CN102614485B - Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease with syndrome of insufficiency of lung, spleen and kidney on stationary phase - Google Patents

Abstract

The invention relates to a traditional Chinese medicine preparation with remarkable curative effect on the chronic obstructive pulmonary disease with syndrome of insufficiency of lung, spleen and kidney on a stationary phase. The traditional Chinese medicine preparation comprises: aconite root, cassia twig, epimedium, ginger, Radix Astragali, Lonicera japonica Thunb, Tetrandra root, prepared rhizome of rehmannia, Tuckahoe, Chinese magnoliaving, white atractylodes rhizome, and tangerine peel. The traditional Chinese medicine preparation is studied, processed and developed according to the local traditional tested prescription, and the traditional Chinese medicine preparation has no toxic or side effect, is safe and reliable and has obvious curative effect; simultaneously, the provided production method is simple and easy to perform; and in the preparation, the raw materials can be easily obtained. The traditional Chinese medicine preparation can supplement Qi and nourish Yin without being tired, and can warm Yang and inspirit Qi without being dry and hot, thus the traditional Chinese medicine preparation can tonify the lung and the kidney, invigorate the spleen, warm the yang, and help the inspiration to relieve asthma, so as to hit the point of the pathogenesis of the chronic obstructive pulmonary disease with syndrome of insufficiency of lung, spleen and kidney on the stationary phase. The traditional Chinese medicine preparation is mainly used for treating the chronic obstructive pulmonary disease with syndrome of insufficiency of lung, spleen and kidney on the stationary phase.

Description

A kind of Chinese medicine preparation of chronic obstructive pulmonary disease for the treatment of stable phase lung spleen nephrasthenia syndrome

Technical field

The present invention is a kind of Chinese medicine preparation, the chronic obstructive pulmonary disease of stable phase lung spleen nephrasthenia syndrome is had the Chinese medicine preparation of significant curative effect.Belong to tcm field

Background technology

Chronic obstructive pulmonary disease is modal respiratory system disease, is also one of the whole world ten large disease killers.China's more than 40 years old crowd incidence of COPD is in 8% left and right.If chronic obstructive pulmonary disease is not effectively intervened, can advance to gradually emphysema, pulmonary heart disease, patient's disability, the quality of life having a strong impact on.Account at present the 4th of the global cause of death, estimate will rise to the 3rd at the year two thousand twenty.Therefore need to take effective comprehensive preventive health measures to intervene.For COPD stable phase patient, how to alleviate clinical symptoms, prevent disease progression, improve health status, improve life quality, clinical treatment means are very limited.Comprise at present smoking cessation, reduce risk factor, vaccination and adopt the measure of Drug therapy all to obtain certain effect, but disease is effectively controlled not yet, especially in the treatment of COPD in stable phase.The advantage of the performance traditional Chinese medical science, can carry out therapeutic intervention to COPD in stable phase.But determined curative effect, the Chinese medicine preparation that can effectively treat COPD in stable phase still lacks very much.

Summary of the invention

The object of the present invention is to provide a kind of chronic obstructive pulmonary disease Chinese medicine preparation for the treatment of stable phase lung spleen nephrasthenia syndrome, to address the above problem.Above-mentioned purpose is realized by following technical scheme: get part according to weight: it is made up of Radix Aconiti Lateralis Preparata 5-10 part, Ramulus Cinnamomi 10-20 part, Herba Epimedii 10-20 part, Rhizoma Zingiberis Recens 5-10 part, Radix Astragali 20-30 part, Semen Lepidii (Semen Descurainiae) 10-20 part, Radix Stephaniae Tetrandrae 10-20 part, Radix Rehmanniae Preparata 10-20 part, Poria 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Pericarpium Citri Reticulatae 10-20 part;

As technique scheme further preferably, described Chinese medicinal composition preparation comprises the raw material of following weight portion:

The optimum ratio of needed raw material medicine is 5 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Ramulus Cinnamomi, 10 parts of Herba Epimedii, 5 parts, Rhizoma Zingiberis Recens, 20 parts of the Radixs Astragali, 10 parts of Semen Lepidii (Semen Descurainiae)s, 10 parts of Radixs Stephaniae Tetrandrae, 10 parts, Radix Rehmanniae Preparata, 10 parts, Poria, 10 parts of Fructus Schisandrae Chinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of compositions of Pericarpium Citri Reticulatae.

Preparation of the present invention is the obtainable preparation of prior art during all Chinese medicine is produced, and comprising: capsule, granule, tablet, pill, oral liquid.

The present invention develops, processes, develops and obtain according to the traditional proved recipe in locality, itself does not have toxic and side effects medicine, more safe and reliable, medicine effect is obvious, the production method simultaneously providing is simple, for the production of crude drug provided by the invention, can not cause the loss of effective ingredient; And in this invention preparation, raw material easily obtains.

In above raw material,

Wherein Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Herba Epimedii warming the spleen warming the kidney are with aid yang qi, Rhizoma Zingiberis Recens temperature cold expelling water, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae spleen reinforcing, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae tonifying the lung diuretic, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Radix Astragali improving inspiration by invigorating the kidney are relievingd asthma, this invention supplementing QI and nourishing YIN and do not grow greasy, warming YANG improving inspiration by invigorating kidney-QI and not scorching, full side gathers the merit of tonifying the lung, kidney tonifying, spleen invigorating, warming YANG helping inspiration to relieve asthma altogether, and stable phase of chronic obstructive pulmonary disease pathogenesis hits.

Traditional medicine thinks that the current understanding of primary disease pathogenesis trends towards deficiency in origin and excess in superficiality more.Take diseases caused by exogenous pathogenic factor six climate exopathogens as main predisposing factors, lung, spleen, the damage of suffering from a deficiency of the kidney, exopathogen, the inherent pathogenesis pathological change that expectorant is turbid, blood stasis is primary disease, pathogenic characteristic is deficiency in origin and excess in superficiality, deficiency in origin is suffered from a deficiency of the kidney as main take lung spleen, real, the blood stasis turbid take exopathogen, expectorant of mark be as main, and expectorant, the stasis of blood, empty three are the touching delay of primary disease, the basic reason of outbreak repeatedly.This disease stable phase is take deficiency in origin as main, and the polyphyly lung spleen damage of suffering from a deficiency of the kidney, belongs to lung Pishenqixu syndrome.Should use supplementing QI and nourishing YIN warming YANG, the method for tonifying the lung tonifying speen and tonifying kidney, so that inside of human body negative and positive of qi and blood balance, function is recovered, immunologic function improves, thereby reduces attack times, improves Nutritional Status of Patients and quality of life.This is dialectical basis of the present invention.The present invention is also fully demonstrating of the traditional Chinese medical science " radical treatment in chronic case ", " prevention of diseae ", " being that disease is preapred for an unfavorable turn of events " principle.The present invention develops, processes, develops and obtain according to locality traditional proved recipe,

The specific embodiment:

The first: by weight: Radix Aconiti Lateralis Preparata 5-10 part, Ramulus Cinnamomi 10-20 part, Herba Epimedii 10-20 part, Rhizoma Zingiberis Recens 5-10 part, Radix Astragali 20-30 part, Semen Lepidii (Semen Descurainiae) 10-20 part, Radix Stephaniae Tetrandrae 10-20 part, Radix Rehmanniae Preparata 10-20 part, Poria 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Pericarpium Citri Reticulatae 10-20 part composition;

The second: by weight: 5 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Ramulus Cinnamomi, 10 parts of Herba Epimedii, 5 parts, Rhizoma Zingiberis Recens, 20 parts of the Radixs Astragali, 10 parts of Semen Lepidii (Semen Descurainiae)s, 10 parts of Radixs Stephaniae Tetrandrae, 10 parts, Radix Rehmanniae Preparata, 10 parts, Poria, 10 parts of Fructus Schisandrae Chinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of compositions of Pericarpium Citri Reticulatae.

Formulation preparation method of the present invention is the obtainable preparation of prior art during all Chinese medicine is produced, and comprising: capsule, granule, tablet, pill, oral liquid.

Contrast test:

1 clinical data:

Case selection diagnosis and inclusive criteria select to meet the COPD stable phase patient of " chronic obstructive pulmonary disease (COPD) diagnosis and treatment guide " [1] diagnostic criteria.Inclusive criteria: age >=40 year old; The 1st second forced expiratory volume (FEV1) < 80% predicted value; Bronchodilation Test feminine gender; In stable phase, within nearly 4 weeks, apnea road infects and acute exacerbation, and rabat has no focus of infection.Chronic cough due to exclusion standard bronchial asthma, bronchiectasis, tumor of bronchus, pulmonary tuberculosis, fungus, irritative gas or the factor such as irritated, patient pants; COPD merges cardiovascular system, Liver and kidney system and serious primary disease and the psychotic of hemopoietic system; Gestation, women breast-feeding their children.

2 physical data

COPD stable phase patient 48 examples that meet above-mentioned inclusive criteria, are divided into 2 groups at random, invention group group (treatment group) group 24 examples, and male's 17 examples, women's 7 examples, at 45～81 years old age, average 69.5 years old, have smoking history 17 examples, average course of disease 12.5 years; Simple western medical treatment group (matched group) 24 examples, male's 18 examples, women's 6 examples; 47～80 years old age, average 70.2 years old; There are smoking history 18 examples, average course of disease 12.7; Above-mentioned case derives from year May in May, 2009 to 2010 the medical patient of my section.

3 Therapeutic Method

Matched group give doctor trained in Western medicine conventional therapy as: advice smoking cessation, is used bronchodilator, the treatments such as inhaled, reconditioning.During treating, occur that acute pulmonary infection exits this research.The same matched group of the above-mentioned doctor trained in Western medicine conventional therapy for the treatment of group, separately gives side's decoction of the present invention, and fried by the systematic unity of boiling medicine when clinical application, every dose of medicine is decocted into 250mL, and point two bags of packings sooner or later respectively take 1 bag, and 20d was 1 course for the treatment of, two groups of each observations for 3 courses for the treatment of.

4 observation index

BODE index scoring: BODE index reference literature [1] method (table 1), comprises that Body Mass Index (BMI), pulmonary function FEV1 account for predicted value percentage ratio (FEV1%pred), dyspnea integration (MMRC), 6min walking distance (6MWD).

Table 1BODE methods of marking

5 statistical analysis:

Adopt SPSS 13.0 softwares to carry out statistical analysis to data.All data all represent with " x ± s ", before and after relatively adopting, contrast t check in group, relatively adopt one factor analysis of variance between group, have statistical significance take P < 0.05 as difference.

Efficacy result: two groups of patient treatment BODE aggregative index, MMRC, FEV1%pred, 6MWD scorings are all improved before treatment, compare on the same group P < 0.05 before and after treatment, have statistical significance.After treatment between group relatively, except BMI, remaining index all has statistical significance (P < 0.05), points out benefiting QI for activating blood circulation to receive this invention of kidney side and can improve preferably COPD stable phase patient clinical symptom.Relatively (table 2) of BODE index scoring before and after two groups of treatments.

Relatively (x ± s) of BODE index scoring before and after the treatment of table 2 liang group

Note: aP < 0.05 with this group before treatment; With comparison bP < 0.05 after treatment of control group; With comparison cP > 0.05 after treatment of control group.

Above experimental data proves that therapeutic effect of the present invention is apparently higher than matched group

Claims (3)

1. treat the suffer from a deficiency of the kidney Chinese medicine preparation of chronic obstructive pulmonary disease of stable phase lung spleen, it is characterised in that: according to weight proportion: it is made up of Radix Aconiti Lateralis Preparata 5-10 part, Ramulus Cinnamomi 10-20 part, Herba Epimedii 10-20 part, Rhizoma Zingiberis Recens 5-10 part, Radix Astragali 20-30 part, Semen Lepidii (Semen Descurainiae) 10-20 part, Radix Stephaniae Tetrandrae 10-20 part, Radix Rehmanniae Preparata 10-20 part, Poria 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Pericarpium Citri Reticulatae 10-20 part.

2. Chinese medicine preparation as claimed in claim 1, is characterized in that: the optimum ratio of needed raw material medicine is 5 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Ramulus Cinnamomi, 10 parts of Herba Epimedii, 5 parts, Rhizoma Zingiberis Recens, 20 parts of the Radixs Astragali, 10 parts of Semen Lepidii (Semen Descurainiae)s, 10 parts of Radixs Stephaniae Tetrandrae, 10 parts, Radix Rehmanniae Preparata, 10 parts, Poria, 10 parts of Fructus Schisandrae Chinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of compositions of Pericarpium Citri Reticulatae.

3. Chinese medicine preparation as claimed in claim 1 or 2, is characterized in that: described Chinese medicine preparation is all made by state of the art, comprising: capsule, granule, tablet, pill, oral liquid.