JP6110474B2 - Ｃｃｒ２の縮合シクロペンチル拮抗薬 - Google Patents

Ｃｃｒ２の縮合シクロペンチル拮抗薬 Download PDF

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JP6110474B2
JP6110474B2 JP2015504745A JP2015504745A JP6110474B2 JP 6110474 B2 JP6110474 B2 JP 6110474B2 JP 2015504745 A JP2015504745 A JP 2015504745A JP 2015504745 A JP2015504745 A JP 2015504745A JP 6110474 B2 JP6110474 B2 JP 6110474B2
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alkyl
formula
disease
salt
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JP2015516968A5 (enExample
JP2015516968A (ja
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ピー． ウィンターズ，マイケル
ピー． ウィンターズ，マイケル
ブラナム，ショーン
イー． ファウズィー，ナージ
イー． ファウズィー，ナージ
カン，フ−アン
レマン，マイケル
ケー． ラッセル，ロナルド
ケー． ラッセル，ロナルド
スイ，ツィフア
エー テレハ，クリストファー
エー テレハ，クリストファー
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ヤンセン ファーマシューティカ エヌ．ベー．
ヤンセン ファーマシューティカ エヌ．ベー．
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    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
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    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
JP2015504745A 2012-04-06 2013-04-05 Ｃｃｒ２の縮合シクロペンチル拮抗薬 Expired - Fee Related JP6110474B2 (ja)

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US201261621138P 2012-04-06 2012-04-06
US61/621,138 2012-04-06
PCT/US2013/035396 WO2013152269A1 (en) 2012-04-06 2013-04-05 Fused cyclopentyl antagonists of ccr2

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JP2015516968A JP2015516968A (ja) 2015-06-18
JP2015516968A5 JP2015516968A5 (enExample) 2016-06-02
JP6110474B2 true JP6110474B2 (ja) 2017-04-05

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US (2) US8822460B2 (enExample)
EP (1) EP2834234B1 (enExample)
JP (2) JP6110474B2 (enExample)
CN (1) CN104619702B (enExample)
AU (1) AU2013243353B2 (enExample)
CA (1) CA2869647A1 (enExample)
ES (1) ES2648175T3 (enExample)
HK (1) HK1210150A1 (enExample)
WO (1) WO2013152269A1 (enExample)

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US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
ES2627010T3 (es) * 2012-07-19 2017-07-26 Janssen Pharmaceutica, N.V. Antagonistas de octahidro-ciclopentapirrolilo de CCR2
DK3050574T3 (da) 2015-01-28 2020-01-20 Univ Bordeaux Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom
RU2726206C2 (ru) 2015-05-21 2020-07-09 Кемосентрикс, Инк. Модуляторы ccr2
CN106366091A (zh) * 2016-08-24 2017-02-01 河北艾林国际贸易有限公司 海南霉素及其衍生物的用途及其海南霉素衍生物和制备方法
EP3687525B1 (en) 2017-09-25 2025-10-29 ChemoCentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
WO2020033791A1 (en) 2018-08-09 2020-02-13 Verseau Therapeutics, Inc. Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
CN110028469B (zh) * 2019-04-28 2022-08-09 南京药石科技股份有限公司 一种非阿片类镇痛药的关键中间体的制备方法及应用
CN116490507A (zh) 2020-09-10 2023-07-25 薛定谔公司 用于治疗癌症的杂环包缩合cdc7激酶抑制剂
TW202300150A (zh) 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法

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US20150080588A1 (en) 2015-03-19
WO2013152269A1 (en) 2013-10-10
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US20140018356A1 (en) 2014-01-16
AU2013243353A1 (en) 2014-10-02
HK1210150A1 (en) 2016-04-15
EP2834234A1 (en) 2015-02-11
US8822460B2 (en) 2014-09-02
US9150532B2 (en) 2015-10-06
EP2834234B1 (en) 2017-09-13
CA2869647A1 (en) 2013-10-10
JP2015516968A (ja) 2015-06-18
CN104619702B (zh) 2017-09-15
CN104619702A (zh) 2015-05-13
ES2648175T3 (es) 2017-12-28

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