CN104622934A - Novel application of olive leaf crude extract in preparation of drugs for treating sphagitis - Google Patents
Novel application of olive leaf crude extract in preparation of drugs for treating sphagitis Download PDFInfo
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Abstract
The invention relates to the field of medicine and healthcare, and especially relates to a novel application of olive leaf crude extract in the preparation of drugs for treating sphagitis. The invention discloses an application of olive leaf crude extract in preparation of drugs or healthcare products for treating sphagitis, and provides a pharmaceutical composition and healthcare product containing olive leaf crude extracts. People find that olive leaf crude extract can treat sphagitis for the first time, moreover, the curative effect is quick and definite, no cell side or toxic effect has been found at the same time, and thus the olive leaf crude extract is an ideal drug or healthcare product for treating sphagitis.
Description
Technical field
The present invention relates to medical health field, particularly relate to the novelty teabag that Chinese olive tree Leave extract prepares Faucitis treatment medicine.
Background technology
In Mediterranean country, thousands of year has been there is in the practice that Fructus Canarii albi leaves is used for prevention and therapy disease among the people, as being used for the treatment of abdominal colic, alopecia, paralysis paralysis, the heating etc. that arthralgia and malaria cause, but about the first official scientific literature report of its therapeutical effect is only to trace back to 1854.In the nineteen fifty-five of the middle of last century, someone reports that its extract has obvious therapeutic action to hypertension.In decades subsequently, people notice gradually, and the cardiovascular disease incidence rate of Mediterranean country and Tumor incidence are that the whole world is minimum.In recent two decades in the past, by the extensive epidemiology comparative study with other regional crowd, and inside and outside cell and zooscopy official confirmation: olive tree products is as Fructus Canarii albi, olive oil and a large amount of uses of Fructus Canarii albi leaves in Mediterranean resident food are the reasons causing this species diversity.
In nearest ten years, people confirm that the medicinal function of Chinese olive tree is rich in antioxidative phytochemistry molecule and has direct relation with it further, these molecules are oleuropein (oleuropein) mainly, hydroxytyrosol (hydroxytyrosol), tyrosol (tyrosol), caffeic acid (caffeic acid), p-Coumaric Acid (p-coumaric acid), vanillic acid (vanillic acid), vanillin (vanillin), digicitrine (luteolin), diosmetin (diosmetin), rutin (rutin), verbascoside (verbascoside), luteolin-7-glucoside (luteolin-7-glucoside), versulin-7-glucoside (apigenin-7-glucoside) and diosmetin-7-glucoside (diosmetin-7-glucoside).
All these medicinal plants chemical moleculars have distribution in the various piece of Chinese olive tree is as Fructus Canarii albi and olive oil, but it is especially the highest with content in leaves, wherein oleuropein accounts for leaves dry weight, different according to the place of production, low can between 6%-9%, high arrives 19%, and the molecule of other various flavonoid accounts for 1.8% at most, and the molecule of various portugal glycoside accounts for 0.8% at most.
In the last few years, goed deep into comparatively fast to the molecular mechanism research of the main component oleuropein inside Fructus Canarii albi leaves and hydroxytyrosol.The data of accumulation shows: they not only have the strong function removing free radical in histiocyte, but also has the strong function to antibacterium, virus, mycete and mycoplasma.Further research finds, the crude extract of Fructus Canarii albi leaves, because containing more how various different bioactive molecule, the ability of its scavenging free radicals and antagonism pathogenic bacteria, than it alone oleuropein and/or hydroxytyrosol, acts on better more greatly, also more economical.In rat body subsequently, acute toxicity test shows, when giving rat oral gavage 2000mg/kg Chinese olive tree Leave extract, observe median lethal not yet, this is medicine carries out toxicity test with it the highest limit at toy, if higher than this limit, academia thinks primitive decision to be nontoxic.The external Chinese olive tree Leave extract preparation that have devised oral liquid and capsule two kinds of commercialized version according to these test datas, for body-care.
Pharyngitis is divided into acute and chronic pharyngitis.Be under pharyngeal mucous membrane, mucosa and adenoid diffusivity chronic inflammatory disease for chronic pharyngitis (chronic pharyngitis), clinical main manifestations is foreign body in pharynx sense, gargalesthesia, burning sensation, dry sensation or hypodynia sense.Inspection is shown in that pharyngeal chronic congestion is kermesinus, thin vessels varicose, and retropharyneal folliculosis or fusion are block in flakes, and protrude from pharynx rear wall, lateral pharyngeal band thickens, and root of the tongue lymphoid tissue hyperplasia is nodositas etc.Be more common in adult, the course of disease is long, and symptom is obstinate, the usual poor effect of antibiotic therapy.According to statistics, in China town dweller, the prevalence of this disease accounts for 10% ~ 20% of disease of pharynx, is commonly encountered diseases, is also Other diseases or Infective morbidity simultaneously, and also easy recurrent exerbation, there is no specific medicament.
Summary of the invention
The object of the invention is to the novelty teabag of open Chinese olive tree Leave extract treatment pharyngolaryngitis, and based on the discovery of Chinese olive tree Leave extract novelty teabag, provide a kind of Faucitis treatment medicine containing Chinese olive tree Leave extract or health product.
First aspect present invention discloses the purposes of Chinese olive tree Leave extract in the medicine or health product of preparation treatment pharyngolaryngitis.
Preferably, described pharyngolaryngitis is selected from acute pharyngitis, chronic pharyngitis, acute laryngitis or chronic laryngitis.
Preferred, described pharyngolaryngitis is chronic pharyngitis.
Chronic pharyngitis of the present invention, includes but not limited to chronic simple pharyngitis, chronic hypertrophic pharyngitis, atrophic and pharyngitis sicca, chronic anaphylaxis pharyngitis, and chronic reflux pharyngitis.
Preferably, described Chinese olive tree Leave extract is the water extract of Fructus Canarii albi leaves.
More excellent, described Chinese olive tree Leave extract is adopted and is prepared with the following method: get Fructus Canarii albi leaves and add 8 ~ 10 times of volume water and decoct, taking liquid after solid-liquid separation, medicinal residues are added water and repeats to decoct, merge each medicinal liquid decocting acquisition, namely obtain Chinese olive tree Leave extract by after the concentration of liquid medicine drying after merging.
Preferably, the time decocted with water is 10 ~ 60min.Preferably, the time decocted with water is 15 ~ 30min.
The number of times repeating to decoct is preferably 1 ~ 7 time.Concentrated and drying is the routine techniques in extract drugs field, concentrates and can adopt such as concentrating under reduced pressure method, heating evaporation, freezing vacuum concentration method etc.; Drying can adopt lyophilization etc.
Chinese olive tree Leave extract of the present invention is Fructus Canarii albi leaves water extract, and this preparation belongs to existing water extraction.
Second aspect present invention discloses a kind of pharmaceutical composition for the treatment of pharyngolaryngitis, containing Chinese olive tree Leave extract in described pharmaceutical composition.
Preferably, in described pharmaceutical composition, Chinese olive tree Leave extract is the sole active ingredient of this pharmaceutical composition.
Preferably, also pharmaceutically acceptable carrier is contained in described pharmaceutical composition.
" pharmaceutically acceptable " composition is the material being applicable to people and/or animal and namely having rational benefit/risk ratio without excessive bad side reaction (as toxicity, stimulation and allergy)." pharmaceutically acceptable carrier " is acceptable solvent, suspending agent or excipient pharmaceutically or on food for fusant albumen of the present invention being sent to animal or human.Carrier can be liquid or solid.
Pharmaceutically acceptable carrier includes, but is not limited to saccharide (as lactose, dextrose plus saccharose), starch (as corn starch and potato starch), cellulose and its derivates is (as sodium carboxymethyl cellulose, ethyl cellulose and methylcellulose), tragacanth gum powder, Fructus Hordei Germinatus, gelatin, Talcum, kollag (as stearic acid and magnesium stearate), calcium sulfate, vegetable oil, as Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, Oleum sesami, olive oil, Semen Maydis oil and cupu oil, polyhydric alcohol is (as propylene glycol, glycerol, Sorbitol, mannitol and Polyethylene Glycol), alginic acid, emulsifying agent is (as Tween, polyoxyethylene castor oil), wetting agent (as sodium lauryl sulfate), coloring agent, flavoring agent, tablet agent, stabilizing agent, antioxidant, antiseptic, apirogen water, isotonic saline solution and phosphate buffer etc., this carrier can improve stability, the activity and biological effectiveness etc. of formula as required.
When pharmaceutical composition of the present invention uses, described Chinese olive tree Leave extract is as sole active ingredient, or described Chinese olive tree Leave extract is as one of effective ingredient, the pharmaceutical dosage form of different way of administration can be made with one or more pharmaceutically acceptable carriers or mixed with excipients.
Preferably, the dosage form of the pharmaceutical composition of described treatment pharyngolaryngitis is tablet, capsule, powder, granule, syrup, solution, oral liquid, spirit, tincture, aerosol, powder spray, injection, injectable sterile powder, or suppository.
Preferred, the dosage form of the pharmaceutical composition of described treatment pharyngolaryngitis is tablet or oral liquid.
Pharmaceutical composition of the present invention can be passed through oral, intravenous, intramuscular or subdermal routes of administration.
Preferably, can be degerming by membrane filtration when pharmaceutical composition of the present invention is produced, or carry out autoclaving.
Chinese olive tree Leave extract can change with the order of severity of mode of administration and disease as the effective dose of active component.For most of large mammal, every day, the taking dose of effective ingredient Chinese olive tree Leave extract was about 0.01 ~ 1000mg.Preferably, the scope of adult's clinical administration amount is 0.01-200mg/ day, is more preferably 0.05-100mg/ day.
Last aspect of the present invention discloses a kind of health product for the treatment of pharyngolaryngitis, and its effective ingredient is Chinese olive tree Leave extract.
Described Chinese olive tree Leave extract is the water extract of Fructus Canarii albi leaves, and the method decocted with water by Fructus Canarii albi leaves is obtained.
Beneficial effect of the present invention is: the purposes of Late Cambrian Chinese olive tree Leave extract in all kinds of pharyngolaryngitis for the treatment of, and Chinese olive tree Leave extract and related drugs thereof are in the therapeutic process of pharyngolaryngitis, have rapid-action, definite effect, the advantages such as acellular toxic and side effects are a kind of medicine or health product of desirable treatment chronic pharyngitis.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.These embodiments are only not used in for illustration of the present invention and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, the usually conveniently conditioned disjunction condition of advising according to manufacturer.Unless otherwise indicated, otherwise all percentage ratio and number all by weight.
Part term definition used in the present invention is as follows:
Chronic pharyngitis (chronic pharyngitis) is under pharyngeal mucous membrane, mucosa and adenoid diffusivity chronic inflammatory disease, and clinical main manifestations is foreign body in pharynx sense, gargalesthesia, burning sensation, dry sensation or hypodynia sense.Inspection is shown in that pharyngeal chronic congestion is kermesinus, thin vessels varicose, retropharyneal folliculosis or fusion are block in flakes, protrude from pharynx rear wall, lateral pharyngeal band thickens, root of the tongue lymphoid tissue hyperplasia is nodositas etc., and the kind of chronic pharyngitis includes but not limited to as chronic simple pharyngitis, chronic hypertrophic pharyngitis, atrophic and pharyngitis sicca, chronic anaphylaxis pharyngitis or chronic reflux pharyngitis.
Pharmaceutical composition: for the present invention or the pharmaceutical composition containing Chinese olive tree Leave extract of the present invention.Usually, when pharmaceutical composition of the present invention is used for such use, described Chinese olive tree Leave extract can make the pharmaceutical dosage form of different way of administration, as tablet, capsule, powder, granule, syrup, solution, oral liquid, spirit, tincture, aerosol, powder spray, injection, injectable sterile powder, suppository etc. with one or more pharmaceutically acceptable carriers or mixed with excipients.
" pharmaceutically acceptable " composition is the material being applicable to people and/or animal and namely having rational benefit/risk ratio without excessive bad side reaction (as toxicity, stimulation and allergy)." pharmaceutically acceptable carrier " is acceptable solvent, suspending agent or excipient pharmaceutically or on food for fusant albumen of the present invention being sent to animal or human.Carrier can be liquid or solid.
Chinese olive tree Leave extract of the present invention can be passed through oral, intravenous, intramuscular or subdermal routes of administration.
In above-mentioned dosage form can the dosage form of oral administration administration be: tablet, capsule, powder, granule, syrup, solution, spirit.Solid-state carrier comprises: starch, lactose, calcium hydrogen phosphate, microcrystalline Cellulose, sucrose, kaolin, micropowder silica gel, Pulvis Talci, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone.And liquid carrier comprises: sterilized water, ethanol, Polyethylene Glycol, nonionic surfactant and edible oil (as Semen Maydis oil, Oleum Arachidis hypogaeae semen and Oleum sesami).In the process of pharmaceutical compositions, normally used adjuvant comprises: flavoring agent, coloring agent, antiseptic (as oxybenzene alkyl butyl ester, sodium benzoate, sorbic acid) and antioxidant (as vitamin E, vitamin C, sodium pyrosulfite and dibenzylatiooluene).
The dosage form that can be used for injection administration in above-mentioned dosage form comprises: injection, injectable sterile powder, and they are forms medicine and one or more pharmaceutically acceptable mixed with excipients made for drug administration by injection.Solvent comprises: sterilized water, ethanol, glycerol, propylene glycol, Polyethylene Glycol.In addition, also need to add antibacterial (as benzyl alcohol, butyl hydroxybenzoate, thimerosal), isoosmotic adjusting agent (as sodium chloride, glucose), suspending agent (as sodium carboxymethyl cellulose, methylcellulose), solubilizing agent (tween 80, lecithin), antioxidant (as vitamin E, vitamin C, sodium pyrosulfite) and filler (as lactose, mannitol).
From the position being easy to preparation and administration, preferred medicinal composition tablets or oral liquid, preferred modes is oral administration.
The method preparation that pharmaceutical composition of the present invention can require according to that know and generally acknowledged pharmaceutical manufacturing.Pharmaceutical composition is suitable comprises Chinese olive tree Leave extract of the present invention and pharmaceutically acceptable carrier, and is suitably unit dosage form.
The above-mentioned feature that the present invention mentions, or the feature that embodiment is mentioned can combination in any.All features that this case description discloses can with any composition forms and use, each feature disclosed in description, anyly can provide identical, alternative characteristics that is impartial or similar object replaces.Therefore apart from special instruction, the feature disclosed is only general example that is impartial or similar features.
The preparation of embodiment 1 Chinese olive tree Leave extract and pharmaceutical preparation
1. the preparation of Chinese olive tree Leave extract
1.1 take Fructus Canarii albi leaves 50g, and the 500ml that adds water decocts 20min, gets supernatant, and slag repeats aforesaid operations, extracts 7 times, merge supernatant.Then freezing vacuum is drained and is concentrated into paste, then lyophilization is to constant weight, obtains brown dry powder, is Chinese olive tree Leave extract.
1.2 take Fructus Canarii albi leaves 50g, and the 400ml that adds water decocts 60min, gets supernatant, and slag repeats aforesaid operations, extracts 1 time, merge supernatant.Then freezing vacuum is drained and is concentrated into paste, then lyophilization is to constant weight, obtains brown dry powder, is Chinese olive tree Leave extract.
1.3 take Fructus Canarii albi leaves 50g, and the 450ml that adds water decocts 10min, gets supernatant, and slag repeats aforesaid operations, extracts 5 times, merge supernatant.Then freezing vacuum is drained and is concentrated into paste, then lyophilization is to constant weight, obtains brown dry powder, is Chinese olive tree Leave extract.
2. the preparation of drug composition oral liquid
Take Fructus Canarii albi leaves 50g, the 500ml that adds water decocts 20min, gets supernatant, and slag repeats aforesaid operations, extracts 7 times, merges supernatant.Then freezing vacuum is drained and is concentrated into paste, then lyophilization is to constant weight, obtains brown dry powder, is Chinese olive tree Leave extract.In Chinese olive tree Leave extract, add 200ml deionized water soaking at room temperature spend the night, electric stirring 2 hours, after ordinary filter paper filters, through 5 μMs, 0,8 μMs and 0.45 μM of filter membrane filter step by step, the last membrane filtration sterilizing using 0.22 μM in super-clean bench again, be Chinese olive tree Leave extract aqueous solution, subpackage, 40C saves backup.
3. the preparation of medicinal composition tablets
Adopt Chinese olive tree Leave extract prepared by the present embodiment method 1.2, by each component mixing in table 1, then direct compression, prepare the pharyngolaryngitis pharmaceutical composition of tablet form, its formula is as follows:
The composition of table 1 pharmaceutical composition
The test of pesticide effectiveness of embodiment 2 Chinese olive tree Leave extract
1. experimental technique
The diagnostic criteria of 1.1 chronic pharyngitiss:
Standard with reference to the guideline of clinical investigations of chronic pharyngitis " new Chinese medicine treatment " defines: clinical symptoms main manifestations be pharyngeally dryly to itch, hypodynia, foreign body sensation, dry cough or burn feeling; Clinical sign is: pharyngeal diffusivity is congested, or dendroid is congested, and with a small amount of sticky secretions, retropharyneal folliculosis, or lateral pharyngeal band enlargement, pharynx mucosa hypertrophy is plump, and it is bright as paraffin paper that part pharyngitis sicca person swallows mucosa color as seen, and have pus crusts to adhere to.Possess any one or one or more person in above-mentioned symptom or sign, can chronic pharyngitis be diagnosed as.
1.2 experimental subjecies:
Experimental subject is 150 routine clinical definites is the patient of chronic pharyngitis, by Principles in Informed Consent accept this method treatment, wherein man 80 example, female 70 example, age range at 35 ~ 61 years old, 5-year courses ~ 31 year.
1.3 Therapeutic Method:
Adopt self-controlled method observe the curative effect, namely take placebo first to the patient being diagnosed as chronic pharyngitis with 150 examples by blind, placebo adopts commercially available Chewable C (Zhejiang health Kangenbei Group Co., Ltd), every day 1 time, each 1, every sheet 213mg, serve on 20 days, and the 21st day to examination in hospital.After inspection, start to take Chinese olive tree Leave extract aqueous solution (oral liquid of embodiment 1 method 2 preparation), instructions of taking is: one day twice, and each 10ml takes 20 days continuously, same 21st examination in hospital therapeutic outcome in the sky.
1.4 efficacy assessment standards:
By the criterion that " guideline of clinical investigations of new Chinese medicine treatment chronic pharyngitis " proposes, therapeutic effect is divided into healing, effectively with invalid.Cure: clinical symptoms and sign disappear, throat hyperemia, follicle hypertrophy and foreign body sensation in the throat disappear; Effective: clinical symptoms and sign disappear or alleviate, throat is congested, follicle hypertrophy obviously alleviates, and foreign body sensation in the throat disappears substantially; Invalid: symptom and sign are without significant change.
2. experimental result
150 routine patients, after taking placebo, chronic pharyngitis has no any change, but takes Chinese olive tree Leave extract aqueous solution after 20 days, cures 30 examples, effective 120 examples, and invalid 0 example, cure rate 20%, total effective rate 100%, has no any untoward reaction.Adopt SPSS21.0 statistical analysis software to carry out statistical analysis, continuous correction chi-square criterion=26.133, P<0.0001, statistics has significant difference, and experimental result is in table 2.
Table 2 therapeutic effect compares
As seen from the results in Table 2, Chinese olive tree Leave extract has obvious Faucitis treatment effect, and rapid-action, definite effect, does not observe cellulotoxic side effect simultaneously.
Claims (10)
1. the purposes of Chinese olive tree Leave extract in the medicine or health product of preparation treatment pharyngolaryngitis.
2. purposes as claimed in claim 1, it is characterized in that, described pharyngolaryngitis is acute pharyngitis, chronic pharyngitis, acute laryngitis or chronic laryngitis.
3. the purposes as described in claim as arbitrary in claim 1 or 2, is characterized in that, described pharyngolaryngitis is chronic pharyngitis.
4. purposes as claimed in claim 1, it is characterized in that, described Chinese olive tree Leave extract is the water extract of Fructus Canarii albi leaves.
5. purposes as claimed in claim 4, it is characterized in that, described Chinese olive tree Leave extract is adopted and is prepared with the following method: get Fructus Canarii albi leaves and add 8 ~ 10 times of volume water and decoct, taking liquid after solid-liquid separation, medicinal residues are added water and repeats to decoct, merge each medicinal liquid decocting acquisition, namely the concentration of liquid medicine drying after merging is obtained Chinese olive tree Leave extract.
6. treat a pharmaceutical composition for pharyngolaryngitis, containing Chinese olive tree Leave extract in described pharmaceutical composition.
7. pharmaceutical composition as claimed in claim 6, is characterized in that, also containing pharmaceutically acceptable carrier in described pharmaceutical composition.
8. pharmaceutical composition as claimed in claim 6, it is characterized in that, the dosage form of described pharmaceutical composition is selected from tablet, capsule, powder, granule, syrup, solution, oral liquid, spirit, tincture, aerosol, powder spray, injection, injectable sterile powder, and any one in suppository.
9. pharmaceutical composition as claimed in claim 8, it is characterized in that, the dosage form of described pharmaceutical composition is tablet or oral liquid.
10. treat health product for pharyngolaryngitis, its effective ingredient is Chinese olive tree Leave extract.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971083A (en) * | 2014-04-08 | 2015-10-14 | 上海交通大学 | Application of olive leaves in preparation or screening of medicines for treating cough |
| CN104971082A (en) * | 2014-04-08 | 2015-10-14 | 上海交通大学 | Application of olive leaves in preparation or screening for medicines for treating ozostomia |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1237356A (en) * | 1999-03-20 | 1999-12-08 | 孙景文 | Olive leaf series products and production process thereof |
| CN1583052A (en) * | 2004-05-24 | 2005-02-23 | 杨寅柯 | Extraction of canarium leaves |
| CN102451235A (en) * | 2010-10-27 | 2012-05-16 | 深圳劲创生物技术有限公司 | Preparation method of olive leaf extract |
| CN103127199A (en) * | 2013-02-08 | 2013-06-05 | 中国人民武装警察部队后勤学院 | Application of green olive extract in preparation of drugs or food or daily necessities for preventing and curing gingivitis |
| CN104127469A (en) * | 2013-05-03 | 2014-11-05 | 上海御先医药科技有限公司 | New application of olive leaf crude extract and tumor therapeutic drug combined kit thereof |
-
2013
- 2013-11-08 CN CN201310552860.1A patent/CN104622934A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1237356A (en) * | 1999-03-20 | 1999-12-08 | 孙景文 | Olive leaf series products and production process thereof |
| CN1583052A (en) * | 2004-05-24 | 2005-02-23 | 杨寅柯 | Extraction of canarium leaves |
| CN102451235A (en) * | 2010-10-27 | 2012-05-16 | 深圳劲创生物技术有限公司 | Preparation method of olive leaf extract |
| CN103127199A (en) * | 2013-02-08 | 2013-06-05 | 中国人民武装警察部队后勤学院 | Application of green olive extract in preparation of drugs or food or daily necessities for preventing and curing gingivitis |
| CN104127469A (en) * | 2013-05-03 | 2014-11-05 | 上海御先医药科技有限公司 | New application of olive leaf crude extract and tumor therapeutic drug combined kit thereof |
Non-Patent Citations (4)
| Title |
|---|
| 刘文兰: ""橄榄叶能抗感染"", 《医药养生保健报》 * |
| 周芳德编著: "《热爱生命：中老年疾病的营养治疗》", 30 November 2010, 西安交通大学出版社 * |
| 唐春红主编: "《天然防腐剂与抗氧化剂》", 31 May 2010, 中国轻工业出版社 * |
| 张鹏主编: "《世界最新医疗保健. 2》", 31 July 2003, 新世界出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971083A (en) * | 2014-04-08 | 2015-10-14 | 上海交通大学 | Application of olive leaves in preparation or screening of medicines for treating cough |
| CN104971082A (en) * | 2014-04-08 | 2015-10-14 | 上海交通大学 | Application of olive leaves in preparation or screening for medicines for treating ozostomia |
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Application publication date: 20150520 |