CN1045297C - 酰化头孢菌酸环上的7－氨基的方法 - Google Patents
酰化头孢菌酸环上的7－氨基的方法 Download PDFInfo
- Publication number
- CN1045297C CN1045297C CN93109357A CN93109357A CN1045297C CN 1045297 C CN1045297 C CN 1045297C CN 93109357 A CN93109357 A CN 93109357A CN 93109357 A CN93109357 A CN 93109357A CN 1045297 C CN1045297 C CN 1045297C
- Authority
- CN
- China
- Prior art keywords
- amino group
- group
- acid
- acylation
- protected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9216759.2 | 1992-08-07 | ||
| GB929216759A GB9216759D0 (en) | 1992-08-07 | 1992-08-07 | Process for the production of 7-amino thiazolyl cephalosporins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1082610A CN1082610A (zh) | 1994-02-23 |
| CN1045297C true CN1045297C (zh) | 1999-09-29 |
Family
ID=10719967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93109357A Expired - Fee Related CN1045297C (zh) | 1992-08-07 | 1993-08-06 | 酰化头孢菌酸环上的7－氨基的方法 |
Country Status (24)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100345847B1 (ko) * | 1994-08-13 | 2002-12-16 | 제일제당주식회사 | 고정화효소에의한세파졸린의제조방법 |
| IT1295935B1 (it) | 1997-10-30 | 1999-05-28 | Acs Dobfar Spa | Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici |
| KR19990045922A (ko) * | 1999-02-13 | 1999-06-25 | 오판원 | 여화용통굽스폰지신발창의제조방법 |
| EP1704153A2 (en) * | 2004-01-16 | 2006-09-27 | Wockhardt Limited | Improved process for the production of cefotaxime sodium |
| US20070111980A1 (en) * | 2004-07-16 | 2007-05-17 | Bandi Parthasaradhi Reddy | Process for preparing pure cephalosporine intermediates |
| WO2007013043A2 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid |
| KR100760429B1 (ko) * | 2006-03-03 | 2007-10-04 | 한미약품 주식회사 | 세팔로스포린 제조용 중간체로 사용되는2-아미노티아졸-4-일 아세틸클로라이드 염산염의 개선된제조방법 |
| CN101045733B (zh) * | 2007-01-26 | 2011-11-16 | 浙江永宁药业股份有限公司 | 一种头孢替安盐酸盐制备方法 |
| CN103012432B (zh) * | 2012-12-04 | 2015-06-03 | 山东鑫泉医药有限公司 | 高纯度头孢替安中间体盐酸盐的制备方法 |
| CN103601737B (zh) * | 2013-12-04 | 2016-02-03 | 哈药集团制药总厂 | 一种盐酸头孢替安的制备方法 |
| CN104356146B (zh) * | 2014-11-14 | 2016-09-14 | 浙江浙邦制药有限公司 | 一种头孢替安盐酸盐的制备方法 |
| CN109336906B (zh) * | 2018-11-21 | 2020-05-22 | 山东罗欣药业集团股份有限公司 | 一种头孢替安盐酸盐干燥工艺 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2120839A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1970-12-25 | 1972-08-18 | Takeda Chemical Industries Ltd | |
| FR2249889A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-11-03 | 1975-05-30 | Bayer Ag | |
| CN87105204A (zh) * | 1986-07-03 | 1988-06-29 | 霍夫曼-拉罗奇有限公司 | 酰基衍生物 |
| CN1036769A (zh) * | 1988-03-16 | 1989-11-01 | 卫材株式会社 | 制备头孢烯衍生物及其中间体的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ176206A (en) * | 1973-12-25 | 1978-03-06 | Takeda Chemical Industries Ltd | Cephalosporins |
| GB1476981A (en) * | 1974-06-05 | 1977-06-16 | Bristol Myers Co | Substituted penicillanic acids |
| US4091245A (en) * | 1974-06-26 | 1978-05-23 | Toyota Jidosha Kogyo Kabushiki Kaisha | Distributor electrode assembly having outer resistive layer for suppressing noise |
| US4500526A (en) * | 1982-06-28 | 1985-02-19 | Bristol-Myers Company | Cephalosporin derivatives |
| US4507487A (en) * | 1982-09-23 | 1985-03-26 | Bristol-Myers Company | Chemical compounds |
| GB2161476B (en) * | 1984-05-25 | 1988-01-27 | Toyama Chemical Co Ltd | 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins |
| DK492289A (da) * | 1988-10-07 | 1990-04-08 | Sankyo Co | 3-aryloxymethyl-cephalosporinderivater og fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende derivaterne |
| AU649275B2 (en) * | 1990-11-06 | 1994-05-19 | Bristol-Myers Squibb Company | Prodrugs for beta-lactamase and uses thereof |
| EP0508375A3 (en) * | 1991-04-12 | 1992-12-09 | Lucky Ltd. | Novel cephalosporin compounds and processes for preparation thereof |
-
1992
- 1992-08-07 GB GB929216759A patent/GB9216759D0/en active Pending
-
1993
- 1993-07-07 US US08/086,849 patent/US5441874A/en not_active Expired - Fee Related
- 1993-07-09 EP EP93111006A patent/EP0582102B1/en not_active Expired - Lifetime
- 1993-07-09 ES ES93111006T patent/ES2110032T3/es not_active Expired - Lifetime
- 1993-07-09 DE DE69315634T patent/DE69315634T2/de not_active Expired - Fee Related
- 1993-07-09 AT AT93111006T patent/ATE161052T1/de not_active IP Right Cessation
- 1993-07-09 DK DK93111006T patent/DK0582102T3/da active
- 1993-08-02 NZ NZ248307A patent/NZ248307A/en unknown
- 1993-08-02 BR BR9303272A patent/BR9303272A/pt not_active Application Discontinuation
- 1993-08-02 IN IN431CA1993 patent/IN176319B/en unknown
- 1993-08-03 IL IL10657493A patent/IL106574A/en not_active IP Right Cessation
- 1993-08-04 AU AU44452/93A patent/AU658761B2/en not_active Ceased
- 1993-08-05 PL PL29994693A patent/PL299946A1/xx unknown
- 1993-08-05 KR KR1019930015169A patent/KR100268959B1/ko not_active Expired - Fee Related
- 1993-08-05 ZA ZA935688A patent/ZA935688B/xx unknown
- 1993-08-06 TW TW082106314A patent/TW242627B/zh active
- 1993-08-06 HU HU9302292A patent/HUT64962A/hu unknown
- 1993-08-06 MX MX9304790A patent/MX9304790A/es unknown
- 1993-08-06 JP JP5196262A patent/JPH06172364A/ja active Pending
- 1993-08-06 CN CN93109357A patent/CN1045297C/zh not_active Expired - Fee Related
- 1993-08-06 RU RU93042473A patent/RU2109017C1/ru active
- 1993-08-06 FI FI933486A patent/FI933486A7/fi unknown
- 1993-08-06 CA CA002103696A patent/CA2103696A1/en not_active Abandoned
-
1995
- 1995-05-01 US US08/432,072 patent/US5654425A/en not_active Expired - Fee Related
-
1997
- 1997-12-30 GR GR970403453T patent/GR3025807T3/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2120839A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1970-12-25 | 1972-08-18 | Takeda Chemical Industries Ltd | |
| FR2249889A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-11-03 | 1975-05-30 | Bayer Ag | |
| CN87105204A (zh) * | 1986-07-03 | 1988-06-29 | 霍夫曼-拉罗奇有限公司 | 酰基衍生物 |
| CN1036769A (zh) * | 1988-03-16 | 1989-11-01 | 卫材株式会社 | 制备头孢烯衍生物及其中间体的方法 |
Also Published As
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Legal Events
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |