CN101125128A (zh) * | 2002-07-25 | 2008-02-20 | 法玛西雅公司 | 含普拉克索的缓释片剂 |
| US20080176913A1 (en) * | 2006-06-29 | 2008-07-24 | Arnaud Grenier | Transdermal compositions of pramipexole having enhanced permeation properties |
| CN101677564A (zh) * | 2007-03-14 | 2010-03-24 | 诺普神经科学股份有限公司 | (6r)-4,5,6,7-四氢-n6-丙基-2,6-苯并噻唑-二胺的改良释放制剂及其使用方法 |
| US20110178114A1 (en) * | 2008-06-30 | 2011-07-21 | Afgin Phara Llc | Topical regional neuro-affective therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
| US7921999B1 (en) * | 2001-12-20 | 2011-04-12 | Watson Laboratories, Inc. | Peelable pouch for transdermal patch and method for packaging |
| US8252321B2 (en) * | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| TW200628175A (en) * | 2004-10-08 | 2006-08-16 | Noven Pharma | Transdermal drug delivert device including an occlusive backing |
| JP5190358B2 (ja) * | 2006-02-28 | 2013-04-24 | 久光製薬株式会社 | 経皮吸収型製剤 |
| WO2008009663A1 (en) * | 2006-07-19 | 2008-01-24 | Boehringer Ingelheim International Gmbh | Treatment of pain |
| WO2010010141A1 (en) * | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Pramipexole for treating cardiomyopathy |
| US20110087153A1 (en) * | 2009-10-13 | 2011-04-14 | Angelov Angel S | Transdermal Methods And Systems For The Delivery Of Rizatriptan |
-
2012
- 2012-08-09 US US13/570,593 patent/US20140045801A1/en not_active Abandoned
-
2013
- 2013-08-02 CA CA2881355A patent/CA2881355A1/en not_active Abandoned
- 2013-08-02 AU AU2013299885A patent/AU2013299885A1/en not_active Abandoned
- 2013-08-02 WO PCT/US2013/053400 patent/WO2014025638A1/en not_active Ceased
- 2013-08-02 JP JP2015526593A patent/JP2015524470A/ja active Pending
- 2013-08-02 EP EP13828337.9A patent/EP2884843A4/en not_active Withdrawn
- 2013-08-02 CN CN201380048419.8A patent/CN104640449A/zh active Pending
- 2013-08-07 TW TW102128319A patent/TW201420133A/zh unknown
-
2015
- 2015-02-04 IN IN912DEN2015 patent/IN2015DN00912A/en unknown
-
2017
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| CN101125128A (zh) * | 2002-07-25 | 2008-02-20 | 法玛西雅公司 | 含普拉克索的缓释片剂 |
| CN1826113A (zh) * | 2003-07-23 | 2006-08-30 | Lts勒曼治疗系统股份公司 | 含有普拉克索活性剂的透皮治疗系统 |
| US20080176913A1 (en) * | 2006-06-29 | 2008-07-24 | Arnaud Grenier | Transdermal compositions of pramipexole having enhanced permeation properties |
| CN101677564A (zh) * | 2007-03-14 | 2010-03-24 | 诺普神经科学股份有限公司 | (6r)-4,5,6,7-四氢-n6-丙基-2,6-苯并噻唑-二胺的改良释放制剂及其使用方法 |
| US20110178114A1 (en) * | 2008-06-30 | 2011-07-21 | Afgin Phara Llc | Topical regional neuro-affective therapy |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022242766A1 (zh) * | 2021-05-21 | 2022-11-24 | 成都文鼎科技发展有限公司 | 一种调节神经病变的方法 |
| CN117752663A (zh) * | 2021-05-21 | 2024-03-26 | 成都文鼎科技发展有限公司 | 一种调节神经病变的方法 |
| CN117752663B (zh) * | 2021-05-21 | 2025-03-25 | 成都文鼎科技发展有限公司 | 一种调节神经病变的方法 |
Also Published As
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| WO2014025638A1 (en) | 2014-02-13 |
| CA2881355A1 (en) | 2014-02-13 |
| WO2014025638A4 (en) | 2014-04-03 |
| EP2884843A4 (en) | 2016-05-11 |
| US20140045801A1 (en) | 2014-02-13 |
| JP2015524470A (ja) | 2015-08-24 |
| TW201420133A (zh) | 2014-06-01 |
| AU2013299885A1 (en) | 2015-03-19 |
| AU2017201316A1 (en) | 2017-03-16 |
| EP2884843A1 (en) | 2015-06-24 |
| IN2015DN00912A (https=) | 2015-06-12 |
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