CN102366426A - Propolis tincture for external use and preparation method thereof - Google Patents
Propolis tincture for external use and preparation method thereof Download PDFInfo
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- CN102366426A CN102366426A CN2011103292309A CN201110329230A CN102366426A CN 102366426 A CN102366426 A CN 102366426A CN 2011103292309 A CN2011103292309 A CN 2011103292309A CN 201110329230 A CN201110329230 A CN 201110329230A CN 102366426 A CN102366426 A CN 102366426A
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Abstract
The invention provides a propolis tincture for external use and a preparation method thereof. The propolis tincture for external use comprises the following ingredients: 5-30 wt% of propolis liquid with a concentration of 0.02 g/mL, 0.1-0.5 wt% of tea tree oil, 0.1-0.5 wt% of mint essential oil, and the balance consisting of ethanol. The propolis tincture for external use is prepared by mixing the three natural ingredients, has remarkable effect of antibiosis and antiphlogosis, good solubility, and improved purity. By avoiding containing heavy metal and other impurities, the propolis tincture for external use has bright, pure and transparent color. According to the invention, allergenic ingredients in propolis is effectively removed, so that the occurrence of allergy in using is reduced. The preparation method has simple operation.
Description
Technical field
The present invention relates to a kind of propolis tincture, and relate to the method for preparing of this propolis tincture.
Background technology
Propolis tincture is a kind of product of processing with wine and propolis, is main with external.Propolis tincture can be controlled mosquito bite special for treating tinea manus and pedis.Propolis is natural cosmetic material, but not only edible, but also external.Edible propolis can be regulated organ dysfunction comprehensively, promotes the subcutaneous tissue blood circulation, and the control dermatosis decomposes mottle, reduces wrinkle, eliminates acne, comedo, dermatitis, eczema, creation of beauty in the body.The external propolis, effect such as nutritious skin care, antifreeze, anticracking, antibacterial, antiinflammatory, antipruritic, pain relieving, hemostasis, infection, promotion tissue regeneration.The external bee glue prepn of common treatment dermatosis has propolis ointment etc.
Propolis tincture of the prior art is made up of propolis, edible ethanol and low alcohol white spirit, during preparation: propolis was put into cryogenic refrigerator freezing several hours, pulverize immediately after the taking-up or smash with wooden mallet and process powder; Immerse in the ethanol, keep more than 20 ℃, lixiviate is more than 3 days; Sway 2-3 every day, makes it abundant dissolving, left standstill 1; Extract supernatant, filter cleaner; Its residue reuse ethanol is in kind made second extraction, merges secondary raffinate after accomplishing, and blends with low high quality liquor, and the propolis wine of content 2% is processed in dilution.This propolis tincture since its raw material propolis be adopt traditional extracting mode be ethanol extraction method extract (be about to behind the propolis virgin rubber freezing and pulverizing soak with ethanol with high concentration after a period of time; Filtering and impurity removing, deleading; Reach food sanitation standard), therefore, there is the shortcoming of heavy metals such as solubility is low, leaded and other organic solvent impurity in this type propolis; Be easy to generate allergy during use, and the heavier color of this propolis special odor is not easy to other components compatibilities more deeply and processes expensive goods.
Summary of the invention
The objective of the invention is to seek a kind of external propolis tincture; This external propolis tincture anti-inflammation effect is remarkable; Have good solubility, do not contain heavy metal and other impurity, color is vivid pure transparent; Use to be difficult for irritated and can to treat the disease that skin or skin mucosa are caused by antibacterial and fungal infection, (the experiment proof is treated superficial part mycete tinea (comprising tinea corporis, tinea cruris, tinea manus and pedis) total effective rate 85.5%); And the method for preparing of this external propolis tincture is provided, this method is simple to operate.
The object of the invention can be realized through following technical scheme:
A kind of external propolis tincture, be made up of following ingredients: concentration is the propolis liquid 5-30% of 0.02g/mL, tea tree ethereal oil 0.1-0.5%, Herba Menthae quintessence oil 0.1-0.5%, surplus is an ethanol, unit is a percent by volume.
Above-mentioned external propolis tincture method for preparing comprises the following steps:
A, preparation propolis liquid, the concentration of propolis liquid is 0.02g/mL;
B, propolis liquid, Herba Menthae quintessence oil, tea tree ethereal oil are fully mixed;
C, the mixture of above-mentioned steps is molten surely through ethanol;
D, will use mix homogeneously through the mixture that ethanol dissolves surely.
Above-mentioned external propolis tincture method for preparing, wherein, said step a is made up of the following step:
A1, employing supercritical CO
2Fluid extraction technology extracts the supercritical propolis extract from the natural propolis raw material;
A2, propolis extract is dissolved in the alcoholic solution, is mixed with the propolis liquid that concentration is 0.02g/mL.
Above-mentioned external propolis tincture method for preparing, wherein, the Herba Menthae quintessence oil among the said step b adopts supercritical CO
2The fluid extraction technology extraction; Tea tree ethereal oil adopts the way of distillation to extract.
Above-mentioned external propolis tincture, wherein, said propolis tincture can be used to prepare treatment skin or the antibacterial of skin mucosa and the cosmetics or the medicine spray of fungal infection and tissue regeneration.
Beneficial effect of the present invention; External propolis tincture of the present invention obtains through the mixing of three kinds of natural constituents materials, make the anti-inflammation effect of this external propolis tincture remarkable, and the present invention has good solubility; Improved product gas purity, avoided the present invention to contain heavy metal and other impurity, made its color vivid pure transparent; In addition; The present invention is through extraction high-purity, the residual natural materials propolis of high concentration organic solvent-free, and sensitization composition in the effective elimination propolis, has reduced the generation of allergic phenomena when using; And can treat the disease that skin or skin mucosa are caused by antibacterial and fungal infection; In addition, method for preparing of the present invention, simple to operate.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
Through specific embodiment the present invention is specified below.
Embodiment 1, and the preparation propolis liquid is dissolved in propolis extract 2g in the alcoholic solution of 100mL; Be mixed with concentration and be 2% supercritical bee-glue liquid; Again 10mL propolis liquid, 0.5mL Herba Menthae quintessence oil, 0.5mL tea tree ethereal oil are fully mixed, dissolve to 100mL surely with ethanol at last, and utilize ultrasonic mix homogeneously; Thereby obtain pure uniform supercritical propolis tincture, the concentration of alcoholic solution is 75% (V/V).
Embodiment 2, and the preparation propolis liquid is got propolis extract 2g and is dissolved in the 100mL alcoholic solution; Be mixed with concentration and be 2% supercritical bee-glue liquid; Propolis liquid, 0.2mL Herba Menthae quintessence oil, 0.2mL tea tree ethereal oil with 15mL fully mixes again, dissolves to 100mL surely with ethanol at last, and utilizes ultrasonic mix homogeneously; Thereby obtain pure uniform supercritical propolis tincture, the concentration of alcoholic solution is 75% (V/V).The Herba Menthae quintessence oil adopts supercritical CO
2The fluid extraction technology extraction.
Embodiment 3; The preparation propolis liquid is got propolis extract 2g and is dissolved in the 100mL75% alcoholic solution, is mixed with concentration and is 2% supercritical bee-glue liquid; Propolis liquid, 0.3mL Herba Menthae quintessence oil, 0.3mL tea tree ethereal oil with 20mL1% fully mixes again; Be settled to 100mL with 75% ethanol at last, and utilize ultrasonic mix homogeneously, thereby obtain pure uniform supercritical propolis tincture.The concentration of alcoholic solution is 75% (V/V).
Embodiment 4; The preparation propolis liquid is got propolis extract 2g and is dissolved in the 100mL alcoholic solution, is mixed with concentration and is 2% supercritical bee-glue liquid; Propolis liquid, 0.4mL Herba Menthae quintessence oil, 0.4mL tea tree ethereal oil with 22mL fully mixes again; Be settled to 100mL with ethanol at last, and utilize ultrasonic mix homogeneously, thereby obtain pure uniform supercritical propolis tincture.
Embodiment 5; The preparation propolis liquid is got propolis extract 2g and is dissolved in the 100mL75% alcoholic solution, is mixed with concentration and is 2% supercritical bee-glue liquid; Propolis liquid, 0.5mL Herba Menthae quintessence oil, 0.5mL tea tree ethereal oil with 25mL fully mixes again; Be settled to 100mL with ethanol at last, and utilize ultrasonic mix homogeneously, thereby obtain even purified supercritical propolis tincture.
Embodiment 6; The preparation propolis liquid is got propolis extract 2g and is dissolved in the 100mL75% alcoholic solution, is mixed with concentration and is 2% supercritical bee-glue liquid; Propolis liquid, 0.5mL Herba Menthae quintessence oil, 0.5mL tea tree ethereal oil with 30mL fully mixes again; Be settled to 100mL with ethanol at last, and utilize ultrasonic mix homogeneously, thereby obtain even purified supercritical propolis tincture.
Propolis extract can pass through following supercritical CO
2Fluid extraction technology extracts: with the propolis raw material freezing and pulverizing to the 40-60 order; With CO
2Gas feeds continuously and is equipped with in the extraction kettle of propolis raw material; Setting the extraction kettle temperature is 40～60 ℃, pressure 35～40MPa; Be dissolved with the CO of propolis
2Flow into separation reactor I and separating still II via the extraction kettle top, set 50～60 ℃ of separation reactor I temperature, pressure 10～11MPa; 30～40 ℃ of separating still II temperature, pressure 5～6MPa reduces pressure and changes temperature through substep, and propolis can be by its character substep from CO
2In separate out and discharge from separating still bottom.CO
2Gas is then discharged retrieval system and is recycled from the separating still top.
The Herba Menthae quintessence oil can adopt following supercritical CO
2Fluid extraction technology extracts: Herba Menthae is dried in the shade is crushed to the 50-60 order; With CO
2Gas feeds continuously and is equipped with in the extraction kettle of Herba Menthae; Setting the extraction kettle temperature is 35～50 ℃, pressure 7～12MPa; CO
2Flow is 30-40L/h, is dissolved with the supercritical CO of Oleum menthae
2Gas flows into separating still via the extraction kettle top, sets 45～60 ℃ of separating still temperature, pressure 10～11MPa, and Oleum menthae is discharged from the separating still bottom.CO
2Gas is then discharged retrieval system and is recycled from the separating still top.
Tea tree ethereal oil can utilize traditional way of distillation to extract.
Propolis tincture of the present invention can be used to prepare treatment skin or the antibacterial of skin mucosa and the cosmetics or the medicine spray of fungal infection and tissue regeneration.
What describe in the above description is the specific embodiment of the present invention; This does not illustrate flesh and blood of the present invention is constituted restriction; Under the those of ordinary skill of technical field after having read description, can make an amendment or be out of shape the foregoing specific embodiment, and do not deviate from essence of an invention and scope.
Claims (5)
1. an external propolis tincture is characterized in that, is made up of following ingredients: concentration is the propolis liquid 5-30% of 0.02g/mL, tea tree ethereal oil 0.1-0.5%, and Herba Menthae quintessence oil 0.1-0.5%, surplus is an ethanol, unit is a percent by volume.
2. external propolis tincture method for preparing as claimed in claim 1 is characterized in that, comprises the following steps:
A, preparation propolis liquid, the concentration of propolis liquid is 0.02g/mL;
B, propolis liquid, Herba Menthae quintessence oil, tea tree ethereal oil are fully mixed;
C, the mixture of above-mentioned steps is molten surely through ethanol;
D, will use mix homogeneously through the mixture that ethanol dissolves surely.
3. external propolis tincture method for preparing as claimed in claim 2 is characterized in that said step
A is made up of the following step:
A1, employing supercritical CO
2Fluid extraction technology extracts the supercritical propolis extract from the natural propolis raw material;
A2, propolis extract is dissolved in the alcoholic solution, is mixed with the propolis liquid that concentration is 0.02g/mL.
4. like claim 2 or 3 described external propolis tincture method for preparinies, it is characterized in that the Herba Menthae quintessence oil among the said step b adopts supercritical CO
2The fluid extraction technology extraction; Tea tree ethereal oil adopts the way of distillation to extract.
5. external propolis tincture according to claim 1 is characterized in that, said propolis tincture can be used to prepare treatment skin or the antibacterial of skin mucosa and the cosmetics or the medicine spray of fungal infection and tissue regeneration.
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| CN2011103292309A CN102366426A (en) | 2011-10-26 | 2011-10-26 | Propolis tincture for external use and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784501A (en) * | 2013-12-20 | 2014-05-14 | 王化金 | Anti-bacteria and sterilization solution for treating burns and scalds and avoiding skin grafting |
| US9205042B1 (en) * | 2012-12-31 | 2015-12-08 | Robert Heiman | Lip and skin care product, dispenser and methods |
| CN105455143A (en) * | 2015-12-28 | 2016-04-06 | 无锡瑞盈生命科学有限公司 | Composite health walnut oil spray and preparation method thereof |
| CN106727250A (en) * | 2017-02-21 | 2017-05-31 | 糖友管家（北京）健康管理有限公司 | A kind of foot cream and preparation method thereof |
| CN108619174A (en) * | 2018-06-08 | 2018-10-09 | 龚联遂 | A kind of high concentration propolis tincture for treating onychomycosis |
| CN110141627A (en) * | 2019-05-16 | 2019-08-20 | 中南苑(深圳)药械研究有限公司 | A kind of skin wound care composition, care agent and preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9205042B1 (en) * | 2012-12-31 | 2015-12-08 | Robert Heiman | Lip and skin care product, dispenser and methods |
| CN103784501A (en) * | 2013-12-20 | 2014-05-14 | 王化金 | Anti-bacteria and sterilization solution for treating burns and scalds and avoiding skin grafting |
| CN105455143A (en) * | 2015-12-28 | 2016-04-06 | 无锡瑞盈生命科学有限公司 | Composite health walnut oil spray and preparation method thereof |
| CN106727250A (en) * | 2017-02-21 | 2017-05-31 | 糖友管家（北京）健康管理有限公司 | A kind of foot cream and preparation method thereof |
| CN108619174A (en) * | 2018-06-08 | 2018-10-09 | 龚联遂 | A kind of high concentration propolis tincture for treating onychomycosis |
| CN110141627A (en) * | 2019-05-16 | 2019-08-20 | 中南苑(深圳)药械研究有限公司 | A kind of skin wound care composition, care agent and preparation method |
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Application publication date: 20120307 |