WO2016074117A1 - Pharmaceutical composition for treating deficiency of kidney and preparation method therefor - Google Patents

Abstract

A pharmaceutical composition for treating deficiency of the kidney and a preparation method therefor. The pharmaceutical composition is prepared by using the following raw materials: 30 to 50 parts of cinnamon, 30 to 50 parts of platycladi seed, 30 to 50 parts of fried peach kernel, 30 to 50 parts of fructus cnidii, 20 to 40 parts of cuscuta chinensis, 20 to 40 parts of atractylodes lancea, 20 to 40 parts of tuckahoe and 10 to 30 parts of acorus gramineus, wherein the raw materials may further comprise 20 to 40 parts of cinnamon and 10 to 30 parts of eucommia.

Description

[Invention name established by ISA according to Rule 37.2] A pharmaceutical composition for treating kidney deficiency and preparation method thereof Technical field

The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition having an anti-renal effect and a preparation method thereof.

Background technique

Traditional Chinese medicine divides the internal organs of the human body into five internal organs, liver, heart, spleen, lung and kidney, and considers the kidney as a very important organ. There is a saying that the kidney is the congenital and the kidney is the source of all diseases. . Chinese medicine believes that kidney and kidney are mainly reproductive, growth, etc.

Chinese medicine believes that the kidney is the innate foundation, the Yuanyin Yuanyang: the congenital nature refers to the person's foundation, "the person begins, the first is refined", and the kidney is refined, so the kidney is the innate. Yuanyin refers to Yinjing, Yuanyang refers to vitality, Yuanyin Yuanyang plays a decisive role in the life activities of human beings - from birth to development and growth. Kidney essence, main growth and development: the main essence of the kidney, with gas for use, is related to human growth and development. Kidney gas rise and fall is directly related to the growth and development of human beings, and even the whole process of aging, but also related to human reproductive ability.

Throughout the life process, it is due to the rise and fall of the essence of the kidney, which shows the different physiological states of birth, long, strong, old, and already. Since childhood, the kidney essence has gradually filled. In the young and middle-aged, the kidney essence is further enriched, and even reaches the extreme, the body is strong and the bones are strong. When the elderly are old, the kidneys are declining, the body is gradually aging, the movement of the whole body and bones is not flexible, and the teeth are shaken and detached, showing the image of the old dragon. For example, if a person is a big tree, the kidney is like the root of a big tree. The root can be leafy, and the kidney is good. Therefore, it can be said that the symptoms of kidney deficiency are the manifestations of human aging. For example, people with tooth loss, vertigo, deafness, whitening of head flowers, and decreased sexual function are all due to kidney deficiency. In the clinical treatment of growth and development disorders and sexual dysfunction, kidney is one of the important treatment methods; tonifying kidney filling is an important means to delay aging and treat senile diseases.

At present, there are many Chinese and Western medicines for treating kidney deficiency, but most of them have less symptoms and the effect is not satisfactory. Western medicine has many toxic side effects and may even damage other organs of the human body. Some drugs are expensive and expensive.

Summary of the invention

The invention aims to overcome the deficiencies in the prior art, and provides a pharmaceutical composition having an anti-renal effect and a preparation method thereof. The pharmaceutical composition is prepared by using traditional Chinese medicine as a raw material, has no toxic and side effects, and has good curative effect.

A first aspect of the present invention provides a pharmaceutical composition having an anti-renal effect, the pharmaceutical composition comprising the following components in parts by weight:

30-50 parts of cinnamon,

30-50 copies of Bai Ziren,

30-50 servings of fried peach kernels,

30-50 servings of Cnidium,

20-40 copies of dodder,

20-40 copies of Atractylodes,

茯苓20-40 servings,

10-30 parts of Shichangpu.

Preferably, the pharmaceutical composition further comprises 20-40 parts of cinnamon and 10-30 parts of Eucommia.

Further preferably, the pharmaceutical composition comprises the following components in parts by weight:

Cinnamon 35-45 servings,

Bai Ziren 35-45 copies,

Fried peach kernel 35-45 servings,

35-45 servings of cnidium,

25-35 servings of dodder,

25-35 copies of Atractylodes,

茯苓25-35 servings,

15-25 parts of Shichangpu,

Cinnamon 25-35 servings,

Eucommia 15-25 parts.

Still more preferably, the pharmaceutical composition comprises the following components in parts by weight:

42 parts of cinnamon,

38 pieces of Bai Ziren,

40 fried peach kernels,

40 cindersticks,

32 pieces of dodder,

29 copies of Atractylodes,

茯苓28 copies,

20 copies of Shichangpu,

30 parts of cinnamon,

Eucommia 18.

Preferably, the pharmaceutical composition is an oral preparation.

Further preferably, the pharmaceutical composition is a powder, a pill, a tablet or a capsule.

It should be understood that the pharmaceutical composition may include, in addition to the above-mentioned pharmaceutically active component, an auxiliary agent commonly used in the field of medicine, such as a flavoring agent, an antioxidant, and the like.

A second aspect of the present invention provides a process for producing a pharmaceutical composition according to the first aspect of the present invention, which comprises the steps of pulverizing and mixing the components of the pharmaceutical composition.

Further, the pharmaceutical composition may be a pellet, and the preparation process is: pulverizing, mixing, and pelletizing the components of the pharmaceutical composition.

Further, the pharmaceutical composition may be a tablet, which is prepared by pulverizing and mixing the components of the pharmaceutical composition to form a tablet.

Further, the pharmaceutical composition may be a capsule, and the preparation process is: pulverizing and mixing the components of the pharmaceutical composition to form a capsule, which is obtained.

The invention adopts traditional Chinese medicine as raw material, scientific compatibility, is suitable for the majority of the population, passes through strong kidney, tonifying kidney, attending the body deficiency, qi deficiency, blood deficiency, facial yellow muscle thinness, limb weakness, darkening tinnitus, night dream nocturnal emission, urination frequency caused by kidney deficiency, Panic, forgetfulness, impotence and other symptoms, good curative effect, no toxic side effects, not easy to relapse.

detailed description

The invention will be further described in conjunction with the specific embodiments in order to better understand the invention.

Example 1

Take 42g of cinnamon, 38g of Baiziren, 40g of fried peach kernel, 40g of Cnidium, 32g of Cuscuta, 29g of Atractylodes, 28g of alfalfa, 20g of Shichangpu, and crushed into pellets, each weighing 1g, which has the effect of preventing kidney combination.

Example 2

35 g of cinnamon, 45 g of cypress kernel, 45 g of fried peach kernel, 35 g of cnidium, 25 g of dodder, 25 g of atractylodes, 35 g of medlar, 15 g of sarcophagus, and pulverized pellets, each weighing 1 g, have a pharmaceutical composition having an anti-renal effect.

Example 3

Take 42g of cinnamon, 38g of Baiziren, 40g of fried peach kernel, 40g of Cnidium, 32g of Cuscuta, 29g of Atractylodes, 29g of Atractylodes, 20g of Acorus calamus, 30g of Cinnamomum, 30g of eucommia, 18g of Eucommia ulmoides, and pulverized into pellets, each weighing 1g, which has an anti-renal effect. Pharmaceutical composition.

Example 4

Take cinnamon 35g, cypress kernel 45g, fried peach kernel 45g, Cnidium 35g, dodder 25g, Atractylodes 25g, 茯苓35g, Shichangpu 15g, cinnamon 25g, Eucommia 25g, crushed pills, 1g weight per pill Pharmaceutical composition.

Example 5

Take cinnamon 45g, cypress kernel 35g, fried peach kernel 35g, Cnidium 45g, dodder seed 35g, Atractylodes 35g, 茯苓25g, Shichangpu 25g, cinnamon 35g, Eucommia 15g, crushed into pellets Pharmaceutical composition.

Example 6

Take 30g of cinnamon, 30g of Baiziren, 50g of fried peach kernel, 50g of Cnidium, 40g of dodder, 20g of Atractylodes, 20g of Atractylodes, 10g of Shichangpu, 40g of Cinnamon, 30g of Eucommia, and pulverized into pellets, each weighing 1g, which has the effect of strengthening kidney Pharmaceutical composition.

Example 7

Take 50g of cinnamon, 50g of Baiziren, 30 of fried peach kernel, 30g of Cnidium, 20g of dodder, 40g of Atractylodes, 茯苓40g, 30g of Shichangpu, 20g of cinnamon, 10g of Eucommia ulmoides, and pulverized pellets, each weighing 1g, has a pharmaceutical composition having an anti-renal effect.

The pharmaceutical composition prepared in Examples 1-7 was used for clinical treatment of patients with kidney deficiency. Usage and dosage: Oral, 20 pills each time, twice a day, about half an hour before meals, delivered with warm wine or salt soup, and treated for January. For a course of treatment. 50 cases of each case. Record the treatment after 3 courses of treatment, in which: recovery: symptoms disappeared; effective: symptom relief; invalid: symptoms did not improve or worsen, if a patient recovered after 1 course of treatment, stop taking the pharmaceutical composition of the present invention, did not heal Continue to take it. If you continue to take it after 2 courses of treatment, stop taking it, and still have not recovered, continue to take the third course of treatment. The results are shown in Table 1.

Table 1 Drug efficacy

	Healed (example)	Effective (example)	Invalid (example)	Total efficiency
					Example 1	38	10	2	96%
Example 2	39	8	3	94%
					Example 3	49	1	0	100%
Example 4	47	3	0	100%
					Example 5	46	4	0	100%
Example 6	44	6	0	100%
					Example 7	43	7	0	100%

As can be seen from Table 1, the total effective rate of the drug of the present invention was over 94% after three courses of treatment, and no significant adverse reaction was observed during the entire treatment period.

Patients were followed up for one year after treatment for three courses and no signs of recurrence were found.

Specific case:

Huang × ×, male, 42 years old, symptoms: backache, weakness, palpitations, insomnia, forgetfulness, mental exhaustion. Treatment: The pharmaceutical composition of the present invention was continuously administered and cured 1 month later.

Wu × ×, male, 60 years old, symptoms: night sleep, night sweats, frequent urination, and even pale, limb weakness, all day long spirits. The pharmaceutical composition of the present invention was continuously administered and recovered after 2 months.

White × ×, male, 43 years old, symptoms: backache, premature ejaculation, dizziness, limb weakness. Taking this hair continuously The pharmaceutical composition of Ming was cured after 2 months.

Liao × ×, male, 42 years old. Symptoms: The sun is not for three years, and it is cold and insomnia below the waist. The symptoms were greatly alleviated after continuous administration of the pharmaceutical composition of the present invention for 3 months.

Xia ×, male, 37 years old. Symptoms: The backache is cold, and there is night dreams and nocturnal emission, and the urine is turbid. The pharmaceutical composition of the present invention was continuously administered for 3 months and then healed.

Wang X, female, 42 years old. Symptoms: Irregular menstruation, over the years from day to night, cold and pain in the lower abdomen, cramps, pain, bloody dark formation, a few days, leucorrhea yellow, odor, pulse weak, pulse life, chills and cold. The pharmaceutical composition of the present invention healed after 2 months.

Huang × ×, female, age, 46 years old, the nose often bleeds from time to time, resulting in thin yellow muscles, limb weakness, dark eyes and tinnitus, lack of energy, forgetfulness. The above conditions were all eliminated after taking the kidney-reinforcing agent of the present invention for 2 weeks.

The specific embodiments of the present invention have been described in detail above, but are merely exemplary, and the invention is not limited to the specific embodiments described above. Any equivalent modifications and substitutions to the invention are also within the scope of the invention. Accordingly, equivalents and modifications may be made without departing from the spirit and scope of the invention.

Claims (7)

1. A pharmaceutical composition having an anti-renal effect, characterized in that the pharmaceutical composition comprises the following components in parts by weight:

   30-50 parts of cinnamon,

   30-50 copies of Bai Ziren,

   30-50 servings of fried peach kernels,

   30-50 servings of Cnidium,

   20-40 copies of dodder,

   20-40 copies of Atractylodes,

   茯苓20-40 servings,

   10-30 copies of Shichangpu,

   20-40 parts of cinnamon,

   Eucommia 10-30 parts.
2. The pharmaceutical composition according to claim 1, wherein the pharmaceutical composition further comprises 20-40 parts of cinnamon and 10-30 parts of eucommia.
3. The pharmaceutical composition according to claim 2, wherein the pharmaceutical composition comprises the following components:

   Cinnamon 35-45 servings,

   Bai Ziren 35-45 copies,

   Fried peach kernel 35-45 servings,

   35-45 servings of cnidium,

   25-35 servings of dodder,

   25-35 copies of Atractylodes,

   茯苓25-35 servings,

   15-25 parts of Shichangpu,

   Cinnamon 25-35 servings,

   Eucommia 15-25 parts.
4. The pharmaceutical composition according to claim 3, wherein the pharmaceutical composition comprises the following components:

   42 parts of cinnamon,

   38 pieces of Bai Ziren,

   40 fried peach kernels,

   40 cindersticks,

   32 pieces of dodder,

   29 copies of Atractylodes,

   茯苓28 copies,

   20 copies of Shichangpu,

   30 parts of cinnamon,

   Eucommia 18.
5. The pharmaceutical composition according to claim 1, wherein the pharmaceutical composition is a powder, a pill, a tablet or a capsule.
6. A method of producing a pharmaceutical composition according to Claim 1, which comprises the steps of pulverizing and mixing the components of the pharmaceutical composition.
7. The preparation method according to Claim 5, which comprises the steps of pulverizing, mixing, pelletizing or tableting or forming a capsule into the pharmaceutical composition.

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