CN103316049A - Anti-allergic rhinitis combination drug - Google Patents

Abstract

The invention discloses an anti-allergic rhinitis combination drug. The drug is prepared from the following ingredients by weight: 10-20mg of vitamin B6, 4-8mg of chlorpheniramine maleate, 0.75-1.5mg of dexamethasone acetate, 150-300mg of pharmaceutical grade calcium hydrogen phosphate and 25-75mg of honeybee comb. Tablets containing the proportions of vitamin B6, chlorpheniramine maleate, dexamethasone acetate and calcium hydrogen phosphate are crushed into fine powder of 150-200 meshes, and the fine powder is mixed with dry and crushed honeybee comb powder of 150-300 meshes and the obtained mixture is filled into capsules. According to the drug, drug ingredients of traditional Chinese medicine and Western medicine are reasonably combined, the synergistic effect of the combination drug on allergic rhinitis has a significant treatment effect within a short period. The combination drug is particularly characterized in that the treatment course is short and relapse is unlikely to occur; the combination drug has no dependence or any side effect and is safe, reliable and convenient to use, the former four ingredients of the combination drug provided by the invention are patent medicine, and the honeybee comb and the patent medicine are commercially available.

Description

Antiallergic rhinitis composition of medicine

Technical field

The present invention relates to a kind of medicine for the treatment of rhinitis, particularly a kind of composition of medicine of antiallergic rhinitis.

Background technology

Allergic rhinitis (Allergic Rhinitis) is the disease of the cardinal symptoms such as a kind of nasal obstruction that sucks extraneous anaphylaxis antigen and cause is obstructed, rhinorrhea, sneeze.Ill have two principal elements: 1. heritability allergic constitution; 2. repeated multiple times exposure and suck extraneous anaphylactogen.The imbedibility antigen that causes primary disease has anemophilous pollen of dirt demodicid mite, dust, animal scurf, various trees and careless class etc., these antigen particles are large (5～25 μ m) generally, therefore can be blocked at nose lower, in nasal cavity generation anaphylactic type (I type) allergy, cause a series of performances such as hyperemia, edema and secretion increase of nasal mucosa, its immunopathogenesis process and induction type bronchial asthma are roughly the same; Other reason such as the decline of autoimmune ability, abuse of antibiotics, environmental pollution, atmospheric pollution, excessively edible irritable food etc. also can bring out this disease, after suffering from rhinitis, variation abnormality to environment, atmosphere is responsive, have a strong impact on patient's work, rest, cause great misery to the patient.

The method for the treatment of of allergic rhinitis has much in the market, such as anti-inflammatory treatment: antihistamine drug, local hormone, the method can only relief of symptoms (febrifuge during similar fever), and its medicine has certain side effect; Specific active immunotherapy (desensitization): the method needed more than 2 years, spent very high, and only effective to single sensitization source; The associated treatment medicine is also more, is used for alleviating the relevant symptom of allergic rhinitis such as loratadine, controls allergic rhinitis with this medicine and has dependency, generally can control the state of an illness more than one hour, later still recurrence; Also have and adopt the Miao Ethnomedicine nose to carve clever spray, this medicine can rapid recovery (general 5 minutes are namely effectively) disease, but after the drug withdrawal approximately 0.5hr still recur; Also useful acupuncture, laser (are the nasal cavity surface to be burned impel its incrustation, the therapeutic process patient is very painful, and is effective in a short time after the treatment, but relapse rate is high), the several different methods such as oral, most of therapeutic effect are not good, though some medicines have certain effect not effect a radical cure.

Summary of the invention

The present invention seeks to the defective that exists for prior art, a kind of safe, effective, no dependence and toxic and side effects are provided, are difficult for the composition of medicine of the antiallergic rhinitis of recurrence after more.

The technical scheme that proposes of the present invention is for achieving the above object: a kind of antiallergic rhinitis composition of medicine is characterized in that this medicine is that each drug component by following weight proportion is mixed with:

Vitamin B6 Tablets, Chlorate, dexamethasone acetate tablets and the phosphoric acid hydrogen calcium tablet that will contain above-mentioned dosage are ground into 150～200 order fine powders, mix incapsulating with 150～200 order honey comb powder of above-mentioned amount drying and crushing.

Described honey comb is the Nidus Vespae more than 2 years.

The present invention has following beneficial effect: the present invention adopts each drug component of Chinese and Western to carry out reasonable assembly, and the synergism of this composition of medicine has significant curative effect to allergic rhinitis within a short period of time, and its maximum characteristics are that the course for the treatment of is shorter, is not easy recurrence after healing; Take this composition of medicine no dependence, without any side effects, safe and reliable; Easy to use, front four kinds of the present invention is patent medicine, and Nidus Vespae and patent medicine all have commercially available.To taking the therapeutic effect of medicine of the present invention, the applicant carried out following on probation and statistics:

From 08 year so far, the patient who uses medicine of the present invention is paid a return visit record at random, 113 examples suffer from the patient of allergic rhinitis altogether, and wherein the male is 62,41 of women, and the age is allergic rhinitis between 25-60.Choose at random 65 examples as experimental group, use compositions of the present invention; Simultaneously to once used in nearly 2 years loratadine (30 example), Miao Ethnomedicine nose carve clever Traditional Chinese medicinal spray (being called for short the Miao Ethnomedicine spray) (18 example) totally 48 examples organize in contrast and add up.

1, medicine preparation:

Vitamin B6 Tablets (2 * specification 10mg=20mg); Chlorate (2 * specification 4mg=8mg); Dexamethasone acetate tablets (2 * specification 0.75mg=1.5mg); Dimension D2 phosphoric acid hydrogen calcium tablet 2 * specification 150mg=calcium hydrogen phosphate 300mg (being WEIDINGGAI PIAN, every phosphoric acid hydrogen calcium 150mg, vitamin D2 500 units); Honey comb 50mg.Vitamin B6 Tablets, Chlorate, dexamethasone acetate tablets and dimension D2 phosphoric acid hydrogen calcium tablet are ground into 150～200 order fine powders, mix incapsulating with 150～200 order honey comb powder of drying and crushing, wherein every capsules weight is about 700mg.

2, using method:

1) experimental group: oral.The adult: one day twice, each one; 10 days is a course for the treatment of.

Indication: allergic rhinitis, rhinitis, non-fever class flu (rhinorrhea, sneeze are had specially good effect);

Untoward reaction: the patient who has has slight sleepy, drowsiness phenomenon, and individual patient also has the polyuria phenomenon, and above phenomenon can be died away after the drug withdrawal; Heart disease, hypertension are had no significant effect other no abnormality seen;

Taboo: the period in a medicine irritable food that avoids pungent food, to avoid tobacco and wine especially;

Attention: drive or be engaged in hazardous occupation person and advise taking night.

2) matched group 1: loratadine tablet, and consumption: 2 times on the one, one time 1 (10mg);

3) matched group 2: Miao Ethnomedicine spray (20ml/ bottle) 3～4 times on the one;

Experimental group and matched group 1, matched group 2 all used 10 days continuously.

3, criterion of therapeutical effect: be produce effects, effective and invalid

Produce effects: sneeze, nasal obstruction, rhinocnesmus, watery nasal discharge transference cure, nasal airflow is good, and concha nasalis is unloose;

Effectively: secretions reduces, and the symptoms such as sneeze, rhinocnesmus, nasal conchae hypertrophy all are improved, but fully abnormal yet;

Invalid: various symptoms are not all improved.

Experimental group and matched group 1,2 therapeutic effect such as following table 1 after 10 days:

(table 1) curative effect of medication is used relative analysis

From above statistical data, composition of medicine effect of the present invention is remarkable, and cure rate reaches more than 80%, and it is then lower that loratadine and nose are carved clever Traditional Chinese medicinal spray cure rate; With any toxic and side effects not occurring in the composition of medicine therapeutic process of the present invention, show according to follow-up investigation, the produce effects case occurred without recurrence in 1 year afterwards substantially in the experimental group of the present invention.

The specific embodiment

Embodiment 1 (drug matching): Vitamin B6 Tablets (2 * specification 10mg=20mg); Chlorate (2 * specification 4mg=8mg); Dexamethasone acetate tablets (2 * specification 0.75mg=1.5mg); Dimension D2 phosphoric acid hydrogen calcium tablet 2 * specification 150mg=calcium hydrogen phosphate 300mg (being WEIDINGGAI PIAN, every phosphoric acid hydrogen calcium 150mg, vitamin D2 500 units); Honey comb 50mg.Vitamin B6 Tablets, Chlorate, dexamethasone acetate tablets and dimension D2 phosphoric acid hydrogen calcium tablet are ground into 150～200 order fine powders, mix incapsulating with 150～200 order honey comb powder of drying and crushing, wherein every capsules weight is about 700mg.

Embodiment 2 (drug matching): Vitamin B6 Tablets (2 * specification 10mg=20mg); Chlorate (1 * specification 4mg=4mg); Dexamethasone acetate tablets (1 * specification 0.75mg=0.75mg); Dimension D2 phosphoric acid hydrogen calcium tablet 2 * specification 150mg=calcium hydrogen phosphate 300mg (being WEIDINGGAI PIAN, every phosphoric acid hydrogen calcium 150mg, vitamin D2 500 units); Honey comb 30mg.Vitamin B6 Tablets, Chlorate, dexamethasone acetate tablets and dimension D2 phosphoric acid hydrogen calcium tablet are ground into 150～200 order fine powders, mix incapsulating with 150～200 order honey comb powder of drying and crushing, wherein every capsules weight is about 550mg.

According to model case being taken passages as follows to composition of medicine treatment observation of the present invention:

Case 1: the patient man 57 years old, the symptoms such as serious rhinorrhea, sneeze occurred after suffering from allergic rhinitis in 1989.Rear more than 30 sneeze of beating at most continuously of getting up morning is attended by that headache, dizziness, tinnitus, the sense of taste disappear, eyes evagination (constantly blow one's nose and cause), and nighttime sleep is repeatedly suppressed awakely because of nasal obstruction, and misery extremely.Used during this time multi-medicament (also beating, also attempt spraying multi-medicament with laser) but poor effect all.Behind the medicament capsule through using embodiment 1 preparation, symptom was alleviated the same day, all disappeared two days later, have a sharp sense of smell, breathe smooth and easyly, sleep quality obviously improves, normal after 10 days, now except once in a while because of edible irritable food is wrong with, always again recurrence orthobiosis.

Case 2: patient woman, 28 years old, got allergic rhinitis during senior middle school, hundred control and do not heal, and the rear sneeze of getting up every morning is constantly, clear nasal mucus is continuous, and toilet paper all the time can not be from hands, and the nasal obstruction watery nasal discharge continues 5 years.Because rhinitis is serious, can not concentrate one's energy on class to pay attention to the class, and has affected Entrance Examination.Use once the medicines such as BIYANKANG, also used the Miao Ethnomedicine spray, all do not have much curative effects.Behind the medicament capsule that began to prepare with the embodiment of the invention 2 since the year before last, symptom is greatly taken on a new look, and through taking of two courses for the treatment of, is almost recovered, in recent years again recurrence.

Case 3: the patient woman, 60 years old, 3 years causes were for joining a morning shift, and five, six o'clock headed on north wind by bike, had suffered from rhinitis.Originally be that nasal obstruction is obstructed, the sense of taste disappears, flows clear nasal mucus, developing into two nostrils has a stuffiness all the time, breathes and breathes by opening one's mouth, having eaten a lot of medicines does not work yet, to hospital's laser therapy, but the symptom before having occurred again gradually after two months, and the state of an illness constantly increases the weight of.Introduce through others, used last year the medicament capsule of the embodiment of the invention 1 preparation after course for the treatment of, symptom fades away, and takes recovery from illness in 15 days, and so far life is normal, without recurring.

Case 4: patient woman, 49 years old, residential quarter Cleaner, start working 3 of mornings every day, and rhinitis has just been suffered from work more than a year, meets dust, the trees allergy such as wadding of wafing, symptom is that sneeze is continuous, nasal obstruction is serious, voice are deep, headache, shed tears the congested swelling of bilateral nasal mucosa, just have a stuffed up nose during beginning, developed into afterwards gustatory anesthesia, flow clear nasal mucus, oneself is not known fully sometimes, and clear nasal mucus has just flowed out.Eaten during this time good several medicines also ineffective, taken and be almost recovered 20 of the present embodiment 1 medicament capsule courses for the treatment of.

Case 5: patient man, 32 years old, the surgeon, catching a cold the year before last has continued a wheat harvesting period and has not had, on the examination in hospital future trouble allergic rhinitis.Eaten several medicines of controlling rhinitis in pharmacy, the court and also had no improvement, taken afterwards the present embodiment 1 medicament capsule and fully recover after a course for the treatment of, in 2 years again without the recurrence.

Case 6: patient man, 48 years old, the rural area greenhouse gardening was managed specialist, and began to have occurred cold symptoms the year before last, flows clear nasal mucus, sneeze, drops tears, forehead is painful, and evening, sleep-respiratory was not smooth, the sleep quality extreme difference; Eating coldrex, to have controlled half wheat harvesting period also ineffective; Dare not see the sun, have a look once in a while continuously sneeze of the sun, symptom is more serious behind the interior crop pollen of contact canopy; After the present embodiment 1 medicament capsule two weeks was taken in friend's introduction, symptom disappeared substantially, till now all the time again recurrence of a year and a half.

Case 7: patient man, 33 years old, every day, life was irregular, February last year illness symptom: nasal obstruction watery nasal discharge, sneeze, headache, hyposmia, slight band blood when play sneeze morning, nasal mucus is sticking, yellow, thick, sleeper effect is poor, the wheat harvesting period of taking medicine also loses thorough improvement.Took afterwards the present embodiment 2 a medicament capsules symptom course for the treatment of and substantially disappeared, so far not again recurrence.

Case 8: patient man, 31 years old, the freezer porter, because the frequent freezer of coming in and going out is suffered from rhinitis, initial symptoms is that nose turns sour, itches, hypodynia is particularly out met when hot more seriously from freezer, sometimes will even make a call to ten sneezes, ceaselessly rhinorrhea.With much controlling drug for treating rhinitis, poor effect.After half a year, take the present embodiment 1 medicament capsule smooth breathing after 10 days course for the treatment of (front 3 day every day 3 times, each), the sense of taste is restored, and has then stopped again sneeze, and sleep quality obviously improves, and now fully recovers recurrence in 1 year.

Case 9: patient man, 43 years old, the cadre of section office of enterprise, because job specification, every day, tobacco and wine were continuous, the allergic rhinitis of suffering from last year, symptom: nasal obstruction watery nasal discharge, headache, hyposmia, the congested swelling of bilateral nasal mucosa, body of the tongue are light red, white and thin fur, deep pulse.Take the present embodiment 1 medicament capsule and breathe smooth and easyly after half an hour, the sense of taste is recovered to some extent, and next day, sneeze obviously alleviated, and front 5 day every day 3 times, each one, shares medicine afterwards recovery from illness in 10 days.

Case 10: patient woman, 31 years old, have a preference for pungent, food roasting because the long-term irritable food of taking in, occur after the flu sneeze constantly, nasal obstruction is serious, voice are deep, headache, shed tears the symptom of bilateral nasal mucosa hyperemia swelling, obstinate.Since taking the present embodiment 1 medicament capsule after 10 days, situation has greatly change, notes simultaneously using less maror, now fully recovers.

Claims (2)

1. antiallergic rhinitis composition of medicine is characterized in that this medicine is that each drug component by following weight proportion is mixed with:

Vitamin B6 Tablets, Chlorate, dexamethasone acetate tablets and the phosphoric acid hydrogen calcium tablet that will contain above-mentioned dosage are ground into 150～200 order fine powders, mix incapsulating with 150～200 order honey comb powder of above-mentioned amount drying and crushing.

2. antiallergic rhinitis composition of medicine according to claim 1, it is characterized in that: described honey comb is the Nidus Vespae more than 2 years.