CN104619697A - 作为抗肿瘤和抗增殖剂的1-(取代的磺酰基)-2-氨基咪唑啉的衍生物 - Google Patents
作为抗肿瘤和抗增殖剂的1-(取代的磺酰基)-2-氨基咪唑啉的衍生物 Download PDFInfo
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- CN104619697A CN104619697A CN201480002363.7A CN201480002363A CN104619697A CN 104619697 A CN104619697 A CN 104619697A CN 201480002363 A CN201480002363 A CN 201480002363A CN 104619697 A CN104619697 A CN 104619697A
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- Prior art keywords
- dihydro
- imidazoles
- amine
- alkylsulfonyl
- phenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
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- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
- C07C247/06—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated and containing rings
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Applications Claiming Priority (5)
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| US201361810276P | 2013-04-10 | 2013-04-10 | |
| US61/810,276 | 2013-04-10 | ||
| PL403491 | 2013-04-10 | ||
| PL403491A PL231063B1 (pl) | 2013-04-10 | 2013-04-10 | Pochodne 1-(podstawionej sulfonylo)-2-aminoimidazoliny jako środki przeciwnowotworowe |
| PCT/IB2014/060200 WO2014167446A1 (en) | 2013-04-10 | 2014-03-27 | Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents |
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| CN104619697A true CN104619697A (zh) | 2015-05-13 |
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| PL (1) | PL231063B1 (https=) |
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| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| WO2021072487A1 (en) | 2019-10-15 | 2021-04-22 | TroBio Therapeutics Pty Ltd | Sulfonamide compounds and the use thereof in the treatment of cancer |
| AU2021331624A1 (en) * | 2020-08-31 | 2023-05-04 | Visus Therapeutics, Inc. | Compounds and formulations for treating ophthalmic diseases |
Citations (1)
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| WO1998007719A1 (en) * | 1996-08-22 | 1998-02-26 | Dong Wha Pharm. Ind. Co., Ltd. | Arylsulfonylimidazolone derivatives as an antitumor agent |
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| CS97860B5 (https=) * | 1959-09-04 | 1960-12-15 | ||
| US3538085A (en) | 1966-03-24 | 1970-11-03 | Geigy Chem Corp | 1-phenylsulfonyl-2-imino-imidazolidines and hexahydropyrimidines |
| CH470397A (de) | 1966-03-24 | 1969-03-31 | Geigy Ag J R | Verfahren zur Herstellung neuer Derivate des Sulfanilamids |
| AU6578090A (en) | 1989-11-06 | 1991-05-09 | Warner-Lambert Company | Acat inhibitors |
| US6184242B1 (en) | 1997-09-04 | 2001-02-06 | Syntex Usa (Llc) | 2-(substituted-phenyl)amino-imidazoline derivatives |
| AU2002363655A1 (en) | 2001-11-14 | 2003-05-26 | Novartis Ag | Non-peptide somatostatin receptor ligands |
| SI1864976T1 (sl) * | 2005-03-31 | 2012-12-31 | Astellas Pharma Inc. | Propan-1,3-dionski derivat ali njegova sol |
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2013
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998007719A1 (en) * | 1996-08-22 | 1998-02-26 | Dong Wha Pharm. Ind. Co., Ltd. | Arylsulfonylimidazolone derivatives as an antitumor agent |
Non-Patent Citations (1)
| Title |
|---|
| STN: "25046-65-5", 《REGISTRY》, 16 November 1984 (1984-11-16) * |
Also Published As
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| IN2015KN00569A (https=) | 2015-07-17 |
| JP2015535239A (ja) | 2015-12-10 |
| PL231063B1 (pl) | 2019-01-31 |
| WO2014167446A1 (en) | 2014-10-16 |
| US8981114B2 (en) | 2015-03-17 |
| AU2014252281A1 (en) | 2015-04-02 |
| EP2875017A1 (en) | 2015-05-27 |
| US9095575B2 (en) | 2015-08-04 |
| PL403491A1 (pl) | 2014-10-13 |
| US20140309240A1 (en) | 2014-10-16 |
| CA2883014A1 (en) | 2014-10-16 |
| US20140309259A1 (en) | 2014-10-16 |
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