CN104606259B - A kind of compound preparation containing lycopene and preparation method thereof - Google Patents
A kind of compound preparation containing lycopene and preparation method thereof Download PDFInfo
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Abstract
The invention mainly relates to a kind of compound preparation containing lycopene and preparation method thereof.The described fraction by weight of the compound preparation containing lycopene includes：5 30 parts of lycopene, 5 25 parts of Cordyceps militaris extract, 1 25 parts of royal jelly freeze-dried powder.Described compound preparation also includes auxiliary material, and auxiliary material is 0.1 1 parts of 25 50 parts of dextrin, 5 30 parts of excipient, 45 parts of disintegrant, 0.1 5 parts of lubricant, 0.1 5 parts of flavouring and food coloring.Material is weighed by above-mentioned formula ratio, is sufficiently mixed, pulverizes and sieves, powder rotary pelleting machine direct tablet compressing, seed-coating machine is coated to obtain the compound preparation.The compound preparation of the present invention has protection prostatitis, anti-oxidant, anti-aging, prevention of cardiovascular disease and other effects；The compound preparation preparation method flow of the present invention is simple, easy to operate, is easy to the large-scale popularization and application of industry.
Description
Technical field
The present invention relates to pharmaceutical field, relates generally to a kind of compound preparation containing lycopene and preparation method thereof.
Background technology
With the fast development of people's living standards continue to improve and modern society, increasing people begins to focus on strong
Kang Guanli.In developed countries such as the U.S., Spain, Italy, the healthy product related to tomato occupy very in daily life
Important position, especially lycopene, it not only assigns tomato product with bright-coloured color and luster, and can capture other bodies
Interior free radical, there is the multi-efficiencies such as prevention kinds cancer, the occurrence probability for reducing atherosclerosis, exactly so, in recent years
Carry out the new lover that lycopene is increasingly becoming international health product in the market.Lycopene (Lycopene), molecular formula C40H36, molecule
Amount 536.85, it is one kind of carotenoid.Scientific research proves that lycopene has anti-oxidant, anti-aging, reduces courage and consolidates
Alcohol, cardiovascular disease, anticancer and other effects are prevented, particularly there is good therapeutic action to prostate cancer, be described as " plant Huang
Gold ".
Cordyceps militaris (Cordycepsmilitaris) is Ascomycotina, ergot Zoopagales, Clavicipitaceae, the pattern of Cordyceps
Kind, also known as northern Chinese caterpillar Fungus, Cordceps militaris etc..The traditional Chinese medical science thinks that cordyceps sinensis enters lung kidney two warp, can tonifying lung it is cloudy, and can kidney-replenishing, cure mainly
Kidney deficiency, impotence and seminal emission, soreness of waist and knee joint, eak after being ill etc., it is a kind of energy while the Chinese medicine of balance adjustment negative and positive.
Royal jelly is a kind of rare nutrient and healthcare products that can not manually manufacture.Chinese economy and trade department is by royal jelly with passing
Chinese medicine ginseng, pilose antler etc. unite side by side, prevention and adjuvant therapy medicaments as five large outlet nutriment and some illness.Pass through
The method of freeze-drying obtains royal jelly freeze-dried powder after fresh royal jelly is dried, and has regulation endocrine, delays climacteric to integrate
Disease, enhance metabolism, the effect of anti-aging, have rehabilitation and prevention effect to some infirmitiess of age, to atherosclerosis
There is significant curative effect with hyperlipemia, nervous system can be adjusted, prevent and treat neurasthenia.In addition, also obvious radiation resistance
Stress ability with raising to mal-condition, there is good health-care effect at anti-aging, aspect of promoting longevity.
CN 103263019A disclose a kind of tonifying Qi body god, the composition and preparation method thereof of strengthen immunity, the combination
Thing includes following each component：Ginseng, cordyceps sinensis or river in Zhejiang Province cordyceps sinensis, lycopene, ganoderma lucidum, Morinda officinalis, the fruit of Chinese wolfberry, Organic Selenium, dimension
Raw plain A, vitamin B12, vitamin C and auxiliary material, and said composition has invigorating qi and refreshing, strengthen immunity, anti-oxidant, anti-ageing
Always, the function of physical fatigue, auxiliary improvement of memory, kidney tonifying etc. is alleviated.
The content of the invention
It is an object of the invention to propose a kind of compound preparation containing lycopene and preparation method thereof, one kind has protection
Prostate, improve health care prevention function and the compound preparations convenient to take such as immunity, anti-aging.
To use following technical scheme up to this purpose, the present invention：
On the one hand, the invention provides a kind of compound preparation containing lycopene, the compound preparation primary raw material includes kind
Lycopene, Cordyceps militaris extract and royal jelly freeze-dried powder, in parts by weight including following component：
Lycopene 5-30 parts
Cordyceps militaris extract 5-25 parts
Royal jelly freeze-dried powder 1-25 parts.
In the present invention, by the anti-oxidation efficacy of lycopene, the increasing of the anti-fatigue effect and royal jelly of Cordyceps militaris extract
After the effect of strong constitution is combined, three is acted synergistically, and each component enables bioactivity to assist by scientific formula
Readjust the distribution and wave, promote mutually, reach effect maximization, realize the height of lycopene, Cordyceps militaris extract and royal jelly freeze-dried powder
Value utilizes.In the present invention, the lycopene comes from commercially available lycopene, and purity is more than 95%.
In the present invention, the Cordyceps militaris extract comes from commercially available Cordyceps militaris extract, and cordycepin content is more than 1%.
In the present invention, the royal jelly freeze-dried powder comes from commercially available royal jelly freeze-dried powder, and royal jelly acid content is more than 3%.
In the present invention, the lycopene for example can be 5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 16 parts, 18 parts,
20 parts, 22 parts, 25 parts, 26 parts, 28 parts or 30 parts.
In the present invention, the Cordyceps militaris extract for example can be 5 parts, 8 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts,
15 parts, 16 parts, 18 parts, 20 parts, 22 parts or 25 parts.
In the present invention, the royal jelly freeze-dried powder for example can be 1 part, 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20
Part, 22 parts, 24 parts or 25 parts.
Preferably, the primary raw material includes following component in parts by weight：
Lycopene 8-25 parts
Cordyceps militaris extract 8-20 parts
Royal jelly freeze-dried powder 5-20 parts.
As optimal technical scheme, described compound preparation also includes auxiliary material.
Preferably, the auxiliary material includes dextrin, excipient, disintegrant, lubricant, flavouring and food coloring.
Preferably, the auxiliary material includes following component in parts by weight：
The dextrin for example can be 25 parts, 28 parts, 30 parts, 32 parts, 35 parts, 38 parts, 40 parts, 42 parts, 45 parts, 48 parts,
49 parts or 50 parts.
The excipient for example can be 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts or
30 parts.
The disintegrant for example can be 4 parts, 4.5 parts, 4.8 parts or 5 parts.
The lubricant for example can be 0.1 part, 0.2 part, 0.5 part, 0.8 part, 1 part, 2 parts, 3 parts, 4 parts or 5 parts.
The Flavouring agents such as can be 0.1 part, 0.2 part, 0.5 part, 0.8 part, 1 part, 2 parts, 3 parts, 4 parts or 5 parts.
The food coloring for example can be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8
Part, 0.9 part or 1 part.
Preferably, the auxiliary material includes following component in parts by weight：
Preferably, described dextrin can be selected from, but not limited to, maltodextrin, alpha-cyclodextrin, beta-schardinger dextrin or γ-ring paste
In essence any one or at least two composition.
Preferably, described excipient can be selected from, but not limited to, microcrystalline cellulose, sodium carboxymethyl starch, carboxymethyl cellulose
In plain sodium, low substituted hydroxy-propyl methylcellulose or PVPP any one or at least two combination
Thing.
Preferably, described disintegrant can be selected from, but not limited to, microcrystalline cellulose, sodium carboxymethyl starch, carboxymethyl cellulose
In plain sodium, low substituted hydroxy-propyl methylcellulose or PVPP any one or at least two combination
Thing.
Preferably, described lubricant can be selected from, but not limited to, any in magnesium stearate, superfine silica gel powder or talcum powder
It is a kind of or at least two composition.
Preferably, described flavouring can be selected from, but not limited to, appointing for Aspartame, stevioside, sorbierite or mannitol
Anticipate a kind of or at least two compositions.
Preferably, described food coloring can be selected from, but not limited to, beet red, more Exocarpium Citri Rubrum, blackcurrant is red, mulberry fruit is red, Portugal
Grape skin is red or chrysanthemum in any one or at least two composition.
As the preferred scheme of the present invention, the compound preparation is compound lozenge, complex capsule, composite particles, Composite Milk
Agent or compound powder, preferably compound lozenge.
On the other hand, present invention also offers a kind of preparation method of compound lozenge described above, comprise the following steps：
Material is weighed by above-mentioned formula ratio, is sufficiently mixed, pulverizes and sieves, powder rotary pelleting machine direct tablet compressing, seed-coating machine is coated to obtain
The compound buccal lozenge.
Preferably, the filler depth of the powder compressing machine is 10mm, and pressure 30kN, obtained tablet thickness is 4mm,
Tablet diameters are 12mm.
Preferably, the coating is realized with coating pan and is coated.
Preferably, 40 degree of the angle of inclination of the coating pan, rotating speed 50r/min.
Preferably, the heating power 450W of the coating pan.
Compared with prior art, the invention has the advantages that：
(1) compound preparation of the invention has protection prostatitis, anti-oxidant, anti-aging, prevention of cardiovascular disease etc.
Effect.Each component is enable bioactivity Coordinated Play, promoted mutually, reached effect maximization, realized by scientific formula
The higher value application of lycopene, Cordyceps militaris extract and royal jelly freeze-dried powder；
(2) a small amount of excipient, lubricant, flavouring and the food for meeting food safety requirements of compound preparation of the invention addition
With pigment, preparation is set to maintain definite shape, and with the mouthfeel of good mouth containing dissolubility and pleasant, overcome traditional mouth
Take the shortcomings that type health products taste inconvenient to carry and edible is bad；
(3) compound preparation preparation method flow of the invention is simple, and easy to operate, high-efficiency and economic is environment-friendly, is easy to work
The large-scale popularization and application of industry.
Embodiment
Further to illustrate the technological means and its effect of the invention taken, enter below by way of embodiment
One step illustrates technical scheme, but the present invention is not limited in scope of embodiments.
Preparation method in following embodiments, it is conventional method unless otherwise specified；Experiment material used, such as nothing
Specified otherwise, it is that can buy commercially available from routine biochemistry chemical reagent work.
In the present invention, lycopene comes from commercially available lycopene, and purity is more than 95%.
In the present invention, Cordyceps militaris extract comes from commercially available Cordyceps militaris extract, and cordycepin content is more than 1%.
In the present invention, royal jelly freeze-dried powder comes from commercially available royal jelly freeze-dried powder, and royal jelly acid content is more than 3%.
Embodiment 1
A kind of compound process for preparing buccal lozenge containing lycopene：
Primary raw material：
Lycopene 5g
Cordyceps militaris extract 15g
Royal jelly freeze-dried powder 10g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 66.1g, material is sufficiently mixed, pulverized and sieved, rotates and presses in powder
Piece machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, and pressure is
30kN, obtained tablet thickness are 4mm, tablet diameters 12mm；Coating realized with coating pan, the angle of inclination 40 of coating pan
Degree, rotating speed 50r/min；The heating power 450W of coating pan.
Compound lozenge 120 or so prepared by embodiment 1, the weight of every tablet of compound lozenge is about 500mg.
Embodiment 2
A kind of compound process for preparing buccal lozenge containing lycopene：
Primary raw material：
Lycopene 20g
Cordyceps militaris extract 5g
Royal jelly freeze-dried powder 25g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 121g, material is sufficiently mixed, pulverized and sieved, rotates and presses in powder
Piece machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, and pressure is
30kN, obtained tablet thickness are 4mm, tablet diameters 12mm；Coating realized with coating pan, the angle of inclination 40 of coating pan
Degree, rotating speed 50r/min；The heating power 450W of coating pan.
Embodiment 2 prepares compound lozenge 120 or so, and the weight of every tablet of compound lozenge is about 1000mg.
Embodiment 3
A kind of compound process for preparing buccal lozenge containing lycopene：
Primary raw material：
Lycopene 30g
Cordyceps militaris extract 25g
Royal jelly freeze-dried powder 1g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 95g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Embodiment 3 prepares compound lozenge 120 or so, and the weight of every tablet of compound lozenge is about 750mg.
Embodiment 4
A kind of compound process for preparing buccal lozenge containing lycopene：
Primary raw material：
Lycopene 10g
Cordyceps militaris extract 13g
Royal jelly freeze-dried powder 12g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 81g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Compound lozenge 120 or so prepared by embodiment 4, the weight of every tablet of compound lozenge is about 650mg.
Comparative example 1
A kind of preparation method of lycopene lozenge：
Primary raw material：
Lycopene 10g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 66g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Lozenge 120 or so prepared by comparative example 1, the weight of every tablet of lozenge is about 550mg.
Comparative example 2
A kind of preparation method of Cordyceps militaris extract lozenge：
Primary raw material：
Cordyceps militaris extract 13g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 66g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Lozenge 120 or so prepared by comparative example 2, the weight of every tablet of lozenge is about 550mg.
Comparative example 3
A kind of preparation method of royal jelly freeze-dried powder lozenge：
Primary raw material：
Royal jelly freeze-dried powder 12g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 66g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Lozenge 120 or so prepared by comparative example 3, the weight of every tablet of lozenge is about 550mg.
Comparative example 4
A kind of preparation method of the compound lozenge of lycopene cordyceps sinensis：
Primary raw material：
Lycopene 10g
Cordyceps militaris extract 13g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 66g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Compound lozenge 120 or so prepared by comparative example 4, the weight of every tablet of compound lozenge is about 550mg.
Comparative example 5
A kind of preparation method of the compound lozenge of lycopene royal jelly：
Primary raw material：
Lycopene 10g
Royal jelly freeze-dried powder 12g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 66g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Compound lozenge 120 or so prepared by comparative example 5, the weight of every tablet of compound lozenge is about 550mg.
Comparative example 6
A kind of preparation method of the compound lozenge of cordyceps sinensis royal jelly：
Primary raw material：
Cordyceps militaris extract 13g
Royal jelly freeze-dried powder 12g
Auxiliary material：
Material is weighed by above-mentioned formula ratio, gross weight 66g, material is sufficiently mixed, pulverized and sieved, in powder rotary tablet compression
Machine direct tablet compressing, seed-coating machine are coated to obtain compound lozenge, and the wherein filler depth of powder compressing machine is 10mm, pressure 30kN,
Obtained tablet thickness is 4mm, tablet diameters 12mm；Coating realized with coating pan, 40 degree of the angle of inclination of coating pan, rotating speed
50r/min；The heating power 450W of coating pan.
Compound lozenge 120 or so prepared by comparative example 6, the weight of every tablet of compound lozenge is about 550mg.
The evaluation of embodiment 1-4 and comparative example 1-6 anti-oxidation efficacy is detected compound respectively using DPPH methods and salicylic acid method
Containing flake products to DPPH free radicals and the elimination effect of hydroxyl radical free radical, as a result as shown in table 1：
Table 1
Embodiment 1-4 and comparative example 1-6 anti-fatigue effect are using mice burden swimming experiment detection sample evaluation：Mouse
Give sample 30 days, after last gives sample 30min, put mouse in swimming trunk went swimming, the depth of water is no less than 30cm, 25 DEG C of water temperature
± 0.5 DEG C, the sheet lead of the body weight of rat-tail root load 5%.Record mouse from swimming to start to the dead time, as mouse swimming
Time (min), as a result as shown in table 2：
Table 2
As it can be seen from table 1 the lozenge made under the cooperation of lycopene, Cordyceps militaris extract and royal jelly freeze-dried powder
DPPH free radical scavenging activities are clear apparently higher than the only free radical of two kinds of components or one-component with hydroxyl radical free radical clearance rate
Except rate.Table 2 is as can be seen that the lozenge mouse made under the cooperation of lycopene, Cordyceps militaris extract and royal jelly freeze-dried powder
Walking weight load is apparently higher than remaining comparative example, it is seen that three kinds of components cooperate so that has reached one the effect of lozenge
Individual qualitative leap.
In summary, in the present invention, lycopene, Cordyceps militaris extract and royal jelly freeze-dried powder are made by scientific formula
Bioactivity can Coordinated Play, mutually promote, reach effect maximization, realize lycopene, Cordyceps militaris extract and honeybee
The higher value application of royal jelly freeze-dried powder；Compound compound preparation adds a small amount of excipient for meeting food safety requirements, lubricant, rectified
Taste agent and food coloring, tablet is maintained definite shape, and with the mouthfeel of good mouth containing dissolubility and pleasant, overcome
The shortcomings that conventional oral type health products tastes inconvenient to carry and edible is bad.
Applicant states that the present invention illustrates the method detailed of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implemented.Art
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., within the scope of all falling within protection scope of the present invention and disclosing.
Claims (6)
1. a kind of compound preparation containing lycopene, it is characterised in that described compound preparation is in parts by weight by following component
It is made：
Lycopene 5-30 parts
Cordyceps militaris extract 5-25 parts
Royal jelly freeze-dried powder 1-25 parts.
2. compound preparation according to claim 1, it is characterised in that described compound preparation is in parts by weight by such as the following group
Divide and be made：
Lycopene 8-25 parts
Cordyceps militaris extract 8-20 parts
Royal jelly freeze-dried powder 5-20 parts.
3. compound preparation according to claim 1 or 2, it is characterised in that described compound preparation also includes auxiliary material.
4. compound preparation according to claim 1, it is characterised in that described compound preparation is compound lozenge, compound adhesive
Capsule, composite particles, multiple emulsion or compound powder.
5. compound preparation according to claim 1, it is characterised in that described compound preparation is compound lozenge.
6. a kind of preparation method for preparing the compound preparation as described in claim 4 or 5, it is characterised in that the compound lozenge
Preparation comprises the following steps：Material is weighed by above-mentioned formula ratio, is sufficiently mixed, pulverizes and sieves, directly pressed on powder compressing machine
Piece, then be coated and produced with seed-coating machine.
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| CN105707800A (en) * | 2016-01-30 | 2016-06-29 | 合肥华方医药科技有限公司 | Royal jelly smell-masking freeze-dried powder, preparation method and application thereof |
| CN108065353A (en) * | 2017-12-13 | 2018-05-25 | 深圳地天国际生物工程科技有限公司 | A kind of pre- anti-aging health food and its preparation process |
| CN110215486A (en) * | 2019-07-08 | 2019-09-10 | 湖北圣峰药业有限公司 | A kind of selenium worm grass compound preparation and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961354A (en) * | 2010-10-21 | 2011-02-02 | 蒋科罡 | Royal jelly-containing Chinese medicament for treating tumors and preparation method thereof |
| CN103263019A (en) * | 2013-06-14 | 2013-08-28 | 海南通宝投资有限公司 | Composition capable of invigorating qi for ascending and enhancing immunity, and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961354A (en) * | 2010-10-21 | 2011-02-02 | 蒋科罡 | Royal jelly-containing Chinese medicament for treating tumors and preparation method thereof |
| CN103263019A (en) * | 2013-06-14 | 2013-08-28 | 海南通宝投资有限公司 | Composition capable of invigorating qi for ascending and enhancing immunity, and preparation method thereof |
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| Title |
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