CN104623515A - Drug for treating chronic pelvic inflammation and preparation method thereof - Google Patents

Abstract

The invention discloses a drug for treating chronic pelvic inflammation and a preparation method thereof. The drug is prepared by compounding the following traditional Chinese herbals: rhizoma sparganic, curcuma rhizome, prunella vulgaris, cortex moutan, green tangerine peel, rheum officinale, curcuma tuber, red sage root, radix astragali, oyster, dandelion, honeysuckle flower, toosendan fruit, coix seed, fructus liquidambaris, and pangolin scale. The drug has the functions of activating blood circulation to remove stasis, clearing heat, removing toxicity, softening the hardness, dissipating the binds, regulating qi, and relieving the pains, and has a prominent effect on treating chronic pelvic inflammation.

Description

A kind of medicine for the treatment of chronic pelvic inflammatory disease and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of chronic pelvic inflammatory disease and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Chronic pelvic inflammatory disease is common gynecological disease, frequently-occurring disease, refer to female internal genital organs and surrounding connective tissue, pelvic peritoneal chronic inflammatory disease, how to be treated not in time by acute pelvic inflammatory disease and to transfer to chronic, have the advantages that the course of disease is long, cure rate is low, relapse rate is high, clinical with lower abdomen falling inflation dull pain, waist sacrum portion Acid pain, menoxenia, leucorrhea amount after many and menstrual phase, tired after, postemphasis of suffering from cold is for main manifestations, if form chronic adnexitis, then lump can be touched.Pelvic inflammatory disease disease time is long, and the state of an illness is more obstinate, easy recurrent exerbation, causes very large harm not only to female friend's physical and mental health, also add the financial burden of female friend.

Modern medicine many employings anti-inflammatory analgetic symptomatic treatment, the drug orals such as application broad ectrum antibiotic.Simple application antibiotic therapy pelvic inflammatory disease, usually easily produces drug resistance because of course of disease delay, especially causes connective tissue proliferation for chronic pelvic inflammatory disease inflammatory infiltration, the extensive adhesion DeGrain of pelvic cavity.

Chinese medicine, without the name of pelvic inflammatory disease, according to the clinical symptoms feature of disease, belongs to the categories such as menoxenia, leukorrheal diseases, married woman's stomachache, puerperal fever, mass in the abdomen, its cause of disease mainly blame in the positive QI-insufficiency of married woman, vessels of the uterus is hollow, outward by cold-evil, or innate deficiency of YANG in the body, yin-cold excess, again by childbirth, miscarriage, or intrauterine surgical, sexual intercourse are unclean etc., make the heresy of cold and heat noxious dampness, be harmonious with chronic disease, cause punching to be appointed impaired, vessels of the uterus is qi-blood disharmony, fights and forms the stasis of blood and send out.First attack, especially acute onset person, integrative therapy mostly can very fast symptom management, not easily causes patient to pay attention to.Chinese medicine is thought, it take blood as this that female belongs to cloudy, how empty prolonged illness is, disease enters network for a long time, therefore to the assurance of its chronic pelvic inflammatory disease etiology and pathogenesis usually with empty, cold, wet, the stasis of blood for emphasis, acute attack then must consider heat, poison, the stasis of blood, vessels of the uterus stasis blocking runs through disease all the time, the course of disease with the passing of time, consider that the state of an illness affects whole body internal organs by local vessels of the uterus, liver,spleen,kidney three is dirty the most easily damaged, has bibliographical information to be mainly dampness and heat stasis, qi depression to blood stasis, cold and damp stagnation, blood stasis due to qi deficiency etc. at clinical middle Treatment of Chronic Pelvic Inflammatory Disease With TCM differentiation of symptoms and signs for classification of syndrome.

Summary of the invention

The present inventor is found by a large amount of clinical researches, and the combination medicine form of Rhizoma Sparganii, Rhizoma Curcumae, Spica Prunellae, Cortex Moutan, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Salviae Miltiorrhizae, the Radix Astragali, Concha Ostreae, Herba Taraxaci, Flos Lonicerae, Fructus Toosendan, Semen Coicis, Fructus Liquidambaris, Squama Manis can provide the effect for the treatment of qi stagnation and blood stasis type chronic pelvic inflammatory disease.

The invention provides a kind of medicine for the treatment of chronic pelvic inflammatory disease, this medicine by comprise Rhizoma Sparganii, Rhizoma Curcumae, Spica Prunellae, Cortex Moutan, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Salviae Miltiorrhizae, the Radix Astragali, Concha Ostreae, Herba Taraxaci, Flos Lonicerae, Fructus Toosendan, Semen Coicis, Fructus Liquidambaris, Squama Manis crude drug make.Medicine of the present invention has blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, hard masses softening and resolving, the effect of regulating QI to relieve pain, and medicine of the present invention has the effect of significant treatment qi stagnation and blood stasis type chronic pelvic inflammatory disease.

Medicine of the present invention, according to the ratio of the weight of crude drug, comprise Rhizoma Sparganii 10-30 part, Rhizoma Curcumae 10-30 part, Spica Prunellae 10-30 part, Cortex Moutan 10-30 part, Pericarpium Citri Reticulatae Viride 10-30 part, Radix Et Rhizoma Rhei 10-20 part, Radix Curcumae 10-20 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Astragali 30-50 part, Concha Ostreae 10-30 part, Herba Taraxaci 20-40 part, Flos Lonicerae 20-40 part, Fructus Toosendan 20-40 part, Semen Coicis 20-40 part, Fructus Liquidambaris 20-40 part, Squama Manis 1-10 part.

In one embodiment of the invention, medicine of the present invention, according to the ratio of the weight of crude drug, comprises Rhizoma Sparganii 20 parts, Rhizoma Curcumae 20 parts, Spica Prunellae 20 parts, Cortex Moutan 20 parts, 20 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 15 parts, Radix Curcumae 15 parts, Radix Salviae Miltiorrhizae 20 parts, the Radix Astragali 40 parts, Concha Ostreae 20 parts, Herba Taraxaci 30 parts, Flos Lonicerae 30 parts, Fructus Toosendan 30 parts, Semen Coicis 30 grams, Fructus Liquidambaris 30 parts, Squama Manis 5 parts.

The pharmacologically active of each crude drug of medicine of the present invention is as follows:

Rhizoma Sparganii this product is the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganium stoloniferum Buch.-Ham..Spring winter to next year excavates, and clean, crust of pruning, dries.[nature and flavor] are pungent, bitter, flat.[return through] returns liver, spleen channel.The circulation of qi promoting of [function cures mainly] removing blood stasis, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.

Rhizoma Sparganii tuber is containing volatile oil, wherein main component is phenethanol (benzeneethanol), hydroquinone (1,4-benzenediol), hexadecylic acid (hexadecanoic acid), also have multiple composition such as dehydrocostuslactone (dehydrocostuslactone).Again containing multiple organic acid: multiple organic acid such as succinic acid (succinic acid), Rhizoma Sparganii acid (sanleng acid), 9-11-octadecadienoic acid (9-11-octadedicenoic acid), 9-12-octadecadienoic acids (9-12-octadedicenoic acid).Isolated small intestines of rabbits motion result shows, and Rhizoma Sparganii can cause intestinal contraction to strengthen, and tonicity raises, but its effect by the atropine of variable concentrations institute antagonism, also can have excitation to isolated rabbit uterus.To the display of rat Blood coagulation tests, the effect that Rhizoma Sparganii has anticoagulant, extends thrombus formation time, shortens thrombosis length and weight reduction, also has the trend extending prothrombin time and part Thrombokinase, reduces whole blood viscosity.These results provide theoretical foundation to traditional drug for invigorating blood circulation and eliminating stasis.

Rhizoma Curcumae this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary Curcuma Kwangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling.The latter practises title " Curcuma wenyujin ".Winter, stem and leaf was excavated after withering, and cleaned, steamed or boil to the saturating heart, dry or remove fibrous root and impurity after cold drying.[nature and flavor] are pungent, bitter, temperature.[return through] returns liver, spleen channel.[function cures mainly] circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.

Rhizoma Curcumae rhizome is containing volatile oil, and the composition contained in oil has Rhizoma Curcumae furanone (curzerenone), table Rhizoma Curcumae furanone (epicurzerenone), Rhizoma Curcumae furan hydrocarbon (curzenene), curdione (curdione), curcumenol (cHrculnol), Camphora, Borneolum Syntheticum etc.There is antitumaous effect; Blood flow can be increased; Inhibitory action is had to the growth of staphylococcus aureus, escherichia coli etc.

Spica Prunellae this product is the dry fruit ear of labiate Spica Prunellae Prunella vulgaris L..Gather when summer, fruit ear was brownish red, removing impurity, dries.[nature and flavor] are pungent, bitter, cold.[return through] returns liver, gallbladder meridian.[function cures mainly] relieves inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.

Spica Prunellae is containing the Multiple components such as anthocyanin of Polysaccharides from Prunella vulgaris L (prunellin) prunellin (prunellin), ursolic acid (ursolic acid), oleanolic acid (oleanolic acid), hyperin (hyperoside), delphinidin (delphinidin) and cyanidin (cyanidin).Have hypotensive effect, antibacterial, antivirus action, also has hypoglycemic activity.

Cortex Moutan this product is the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Autumn excavates root, and removing radicula, strips root bark, dry.[nature and flavor] are bitter, pungent, are slightly cold.[return through] GUIXIN, liver, kidney channel.[function cures mainly] clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.

Cortex Moutan is containing multiple glycoside and volatile oil such as paeonol (paeonol), the former glycosides of Cortex Moutan (paeonolide), peoniflorin (paeoniflorin), Hydroxy peoniflorin, benzoylpaeoniflorins.Decoct all has inhibitory action to various pathogen; Can reduce blood pressure; There are calmness, anticonvulsant effect, in addition, also have the effect of antiinflammatory and antiallergic action.

Pericarpium Citri Reticulatae Viride this product is the dry young fruit of rutaceae orange Citrus reticulata Blanco and variety thereof or the peel of immature fruit.5 ~ June collects the young fruit from falling, and dries, and practises and claiming " FTUCTUS CITRI IMMATURI " or " Pericarpium Citri Reticulatae Viride "; Gather for 7 ~ August green fruit, on peel, vertical profile becomes pintongs to base portion, eliminates flesh lobe, dries, and practises and claims " Sihuaqingpi ".[nature and flavor] are bitter, pungent, temperature.[return through] returns liver, gallbladder, stomach warp.[function cures mainly] is soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.

Pericarpium Citri Reticulatae Viride is containing boosting effective ingredient: left-handed Neosynephrine acetate (synephrine acetate).Also containing aspartic acid (aspartic acid), glutamic acid (glutamic acid), proline (proline), glycine (glycine), alanine (alanine), cystine (cystine), valine (valine), leucine (leucine), isoleucine (isoleucine), phenylalanine (phenylalanine), histidine (histidine), arginine (arginine), tyrosine (tyrosine) and other multiple organic principles.Have effect to smooth muscle, have eliminate the phlegm, antiasthmatic effect, boosting, Antishock function.

Radix Et Rhizoma Rhei this product is the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing, and removing radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.[nature and flavor] are bitter, cold.[return through] returns spleen, stomach, large intestine, liver, pericardium channel.[function cures mainly] purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system, for conjunctival congestion pharyngeal swelling, and gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, and eliminating fire and detoxication, for pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding, and has stasis of blood hemorrhage for heat in blood.

Dissociated anthraquinone contained by Radix Et Rhizoma Rhei has chrysophanol (chrysophanol), emodin (emodin), emodin ether (php-scion), aloe-emodin (aloe-emodin), chrysophanic acid (rhein); Combined anthraquinone has chrysophanol-l-glucoside, Chrysophanol8-O-β-D-glucopyranoside, emodin-1-O-β-D-Glucose glycosides, emodin-8-O-β-D-glucosule, physcione-8-O β-D-Glucose glycosides, physcione-8-O-β-D-O-gentibioside, aloe-emodin-8-O-β-D-Glucose glycosides, aloe-emodin-3-O-β-D-Glucose glycosides, chrysophanic acid-8-O-β-D-Glucose glycosides, chrysophanic acid-8-O-β-D(6 '-oxalyl)-glucoside, chrysophanic acid two glucoside A, B, C, D; Dianthracene ketone has sorrel dianthrone (Palmidin) A, B, C, sannidin (srheidin) A, B, C, sennoside (sennosiBe) B, B, C, D, E, F.Radix Et Rhizoma Rhei is also containing stilbene glycoside and other Multiple components.To have under rushing down, profit be bright, protect the liver, anti-gastric duodenal ulcer, antibacterial, antiinflammatory, the effect such as hemostasis.

Radix Curcumae this product is the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S.G.Lee et C.F.Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, and all the other are practised by character difference and claim " osmanthus Radix Curcumae " or " green filament Radix Curcumae ".Winter, stem and leaf was excavated after withering, and removing silt and radicula, steam or boil to the saturating heart, dry.[nature and flavor] are pungent, bitter, cold.[return through] returns liver, the heart, lung meridian.[function cures mainly] regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.

Radix Curcumae tuber is containing curcumin chemical compounds: curcumin (curcumin), demethoxycurcumin (demethoxycurcumin), bisdemethoxycurcumin (bisdemethoxycurcumin), also containing sesquiterpene alcohols, Camphora, camphene, still containing curcumin, demethoxycurcumin, turmerone and polysaccharide etc.Volatile oil can regulate the humoral immunization of toxic hepatitis mice, has immunosuppressant and antifungic action.Polysaccharide has stronger reticuloendothelial system Activation Activity; Plasma fibrinogen, T-CHOL, content of triglyceride can be reduced; Gastric acid secretion, improves the content of gastrin, secretin in serum, and promotes the discharge of bile.

Radix Salviae Miltiorrhizae this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Spring, Qiu Erji excavate, removing silt, dry.[nature and flavor] are bitter, are slightly cold.[return through] GUIXIN, Liver Channel.[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Radix Salviae Miltiorrhizae has the effect of blood circulation promoting and blood stasis dispelling, its chemical composition is diterpene Quinone Pigments mainly, TANSHINONES (tanshinone) I, II A, II B, cryptotanshinone (cryptotanshinone), iso tanshinone (isotanshinones) I, II, different cryptotanshinone (1socryptotanshinone), miltirone (miltirone), Methyl tanshinoate (methyl tanshinonate), hydroxytanshinone ⅡA Hydroxytanshinone IIA. (hydroxytanshinone), dihydrotanshinone Ⅰ (dihydrotanshinone I), neotanshinone A, second, third, methylene tanshinquinone (methylenetanshinquinone) and carnosol (salviol).Another report closes ferruginal (ferruginol), Δ l-miltirone (Δ l-dehydromiltirone), Δ l-tanshinone IIA (Δ l-dehydrotanshinone IIA), danshenxinkun fourth (danshenxinkun D) and 1,2-dihydro Radix Salviae Miltiorrhizae quinone etc.Have and improve microcirculation, promote the reparation of tissue and regeneration, suppress the effect of the fibroblast of hyperplasia.

Radix Astragali this product is cylindrical, and what have has branch, and upper end is comparatively thick, long 30 ~ 90cm, diameter 1 ~ 3.5cm.Surface light brown yellow or light brown brown, have irregular vertical wrinkle or longitudinal furrow.Matter is hard and tough, not frangibility, and section fibrous is strong, and aobvious mealiness, skin zone's yellow-white, and woody part is faint yellow, has radial texture and crack, and Lao Gen center is even dry and decayed shape, pitchy or in cavity.Feeble QI, taste is micro-sweet, and that chews micro-ly has beany flavor.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

The Radix Astragali, containing flavones ingredient calycosin (calycosin), 3-hydroxy-9,10-dimethoxy pterocarpane, also contains the Multiple components such as Radix Astragali saponin I ~ VIII (astragaloside I ~ VIII).The physiological metabolism effect of cell can be made to strengthen, have promotion myeloid element DNA synthesis, accelerate nucleated cell fission process, alleviate nephropathy and diuresis; Protective effect is had to experimental hepatitis.In addition the effect such as defying age, antibacterial, blood pressure lowering, calmness, analgesia is also had.

Concha Ostreae this product is the shell of Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Crosse or Crassostrea rivularis Ostrea rivularis Gould.The whole year all can gather, fleshing, cleans, dries.[nature and flavor] are salty, are slightly cold.[return through] returns liver, gallbladder, kidney channel.[function cures mainly] tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Concha Ostreae is containing glycogen, taurine (Taurine), 10 kinds of required compositions such as propylhomoserin, inorganic salt (copper, zinc, manganese, barium, phosphorus, calcium).Contained calcium carbonate has the effect such as convergence, antacid, only epilepsy, is conducive to the healing of gastric and duodenal ulcers; This product may have the whole corticocerebral function of adjustment, and well, forging Concha Ostreae has restrains astringent or styptic treatment for spontaneous sweating effect for raw calmness, solution thermal effect.In addition the effect such as immunity, antitumor is strengthened in addition.

Herba Taraxaci this product is the curling agglomerate of shrinkage.Root conically, bends more, long 3 ~ 7cm; Surface sepia, shirring; Root head has the fine hair of sepia or yellow-white, and what have comes off.Phyllopodium is raw, and many shrinkages are broken, and intact leaf is in falling lanceolar, green and brown color or lead, and tip point or blunt, edge is shallow to be split or pinnation, and base portion is gradually narrow, and downward in handle, lower surface master pulse is obvious.Scape 1 is to several, and every bar top repiece locusta, phyllary multilamellar, inner face one deck is longer, corolla yellowish-brown or yellowish white.The oblong achene of the visible most tool white pappus had.Feeble QI, mildly bitter flavor.[nature and flavor] are bitter, sweet, cold.[return through] returns liver, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Herba Taraxaci herb is containing taraxasterol (taraxasterol), choline (choline), inulin (inulin), pectin (pectin) etc.Have very strong killing action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus, alcohol extract can suppress tubercule bacillus, can also kill leptospira, helicobacter pylori and some fungus.In addition also have antitumor, protect the liver, function of gallbladder promoting, diuresis, excitement or the suppression effect such as heart, gastric acid secretion inhibiting.

The flower that Flos Lonicerae this product is caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., the dry flower of Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or band are just opened.Early summer the flowers are in blossom put before gather, dry.[nature and flavor] are sweet, cold.[return through] returns lung, the heart, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.

Flos Lonicerae is containing chlorogenic acid (chlorogenic acid), isochlorogenic acid (isochlorogenic acid), luteolin (luteolin), Flos Lonicerae alcohol, linalool (linalool) etc.There is antibacterial, antivirus action; Can antiendotoxin; There is infection, antipyretic effect; Leukocytic phagocytic function can be promoted and promote the phagocytic function of inflammatory cell, can also activated T lymphocytes function, improve lymphocytic conversion ratio.In addition blood fat reducing and antiearly pregnancy effect is also had.

Fructus Toosendan this product is the dry mature fruit of Meliaceae plant Fructus Toosendan Melia toosendan Sieb.et Zucc..Gather during fruit maturation in winter, removing impurity, dry.[nature and flavor] are bitter, cold; Slightly poisonous.[return through] returns liver, small intestinal, urinary bladder channel.[function cures mainly] soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.

Fructus Toosendan is containing driving ascarid effective ingredient Toosendanin (toosendanin), and the Triterpenoid of multiple bitterness, Fructus Toosendan ketone (melianone), fat melianol (lipomelianol), 21-O-acetyl Fructus Toosendan triol (21-O-acetyltoosendantriol), 21-O-methyl Fructus Toosendan pentol (21-O-methyltoosendan-pentaol).Make to strengthen at body and excised tea fresh leaves tension force and contractility; Propagation function between the alternative block nerves-neuromuscular junction of the Toosendanin contained by it; There is anthelmintic action; It is irritant to gastrointestinal, therefore taste-blindness rate patient should not take; Inhibitory action is had to staphylococcus aureus; In-vitro screening result shows there is inhibitory action to human cervical carcinoma.

Semen Coicis this product is grass Semen Coicis Coix lacryma-jobi L.var.ma-yuen(Roman.) dry mature kernal of Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, except decapsidate, yellowish-brown seed coat and impurity, collect kernel.[nature and flavor] are sweet, light, cool.[return through] returns spleen, stomach, lung meridian.[function cures mainly] spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.

Semen Coicis is containing coixenolide (coixenolide), crude protein, lipid.Another fatty oil, containing Palmic acid, oleic acid etc. in oil.Semen Coicis oil low dose has excitation to breathing, and heavy dose then has paralysis effect, and Pulmonary Vascular can be made significantly to expand; To isolated frog heart and isolated rabbit intestinal, low concentration is excitation, and high concentration has inhibitory action; There is antidiuretic activity; Coixenolide has antitumor action.

Fructus Liquidambaris this product is the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum Liquidambar formosana Hance.Winter gathers after fruit maturation, removing impurity, dry.[nature and flavor] are bitter, flat.[return through] returns liver, kidney channel.[function cures mainly] dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.

Chinese sweet gum fruit is containing β-terpinene, nopinene, limonene, α-terpinene etc. separately containing oleanolic acid, ursolic acid, daucosterol, betulonic acid, gallic acid etc.Be separated the betulonic acid obtained in its methanolic extract and there is obvious anti-hepatotoxicity active function; Volatile oil experiment in vitro contained by it can make Sanguis Leporis seu oryctolagi bolt contraction in length, weight (dry weight and weight in wet base) alleviates, and experiment in vivo can obviously suppress rat suppository to be formed.Betulonic acid has obvious anti-hepatocyte cytotoxic activity, and this crude drug makes hepatoprotective in Taiwan.

Squama Manis this product is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus, collects scute, cleans, dries, and size separately, is shone by " Chinese Pharmacopoeia " and scalded method (appendix II D) with stir-baking in sand to heaving, cleaning, drying.Used time smashs to pieces.[nature and flavor] are salty, cool.[return through] enters liver, stomach warp.The routed carbuncle of [function cures mainly] detumescence, searches wind active, stimulating milk secretion of stimulating the menstrual flow.Control carbuncle skin ulcer kind, anemofrigid-damp arthralgia, amenorrhea, galactostasis.External is stopped blooding.

[cvclo-(L-seryl-L-tyrosyl) 1, D-silk-L-cheese Cyclic dipeptides etc., again containing 18 kinds of elements such as zinc, sodium, titanium, calcium, lead, silicon, phosphorus, ferrum, manganese, chromium, magnesium, nickel, copper, barium, boron, aluminum, molybdenum, stannum containing keratin, several amino acids, cholesterol, two tridecanoyl butylamine, L-silk-L-cheese Cyclic dipeptides for the scale of Squama Manis.Also containing volatile oil and water-soluble alkaloid etc.Have the effect reducing blood viscosity, antiinflammatory, suppression mutation, in addition, the Cyclic dipeptides VI and VII in Squama Manis sheet can improve the tolerance of white mice normobaric hypoxia.

The medicine that the present invention treats chronic pelvic inflammatory disease conventionally can make the various dosage forms on pharmaceutics, comprises tablet, capsule, pill, granule, oral liquid, colloid, syrup etc.Concrete preparation method comprises:

1) be soaked in water crude drug 30-60 minute, decocts 20-40 minute, pour out medicinal liquid;

2) decoct with water 10-30 minute again, pour out medicinal liquid;

3) above-mentioned medicinal liquid is merged, normal pressure or be evaporated to thick paste.

4) add pharmaceutic adjuvant, make the various dosage forms such as capsule, tablet, pill.

Pharmaceutical composition of the present invention have followed the theory of traditional Chinese medical science monarch, have followed the theory of instruction of Chinese Medicine theory application in TCM, with Radix Salviae Miltiorrhizae, Rhizoma Curcumae, Rhizoma Sparganii, Radix Curcumae blood circulation promoting and blood stasis dispelling menstruction regulating and pain relieving for monarch; With Flos Lonicerae, Herba Taraxaci, Spica Prunellae, the detumescence of Cortex Moutan heat-clearing and toxic substances removing eliminating stagnation for minister; With Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Radix Astragali QI invigorating liver-smoothing, qi-regulating for assistant; With Squama Manis, Fructus Liquidambaris, Semen Coicis, Concha Ostreae, Radix Et Rhizoma Rhei dredging collateral dampness removing hard masses softening and resolving removing toxicity for eliminating carbuncles purging heat to relax the bowels for making.There is blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, hard masses softening and resolving, regulating QI to relieve pain effect.

Detailed description of the invention

The invention will be further described by the following examples, but this is not limitation of the present invention, those skilled in the art, according to basic thought of the present invention, can make various amendment or improvement, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.Prepared by embodiment 1 medicine

Rhizoma Sparganii 20 grams

Rhizoma Curcumae 20 grams

Spica Prunellae 20 grams

Cortex Moutan 20 grams

20 grams, Pericarpium Citri Reticulatae Viride

Radix Et Rhizoma Rhei 15 grams

Radix Curcumae 15 grams

Radix Salviae Miltiorrhizae 20 grams

The Radix Astragali 40 grams

Concha Ostreae 20 grams

Herba Taraxaci 30 grams

Flos Lonicerae 30 grams

Fructus Toosendan 30 grams

Semen Coicis 30 grams

Fructus Liquidambaris 30 grams

Squama Manis 5 grams.

A. above-mentioned medical material is taken;

B. add room temperature drinking water and soak 30-60 minute, decoct 20-40 minute, pour out medicinal liquid;

C. add room temperature drinking water again and decoct 10-30 minute, pour out medicinal liquid;

D. above-mentioned medicinal liquid is merged;

E. normal pressure or be evaporated to thick paste.

Gained thick paste adds pharmaceutic adjuvant further, can be prepared into capsule or tablet or pill.

Embodiment 2 pharmacodynamic experiment checks medicine of the present invention on the impact of rat uterus inflammation

Drug study group of the present invention: medicine thick paste evaporate to dryness embodiment 1 prepared, pulverizes, adding distil water supending.

HUAHONG KELI matched group: HUAHONG KELI is pulverized, adding distil water supending.

Chinese patent CN200810157888.4 matched group: by Chinese medicine composition thick paste evaporate to dryness disclosed in CN200810157888.4, pulverizes, adding distil water supending.

Get body weight 200-250g Wistar rat 50, female, under ether light anaesthesia aseptic condition, expose uterus in median incision of lower abdomen 2cm, do a transverse incision along 1cm place on left uterine angle, by plastic tube (caliber 2mm, long 0.5cm, heavy 2mg, alcohol disinfecting) imbed intrauterine, fix with Uterine repair, with slip-off preventing.Wound instillation penicillin 0.1mg (dissolving in water for injection 0.2ml), in case infect.Rat is divided into 5 groups by postoperative 2h, often organize 10, grouping after administration or give equal-volume distilled water, dosage (weighing scale by every kg body weight institute drug dry powder) is in table 1.Every day gavage 1 time, continuous 7 days, after last administration 40min put to death animal, get uterus, both sides, analytical balance is weighed, and the difference that the left uterine weight of every Mus deducts right uterine weight is inflammation swelling degree, and obtain the inhibitory rate of intumesce of administration group, the results are shown in Table 1.

Table 1 medicine of the present invention is on the impact of rat uterus inflammation

T checks, and compares * P < 0.05, * * P < 0.01 with matched group

Result shows, medicine of the present invention each dosage group has obvious inhibitory action to the swelling of rat uterus inflammation, is better than pharmaceutical composition disclosed in HUAHONG KELI and Chinese patent CN200810157888.4.

Claims (3)

1. treat a medicine for chronic pelvic inflammatory disease, comprise the crude drug of following weight portion:

Rhizoma Sparganii 10-30 part, Rhizoma Curcumae 10-30 part, Spica Prunellae 10-30 part, Cortex Moutan 10-30 part, Pericarpium Citri Reticulatae Viride 10-30 gram, Radix Et Rhizoma Rhei 10-20 part, Radix Curcumae 10-20 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Astragali 30-50 part, Concha Ostreae 10-30 part, Herba Taraxaci 20-40 part, Flos Lonicerae 20-40 part, Fructus Toosendan 20-40 part, Semen Coicis 20-40 part, Fructus Liquidambaris 20-40 part and Squama Manis 1-10 part.

2. medicine according to claim 1, is characterized in that, wherein the weight proportion of each crude drug is:

Rhizoma Sparganii 20 parts, Rhizoma Curcumae 20 parts, Spica Prunellae 20 parts, Cortex Moutan 20 parts, 20 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 15 parts, Radix Curcumae 15 parts, Radix Salviae Miltiorrhizae 20 parts, the Radix Astragali 40 parts, Concha Ostreae 20 parts, Herba Taraxaci 30 parts, Flos Lonicerae 30 parts, Fructus Toosendan 30 parts, Semen Coicis 30 parts, Fructus Liquidambaris 30 parts and Squama Manis 5 parts.

3. the preparation method of medicine described in any one in claim 1-2, comprises the following steps:

1) be soaked in water crude drug 30-60 minute, decocts 20-40 minute, pour out medicinal liquid;

2) decoct with water 10-30 minute again, pour out medicinal liquid;

3) above-mentioned medicinal liquid is merged, normal pressure or be evaporated to thick paste;

4) add pharmaceutic adjuvant, be prepared into required dosage form.