CN1583052A - Extraction of canarium leaves - Google Patents
Extraction of canarium leaves Download PDFInfo
- Publication number
- CN1583052A CN1583052A CN 200410023233 CN200410023233A CN1583052A CN 1583052 A CN1583052 A CN 1583052A CN 200410023233 CN200410023233 CN 200410023233 CN 200410023233 A CN200410023233 A CN 200410023233A CN 1583052 A CN1583052 A CN 1583052A
- Authority
- CN
- China
- Prior art keywords
- olive
- extracting method
- olive leaf
- folium
- leaf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000605 extraction Methods 0.000 title claims description 7
- 241000644798 Canarium <sea snail> Species 0.000 title 1
- 240000007817 Olea europaea Species 0.000 claims abstract description 47
- 235000002725 Olea europaea Nutrition 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- OSVXSBDYLRYLIG-UHFFFAOYSA-N chlorine dioxide Inorganic materials O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000019398 chlorine dioxide Nutrition 0.000 claims abstract description 12
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 10
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 14
- 239000004155 Chlorine dioxide Substances 0.000 claims description 11
- 238000004659 sterilization and disinfection Methods 0.000 claims description 9
- 238000004108 freeze drying Methods 0.000 claims description 8
- 238000007602 hot air drying Methods 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims 1
- 244000269722 Thea sinensis Species 0.000 abstract description 5
- 239000000284 extract Substances 0.000 abstract description 5
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000036039 immunity Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 244000012254 Canarium album Species 0.000 description 1
- 235000009103 Canarium album Nutrition 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A process for preparing the extract of olive leaf includes such steps as aerating ClO2 in clean water, rinsing the olive leaves, drying in hot air, extracting in alcohol, vacuum concentrating, adding water-soluble tea polyphenol, and freeze (or spray) drying.
Description
Technical field
The present invention relates to a kind of Olive leaf P.E and extract preparation method.
Background technology
The medicine expert Robert professor and professor Lang Si of Chicago Northwest University medicine institute say " above the human health diversified microorganism is arranged; by various histoorgans; these all are found recently; their interact, with human itself, even also interact; they can protect us to avoid suffering the harm of extraneous pathogen sometimes; but they can be harmful to sometimes with potential pathogenic bacteria, excessive multiplication makes troubles to people.
Although the advanced method and the medicine that have treatment and keep off infection.Antibiotic for example, the enhancing immunity medicine, modern good good sanitary condition, infectious disease still is the main cause of most severe disease.
We need a kind of natural, at any time available preparation, not only can eliminate cause such as the virus of diseases such as influenza, flu but also to human body cell without any harm, this preparation exists really---it is exactly long on Chinese olive tree, the flour of this Olive leaf P.E not only can kill virus, can also kill the microorganism that can cause disease of other type.
Olive leaf P.E can kill virus, antibacterial, fungus and parasite, improves the effect of immunity.
And when at present the effective ingredient of Folium olive being extracted, conventional common drug extracting method can not finely be sterilized, sterilization, and yield is not high, and the active constituent content in the product is lower.
It is good that purpose of the present invention aims to provide a kind of extraction effect, can well sterilize, and sterilization can be placed for a long time, preserves a kind of Olive leaf P.E extracting method of its effective ingredient effect effectively.
The objective of the invention is to realize by following manner:
Folium olive is through the clear water rinsing, inject disinfection by chlorine dioxide in the clear water, with the Folium olive hot air drying of handling, adopt alcohol to extract then for solvent, after vacuum decompression concentrates, in concentrated solution, add antioxidant-tea polyphenols (water solublity), through lyophilization or spray drying and Olive leaf P.E.
Described chlorine dioxide concentration is 50-150PPM.
Described antioxidant-tea polyphenols, additive capacity are 50-200PPM.
Described solvent is methanol or ethanol, and methanol concentration is 40-70%, and concentration of alcohol is 50-80%.
Described alcohol is 50% methanol aqueous solution of 10-15 volume.
Described lyophilization temperature is controlled at-4 ℃--and 20 ℃.
Described hot air drying temperature is 40-80 ℃.
Described Folium olive is moisture dried Folium olive below 4%.
Described Folium olive adopts the lucifuge low temperature dewatering.
Folium olive is plucked after clear water cleans, and clear water injects chlorine dioxide, and activated processing sterilization, aeration-drying, lucifuge low temperature dewatering, reuse alcohol extraction.
Add excipient during described spray drying.
Because the present invention adds the antioxidant tea polyphenols, can effectively protect the Olive leaf P.E effective ingredient not go to pot, improve the content of extract.In addition, the present invention adds chlorine dioxide and carries out disinfection, can remove harmful components in the Folium olive effectively, make Olive leaf P.E need not to carry out high temperature virus killing, sterilization, make that effective ingredient is kept preferably in the Folium olive, avoid the forfeiture of effective ingredient in the pyroprocess, thereby the content of extract is improved.The present invention can select to adopt lyophilization or spray drying as required, if adopt lyophilization then to can further improve extractive content, but the yield meeting is lower slightly, if adopt then further raising of yield of spray drying, but content can be lower slightly.
The specific embodiment
Embodiment 1
70 kilograms of water content are in the dried Folium olive roguing below 4%, the clear water rinsing, injecting germ-resistant chlorine dioxide concentration is 100PPM, 60 ℃ of hot air dryings, with 10 times of volume 50% methanol is that solvent carries out the secondary back extraction, vacuum decompression concentrates, and adds antioxidant tea polyphenols (water solublity) 100PPM in the concentrated solution, and it is 1 kilogram of 34% Olive leaf P.E that-4 ℃ of following lyophilizations get content.
Embodiment 2
70 kilograms of water content are in the dried Folium olive roguing below 4%, the clear water rinsing, injecting germ-resistant chlorine dioxide concentration is 150PPM, 40 ℃ of hot air dryings, with 15 times of volume 75% ethanol/waters is that solvent carries out the secondary back extraction, vacuum decompression concentrates, and adds antioxidant tea polyphenols (water solublity) 180PPM in the concentrated solution, and it is 1.1 kilograms of 33% Olive leaf P.Es that-15 ℃ of following lyophilizations get content.
Embodiment 3
70 kilograms of water content are in the dried Folium olive roguing below 4%, the clear water rinsing, injecting germ-resistant chlorine dioxide concentration is 100PPM, 70 ℃ of hot air dryings, with 15 times of volume 50% methanol is that solvent carries out the secondary back extraction, vacuum decompression concentrates, and adds antioxidant tea polyphenols (water solublity) 150PPM in the concentrated solution, and it is 1.5 kilograms of 20% Olive leaf P.Es that spray-dried adding excipient (powder-beta-dextrin) gets content.
Embodiment 4
Folium olive is plucked after clear water cleans, and it is 50PPM that clear water injects the chlorine dioxide optical concentration, and activated processing sterilization, aeration-drying, and behind the lucifuge low temperature dewatering, 50 ℃ of hot air dryings of the Folium olive that will handle again obtain water content at dried Folium olive below 4%.Getting 10 times of volume 60%7 alcohol of 70 kilograms of usefulness of dried Folium olive is that solvent extracts, after vacuum decompression concentrates, in concentrated solution, add antioxidant-tea polyphenols (water solublity) 160PPM, spray-dried adding excipient (powder-beta-dextrin) and content be 1.6 kilograms of 19% Olive leaf P.Es.
Claims (10)
1, a kind of Olive leaf P.E extracting method, Folium olive is through the clear water rinsing, inject disinfection by chlorine dioxide in the clear water, with the Folium olive hot air drying of handling, adopt alcohol to extract then for solvent, after vacuum decompression concentrates, in concentrated solution, add antioxidant-tea polyphenols (water solublity), through lyophilization or spray drying and Olive leaf P.E.
2, a kind of Olive leaf P.E extracting method according to claim 1, described Folium olive are moisture dried Folium olive below 4%.
3, a kind of Olive leaf P.E extracting method according to claim 2, described Folium olive adopts the lucifuge low temperature dewatering.
4, a kind of Olive leaf P.E extracting method according to claim 1, Folium olive are plucked after clear water cleans, and clear water injects chlorine dioxide, and activated processing sterilization, aeration-drying, the alcohol extraction of lucifuge low temperature dewatering reuse.
5, according to claim 1 or 2 or 3 or 4 described a kind of Olive leaf P.E extracting method, described chlorine dioxide concentration is 50-150PPM.
6, according to claim 1 or 2 or 3 or 4 described a kind of Olive leaf P.E extracting method, described antioxidant-tea polyphenols, additive capacity are 50-200PPM.
7, a kind of Olive leaf P.E extracting method according to claim 1, described alcohol is 40-70% methanol aqueous solution or 50-80% ethanol water.
8, a kind of Olive leaf P.E extracting method according to claim 1, described alcohol are 50% methanol aqueous solution of 10-15 volume.
9, a kind of Olive leaf P.E extracting method according to claim 1, described lyophilization temperature is controlled at-4 ℃--and 20 ℃.
10, a kind of Olive leaf P.E extracting method according to claim 1, described hot air drying temperature is 40-80 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410023233XA CN1309396C (en) | 2004-05-24 | 2004-05-24 | Extraction of canarium leaves |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410023233XA CN1309396C (en) | 2004-05-24 | 2004-05-24 | Extraction of canarium leaves |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1583052A true CN1583052A (en) | 2005-02-23 |
| CN1309396C CN1309396C (en) | 2007-04-11 |
Family
ID=34600741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200410023233XA Expired - Fee Related CN1309396C (en) | 2004-05-24 | 2004-05-24 | Extraction of canarium leaves |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1309396C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102260588A (en) * | 2011-06-21 | 2011-11-30 | 西北师范大学 | Method for synchronously extracting pomace oil and polyphenol from olive processing waste residue |
| CN104622934A (en) * | 2013-11-08 | 2015-05-20 | 上海交通大学 | Novel application of olive leaf crude extract in preparation of drugs for treating sphagitis |
| CN106421741A (en) * | 2016-09-26 | 2017-02-22 | 南京中生生物科技有限公司 | Water-soluble olive leaf extract health-care product and preparation method thereof |
| CN113368147A (en) * | 2020-02-25 | 2021-09-10 | 上海交通大学 | New application of olive leaf extract |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101575268B (en) * | 2009-06-22 | 2012-08-29 | 西北大学 | Method for purifying tyrosol from coarse product of olive polyphenol |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714150A (en) * | 1997-01-08 | 1998-02-03 | Nachman; Leslie | Method for producing extract of olive leaves |
| CN1175749C (en) * | 2002-12-31 | 2004-11-17 | 北京华源生命科贸发展有限公司 | Olive-leaf foods and its preparation method and use |
-
2004
- 2004-05-24 CN CNB200410023233XA patent/CN1309396C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102260588A (en) * | 2011-06-21 | 2011-11-30 | 西北师范大学 | Method for synchronously extracting pomace oil and polyphenol from olive processing waste residue |
| CN102260588B (en) * | 2011-06-21 | 2013-01-02 | 西北师范大学 | Method for synchronously extracting pomace oil and polyphenol from olive processing waste residue |
| CN104622934A (en) * | 2013-11-08 | 2015-05-20 | 上海交通大学 | Novel application of olive leaf crude extract in preparation of drugs for treating sphagitis |
| CN106421741A (en) * | 2016-09-26 | 2017-02-22 | 南京中生生物科技有限公司 | Water-soluble olive leaf extract health-care product and preparation method thereof |
| CN113368147A (en) * | 2020-02-25 | 2021-09-10 | 上海交通大学 | New application of olive leaf extract |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1309396C (en) | 2007-04-11 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: YANG YINKE; APPLICANT Free format text: FORMER OWNER: YANG YINKE Effective date: 20060707 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20060707 Address after: No. 88 Central South University Xiangya Medical College of Hunan province 410078 Changsha 1 Xiangya Road No. 182. Applicant after: Yang Yinke Co-applicant after: Li Yinuan Address before: No. 88 Central South University Xiangya Medical College of Hunan province 410078 Changsha Xiangya Road No. 182. Applicant before: Yang Yinke |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Changsha Nutramax Inc. Assignor: Yang Yinke|Li Yinuan Contract fulfillment period: 2009.10.20 to 2017.10.19 Contract record no.: 2009430000208 Denomination of invention: Extraction of canarium leaves Granted publication date: 20070411 License type: Exclusive license Record date: 20091125 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.10.20 TO 2017.10.19; CHANGE OF CONTRACT Name of requester: CHANGSHA NUTRAMAX INC. Effective date: 20091125 |
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| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Changsha Nutramax Inc. Assignor: Yang Yinke|Li Yinuan Contract record no.: 2009430000208 Date of cancellation: 20111221 |
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Owner name: YANG DENGKE Free format text: FORMER OWNER: LI YINUAN Effective date: 20120627 |
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Effective date of registration: 20120627 Address after: No. 88 Central South University Xiangya Medical College of Hunan province 410078 Changsha Xiangya Road No. 182. Co-patentee after: Yang Dengke Patentee after: Yang Yinke Address before: No. 88 Central South University Xiangya Medical College of Hunan province 410078 Changsha Xiangya Road No. 182. Co-patentee before: Li Yinuan Patentee before: Yang Yinke |
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Owner name: SHENZHEN BOSHENGKANG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: YANG YINKE Effective date: 20130531 Free format text: FORMER OWNER: YANG DENGKE Effective date: 20130531 |
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Free format text: CORRECT: ADDRESS; FROM: 410078 CHANGSHA, HUNAN PROVINCE TO: 518172 SHENZHEN, GUANGDONG PROVINCE |
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Effective date of registration: 20130531 Address after: Dragon Street Longgang District of Shenzhen City, 518172 forest road in Guangdong province Shenzhen city students (Longgang) Business Park Park 307 Patentee after: SHENZHEN BIOSCIEN PHARMACEUTICALS CO., LTD. Address before: No. 88 Central South University Xiangya Medical College of Hunan province 410078 Changsha Xiangya Road No. 182. Patentee before: Yang Yinke Patentee before: Yang Dengke |
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| CF01 | Termination of patent right due to non-payment of annual fee |