JP2015524470A - 重度頭痛のためのプラミペキソール経皮送達 - Google Patents
重度頭痛のためのプラミペキソール経皮送達 Download PDFInfo
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- JP2015524470A JP2015524470A JP2015526593A JP2015526593A JP2015524470A JP 2015524470 A JP2015524470 A JP 2015524470A JP 2015526593 A JP2015526593 A JP 2015526593A JP 2015526593 A JP2015526593 A JP 2015526593A JP 2015524470 A JP2015524470 A JP 2015524470A
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- Prior art keywords
- pramipexole
- drug
- patch
- migraine
- transdermal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 2
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- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 2
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Classifications
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Abstract
Description
Claims (13)
- ヒト患者における群発頭痛および片頭痛を治療または予防する方法であって、前記ヒト患者にプラミペキソールを経皮的に投与する工程を含み、
経皮送達が、経皮パッチの形態であり、前記経皮パッチが、接着剤における単層薬物、接着剤における多層薬物、モノリシックパッチおよび蒸気パッチのうち少なくとも1種から選択される、方法。 - 群発頭痛および片頭痛が、再発性または慢性である、請求項1に記載の方法。
- プラミペキソールが、1日当たり0.01mg〜10mgの用量で1〜7日間送達される、請求項1に記載の方法。
- 患者への薬物の投与速度が、1時間当たり1μg〜200μgに及ぶ、請求項3に記載の方法。
- プラミペキソールが、その遊離塩基形態で送達される、請求項1に記載の方法。
- 頭痛の治療または予防に有用な追加的な薬物をさらに含む、請求項1に記載の方法。
- 追加的な薬物が、セロトニン受容体アゴニスト、NSAID、抗うつ薬、麦角アルカロイド、オピオイド、抗てんかん薬、抗痙攣薬、カルシウムチャネル遮断薬およびベータ遮断薬のうち少なくとも1種から選択される、請求項6に記載の方法。
- セロトニン受容体アゴニストが、スマトリプタン、エレトリプタン(elitriptan)、フロバトリプタン(frovotriptan)、ゾルミトリプタン、ナラトリプタン、リザトリプタンおよびアルモトリプタンのうち少なくとも1種から選択される、請求項7に記載の方法。
- NSAIDが、イブプロフェン、ナプロキセン、アスピリン、アセトアミノフェン、インドメタシンおよびケトプロフェンのうち少なくとも1種から選択される、請求項7に記載の方法。
- 抗うつ薬が、アミトリプチリンである、請求項7に記載の方法。
- 麦角アルカロイドが、エルゴタミンである、請求項7に記載の方法。
- オピオイドが、オキシコドンおよびヒドロコドンのうち少なくとも1種から選択される、請求項7に記載の方法。
- 抗てんかん薬が、ガバペンチン、トピラメートおよびレベチラセタムのうち少なくとも1種から任意選択で選択され、抗痙攣薬が、任意選択で吉草酸ナトリウムであり、カルシウムチャネル遮断薬が、ベラパミルおよびアムロジピンのうち少なくとも1種から任意選択で選択され、ベータ遮断薬が、プロプラノロール(propanolol)、メトプロロール、カルベジロールおよびアテノロールのうち少なくとも1種から任意選択で選択される、請求項7に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US13/570,593 | 2012-08-09 | ||
US13/570,593 US20140045801A1 (en) | 2012-08-09 | 2012-08-09 | Pramipexole transdermal delivery for severe headaches |
PCT/US2013/053400 WO2014025638A1 (en) | 2012-08-09 | 2013-08-02 | Pramipexole transdermal delivery for severe headaches |
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JP2015524470A true JP2015524470A (ja) | 2015-08-24 |
JP2015524470A5 JP2015524470A5 (ja) | 2016-09-23 |
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JP2015526593A Pending JP2015524470A (ja) | 2012-08-09 | 2013-08-02 | 重度頭痛のためのプラミペキソール経皮送達 |
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US (1) | US20140045801A1 (ja) |
EP (1) | EP2884843A4 (ja) |
JP (1) | JP2015524470A (ja) |
CN (1) | CN104640449A (ja) |
AU (2) | AU2013299885A1 (ja) |
CA (1) | CA2881355A1 (ja) |
IN (1) | IN2015DN00912A (ja) |
TW (1) | TW201420133A (ja) |
WO (1) | WO2014025638A1 (ja) |
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WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
EP2946776A1 (de) * | 2014-05-20 | 2015-11-25 | LTS LOHMANN Therapie-Systeme AG | Transdermales therapeutisches System zur Abgabe von Amitriptylin |
DK3169315T3 (da) | 2014-07-17 | 2020-08-10 | Pharmaceutical Manufacturing Res Services In | Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse |
AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
CN104523709A (zh) * | 2014-12-22 | 2015-04-22 | 青岛正大海尔制药有限公司 | 一种含有琥珀酸夫罗曲坦的复方缓释制剂 |
US20220401391A1 (en) * | 2019-05-09 | 2022-12-22 | Apkarian Tech Llc | Methods and compositions for treating pain |
EP4342471A1 (en) * | 2021-05-21 | 2024-03-27 | Chengdu Wending Technology Development Co., Ltd. | Method for modulating neuropathies |
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JP2006528144A (ja) * | 2003-07-23 | 2006-12-14 | エルテーエス ローマン テラピー−ジステーメ アーゲー | プラミペキソール活性剤を含む経皮治療システム |
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US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
US7921999B1 (en) * | 2001-12-20 | 2011-04-12 | Watson Laboratories, Inc. | Peelable pouch for transdermal patch and method for packaging |
MY136318A (en) * | 2002-07-25 | 2008-09-30 | Pharmacia Corp | Sustained-release tablet composition |
US8252321B2 (en) * | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
TW200628175A (en) * | 2004-10-08 | 2006-08-16 | Noven Pharma | Transdermal drug delivert device including an occlusive backing |
US8524273B2 (en) * | 2006-02-28 | 2013-09-03 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal absorption preparation |
WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
WO2008009663A1 (en) * | 2006-07-19 | 2008-01-24 | Boehringer Ingelheim International Gmbh | Treatment of pain |
EP2136638A4 (en) * | 2007-03-14 | 2010-05-12 | Knopp Neurosciences Inc | MODIFIED RELEASE FORMULATIONS OF (6R) -4,5,6,7-TETRAHYDRO-N6-PROPYL-2,6-BENZOTHIAZOLE DIAMINE AND METHODS OF USE THEREOF |
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WO2010010141A1 (en) * | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Pramipexole for treating cardiomyopathy |
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-
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- 2012-08-09 US US13/570,593 patent/US20140045801A1/en not_active Abandoned
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- 2013-08-02 JP JP2015526593A patent/JP2015524470A/ja active Pending
- 2013-08-02 AU AU2013299885A patent/AU2013299885A1/en not_active Abandoned
- 2013-08-02 CN CN201380048419.8A patent/CN104640449A/zh active Pending
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- 2013-08-07 TW TW102128319A patent/TW201420133A/zh unknown
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JP2006528144A (ja) * | 2003-07-23 | 2006-12-14 | エルテーエス ローマン テラピー−ジステーメ アーゲー | プラミペキソール活性剤を含む経皮治療システム |
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IN2015DN00912A (ja) | 2015-06-12 |
EP2884843A1 (en) | 2015-06-24 |
US20140045801A1 (en) | 2014-02-13 |
TW201420133A (zh) | 2014-06-01 |
WO2014025638A1 (en) | 2014-02-13 |
WO2014025638A4 (en) | 2014-04-03 |
CN104640449A (zh) | 2015-05-20 |
AU2017201316A1 (en) | 2017-03-16 |
EP2884843A4 (en) | 2016-05-11 |
CA2881355A1 (en) | 2014-02-13 |
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