CN1240378C - Externally applied preparation for removing dampness and relieving osteodynia - Google Patents
Externally applied preparation for removing dampness and relieving osteodynia Download PDFInfo
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- CN1240378C CN1240378C CNB2004100336324A CN200410033632A CN1240378C CN 1240378 C CN1240378 C CN 1240378C CN B2004100336324 A CNB2004100336324 A CN B2004100336324A CN 200410033632 A CN200410033632 A CN 200410033632A CN 1240378 C CN1240378 C CN 1240378C
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- propolis
- externally applied
- liniment
- camphora
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Abstract
The present invention relates to a pure traditional Chinese medicine, namely an externally applied preparation for removing dampness and relieving osteodynia. The externally applied preparation adopts 2 to 15% of propolis and 0.5 to 5% of camphor as the main active ingredients. The preparation can be various conventional forms, preferably liniment. The liniment is basically prepared from 2 to 15% of propolis, 0.5 to 5% of camphor and a polar solvent, preferably alcohol, and more preferably alcohol of 96%(v/v), as the rest. The externally applied preparation has an obvious therapeutic effect, and is very convenient for use by spreading at an affected part only. Through a good deal of clinical experiments, the preparation has an obvious therapeutic effect on sinew and bone pain caused by rheumatism, rheumatoid arthritis, arthrocele and various pains in shoulders, loins and legs, including periarthritis of shoulders, cervical syndrome, rigid and hyperplasic spondylitis, tennis elbow, sciatica, spinal stenosis, lumbar muscle strain, numbness of limbs, etc., disturbing people. The cure rate of the preparation can achieve more than 85%, and the preparation does not have any toxic or side effects.
Description
Technical field
The invention belongs to the field of Chinese medicines.Particularly, the present invention relates to a kind of dehumidifying pain external preparation and its production and application of boning.
Background technology
Rheumatism belongs to multiple disease, the sickness rate height, and the course of disease is long, and treatment is slow, and is difficult to radical cure.The Western medicine for the treatment of this class disease is a lot, but costs an arm and a leg and side effect is arranged, and the drug side effect of hormones is more obvious.Traditional Chinese medicine preparation also finds no the obvious results example.The research of being devoted in this respect is a lot, a kind of external rheumatism liniment for the treatment of rheumatic arthritis class disease is disclosed as CN1453010A, be with multiple compatibility of drugss such as Radix Saposhnikoviae, Radix Aconiti Preparata, Semen Sinapis Albae, Camphora, Mylabris, add and soak more than 40 days with Chinese liquor, airtight the sealing up for safekeeping of tablet vinegar, also will make dope through clear liquid, filtration, squeezing medicinal residues, row leaves standstill 24 hours after-filtration again.Technical process is loaded down with trivial details.What also have will select tens of flavor drug matchings for use, must remove because of medicinal residues, and technology can not be simplified.And, multiple compatibility of drugs, though can be complementary on drug effect, pharmacology, also must have the melancholy of mutual restriction or checking relation in five elements simultaneously, so that affect the treatment.
Summary of the invention
The objective of the invention is to, overcome the deficiencies in the prior art, for example technical process is loaded down with trivial details, and curative effect is abundant inadequately etc., provides a kind of making and use all very easy, the tangible pain external preparation of boning that dehumidifies of curative effect.
The present invention is achieved through the following technical solutions: a kind of pure Chinese medicine dehumidifying pain external preparation of boning, it contains propolis 2-15%, Camphora 0.5-5% as main active ingredient.
The dehumidifying of the present invention pain external preparation of boning can be the external preparation form of various routines, for example liniment, Emulsion, cream, ointment, liniment, tincture, patch or other preparation capable of permeating skin form.But liniment form preferably.
In the external preparation of the present invention except that containing main active component propolis and Camphora, also can be as required, comprise preparation external preparation excipient commonly used, as solvent, cosolvent, Percutaneous absorption enhancer, surfactant, emulsifying agent, antioxidant, antiseptic, stabilizing agent, ointment base, emulsion matrix etc., and be prepared by conventional method.As long as the adding of these adjuvant can not influence the drug effect of external preparation of the present invention and the stability of product, and can not produce side effect such as skin irritation and get final product.
For the preparation of Emulsion or cream, can make oil-in-water or water in oil form, for example a certain proportion of propolis and Camphora are ground and be added in the emulsion bases, perhaps be dissolved in the small amount of polar solvent, be added to again in the conventional emulsion bases and get final product.If desired, wherein also can add antioxidant, stabilizing agent etc.
For the preparation of ointment, can adopt usually and grind and method, molten and method, emulsion process etc.For example, in advance a certain proportion of propolis and Camphora are ground, add a small amount of substrate or liquid component, further grind into paste as liquid paraffin, vegetable oil, glycerol etc., again with all the other substrate mixings; Perhaps a certain proportion of propolis and Camphora are dissolved in minimum solvent, in ethanol, add mixing in the substrate again; Perhaps directly be dissolved in the hot radical matter that is heated to uniform temperature, then cooling.
For the preparation in the liniment, normally, for example, be dissolved in organic solvent as polyvinyl alcohol, polyvinyl formal-acetal etc. with a certain proportion of propolis and Camphora and macromolecule filming material, make as ethanol, acetone etc.As required, also can add plasticizer, as diethyl phthalate etc.
Liniment of the present invention is made up of the component of following weight ratio substantially: propolis 2-15% and Camphora 0.5-5%, surplus is a solvent.Wherein the weight ratio of propolis is preferably 4-8%, and for example 3%, Camphora is preferably 1-3%, and for example 2%.Solvent wherein is polar solvent preferably, for example ethanol, glycerol, propylene glycol, Polyethylene Glycol, dimethyl sulfoxide etc., more preferably aqueous alcohol, the aqueous alcohol of concentration more than 70% for example, the ethanol of most preferable concentrations 96% (v/v).When selecting other polar solvent for use, as required, also can add cosolvent and/or Percutaneous absorption enhancer in the liniment of the present invention, as azone etc.
It is the ethanol 96.1% of 96% (v/v) that the best group of liniment of the present invention becomes propolis 2.9%, Camphora 1.0%, concentration.But also can use the polar solvent that other routines that can dissolve propolis and Camphora can be medical or medicinal, but preferred aqueous alcohol, for example more preferably 96% ethanol as solvent, because the liniment zest minimum and the effect that make like this are remarkable.
The manufacture method of described liniment is, for example adopt conventional method that a certain proportion of propolis and Camphora are dissolved in solvent, obtain brown liquid after the filtration, wherein the addition sequence of propolis and Camphora does not have special provision, as long as they are dissolved in polar solvent, ethanol etc. for example, more preferably concentration is to get final product in 96% the ethanol.As previously mentioned, as required, wherein can also add conventional cosolvent and/or Percutaneous absorption enhancer.
Propolis is a kind of bee product of preciousness, and its basis is flavonoid, multivitamin, enzyme, aminoacid and trace element.Have various functions such as anti-Proteolytic enzyme, sterilization and antibacterial antioxidation, enhance immunity, antitumor, the metabolism of promotion epithelial cell, microcirculation improvement, accelerating wound, and importing property is good; But blood fat reducing for oral administration, blood viscosity lowering are used for the treatment of hyperlipidemia, arteriosclerosis clinically; Take orally and can also treat psoriasis, peptic ulcer, chronic gastritis, enteritis.Camphora fragrance walks to go here and there blood circulation promoting and dispersing pathogen accumulation, and dispelling wind and relieving pain is dispeled cold and dried, and can promote QI-blood circulation; The two compatibility external reaches synergistic function, has very strong blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, softening bony spur effect, and the two promotes each other, brings out the best in each other, without any bad interference.
When being mixed with liniment, Camphora and propolis all are dissolved in ethanol, do not have residue substantially, once filter to get final product, and make very easy.Ethanol also can promote drug osmotic and absorption except that as the solvent, and it is permanent to keep drug effect, and itself also has the effect of relaxing muscles and tendons to promote blood circulation.
Only need apply affected part and diseased region during use, massage local pyrexia and get final product, every day 2-3 time, very convenient.
Through a large amount of clinical experiments, external preparation of the present invention is for puzzlement human rheumatism, rheumatoid arthritis, all kinds of neck, shoulder, waist and leg pain, hyperosteogeny, hypertrophy, ankylosing spondylitis, the bones and muscles pain therapeutic effect that scapulohumeral periarthritis, cervical spondylosis, tennis elbow, sciatica, spinal canal stenosis, lumbar muscle strain, numb limbs and tense tendons etc. cause is outstanding.The present invention can prevent and treat above various diseases simultaneously, and cure rate reaches more than 85%, and is without any side effects, is the ideal medicament of extensive patients.
Preparation of the present invention is obvious through clinical application effect.In one group of rheumatism, rheumatoid, 100 cases of ankylosing spondylitis (being the out-patient), wherein male 45 examples, women 55 examples.The course of disease 5 months-10 years.Diagnostic criteria: rheumatic arthritis, according in April, 1988 Kunming stipulate that the standard that national combination of Chinese and Western medicine rheumatism, rheumatoid disease academic conference formulates is accurate; Rheumatoid arthritis, the 51st Americanism damp disease association revised standard according to June in 1987, and ankylosing spondylitis is formulated with reference to nineteen sixty-eight New York diagnostic criteria.Utilize the pure Chinese medicine dehumidifying of the invention pain external preparation of boning, every day 3-4 time, embrocating the affected part 15 days was a course of treatment.Recovery from illness 65 examples after medication 4 courses of treatment, produce effects 30 examples, invalid 5 examples.
Model case:
Chen Dahai, the man, 49 years old, first visit on May 25 in 1997, the trifle numb pain is pointed in readme over 4 years, the state of an illness increases the weight of during Changes in weather, through chemically examining the anti-O positive, through take traditional Chinese medicine, Western medicine do not see positive effect.With a pure Chinese medicine dehumidifying of the present invention pain external preparation transference cure course of treatment of boning, use 5 recoveries from illness courses of treatment continuously, so far not recurrence.
This group case is disease 100 examples that hyperosteogeny causes, wherein male 60 examples, and women 40 examples, 3 days to the 6 years course of treatment, through the X ray examination, the cervical spondylosis, scapulohumeral periarthritis, the intervertebral disk hernia that have hyperosteogeny to cause, sciatica.Utilize this preparation every day to embrocate the affected part 2-3 time, 10 days is a course of treatment.5 courses of treatment of medication, the symptom that hyperosteogeny causes fully recover 60 examples, produce effects 39 examples, invalid 1 example.
Li Aixia, the woman, 48 years old, be sitting in during prescription on individual diagnosis on the tricycle, left lower limb can not be walked, and the pain increased, outstanding through CT examination 4-5 lumbar intervertebral disc hypertrophy, the compressing sciatica.Utilize this preparation every day to embrocate the affected part 2-3 time, 10 days is a course of treatment, symptom complete obiteration after the course of treatment.
The specific embodiment
Embodiment one
Get propolis 3g, Camphora 1g and dissolve in the ethanol of 100g 96% concentration, obtain henna clear liquid after filtration and get final product.
Embodiment two
Get propolis 6g, Camphora 2g and dissolve in the ethanol of 100g 90% concentration, obtain henna clear liquid after filtration and get final product.
Embodiment three
Get propolis 2g, Camphora 5g and dissolve in the ethanol of 150g 75% concentration, obtain henna clear liquid after filtration and get final product.
Embodiment four
Get propolis 15g, Camphora 0.5g and dissolve in the ethanol of 120g 96% concentration, obtain henna clear liquid after filtration and get final product.
Embodiment five
Get propolis 3g and Camphora 1g fine powder, add the 5g liquid paraffin and be ground into paste,, filter, when treating that temperature is reduced to non-scald on hand, adds ground liquid paraffin and medicated powder in addition with lanoline 10g, white vaseline 100g, an amount of heating and melting of paraffin, cool off ointment.
Embodiment six
It is in 96% the ethanol that propolis 3g and Camphora 1g are dissolved in a small amount of concentration, filters, and this solution is added to contains filmogen again, in the alcoholic solution as polyvinyl formal-acetal, makes liniment.
Embodiment seven
Get propolis 6g, Camphora 2g porphyrize, mix the back and mix with Oleum sesami 100ml, add freshly prepared aqua calcis (including glycerol, liquefied phenol) gradually to 200ml, emulsifying fully promptly makes Emulsion.
Claims (2)
1. the dehumidifying pain external preparation of boning is characterized in that being made up of the crude drug of following weight ratio: propolis 2.9%, Camphora 1.0%, ethanol 96.1%.
2. the bone preparation method of pain external preparation of dehumidifying as claimed in claim 1 comprises propolis and Camphora are dissolved in the ethanol, filters, and obtains preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100336324A CN1240378C (en) | 2004-04-14 | 2004-04-14 | Externally applied preparation for removing dampness and relieving osteodynia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100336324A CN1240378C (en) | 2004-04-14 | 2004-04-14 | Externally applied preparation for removing dampness and relieving osteodynia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1541703A CN1541703A (en) | 2004-11-03 |
| CN1240378C true CN1240378C (en) | 2006-02-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100336324A Expired - Fee Related CN1240378C (en) | 2004-04-14 | 2004-04-14 | Externally applied preparation for removing dampness and relieving osteodynia |
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| Country | Link |
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| CN (1) | CN1240378C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228480B (en) * | 2011-06-24 | 2012-12-05 | 昆明医学院附属口腔医院 | Application of propolis in Xuanwei and Caoba of Yunnan in medicine for promoting proliferation of osteoblast |
| CN102366426A (en) * | 2011-10-26 | 2012-03-07 | 江苏江大源生态生物科技有限公司 | Propolis tincture for external use and preparation method thereof |
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2004
- 2004-04-14 CN CNB2004100336324A patent/CN1240378C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1541703A (en) | 2004-11-03 |
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Granted publication date: 20060208 Termination date: 20130414 |