CN104619702B - Ccr2的稠合环戊基拮抗剂 - Google Patents

Ccr2的稠合环戊基拮抗剂 Download PDF

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Publication number
CN104619702B
CN104619702B CN201380029978.4A CN201380029978A CN104619702B CN 104619702 B CN104619702 B CN 104619702B CN 201380029978 A CN201380029978 A CN 201380029978A CN 104619702 B CN104619702 B CN 104619702B
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compound
pyran
formula
salt
disease
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CN104619702A (zh
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S.布拉努姆
N.E.法兹
F-A.康
M.雷曼
R.K.鲁斯塞尔
Z.隋
C.A.特勒哈
M.P.温特斯
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Janssen Pharmaceutica NV
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CN201380029978.4A 2012-04-06 2013-04-05 Ccr2的稠合环戊基拮抗剂 Expired - Fee Related CN104619702B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261621138P 2012-04-06 2012-04-06
US61/621138 2012-04-06
PCT/US2013/035396 WO2013152269A1 (en) 2012-04-06 2013-04-05 Fused cyclopentyl antagonists of ccr2

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CN104619702A CN104619702A (zh) 2015-05-13
CN104619702B true CN104619702B (zh) 2017-09-15

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US (2) US8822460B2 (enExample)
EP (1) EP2834234B1 (enExample)
JP (2) JP6110474B2 (enExample)
CN (1) CN104619702B (enExample)
AU (1) AU2013243353B2 (enExample)
CA (1) CA2869647A1 (enExample)
ES (1) ES2648175T3 (enExample)
HK (1) HK1210150A1 (enExample)
WO (1) WO2013152269A1 (enExample)

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US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
JP6204983B2 (ja) * 2012-07-19 2017-09-27 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２のオクタヒドロ−シクロペンタピロリル拮抗薬
EP3050574B1 (en) 2015-01-28 2019-10-09 Universite De Bordeaux Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease
CN108135168B (zh) 2015-05-21 2021-07-20 凯莫森特里克斯股份有限公司 Ccr2调节剂
CN106366091A (zh) * 2016-08-24 2017-02-01 河北艾林国际贸易有限公司 海南霉素及其衍生物的用途及其海南霉素衍生物和制备方法
AR112831A1 (es) 2017-09-25 2019-12-18 Chemocentryx Inc Terapia de combinación usando un antagonista del receptor 2 de quimiocina (ccr2) y un inhibidor de pd-1 / pd-l1
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
EP3833762A4 (en) 2018-08-09 2022-09-28 Verseau Therapeutics, Inc. Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
CN110028469B (zh) * 2019-04-28 2022-08-09 南京药石科技股份有限公司 一种非阿片类镇痛药的关键中间体的制备方法及应用
TW202300150A (zh) 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法

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Reduction of carbonyl compounds with chiral oxazaborolidine catalysts:A new paradigm for enantioselective catalysis and a powerful new synthetic method;Elias J. Corey et al.;《Angew. Chem. Int. Ed.》;19981217;第37卷(第15期);第1989页表1，第1990-1992页3.0-4.3以及表2 *

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JP6110474B2 (ja) 2017-04-05
US8822460B2 (en) 2014-09-02
CA2869647A1 (en) 2013-10-10
CN104619702A (zh) 2015-05-13
US20150080588A1 (en) 2015-03-19
HK1210150A1 (en) 2016-04-15
JP2017095499A (ja) 2017-06-01
AU2013243353B2 (en) 2017-07-20
ES2648175T3 (es) 2017-12-28
US9150532B2 (en) 2015-10-06
AU2013243353A1 (en) 2014-10-02
EP2834234A1 (en) 2015-02-11

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