CN104547857A - Preparation method of honeybee comb nano spray - Google Patents
Preparation method of honeybee comb nano spray Download PDFInfo
- Publication number
- CN104547857A CN104547857A CN201410802249.4A CN201410802249A CN104547857A CN 104547857 A CN104547857 A CN 104547857A CN 201410802249 A CN201410802249 A CN 201410802249A CN 104547857 A CN104547857 A CN 104547857A
- Authority
- CN
- China
- Prior art keywords
- preparation
- honey comb
- reflux
- medicinal alcohol
- extracting solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a honeybee comb nano spray. The preparation method comprises the following technological steps: (1) combining 7-12wt% of white mulberry root bark, 5-15wt% of salvia miltiorrhiza and 8-12wt% of fructus amomi with 61-75wt% of a honeybee comb extracting solution, and grinding the medicinal materials obtained from combining into coarse powder; (2) adding the coarse powder to a reflux pot, adding medicinal ethanol, heating, refluxing and releasing an extracting solution; (3) decompressing the extracting solution in a vacuum environment and recovering medicinal ethanol so as to obtain an extract and collecting the extract; and (4) weighing the extract, adding distilled water to the extract to prepare a solution, and carrying out superfine grinding on the solution so as to obtain a crude medicine nanoparticle suspension which is the required honeybee comb nano spray. The preparation method of the honeybee comb nano spray disclosed by the invention is simple, and the prepared honeybee comb nano spray is rapid to take effect; and moreover, the treatment or health care effect of the nano spray is fully guaranteed.
Description
Technical field
The present invention relates to honey comb field, particularly relate to a kind of preparation method of honey comb nanometer spray.
Background technology
Honey comb is the thousands of lair compositions that Apis Cera Flava is built, the Nidus Vespae being made up of Apis several to tens Nidus Vespaes, wherein contains a large amount of bioactive substances as compositions such as resin, oils and fats, alkaloid, tannin, organic acid, aminoacid, protein, enzyme, insect hormone, polysaccharide and glycosides.Recent study finds, honey comb has various biological and pharmacological interest as Animal Medicine, such as honey comb can be used for treating rhinitis, and its effect to improve nasal obstruction, olfactory sensation, reduces nasal mucus, alleviate headache, giddy, sleep is improved, in using, also finds that honey comb also has good medical effect to hepatitis, can allaying tiredness, enhancing body resistance, impels transaminase to decline.Therefore honey comb is made into medicament widely uses.
In recent years, honey comb is made into a feast for the eyes oral liquid, in addition, honey comb also directly joins in Mel edible by someone, although certain treatment or health-care effect can be played, because the restriction of dosage form, extend honey comb and be correlated with onset time of medicine or health product, and also because the difference of individual intestinal absorption ability, the treatment of honey comb or health-care effect can not be not fully exerted.
Summary of the invention
The technical problem to be solved in the present invention is, to be correlated with onset time of medicine or health product long and effect above-mentioned defect that can not be not fully exerted for honey comb in prior art, a kind of preparation method of honey comb nanometer spray is provided, the onset time of the honey comb nanometer spray utilizing the method to prepare short and can also ensure its treatment or health-care effect be not fully exerted.
The technical solution adopted for the present invention to solve the technical problems is as follows:
A preparation method for honey comb nanometer spray, comprises following processing step:
(1) pulverizing medicinal materials: choose Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, and the pulverizing medicinal materials that compatibility obtains is become coarse powder, wherein, the weight proportion of medical material is as follows: Cortex Mori 7 ~ 12wt%, Radix Salviae Miltiorrhizae 5 ~ 15wt%, Fructus Amomi 8 ~ 12wt% and honey comb extracting solution 61 ~ 75wt%;
(2) coarse powder backflow: the coarse powder that will be obtained by step (1) drops in backflow pot, adds medicinal alcohol and releases extracting solution after reflux;
(3) medicinal alcohol reclaims: the extracting solution that step (2) obtains is carried out vacuum decompression and reclaim medicinal alcohol, until extractum shape, collect extractum;
(4) former medicine nanoparticle suspension preparation: take a certain amount of extractum, and in extractum, add distilled water wiring solution-forming, and obtaining former medicine nanoparticle suspension after solution is carried out superfine grinding, former medicine nanoparticle suspension is required honey comb spray.
In the preparation method of honey comb nanometer spray of the present invention, Cortex Mori has blood pressure lowering, antiinflammatory, antibacterial action; Salvia Miltriorrhiza Bge On The Central Nervous System has inhibitory action, immune system is had to the effect of immunity moderation, and respiratory system is had to prevention Respiratory distress syndrome, alleviates the effects such as pulmonary fibrosis, and in addition, it also has the effect such as anti-tumor activity, anti-inflammation; Fructus Amomi has warming the spleen and kidney, therapeutic method to keep the adverse QI flowing downwards pain relieving, the chest stuffiness relieving diaphragm, dredges the stagnation of QI, except vomiting, increases appetite, changes effect that is stagnant and that help digestion; By Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution is not only made to play respective effectiveness, and can also complement each other, make between each component, to play complementary synergism, therefore the honey comb nanometer spray adopting the preparation method of honey comb nanometer spray of the present invention to prepare has antioxidation, antibacterial action, can immunity of organisms be improved, and can also the effective disease such as treatment of allergic rhinitis.
In above-mentioned steps (2), add medicinal alcohol and reflux in coarse powder, wherein, medicinal alcohol is for extracting the effective ingredient in coarse powder.
In above-mentioned steps (4), in extractum, add distilled water wiring solution-forming, this solution is carried out superfine grinding, make the solid content in this solution be ground into the powder of micron to submicron order at short notice.
The honey comb nanometer spray adopting the preparation method of honey comb nanometer spray of the present invention to obtain is sprayed directly on to affected part, not only onset time is short, and do not need to be absorbed by human body intestinal canal just to reach treatment or health-care effect, this eliminates the problem of individual intestinal absorption difference of ability, the treatment of honey comb nanometer spray or health-care effect can be not fully exerted.
One as the preparation method to honey comb nanometer spray of the present invention is improved, in step (2), coarse powder is dropped in backflow pot, add 70% ~ 90% medicinal alcohol, obtain extracting solution and first time reflux after reflux 3 ~ 5h, and the weight ratio of coarse powder and medicinal alcohol is 1:6 ~ 1:10.
In the preparation method of honey comb nanometer spray of the present invention, the concentration of medicinal alcohol is 70% ~ 90%, if its concentration is greater than 90% or lower than 70%, all can affect the extraction efficiency of medicinal alcohol; The weight ratio of coarse powder and medicinal alcohol is chosen as 1:6 ~ 1:10, if weight ratio is less than 1:6, then the extracts active ingredients in coarse powder can be made incomplete, if weight ratio is greater than 1:10, then can cause the waste of medicinal alcohol, be unfavorable for the reduction of Financial cost; In addition, add medicinal alcohol in coarse powder after, extracting solution and first time reflux is obtained after backflow 3 ~ 5h, if return time is shorter than 3h, then can cause extracts active ingredients in coarse powder incomplete, if return time is greater than 5h, then the wasting of resources can be caused, and the extracted amount of effective ingredient also can not increase along with the prolongation of time.
One as the preparation method to honey comb nanometer spray of the present invention is improved, in step (2), 70% ~ 90% medicinal alcohol is added in first time reflux, obtain extracting solution and second time reflux after reflux 3 ~ 5h, and the weight ratio of reflux and medicinal alcohol is 1:6 ~ 1:10 for the first time.
In the preparation method of honey comb nanometer spray of the present invention, as mentioned above, the concentration of medicinal alcohol is chosen as 70% ~ 90%, if its concentration is greater than 90% or lower than 70%, all can affect the extraction efficiency of medicinal alcohol; By first time reflux and the weight ratio of medicinal alcohol be chosen as 1:6 ~ 1:10, if weight ratio is less than 1:6, then the extracts active ingredients in first time reflux can be made incomplete, if weight ratio is greater than 1:10, then can cause the waste of medicinal alcohol, be unfavorable for the reduction of Financial cost; In addition, return time is also set to 3 ~ 5h, if return time is shorter than 3h, then can cause extracts active ingredients in first time reflux incomplete, if return time is more than 5h, then also the wasting of resources can be caused, and the extracted amount of effective ingredient also can not increase along with the prolongation of time.
One as the preparation method to honey comb nanometer spray of the present invention is improved, in step (2), 70% ~ 90% medicinal alcohol is added in second time reflux, obtain extracting solution and third time reflux after reflux 2 ~ 3h, and the weight ratio of second time reflux and medicinal alcohol is 1:3 ~ 1:5.
In the preparation method of honey comb nanometer spray of the present invention, as mentioned above, also the concentration of medicinal alcohol is chosen as 70% ~ 90%, if its concentration is greater than 90% or lower than 70%, all can affects the extraction efficiency of medicinal alcohol; The weight ratio of second time reflux and medicinal alcohol is chosen as 1:3 ~ 1:5, if weight ratio is less than 1:3, then the extracts active ingredients in second time reflux can be made incomplete, if weight ratio is greater than 1:5, then can cause the waste of medicinal alcohol, also be unfavorable for the reduction of Financial cost; In addition, return time is also set to 2 ~ 3h, if return time is shorter than 2h, then can cause extracts active ingredients in second time reflux incomplete, if return time is more than 3h, then also the wasting of resources can be caused, and the extracted amount of effective ingredient also can not increase along with the prolongation of time.
One as the preparation method to honey comb nanometer spray of the present invention is improved, and in step (3), extracting solution step (2) obtained is 35 ~ 45
owhen C, vacuum are below-0.08MP, vacuum decompression reclaims medicinal alcohol to extractum shape.
In the preparation method of honey comb nanometer spray of the present invention, in step (3), extracting solution is reclaimed medicinal alcohol under vacuo, and by vacuum degree control at below-0.08MP, otherwise the organic efficiency of medicinal alcohol may be affected; In addition, the temperature that vacuum reclaims is arranged on 35 ~ 45
obetween C, contribute to improving the organic efficiency of medicinal alcohol and the completeness of recovery, if temperature is lower than 35
oc, then also can affect the organic efficiency of medicinal alcohol, if temperature is higher than 45
oc, then can cause medicinal alcohol boiling, volatilization in the removal process of medicinal alcohol.
One as the preparation method to honey comb nanometer spray of the present invention is improved, and in step (4), add distilled water wiring solution-forming in extractum, and in solution, the concentration of solid content is 15% ~ 20%.If the concentration of solid content is lower than 15% in solution, then can have influence on the concentration of former medicine nanoparticle suspension, if the concentration of solid content is higher than 20% in solution, the too high levels of solid content in solution, the viscosity of solution can be caused large, affect the superfine grinding of solution, thus the dispersibility of solution can be had influence on.
One as the preparation method to honey comb nanometer spray of the present invention is improved, in step (4), utilize crusher that solution is carried out superfine grinding, and the speed of mainshaft of crusher is 1200 ~ 1500r/min, and the particle diameter of particle in former medicine nanoparticle suspension is 120 ~ 150nm.
In the preparation method of honey comb nanometer spray of the present invention, the speed of mainshaft of crusher is set to 1200 ~ 1500r/min, when the speed of mainshaft is constant, along with the prolongation of grinding time, under the effect of powerful centrifugal force and shearing force, the average-size of pulverized particles reduces gradually, and when particle size is reduced to a certain degree, this variation tendency will be no longer obvious, if therefore by the speed of mainshaft of crusher lower than 1200r/min, then can make the average-size super large of pulverized particles, can not meet the demands, if when the speed of mainshaft of crusher is higher than 1500r/min, then can cause larger loss to the ceramic ring of pulverizer.
In addition, the particle diameter of the particle in the former medicine nanoparticle suspension after crusher superfine grinding is 120 ~ 150nm, if the particle diameter of particle is less than 120nm, particle concentration then in former medicine nanoparticle suspension is too high, polymer substance then in suspension such as starch and fiber can make the viscosity of suspension too high, hinder the superfine grinding of raw particles, and bring difficulty for testing graininess, and hypotelorism between particle can be made, and the repulsion of like charges is strong, therefore these nanoparticles are not easy the particle being agglomerated into greater particle size; And if the particle diameter of particle is more than 150nm, then the concentration of former medicine nanoparticle suspension is too low, also can cause larger loss to the ceramic ring of crusher.
One as the preparation method to honey comb nanometer spray of the present invention is improved, and add dispersant, and the weight ratio of dispersant and former medicine nanoparticle suspension is (0.4% ~ 0.6%): 1 in the former medicine nanoparticle suspension obtained by step (4).What in former medicine nanoparticle suspension, add dispersant mainly plays the stability improving former medicine nanoparticle suspension, the weight ratio of dispersant and former medicine nanoparticle suspension is designed to (0.4% ~ 0.6%): 1, if the weight ratio of dispersant and former medicine nanoparticle suspension is less than 0.4%:1 or is greater than 0.6%:1, capital affects the peptizaiton of dispersant to former medicine nanoparticle suspension, thus can affect the stability of former medicine nanoparticle suspension.
One as the preparation method to honey comb nanometer spray of the present invention is improved, and dispersant is one or more in sodium carboxymethyl cellulose CMCNa, polyvinylpyrrolidone PVP or Tween 80.
In addition, in technical scheme of the present invention, to be allly not specifically noted, all by adopting the conventional means in this area to realize the technical program.
Therefore, the preparation method of honey comb nanometer spray provided by the invention is simple, and the onset time of its honey comb nanometer spray prepared is short, and can also ensure that its treatment or health-care effect are not fully exerted.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment one:
A preparation method for honey comb nanometer spray, comprises following processing step:
(1) pulverizing medicinal materials: choose Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, and the pulverizing medicinal materials that compatibility obtains is become 60 object coarse powder, wherein, the weight proportion of medical material is as follows: Cortex Mori 7wt%, Radix Salviae Miltiorrhizae 10wt%, Fructus Amomi 11wt% and honey comb extracting solution 72wt%;
(2) coarse powder backflow: comprise three backflows, be specially:
First, the coarse powder that will be obtained by step (1) drops in backflow pot, adds 70% medicinal alcohol, release extracting solution and first time reflux, and the weight ratio of coarse powder and medicinal alcohol is 1:10 after reflux 5h;
Secondly, in first time reflux, add 70% medicinal alcohol, after reflux 5h, obtain extracting solution and second time reflux, and first time reflux and the weight ratio of medicinal alcohol be 1:10;
Finally, in above-mentioned second time reflux, add 70% medicinal alcohol, obtain extracting solution and third time reflux after reflux 3h, and the weight ratio of second time reflux and medicinal alcohol is 1:5;
(3) medicinal alcohol reclaims: 35 after the extracting solution merging of three backflows step (2) obtained
oc, vacuum carry out vacuum decompression to reclaim medicinal alcohol when-0.17MP, until extractum shape, collect extractum;
(4) former medicine nanoparticle suspension preparation: take a certain amount of extractum, and in extractum, add distilled water wiring solution-forming, and the concentration of solid content is 15% in solution, and obtaining former medicine nanoparticle suspension after this solution is carried out superfine grinding by HSCS crusher, this former medicine nanoparticle suspension is required honey comb spray.
In above-mentioned steps (4), when utilizing HSCS crusher to carry out superfine grinding to solution, the speed of mainshaft of HSCS crusher is set to 1500r/min, and the particle diameter of particle after superfine grinding is 120nm.
Embodiment two:
A preparation method for honey comb nanometer spray, comprises following processing step:
(1) pulverizing medicinal materials: choose Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, and the pulverizing medicinal materials that compatibility obtains is become 65 object coarse powder, wherein, the weight proportion of medical material is as follows: Cortex Mori 11wt%, Radix Salviae Miltiorrhizae 5wt%, Fructus Amomi 10wt% and honey comb extracting solution 74wt%;
(2) coarse powder backflow: comprise three backflows, be specially:
First, the coarse powder that will be obtained by step (1) drops in backflow pot, adds 75% medicinal alcohol, release extracting solution and first time reflux, and the weight ratio of coarse powder and medicinal alcohol is 1:9 after reflux 4.5h;
Secondly, in first time reflux, add 75% medicinal alcohol, after reflux 4.5h, obtain extracting solution and second time reflux, and first time reflux and the weight ratio of medicinal alcohol be 1:9;
Finally, in above-mentioned second time reflux, add 75% medicinal alcohol, obtain extracting solution and third time reflux after reflux 2.8h, and the weight ratio of second time reflux and medicinal alcohol is 1:4.4;
(3) medicinal alcohol reclaims: 38 after the extracting solution merging of three backflows step (2) obtained
oc, vacuum carry out vacuum decompression to reclaim medicinal alcohol when-0.20MP, until extractum shape, collect extractum;
(4) former medicine nanoparticle suspension preparation: take a certain amount of extractum, and in extractum, add distilled water wiring solution-forming, and the concentration of solid content is 16% in solution, and obtaining former medicine nanoparticle suspension after this solution is carried out superfine grinding by HSCS crusher, this former medicine nanoparticle suspension is required honey comb spray.
In above-mentioned steps (4), when utilizing HSCS crusher to carry out superfine grinding to solution, the speed of mainshaft of HSCS crusher is set to 1400r/min, and the particle diameter of particle after superfine grinding is 130nm.
Dispersant is added in the former medicine nanoparticle suspension obtained by above-mentioned steps (4), and the weight ratio of this dispersant and former medicine nanoparticle suspension is (0.4% ~ 0.6%): 1, specifically can be 0.4%:1,0.45%:1,0.5%:1,0.55%:1 or 0.6%:1, and this dispersant is one or more in sodium carboxymethyl cellulose CMCNa, polyvinylpyrrolidone PVP or Tween 80.
Embodiment three:
A preparation method for honey comb nanometer spray, comprises following processing step:
(1) pulverizing medicinal materials: choose Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, and the pulverizing medicinal materials that compatibility obtains is become 70 object coarse powder, wherein, the weight proportion of medical material is as follows: Cortex Mori 10wt%, Radix Salviae Miltiorrhizae 14wt%, Fructus Amomi 8wt% and honey comb extracting solution 68wt%;
(2) coarse powder backflow: comprise three backflows, be specially:
First, the coarse powder that will be obtained by step (1) drops in backflow pot, adds 80% medicinal alcohol, release extracting solution and first time reflux, and the weight ratio of coarse powder and medicinal alcohol is 1:6 after reflux 4h;
Secondly, in first time reflux, add 80% medicinal alcohol, after reflux 4h, obtain extracting solution and second time reflux, and first time reflux and the weight ratio of medicinal alcohol be 1:8;
Finally, in above-mentioned second time reflux, add 80% medicinal alcohol, obtain extracting solution and third time reflux after reflux 2.6h, and the weight ratio of second time reflux and medicinal alcohol is 1:3;
(3) medicinal alcohol reclaims: 40 after the extracting solution merging of three backflows step (2) obtained
oc, vacuum carry out vacuum decompression to reclaim medicinal alcohol when-0.08MP, until extractum shape, collect extractum;
(4) former medicine nanoparticle suspension preparation: take a certain amount of extractum, and in extractum, add distilled water wiring solution-forming, and the concentration of solid content is 17% in solution, and obtaining former medicine nanoparticle suspension after this solution is carried out superfine grinding by HSCS crusher, this former medicine nanoparticle suspension is required honey comb spray.
In above-mentioned steps (4), when utilizing HSCS crusher to carry out superfine grinding to solution, the speed of mainshaft of HSCS crusher is set to 1300r/min, and the particle diameter of particle after superfine grinding is 135nm.
In the former medicine nanoparticle suspension obtained by above-mentioned steps (4), add distilled water dilute, be conducive to preventing that the particle diameter of former medicine nanoparticle suspension generation particle from becoming large, distribution broadens and the phenomenon of particle aggregation occurs like this.
Embodiment four:
A preparation method for honey comb nanometer spray, comprises following processing step:
(1) pulverizing medicinal materials: choose Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, and the pulverizing medicinal materials that compatibility obtains is become 75 object coarse powder, wherein, the weight proportion of medical material is as follows: Cortex Mori 12wt%, Radix Salviae Miltiorrhizae 15wt%, Fructus Amomi 12wt% and honey comb extracting solution 61wt%;
(2) coarse powder backflow: comprise three backflows, be specially:
First, the coarse powder that will be obtained by step (1) drops in backflow pot, adds 85% medicinal alcohol, release extracting solution and first time reflux, and the weight ratio of coarse powder and medicinal alcohol is 1:7 after reflux 3.5h;
Secondly, in first time reflux, add 85% medicinal alcohol, after reflux 3.5h, obtain extracting solution and second time reflux, and first time reflux and the weight ratio of medicinal alcohol be 1:6;
Finally, in above-mentioned second time reflux, add 85% medicinal alcohol, obtain extracting solution and third time reflux after reflux 2.3h, and the weight ratio of second time reflux and medicinal alcohol is 1:3.6;
(3) medicinal alcohol reclaims: 42 after the extracting solution merging of three backflows step (2) obtained
oc, vacuum carry out vacuum decompression to reclaim medicinal alcohol when-0.12MP, until extractum shape, collect extractum;
(4) former medicine nanoparticle suspension preparation: take a certain amount of extractum, and in extractum, add distilled water wiring solution-forming, and the concentration of solid content is 18% in solution, and obtaining former medicine nanoparticle suspension after this solution is carried out superfine grinding by HSCS crusher, this former medicine nanoparticle suspension is required honey comb spray.
In above-mentioned steps (4), when utilizing HSCS crusher to carry out superfine grinding to solution, the speed of mainshaft of HSCS crusher is set to 1250r/min, and the particle diameter of particle after superfine grinding is 145nm.
For ensureing the uniform particle distribution in former medicine nanoparticle suspension, and reach effectively by the soft-agglomerated object opened of nano-particle, in the present embodiment, utilize and ultrasonic cavitation and acoustic streaming comprehensive function are carried out to former medicine nanoparticle suspension, and be 100 ~ 150w by ultrasonic power setting, the time of ultrasonication is 25 ~ 30s.Ultrasonic power specifically can be 100w, 110w, 120w, 130w, 140w or 150w, as ultrasonic power is less than 100w, then may not reach desirable dispersibility effect, also can not make the soft-agglomerated smaller volume of nano-particle; If ultrasonic power is greater than 150w, then may there is impact to the stability of former medicine nanoparticle suspension.Ultrasonic time can be 25s, 26s, 27s, 28s, 29s or 30s, as ultrasonic time is shorter than 25s, may not reach reasonable dispersibility effect, can not be opened by the soft-agglomerated of nano-particle completely, affect the distribution of particle in former medicine nanoparticle suspension; If ultrasonic time is more than 20s, then can cause the unnecessary wasting of resources.
Embodiment five:
A preparation method for honey comb nanometer spray, comprises following processing step:
(1) pulverizing medicinal materials: choose Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, and the pulverizing medicinal materials that compatibility obtains is become 80 object coarse powder, wherein, the weight proportion of medical material is as follows: Cortex Mori 8wt%, Radix Salviae Miltiorrhizae 8wt%, Fructus Amomi 9wt% and honey comb extracting solution 75wt%;
(2) coarse powder backflow: comprise three backflows, be specially:
First, the coarse powder that will be obtained by step (1) drops in backflow pot, adds 90% medicinal alcohol, release extracting solution and first time reflux, and the weight ratio of coarse powder and medicinal alcohol is 1:8 after reflux 3h;
Secondly, in first time reflux, add 90% medicinal alcohol, after reflux 3h, obtain extracting solution and second time reflux, and first time reflux and the weight ratio of medicinal alcohol be 1:7;
Finally, in above-mentioned second time reflux, add 90% medicinal alcohol, obtain extracting solution and third time reflux after reflux 2h, and the weight ratio of second time reflux and medicinal alcohol is 1:4;
(3) medicinal alcohol reclaims: 45 after the extracting solution merging of three backflows step (2) obtained
oc, vacuum carry out vacuum decompression to reclaim medicinal alcohol when-0.25MP, until extractum shape, collect extractum;
(4) former medicine nanoparticle suspension preparation: take a certain amount of extractum, and in extractum, add distilled water wiring solution-forming, and the concentration of solid content is 20% in solution, and obtaining former medicine nanoparticle suspension after this solution is carried out superfine grinding by HSCS crusher, this former medicine nanoparticle suspension is required honey comb spray.
In above-mentioned steps (4), when utilizing HSCS crusher to carry out superfine grinding to solution, the speed of mainshaft of HSCS crusher is set to 1200r/min, and the particle diameter of particle after superfine grinding is 150nm.
Should be understood that, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (9)
1. a preparation method for honey comb nanometer spray, is characterized in that, comprises following processing step:
(1) pulverizing medicinal materials: choose Cortex Mori, Radix Salviae Miltiorrhizae, Fructus Amomi and honey comb extracting solution compatibility, and the pulverizing medicinal materials that compatibility obtains is become coarse powder, wherein, the weight proportion of described medical material is as follows: Cortex Mori 7 ~ 12wt%, Radix Salviae Miltiorrhizae 5 ~ 15wt%, Fructus Amomi 8 ~ 12wt% and honey comb extracting solution 61 ~ 75wt%;
(2) coarse powder backflow: the coarse powder that will be obtained by step (1) drops in backflow pot, adds medicinal alcohol and releases extracting solution after reflux;
(3) medicinal alcohol reclaims: the extracting solution that step (2) obtains is carried out vacuum decompression and reclaim medicinal alcohol, until extractum shape, collect extractum;
(4) former medicine nanoparticle suspension preparation: take a certain amount of extractum, and in extractum, add distilled water wiring solution-forming, and obtaining former medicine nanoparticle suspension after described solution is carried out superfine grinding, described former medicine nanoparticle suspension is required honey comb spray.
2. the preparation method of honey comb nanometer spray according to claim 1, it is characterized in that, in described step (2), coarse powder is dropped in backflow pot, add 70% ~ 90% medicinal alcohol, obtain extracting solution and first time reflux after reflux 3 ~ 5h, and the weight ratio of described coarse powder and medicinal alcohol is 1:6 ~ 1:10.
3. the preparation method of honey comb nanometer spray according to claim 2, it is characterized in that, in described step (2), 70% ~ 90% medicinal alcohol is added in described first time reflux, obtain extracting solution and second time reflux after reflux 3 ~ 5h, and described first time reflux and the weight ratio of medicinal alcohol be 1:6 ~ 1:10.
4. the preparation method of honey comb nanometer spray according to claim 3, it is characterized in that, in described step (2), 70% ~ 90% medicinal alcohol is added in described second time reflux, obtain extracting solution and third time reflux after reflux 2 ~ 3h, and the weight ratio of described second time reflux and medicinal alcohol is 1:3 ~ 1:5.
5. according to the preparation method of the honey comb nanometer spray in claim 1-4 described in any one, it is characterized in that, in described step (3), extracting solution step (2) obtained is 35 ~ 45
owhen C, vacuum are below-0.08MP, vacuum decompression reclaims medicinal alcohol to extractum shape.
6. the preparation method of honey comb nanometer spray according to claim 1, is characterized in that, in described step (4), adds distilled water wiring solution-forming in extractum, and in solution, the concentration of solid content is 15% ~ 20%.
7. the preparation method of the honey comb nanometer spray according to claim 1 or 6, it is characterized in that, in described step (4), utilize crusher that described solution is carried out superfine grinding, and the speed of mainshaft of described crusher is 1200 ~ 1500r/min, and the particle diameter of particle in described former medicine nanoparticle suspension is 120 ~ 150nm.
8. the preparation method of the honey comb nanometer spray according to claim 1 or 6, it is characterized in that, in the former medicine nanoparticle suspension obtained by described step (4), add dispersant, and the weight ratio of described dispersant and former medicine nanoparticle suspension is (0.4% ~ 0.6%): 1.
9. the preparation method of honey comb nanometer spray according to claim 8, is characterized in that, described dispersant is one or more in sodium carboxymethyl cellulose CMCNa, polyvinylpyrrolidone PVP or Tween 80.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410802249.4A CN104547857A (en) | 2014-12-22 | 2014-12-22 | Preparation method of honeybee comb nano spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410802249.4A CN104547857A (en) | 2014-12-22 | 2014-12-22 | Preparation method of honeybee comb nano spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104547857A true CN104547857A (en) | 2015-04-29 |
Family
ID=53065628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410802249.4A Pending CN104547857A (en) | 2014-12-22 | 2014-12-22 | Preparation method of honeybee comb nano spray |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104547857A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130060611A (en) * | 2011-11-30 | 2013-06-10 | (주)제주사랑농수산 | Anti-inflammatory composition using a flower extract of citrus unshiu |
| CN103316049A (en) * | 2013-06-05 | 2013-09-25 | 武文栋 | Anti-allergic rhinitis combination drug |
-
2014
- 2014-12-22 CN CN201410802249.4A patent/CN104547857A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130060611A (en) * | 2011-11-30 | 2013-06-10 | (주)제주사랑농수산 | Anti-inflammatory composition using a flower extract of citrus unshiu |
| CN103316049A (en) * | 2013-06-05 | 2013-09-25 | 武文栋 | Anti-allergic rhinitis combination drug |
Non-Patent Citations (3)
| Title |
|---|
| 张肇宇: "纳米化中药舒鼻喷剂治疗变应性鼻炎之实验室相关研究", 《广州中医药大学博士学位论文》 * |
| 殷玲等: "蜜蜂巢脾抑菌和抗氧化物质的最优提取工艺研究", 《安徽农业科学》 * |
| 王坚成等: "纳米悬浮液作为颗粒性药物制剂在治疗中的应用及未来展望", 《国外医学药学分册》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101987123B (en) | Medicament for easing pain of human body and preparation method thereof | |
| CN101987122B (en) | Medicament for easing pain of human body and preparation method thereof | |
| CN105169118A (en) | Dendrobium officinale compound health buccal tablet and preparation method thereof | |
| CN101579364A (en) | Pharmaceutical composition and preparation method thereof | |
| CN1899535A (en) | Method for preparing dermopathic blood toxic capsule | |
| CN101579363A (en) | Traditional Chinese medicine ophthalmic preparation and preparation method thereof | |
| CN102284022A (en) | Cough medicament and preparation method thereof | |
| CN103202865B (en) | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof | |
| CN105943576A (en) | Extracting method of radix acanthopanacis semticosi and radix acanthopanacis semticosi health product | |
| CN104547857A (en) | Preparation method of honeybee comb nano spray | |
| CN101249111A (en) | Natural biological nano preparation technique of herbal medicine | |
| CN101623474B (en) | Preparation method of Shengui antler oral solid preparation | |
| CN101352520B (en) | Sperm-nourishing capsules for treating male sexual disfunction and preparation method thereof | |
| CN103652450A (en) | Pig feed and preparation method thereof | |
| CN106733065A (en) | A kind of Chinese medicine nanometer pulverization method | |
| CN101214325B (en) | Method for preparing compound 'chenxiangwei'medicine and new use thereof | |
| CN105362792A (en) | Nanometer Chinese herbal medicine care solution for pruritus vulvae and preparation method of care solution | |
| CN101690791B (en) | Traditional Chinese medicine for treating epidemic encephalitis B | |
| CN101057954B (en) | Traditional Chinese medicine compound for treating transient ischemic attack and its preparation method | |
| CN115887590B (en) | Mongolian medicinal bath composition for treating psoriasis, and preparation method and application thereof | |
| CN104012966A (en) | Plant body-perfuming health-care oral agent and production method thereof | |
| CN105213818A (en) | A kind of Chinese medicine composition being used for the treatment of apoplexy sequela and preparation method thereof | |
| CN102512596A (en) | Traditional Chinese medicine for treating allergic purpura | |
| CN100446754C (en) | Prepn process of skin icing snake fat ointment | |
| CN102008547B (en) | Drug applying plant Mentha Spicata.L extract in curing habitual constipation and preparation methods of drug and extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned | ||
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20180928 |