CN104623588A - Traditional Chinese medicine composition for treating chronic pulmonary heart disease in stable phase - Google Patents
Traditional Chinese medicine composition for treating chronic pulmonary heart disease in stable phase Download PDFInfo
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- CN104623588A CN104623588A CN201410857156.1A CN201410857156A CN104623588A CN 104623588 A CN104623588 A CN 104623588A CN 201410857156 A CN201410857156 A CN 201410857156A CN 104623588 A CN104623588 A CN 104623588A
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Abstract
The invention provides a traditional Chinese medicine composition for treating chronic pulmonary heart disease in the stable phase. The composition is prepared from radix aconite lateralis preparata, cassia twig, cinnamon, herba epimedii, raw ginger, astragalus membranaceus, semen lepidii, earthworm, angelica sinensis, poria cocos, schisandra chinensis, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, salviae miltiorrhizae and fructus psoraleae. The composition is researched, processed and developed according to a local traditional method, does not have toxic or side effect, is safe and reliable, and has remarkable effect; and the preparation method is simple and feasible, and the raw materials are easily available. The traditional Chinese medicine composition has the effects of tonifying qi and yin without grease, warming yang and promoting inspiration without dry-heat, can be used for comprehensively achieving the functions of nourishing lung, tonifying kidney, strengthening spleen, warming yang, promoting inspiration, relieving asthma, promoting blood circulation to remove stasis, and can hit the pathogenesis of the chronic pulmonary heart disease in the stable phase. The traditional Chinese medicine composition is mainly used for treating chronic pulmonary heart disease in the stable phase.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of stable phase chronic pulmonary heart disease, belong to tcm field
Background technology
Chronic pulmonary heart disease, is called for short pulmonary heart disease, is because lung tissue, thorax or Pulmonic chronic disease cause pulmonary vascular resistance increase, pulmonary hypertension, causes right ventricle plumpness, expands, finally develop into a kind of disease of right heart failure and respiratory failure.Acute exacerbation is many in winter-spring season, and Abwehrkraft des Koepers difference easy catching a cold is the basic inducement of its acute exacerbation.Early stage cardio-pulmonary function still can be compensatory, and respiratory failure appears in late period, often with multiple complications.Primary disease is very common in China rural area, disability rate and fatality rate high.Therefore need to take effectively preventing measure to intervene.Current clinical groundwork focuses on treatment pulmonary heart disease acute exacerbation, and for stable phase patients with cor pulmonale, how to alleviate clinical symptoms, and reduce acute exacerbation, delay disease progression, improve health status, improve life quality, means are very limited.Comprise smoking cessation, minimizing risk factor, vaccination at present and adopt the measure of Western medicine medicine treatment all to obtain certain effect, but disease obtains Satisfactory Control not yet, especially in the treatment of stable phase chronic cardiopulmonary disease.Play the advantage of the traditional Chinese medical science, therapeutic intervention can be carried out to stable phase chronic pulmonary heart disease, reduce acute exacerbation, reduce recurrence, improve clinical symptoms.But determined curative effect, the Chinese medicine preparation effectively can treating stable phase chronic pulmonary heart disease lacks still very much.The present invention has no side effect, safe and reliable, medicine successful, and production method is simple simultaneously, and raw material easily obtains, and Conventional processing methods is used for, in production of raw medicine provided by the invention, can not causing the loss of effective ingredient, cutting determined curative effect.
Summary of the invention
The object of the present invention is to provide a kind of therapeutic effect good, have no side effect, the Chinese medicine preparation of the treatment stable phase chronic pulmonary heart disease of determined curative effect.
The technical scheme that the present invention solves the problems of the technologies described above is as follows:
Treat a Chinese medicine composition for stable phase chronic pulmonary heart disease, be made up of the raw material of following weight portion:
By Radix Aconiti Lateralis Preparata 5-10 part, Ramulus Cinnamomi 10-20 part, Cortex Cinnamomi 10-20 part, Herba Epimedii 10-20 part, Rhizoma Zingiberis Recens 5-10 part, Radix Astragali 20-30 part, Semen Lepidii (Semen Descurainiae) 20-30 part, Pheretima 10-20 part, Radix Angelicae Sinensis 10-20 part, Poria 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Fructus Psoraleae 10-20 part.
As technique scheme further preferably, described composite preparation is made up of the raw material of following weight portion:
Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts.
Preparation of the present invention is said dosage form on any one pharmaceutics, comprises capsule preparations, dissolved granule, tablet, pill or oral liquid formulations.
In technique scheme, each taste Chinese medicine in compositing formula has following effect:
This invention forms primarily of 15 kinds of Chinese medicines, and wherein Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Herba Epimedii, Fructus Psoraleae warming the spleen warming the kidney are with aid yang qi; Rhizoma Zingiberis Recens temperature cold expelling water, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae spleen reinforcing; Cortex Cinnamomi, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Radix Astragali improving inspiration by invigorating the kidney are relievingd asthma; Semen Lepidii (Semen Descurainiae) tonifying the lung diuretic; Radix Angelicae Sinensis nourishing blood and promoting blood circulation; Radix Salviae Miltiorrhizae, Pheretima blood circulation promoting and blood stasis dispelling.This invention supplementing QI and nourishing YIN and do not grow greasy, warming YANG improving inspiration by invigorating kidney-QI and not scorching, full side gather altogether tonifying the lung, kidney tonifying, spleen invigorating, warming YANG improving inspiration by invigorating kidney-QI, relieving asthma, the merit of blood circulation promoting and blood stasis dispelling, hit chronic stable phase pulmonary heart disease pathogenesis.
The present invention carries out developing, process, develop and obtaining according to the traditional proved recipe in locality, medicine itself does not have toxic and side effects, more safe and reliable, medicine successful, its production method is simple simultaneously, Conventional processing methods is used for, in the production of crude drug provided by the invention, can not causing the loss of effective ingredient; And in this invention preparation, raw material easily obtains.
Traditional medicine is thought that primary disease pathogenesis is familiar with at present and is trended towards deficiency in origin and excess in superficiality more.With diseases caused by exogenous pathogenic factor six climate exopathogens for main predisposing factors, lung, spleen, damage of suffering from a deficiency of the kidney, the inherent pathogenesis pathological change that the stagnation of QI, expectorant are turbid, blood stasis, diseases caused by retention of fluid are primary disease, pathogenic characteristic is deficiency in origin and excess in superficiality, deficiency in origin is suffered from a deficiency of the kidney based on lung spleen, mark real, blood stasis, diseases caused by retention of fluid turbid based on the stagnation of QI, expectorant, phlegm retention, blood stasis, deficiency of vital energy three are the basic reasons of the touching delay of primary disease, recurrent exerbation.This sick stable phase is based on deficiency in origin, and polyphyly lung spleen is suffered from a deficiency of the kidney damage, belongs to lung Pishenqixu syndrome.Should use supplementing QI and nourishing YIN warming YANG, tonifying the lung tonifying speen and tonifying kidney, the method for blood circulation promoting and blood stasis dispelling, to make inside of human body negative and positive of qi and blood balance, function is recovered, and immunologic function improves, thus reduces attack times, improves Nutritional Status of Patients and quality of life.This is dialectical basis of the present invention.The present invention is also the traditional Chinese medical science " radical treatment in chronic case ", " prevention of diseae ", the fully demonstrating of " namely disease is preapred for an unfavorable turn of events " principle.
Owing to have employed technique scheme, the present invention has supplementing QI and nourishing YIN warming YANG, tonifying the lung tonifying speen and tonifying kidney, effect of blood circulation promoting and blood stasis dispelling.Inventor started to apply technical solutions according to the invention before the several years, and treatment hundreds chronic stable phase patients with cor pulmonale, obtains good curative effect.
Detailed description of the invention:
The first: get Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts, above-mentioned raw materials medicine is fried into decoction take, every day potion, be divided into and sooner or later take for twice, serve on 30 days.
The second: by weight: Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts, by above-mentioned raw materials medicine kilogram to be that unit of weight is fried concentrated, honey is smelt ball.Every ball weighs 0.5 gram, sooner or later respectively takes 6 balls, takes 30 days continuously.
The third: by weight: Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts, by above-mentioned raw materials medicine kilogram to be jointly processed into fine powder for unit of weight, cross 100 orders with top sieve, mix homogeneously, ozone sterilization 20 minutes, technique makes capsule routinely, every heavy 0.5 gram, sooner or later 4-6 grain is respectively taken, warm water delivery service, takes 30 days continuously.
4th kind: by weight: Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts, above-mentioned raw materials medicine is added 500ml water, after being fully mixed into medicinal liquid, medicinal liquid is decocted into cream, is condensed into granule, pack, every bag heavy 3 grams, sooner or later respectively take 1 bag, warm water delivery service, take 30 days continuously.
5th kind: by weight: Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts, above-mentioned raw materials medicine is added 1000ml water, after being fully mixed into medicinal liquid, oral liquid processing technology routinely again, medicinal liquid is decocted and is concentrated into 200ml, the oral liquid formulations of the present invention that can make.The instructions of taking of oral liquid: every day twice, each 10-20ml, warm water delivery service, takes 30 days continuously.
6th kind: by weight: Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts, by above-mentioned raw materials medicine kilogram to be jointly processed into fine powder for unit of weight, tablet processing technology routinely again, medicated powder is pressed into the tablet of 0.3 gram every, the tablet of the present invention that can make.The instructions of taking of tablet: every day twice, each 3-4 sheet, warm water delivery service, takes 30 days continuously.
Clinical practice:
1 clinical data
Pulmonary heart disease diagnoses the standard formulated according to 1980 national pulmonary heart disease specialized conferences, select stable phase patients with cor pulmonale 56 example, be divided into 2 groups at random, invention group group (treatment group) organizes 28 examples, male 17 example, women 11 example, 47 ~ 76 years old age, average 64.5 years old, there is smoking history 21 example, average course of disease 12.5; Simple western medical treatment group (matched group) 28 example, male 18 example, women 10 example; 47 ~ 75 years old age, average 63.2 years old; There is smoking history 22 example, average course of disease 13.7; Above-mentioned case derives from the patient reaching stable phase year June in March, 2011 to 2011 and leave hospital after my section's hospitalization, and completed treatment is observed, and informed consent.
2 Therapeutic Method
Matched group give western medicine routine treatment as: advice smoking cessation, uses the treatment such as bronchodilator, expectorant, reconditioning.Occur that acute pulmonary infection then exits this research at treatments period.The same matched group of the above-mentioned western medicine routine treatment for the treatment of group, separately gives side's decoction of the present invention, fried by systematic unity of boiling medicine during clinical application, and 200mL decocted into by every agent medicine, point two bags of packagings, and sooner or later respectively take 1 bag, 30d was 1 course for the treatment of, observing effect after continuous 3 courses for the treatment of.
3 curative effect judging standards
Effective: cough, expectoration, uncomfortable in chest, feel suffocated, the symptom such as cyanosis disappears substantially, the dry moist rales of two lungs, two lower limbs edema disappear substantially, and cardiac function improves secondary; Effective: above-mentioned symptom is improved in varying degrees, cardiac function improves one-level; Invalid: with symptom before treatment without improving or worsening.
4. result
After 3 courses for the treatment of of two groups of patients, effect is as follows:
Effectiveness comparison (x ± s) before and after two groups of treatments
Note: compare P < 0.05 with after treatment of control group.
In a word, use this invention to treat chronic stable phase pulmonary heart disease, directly for the pathogenesis of primary disease, determined curative effect, toxic and side effects is little, is the effective ways be worthy to be popularized.
Claims (3)
1. treat a Chinese medicine composition for stable phase chronic pulmonary heart disease, its feature is: according to weight proportion: it is made up of Radix Aconiti Lateralis Preparata 5-10 part, Ramulus Cinnamomi 10-20 part, Cortex Cinnamomi 10-20 part, Herba Epimedii 10-20 part, Rhizoma Zingiberis Recens 5-10 part, Radix Astragali 20-30 part, Semen Lepidii (Semen Descurainiae) 20-30 part, Pheretima 10-20 part, Radix Angelicae Sinensis 10-20 part, Poria 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Pericarpium Citri Reticulatae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Fructus Psoraleae 10-20 part.
2. as right 1 require as described in the Chinese medicine composition for the treatment of stable phase chronic pulmonary heart disease, its feature is: the optimum ratio of needed raw material medicine is Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 10 parts, 5 parts, Rhizoma Zingiberis Recens, the Radix Astragali 20 parts, Semen Lepidii (Semen Descurainiae) 20 parts, Pheretima 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Schisandrae Chinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Psoraleae 10 parts composition.
3. treat the preparation of the Chinese medicine composition of stable phase chronic pulmonary heart disease as claimed in claim 1 or 2, its feature is: described preparation is obtainable preparation during all Chinese medicine is produced, and comprising: capsule, granule, tablet, pill, oral liquid.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010071421A1 (en) * | 2008-12-17 | 2010-06-24 | N.V. Nutricia | Probiotics for the treatment and/or prevention of pulmonary hypertension |
| CN102614485A (en) * | 2012-04-09 | 2012-08-01 | 邹德奇 | Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease with syndrome of insufficiency of lung, spleen and kidney on stationary phase |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010071421A1 (en) * | 2008-12-17 | 2010-06-24 | N.V. Nutricia | Probiotics for the treatment and/or prevention of pulmonary hypertension |
| CN102614485A (en) * | 2012-04-09 | 2012-08-01 | 邹德奇 | Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease with syndrome of insufficiency of lung, spleen and kidney on stationary phase |
Non-Patent Citations (3)
| Title |
|---|
| 吴银根: "《常见肺系疾病的中医预防和护养》", 31 October 2013 * |
| 程时平等: "《难治内科病名医绝技》", 30 April 2012 * |
| 黄庆田等: "《呼吸病中西医结合诊断与治疗》", 31 July 2009 * |
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Inventor after: Fang Fang Inventor after: Zhao Nan Inventor after: Zou Deqi Inventor before: Zou Deqi |
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Effective date of registration: 20180329 Address after: 150040 Heping Road, Xiangfang District, Heilongjiang, Harbin, China, 24 Applicant after: HEILONGJIANG University OF CHINESE MEDICINE Address before: The third people's Hospital of Haiyang City, Shandong province 265100 No. 3 Yantai Haiyang Sea Road Applicant before: Zou Deqi |
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