CN110215486A - A kind of selenium worm grass compound preparation and its preparation method and application - Google Patents
A kind of selenium worm grass compound preparation and its preparation method and application Download PDFInfo
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- CN110215486A CN110215486A CN201910608050.0A CN201910608050A CN110215486A CN 110215486 A CN110215486 A CN 110215486A CN 201910608050 A CN201910608050 A CN 201910608050A CN 110215486 A CN110215486 A CN 110215486A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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Abstract
The present invention provides a kind of selenium worm grass compound preparations, including following component by mass percentage: selenium Cordyceps militaris 10~40%, tomato extract 5~30%, allicin 10~40%, starch and/or table sugar 10~40%, auxiliary material 2~10%.In addition, the present invention also provides the preparation method of the selenium worm grass compound preparation and its applications in preparation treatment prostatic disorders drug.The selenium worm grass compound preparation is merged various functional components by the organic assembling of various components, and by the synergistic effect between effective component, humidification effect is significant in efficacy to prostate patient, and has no toxic side effect, safely and effectively.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of selenium worm grass compound preparation and its preparation method and application.
Background technique
Prostate is the position most often to go wrong in male genetic urinary system, is common in the forefront of all ages male
Adenositis can be divided into it is acute and chronic, usually by other positions of body bacterium infection invade prostate caused by, prostatitis can
Completely or partially hinder urine flowed out by bladder, cause urine to be detained, so cause distended bladder, weak, susceptible (because
The bacterium accumulated in urine increases), bladder infection is easy to reach kidney via ureter, and the symptom of acute prostatitis is yin
Capsule is to pain, fever, pollakiuria between rectum and has burning heat sensation, and urine contains blood or purulence；The symptom of chronic prostatitis is then pollakiuria
And burning heat sensation, urine band blood, lower half backache, impotence, prostatitis is more serious, and urination is more difficult.The prostatitis cause of disease: only few
Number patient has acute medical history, shows as chronic, recurrent more and passes through, pathogen is mostly pathogenic entero becteria, conventional bacteriological inspection
Only about 20% patient finds bacterium.Recent research indicate that prostatitis patient urodynamics test finds Posterior urethral pressure
Increase, symptom mitigates or disappears after taking α adrenomimetic drug energy receptor antagonist orally, and prostate Posterior urethral smooth muscle ability is prompted to increase
Height makes urine turbulent flow, and urine reflux enters prostate, and the uric acid in urine generates chemical stimulation, causes pain, pathogen is with urine
Invade prostate.
Currently, clinic is mostly treated with antibiotic, regardless of which kind of antibiotic is different for prostate patient
The toxic side effect and drug resistance of degree.
Summary of the invention
The purpose of the present invention is to prostatic disorders and culture of patients with urinary system infection, provide a kind of to prepare that simple, curative effect is aobvious
The selenium worm grass compound preparation write, having no toxic side effect.
The technical solution of the present invention is to provide a kind of selenium worm grass compound preparations, including by mass percentage such as the following group
Point: selenium Cordyceps militaris 10~40%, tomato extract 5~30%, allicin 10~40%, starch and/or table sugar 10~40%, auxiliary material
2~10%.
Further, the selenium Cordyceps militaris is crushed to Ultramicro-powder, partial size≤75 μm.
Further, the selenium Selenium in Cordyceps content is 50~150mg/kg, and cordycepin content is greater than 0.3%.
Further, lycopene content >=20% in the tomato extract.
Further, the auxiliary material is sodium carboxymethyl starch, acesulfame potassium and magnesium stearate.
Further, the table sugar is isomaltoketose or sucrose.
Specifically, the selenium worm grass compound preparation includes following component by mass percentage: selenium Cordyceps militaris 30%, kind
Eggplant extract 8%, allicin 30%, starch 10%, table sugar 20%, auxiliary material 2%.
In addition, the present invention also provides the preparation method of above-mentioned selenium worm grass compound preparation, by following mass percent meter
Component be successively prepared through sieving, weighing, mixing, granulation, drying, whole grain, total mix, tabletting, enrobing processes: selenium Cordyceps militaris
10~40%, tomato extract 5~30%, allicin 10~40%, starch and/or table sugar 10~40%, auxiliary material 2~10%.
This selenium worm grass compound preparation provided by the invention can be in the application in preparation treatment prostatic disorders drug.
In the present invention, the Coragyceps militaris bacterium that selenium Cordyceps militaris selects poly- selenium ability especially strong, using bestowing favour, natural selenium is provided
Selenium source of the source as culture medium is tamed repeatedly and is converted with biology, inorganic selenium is made to pass through cordyceps sinensis using modern biotechnology tissue culture technology
The decomposition of bacterium absorbs, is converted to the organic selenium fruiting bodies of cordyceps militaris being easily immediately used by the body, and distinctive functional component cordycepin contains
Amount is greater than 0.3%, is higher by 35~59 times of cordycepin in cordyceps sinensis and Cordceps militaris, adenosine is higher by 4~5 times, and Se content can reach
100mg/kg or more, even more hundred times of cordyceps sinensis and Cordceps militaris, cordycepic acid and Cordyceps sinensis polysaccharide also rich in.And wherein,
Cordycepin is first nucleoside antibiotic separated from fungi, has the function of broad-spectrum antiseptic, it can inhibit hammer
The growth of the pathogens such as bacterium, Actinobacillus mallei, bacillus anthracis, pig hueppe's disease bacillus and staphylococcus.(i.e. D- is sweet for cordycepic acid
Reveal alcohol) it is a kind of mannitol, it is the isomeric compound of the peaceful acid of silicon.Mannitol is monosaccharide, is not metabolized in vivo, and mannitol is small through kidney
Liquid osmotic concentration in renal tubule can be improved, play the role of osmotic diuresis seldom by reabsorption in renal tubule after ball filtration.Cordyceps sinensis
The polysaccharide that polysaccharide is made of mannose, adenosine, galactolipin, arabinose, xylose essence, glucose, fucose, can activate huge
Phagocyte stimulates antibody to generate, and improves human immunological competence.Selenium is microelement necessary to humans and animals life, and selenium is applied to
Clinical treatment mainly has 5 effects, i.e. antimutagenic effect, antioxidation, the carcinogenic internal deactivation of promotion, anti-cell
Proliferation function, enhancing immunity of organisms effect；A large amount of organic seleniums are rich in selenium Cordyceps militaris of the invention, main occurrence status is
Selenomethionine, L- selenium-methyl selenium substituted aminothiopropionic and selenium polysaccharide have preferable biological effect.
Tomato extract is from natural plants tomato, and extracted to refine, active ingredient is lycopene, is
One Carotenoids and beta carotene belong to family.Tomato extract is not only the basic nutrition composition of human body, Er Qie
Increase immune function of human body, inhibits mutagenesis, it is anti-oxidant etc. to have its unique pharmacological action, it can especially help to prevent and improve
The disease in the urological systems such as hyperplasia of prostate, prostatitis, and help to improve mankind spermatozoon quality.
Allicin is a kind of organosulfur compound extracted from the bulb (garlic) of green onion section allium garlic, scientific name
Diallyl thiosulfinates；Allicin is a kind of broad spectrum antibiotic, has suppression to a variety of coccuses, bacillus, fungi, virus etc.
System or killing effect.
Compared with prior art, beneficial effects of the present invention:
This selenium worm grass compound preparation provided by the invention is melted various functional components by the organic assembling of various components
It closes, and by the synergistic effect between effective component, humidification effect is significant in efficacy to prostate patient, and nontoxic secondary work
With, safely and effectively.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel all other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
Embodiment 1:
A kind of selenium worm grass compound preparation is present embodiments provided, is calculated with 50kg, including following component: selenium Cordyceps militaris 15.0kg,
Tomato extract 4.0kg, allicin 15.0kg, starch 5kg, isomaltoketose 10kg, auxiliary material 1.0kg.Wherein, auxiliary material is carboxylic first
Base sodium starch, acesulfame potassium and magnesium stearate.
In the present embodiment, the preparation process of selenium Cordyceps militaris: firstly, selecting the fruiting bodies of cordyceps militaris of selenium-rich domestication in inoculating hood
In be cut into book piece access slant medium (including potato 200g take juice, 10~30g of glucose, 10~20g of peptone, agar
15~30g, 1~3g of potassium dihydrogen phosphate) it is intermediate, notch is upward, and constant temperature incubation is taken out after mycelia light-exposed to covering with for a period of time, dissipates
Illumination is penetrated to mycelia annesl, mycelia is selected and grows smooth selenium-enriched cordceps militaris parent species without miscellaneous bacteria；Selenium-enriched cordceps militaris parent species are connect again
Kind liquid spawn culture medium (including glucose 20g, peptone 10g, potassium dihydrogen phosphate 1g, magnesium sulfate 1g and with selenium spring it is dense
Contracting liquid constant volume is that 10~30ppm of selenium content inoculated and cultured to parent species into 1000ml) grow mycelia, obtains selenium-enriched cordceps militaris liquid
Strain；Then, selenium-enriched cordceps militaris liquid spawn is seeded in solid medium (solid medium rice 30%+ wheat 10%+ nutrition
Liquid 50%, wherein the main component in nutrient solution is glucose 20g, peptone 10g, potassium dihydrogen phosphate 1g, magnesium sulfate 1g, dimension are given birth to
Plain B1100mg, and using selenium spring concentrate constant volume as on 30~80ppm of selenium content to 1000ml), immigration darkroom controls temperature 20
~22 DEG C of bacterium germinations, media surface all cover with mycelia i.e. visible light, then annesl culture is carried out in the case where scattering illumination, control temperature
20~22 DEG C, relative humidity 80~85% is picked until there is fruit body primordium to sporophore growth maturation, finally will picking
The fructification of selenium Cordyceps militaris dry be no more than 8% to moisture content.The selenium Selenium in Cordyceps content 50 prepared by this method
~150mg/kg, cordycepin content are greater than 0.3%, which are crushed to Ultramicro-powder, partial size≤75 μm.In addition, selected
Lycopene content >=20% in tomato extract.
The preparation method of the selenium worm grass compound preparation, by the above material through sieving, weighing, mixing, granulation, drying, whole grain,
Tablet is made in total mix, tabletting, enrobing processes, which is 0.5g/ piece, and detailed process is as follows:
Sieving: by qualified selenium Cordyceps militaris Ultramicro-powder, tomato extract, allicin, pregelatinized starch, cornstarch, dextrin, carboxylic
Methyl starch sodium, isomalt, acesulfame potassium, magnesium stearate cross 80 meshes respectively, spare.
It weighs: supplementary material and transparent coating powder being pressed into formula ratio respectively and weighed, it is spare.
Mixing: by load weighted selenium Cordyceps militaris Ultramicro-powder, tomato extract, allicin, pregelatinized starch, cornstarch,
Dextrin, isomalt, acesulfame potassium are mixed about 30min with mixing machine, obtain mixed powder.
Softwood processed, granulation: 6% starch slurry (extracting corn starch adds purified water to prepare using slurry processes are rushed) of mixed powder is moistened
Wet, 150~200mL starch slurry is added by every 1000g material in wetting agent, until softwood is up to " holding is agglomerating, and flicking dissipates ", granulation is used
The granulation of 14 meshes.
Dry: wet granular is dried, temperature 70 C or so, and drying time 2~4 hours, moisture was controlled≤5%.
Whole grain: dry particle crosses 14 mesh sieves, obtains dry particl.
Total mix: addition magnesium stearate, sodium carboxymethyl starch mix about 10 minutes to obtain total hybrid particles, spare.
Tabletting: total mix particle carries out tabletting, and specification is 0.5g/ piece, and content is ± 5%.
Coating: taking and claim coating powder 1.1kg, adds purified water 7.5L, stirring makes it, and all dissolution is to get coating solution, by tabletting
Be put into coating pan carry out spray coating, wherein control inlet air temperature (inlet air temperature is 60 DEG C or so, leaving air temp is 45 DEG C,
3~8r/min of revolving speed), so that tabletting is uniformly wrapped one layer of coating membrane, increase weight range 2~4%.
Embodiment 2:
A kind of selenium worm grass compound preparation is present embodiments provided, is calculated with 50kg, including following component: selenium Cordyceps militaris 20kg, kind
Eggplant extract 2.5kg, allicin 12.5kg, starch 5kg, sucrose 7.5kg, auxiliary material 1.0kg.Wherein, selenium Cordyceps militaris is crushed to super
Micro mist, partial size≤75 μm, auxiliary material are sodium carboxymethyl starch, acesulfame potassium and magnesium stearate.
The preparation method of the selenium worm grass compound preparation, by the above material through sieving, weighing, mixing, granulation, drying, whole grain,
Tablet is made in total mix, tabletting, enrobing processes, which is 0.5g/ piece, and detailed process is same as Example 1.
Embodiment 3:
A kind of selenium worm grass compound preparation is present embodiments provided, is calculated with 50kg, including following component: selenium Cordyceps militaris 5kg, tomato
Extract 10kg, allicin 20kg, starch 3kg, isomaltoketose 7kg, auxiliary material 5kg.Wherein, selenium Cordyceps militaris is crushed to ultra micro
Powder, partial size≤75 μm, auxiliary material are sodium carboxymethyl starch, acesulfame potassium and magnesium stearate.
The preparation method of the selenium worm grass compound preparation, by the above material through sieving, weighing, mixing, granulation, drying, whole grain,
Tablet is made in total mix, tabletting, enrobing processes, which is 0.5g/ piece, and detailed process is same as Example 1.
Embodiment 4:
A kind of selenium worm grass compound preparation is present embodiments provided, is calculated with 50kg, including following component: selenium Cordyceps militaris 10kg, kind
Eggplant extract 15kg, allicin 5kg, starch 6kg, isomaltoketose 10kg, auxiliary material 4kg.Wherein, selenium Cordyceps militaris is crushed to ultra micro
Powder, partial size≤75 μm, auxiliary material are sodium carboxymethyl starch, acesulfame potassium and magnesium stearate.
The preparation method of the selenium worm grass compound preparation, by the above material through sieving, weighing, mixing, granulation, drying, whole grain,
Tablet is made in total mix, tabletting, enrobing processes, which is 0.5g/ piece, and detailed process is same as Example 1.
Application Example:
Selenium worm grass compound preparation produced by the present invention is applied to the chronic property prostatitis of 42 male, hyperplasia of prostate and urinary system
Infected patient, said preparation instructions of taking: 2 times a day, 2 tablets once, every 0.5g.
After continuously taking 1~2 day, urgent urination, urodynia symptom improve 39 (92.8%)；Urine retention symptom improves 35
(83.3%).
The foregoing examples are only illustrative of the present invention, does not constitute the limitation to protection scope of the present invention, all
It is within being all belonged to the scope of protection of the present invention with the same or similar design of the present invention.
Claims (9)
1. a kind of selenium worm grass compound preparation, which is characterized in that including following component by mass percentage: selenium Cordyceps militaris 10~
40%, tomato extract 5~30%, allicin 10~40%, starch and/or table sugar 10~40%, auxiliary material 2~10%.
2. a kind of selenium worm grass compound preparation as described in claim 1, it is characterised in that: the selenium Cordyceps militaris is crushed to ultra micro
Powder, partial size≤75 μm.
3. a kind of selenium worm grass compound preparation as described in claim 1, it is characterised in that: the selenium Selenium in Cordyceps content is 50
~150mg/kg, cordycepin content are greater than 0.3%.
4. a kind of selenium worm grass compound preparation as described in claim 1, it is characterised in that: lycopene in the tomato extract
Content >=20%.
5. a kind of selenium worm grass compound preparation as described in claim 1, it is characterised in that: the auxiliary material be sodium carboxymethyl starch,
Acesulfame potassium and magnesium stearate.
6. a kind of selenium worm grass compound preparation as described in claim 1, it is characterised in that: the table sugar be isomaltoketose or
Sucrose.
7. a kind of selenium worm grass compound preparation as described in claim 1, it is characterised in that: as follows including by mass percentage
Component: selenium Cordyceps militaris 30%, tomato extract 8%, allicin 30%, starch 10%, table sugar 20%, auxiliary material 2%.
8. a kind of preparation method of selenium worm grass compound preparation as described in any one of claims 1 to 7, which is characterized in that its by
The component of following mass percent meter is successively through sieving, weighing, mixing, granulation, drying, whole grain, total mix, tabletting, enrobing processes
It is prepared: selenium Cordyceps militaris 10~40%, tomato extract 5~30%, allicin 10~40%, starch and/or table sugar 10~
40%, auxiliary material 2~10%.
9. a kind of selenium worm grass compound preparation as described in any one of claims 1 to 7 is in preparation treatment prostatic disorders drug
Application.
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| CN101467690A (en) * | 2007-12-27 | 2009-07-01 | 百泰生物科技股份有限公司 | Nutritive composition containing five kinds of processed vegetable and fruit articles |
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| CN104606259A (en) * | 2015-01-27 | 2015-05-13 | 中国农业科学院农产品加工研究所 | Compound preparation containing lycopene and preparation method for compound preparation |
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-
2019
- 2019-07-08 CN CN201910608050.0A patent/CN110215486A/en active Pending
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| CN101467690A (en) * | 2007-12-27 | 2009-07-01 | 百泰生物科技股份有限公司 | Nutritive composition containing five kinds of processed vegetable and fruit articles |
| CN102138436A (en) * | 2010-12-28 | 2011-08-03 | 湖北圣峰药业有限公司 | Method for culturing selenium-enriched Cordyceps militaris |
| CN102428834A (en) * | 2011-09-20 | 2012-05-02 | 骆新春 | Cultivation method of selenium-enriched Cordyceps militaris mother culture |
| CN104940659A (en) * | 2014-03-25 | 2015-09-30 | 上海宣泰医药科技有限公司 | Nutrient composition for treating male infertility or prostate enlargement |
| CN104606259A (en) * | 2015-01-27 | 2015-05-13 | 中国农业科学院农产品加工研究所 | Compound preparation containing lycopene and preparation method for compound preparation |
Non-Patent Citations (1)
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Application publication date: 20190910 |