CN104619839A - 药物递送蛋白质的增强运输的突变体的分离 - Google Patents

药物递送蛋白质的增强运输的突变体的分离 Download PDF

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Publication number
CN104619839A
CN104619839A CN201380041215.1A CN201380041215A CN104619839A CN 104619839 A CN104619839 A CN 104619839A CN 201380041215 A CN201380041215 A CN 201380041215A CN 104619839 A CN104619839 A CN 104619839A
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phage
seq
vector
cells
cell
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拉里·K·梅迪纳-考维
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Cedars Sinai Medical Center
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Cedars Sinai Medical Center
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N2710/10011—Adenoviridae
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector

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  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Ecology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201380041215.1A 2012-08-03 2013-08-02 药物递送蛋白质的增强运输的突变体的分离 Pending CN104619839A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261679306P 2012-08-03 2012-08-03
US61/679,306 2012-08-03
PCT/US2013/053493 WO2014022811A1 (en) 2012-08-03 2013-08-02 Isolating traffic-enhancing mutants of drug delivery protein

Publications (1)

Publication Number Publication Date
CN104619839A true CN104619839A (zh) 2015-05-13

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CN201380041215.1A Pending CN104619839A (zh) 2012-08-03 2013-08-02 药物递送蛋白质的增强运输的突变体的分离

Country Status (18)

Country Link
US (2) US10036009B2 (https=)
EP (1) EP2880160B1 (https=)
JP (2) JP6618360B2 (https=)
KR (1) KR102115630B1 (https=)
CN (1) CN104619839A (https=)
AU (2) AU2013296218B2 (https=)
BR (1) BR112015002004A2 (https=)
CA (1) CA2881582A1 (https=)
DK (1) DK2880160T3 (https=)
ES (1) ES2703052T3 (https=)
IL (1) IL236955A0 (https=)
IN (1) IN2015DN01196A (https=)
MX (1) MX366347B (https=)
PL (1) PL2880160T3 (https=)
PT (1) PT2880160T (https=)
RU (1) RU2015105052A (https=)
WO (1) WO2014022811A1 (https=)
ZA (1) ZA201500739B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009009441A2 (en) 2007-07-06 2009-01-15 Cedars-Sinai Medical Center Self-assembling complex for targeting chemical agents to cells
WO2010085665A2 (en) 2009-01-23 2010-07-29 Cedars-Sinai Medical Center Targeted delivery system
US10036009B2 (en) * 2012-08-03 2018-07-31 Cedars-Sinai Medical Center Isolating traffic-enhancing mutants of drug delivery protein
RU2674146C2 (ru) 2013-05-08 2018-12-07 Седарс-Синай Медикал Центр Нацеленные корролы, проявляющие опухолевую токсичность и предназначенные для мрт
JP6608370B2 (ja) 2014-01-17 2019-11-20 シーダーズ―シナイ メディカル センター 受容体標的化構築物およびその使用
US9850293B2 (en) 2014-04-04 2017-12-26 Cedars-Sinai Medical Center Targeting trastuzumab-resistant HER2+ breast cancer with a HER3-targeting nanoparticle

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WO2002024934A1 (en) * 2000-09-22 2002-03-28 Consorzio Interuniversitario Per Le Biotecnologie Chimeric vectors and their use for heterologous genes transfer
EP1266963A1 (en) * 2001-06-15 2002-12-18 Crucell Holland B.V. Chimaeric phages
WO2009009441A2 (en) * 2007-07-06 2009-01-15 Cedars-Sinai Medical Center Self-assembling complex for targeting chemical agents to cells

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US10036009B2 (en) 2012-08-03 2018-07-31 Cedars-Sinai Medical Center Isolating traffic-enhancing mutants of drug delivery protein
RU2674146C2 (ru) 2013-05-08 2018-12-07 Седарс-Синай Медикал Центр Нацеленные корролы, проявляющие опухолевую токсичность и предназначенные для мрт
JP6608370B2 (ja) 2014-01-17 2019-11-20 シーダーズ―シナイ メディカル センター 受容体標的化構築物およびその使用
US9850293B2 (en) 2014-04-04 2017-12-26 Cedars-Sinai Medical Center Targeting trastuzumab-resistant HER2+ breast cancer with a HER3-targeting nanoparticle
BR112018074304A2 (pt) * 2016-05-27 2019-10-01 Cedars Sinai Medical Center composições de nanopartículas, kit e método para tratar um indivíduo com câncer resistente a fármacos

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US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
WO2002024934A1 (en) * 2000-09-22 2002-03-28 Consorzio Interuniversitario Per Le Biotecnologie Chimeric vectors and their use for heterologous genes transfer
EP1266963A1 (en) * 2001-06-15 2002-12-18 Crucell Holland B.V. Chimaeric phages
WO2009009441A2 (en) * 2007-07-06 2009-01-15 Cedars-Sinai Medical Center Self-assembling complex for targeting chemical agents to cells

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Publication number Publication date
WO2014022811A1 (en) 2014-02-06
JP6618360B2 (ja) 2019-12-11
EP2880160A4 (en) 2016-04-20
EP2880160A1 (en) 2015-06-10
PT2880160T (pt) 2018-12-17
AU2013296218B2 (en) 2019-07-18
US10752893B2 (en) 2020-08-25
US20150240231A1 (en) 2015-08-27
IN2015DN01196A (https=) 2015-06-26
PL2880160T3 (pl) 2019-03-29
DK2880160T3 (en) 2019-01-14
CA2881582A1 (en) 2014-02-06
ES2703052T3 (es) 2019-03-06
MX366347B (es) 2019-07-05
IL236955A0 (en) 2015-03-31
JP2015527343A (ja) 2015-09-17
AU2019204815A1 (en) 2019-07-25
US20180298376A1 (en) 2018-10-18
KR20150038543A (ko) 2015-04-08
KR102115630B1 (ko) 2020-05-27
ZA201500739B (en) 2018-07-25
RU2015105052A (ru) 2016-09-27
US10036009B2 (en) 2018-07-31
MX2015001366A (es) 2015-08-13
AU2013296218A1 (en) 2015-02-19
EP2880160B1 (en) 2018-09-19
BR112015002004A2 (pt) 2017-07-04
JP2020002138A (ja) 2020-01-09

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Application publication date: 20150513