CN104524104A - Pseudo-ginseng sleeping capsule and preparation method thereof - Google Patents
Pseudo-ginseng sleeping capsule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pseudo-ginseng sleeping capsule and a preparation method thereof. The pseudo-ginseng sleeping capsule comprises the following raw materials in parts by weight: 15-24 parts of pseudo-ginseng, 5-10 parts of yams, 3-8 parts of glossy privet fruits, 6-12 parts of eclipta, 8-14 parts of polygala tenuifolia and 5-12 parts of safflower carthamus. By taking the precious herb pseudo-ginseng as the main raw material and adding the glossy privet fruits, the Chinese yam, the safflower carthamus, the eclipta and the polygala tenuifolia to match reasonably and carry out joint action, the pseudo-ginseng sleeping capsule focuses on recuperating viscera as well as qi, blood, yin and yang thereof under medical treatment, has the advantages of coordinating heart-kidney, nourishing yin and calming nerves, promoting blood circulation to remove meridian obstruction, smoothing qi and blood, quieting mind, treating insomnia, regulating endocrine and resisting ageing, and has a remarkable curative effect for chloasma and acne.
Description
Technical field
The invention belongs to Chinese medicine health-care field, specifically, relate to a kind of Sanqi Shuishu Capsule and preparation method thereof.
Background technology
Insomnia is due to feelings will, diet internal injury, or after being ill and old, the cause of disease such as innate deficiency, timidness due to deficiency of the heart, causes lack of preservation of spirit or irritability, thus cause often obtaining the class disease that ortho sleep is feature.
Main manifestations be the length of one's sleep degree of depth deficiency and can not allaying tiredness, regain one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up, heavy then be insomnia all night.Insomnia's Chinese medicine is referred to as " being insomnia ", and the traditional Chinese medical science is controlled debate from liver and demonstrate,proved common typing and have that excessive rising of liver-YANG, stagnation of liver-QI stasis blocking, pathogenic fire derived from stagnation of liver-QI (wind), stagnation of liver-QI violate stomach (perverse and unreasonable manner), the anti-heart of stagnation of liver-QI, liver is high suffers from a deficiency of the kidney.Though insomnia does not belong to critical illness, but hinder people orthobiosis, work, study and health, and can increase the weight of or bring out cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy etc., also usually along with the appearance of the disease such as chloasma, acne, and have a sleepless night, the disease such as chloasma, acne all because of stagnation of liver-QI with deficiency of the spleen, caused by blood stasis due to qi deficiency.
At present, the conventional western medicine insomnia as the calmness such as barbiturates, Benzodiazepines and other non-barbiturates, hypnosis clinically, there is drug resistance, dependency, additive and occur ataxia, the untoward reaction such as forgetful in this type of medicine long-term taking, and have infringement in various degree to Liver and kidney, and effect be there is no to some diseases produced with insomnia.
Summary of the invention
For the problems referred to above, the present invention proposes a kind of Sanqi Shuishu Capsule and preparation method thereof, with valuable ingredient of Chinese medicine Radix Notoginseng for primary raw material, add Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Flos Carthami, Herba Ecliptae, Radix Polygalae carry out rational proportion, synergy, there is QI and blood regulating, promoting blood circulation to remove obstruction in the collateral, QI invigorating Fructus Alpiniae Oxyphyllae, nourish conscience, tranquilizing by nourishing the heart, antidotal function, can effective improving water flood, also there is significant curative effect to the chloasma of insomnia generation, acne.
In order to solve the problem, the technical solution adopted in the present invention: a kind of Sanqi Shuishu Capsule, is made up of the raw material of following weight ratio part: Radix Notoginseng 15 ~ 24 parts, Rhizoma Dioscoreae 5 ~ 10 parts, Fructus Ligustri Lucidi 3 ~ 8 parts, Herba Ecliptae 6 ~ 12 parts, Radix Polygalae 8 ~ 14 parts, 5 ~ 12 parts, Flos Carthami.
According to the preferred version of a kind of Sanqi Shuishu Capsule of the present invention, Sanqi Shuishu Capsule is made up of the raw material of following weight percentage: Radix Notoginseng 20 parts, Rhizoma Dioscoreae 8 parts, Fructus Ligustri Lucidi 6 parts, Herba Ecliptae 10 parts, Radix Polygalae 12 parts, 8 parts, Flos Carthami.
The preparation method of above-mentioned Sanqi Shuishu Capsule, is made up of following steps:
1) to pretreatment of raw material: Radix Notoginseng: clean, clean, dry for subsequent use; Rhizoma Dioscoreae: clean, cleans, and section, dries, and stir-fry is steamed for subsequent use; Fructus Ligustri Lucidi: clean, cooks, and dries for subsequent use; Herba Ecliptae: clean, cleans, cooks, dry for subsequent use; Radix Polygalae: clean, dries for subsequent use; Flos Carthami: clean, dries for subsequent use;
2) crude drug is pulverized, get formulation weight adds 60% ethanol than the Radix Notoginseng of part, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Polygalae, Flos Carthami, extract twice, alcohol adding amount is followed successively by 8 times, 6 times, each two hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into relative density 1.25 at 65-70 DEG C;
3) by step 2) concentrated filtrate of gained carries out spraying dry, obtained effective ingredient;
4) by the effective ingredient spray granulation of step 3) gained, 60 DEG C of dryings, cross 14 mesh sieves, incapsulate, 0.4g/ grain, packaging, and inspection, gets product.
Effect of each constituent of the present invention is as follows:
Radix Notoginseng: sweet in the mouth, micro-hardship, temperature, returns liver, stomach warp; Have and improve myocardial ischemia, anoxia, blood fat reducing, blood pressure lowering, antithrombotic, shock, fibrosis activity, anti-inflammatory and antalgic, blood sugar lowering, defying age, tranquillizing and allaying excitement, enhancing immunity and hepatic cholagogic effect, and do not have a side effect of addiction.
Rhizoma Dioscoreae contains the material such as amylase, polyphenol oxidase, is conducive to taste digestive and absorptive functions, is the product of the medicine-food two-purpose of flat tonifying the spleen and stomach simply, conventionally clinically controls that weakness of the spleen and stomach, lack of appetite body are tired, the disease such as to have loose bowels; Rhizoma Dioscoreae contains various nutrients, has strong body, the effect of kidney nourishing and replenishing vital essence; Rhizoma Dioscoreae contains Saponin, lymphatic temperament, has lubrication, moist effect, thus can lung benefiting gas, support lung yin, the disease of deficiency of the lung phlegmatic cough chronic cough can be treated; Rhizoma Dioscoreae contains mucus protein, has and falls hypoglycemic effect, can be used for treating diabetes; Rhizoma Dioscoreae contains a large amount of mucus albumen, electrolytes and minerals, can effectively stop blood fat in the precipitation of blood vessel wall, and prevention cardiovascular diseases, obtains effect of intelligent promoting and the mind tranquilizing, life lengthening.
The property of medicine of Fructus Ligustri Lucidi is more gentle, has nourishing the liver and kidney, improving eyesight black hair, blood fat reducing and arteriosclerosis, blood sugar lowering, improves cellular immunization and humoral immune function, endocrine regulation system, also has the effect of antiinflammatory, anticancer, mutation.Also for optic neuritis, leukopenia, chronic hepatitis, hyperlipidemia, coronary heart disease, hypertension, Chidren Poisoning auditory dysesthesia, neurasthenia, alopecia etc. on modern clinic.
Herba Ecliptae has another name called Herba Ecliptae, Herba Ecliptae, is the herb of feverfew Eclipta prostrata, and annual summer, season in autumn two extract herb, and removing silt, dries or dry in the shade and can be used as medicine.Herba Ecliptae has hemostasis, improves immunity, protects the liver, scavenging free radicals and anti-dye bulk damage, antibacterial, defying age and the effect such as mutation, growing and blacking hair; Can be used for menopause syndrome of releiving clinically, treating the liver kidney yin deficient syndrome, control the disease of losing blood of YinXuXueRe, control allergic rhinitis.
The agents area of Radix Polygalae is mainly the root of Radix Polygalae, and root, containing Saponin, can get two kinds of ruscogenin crystallizations, presenegenin A and presenegenin B after hydrolysis, separately containing polygalytol, 2-Acetamido-2-deoxy-D-glucose, alkaloid tenuidine, fatty oil, resin etc.Be mainly used in insomnia and dreamful sleep, severe palpitation, forgetful, epilepsy mania and irritation, cough with copious phlegm, skin sore, breast swell and pain, sore throat clinically.
Flos Carthami is containing Carthamus yellow and carthamin, and carthamin, through hydrochloric acid hydrolysis, obtains glucose Flos Carthami element, and separately still fatty oil claims safflower oil, is the glyceride type of Palmic acid, stearic acid, arachidic acid, oleic acid, linoleic acid, linolenic acid etc.Energy promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, be mainly used in treatment acute and chronic muscular strain clinically, treatment injures by a crashing object, sprains caused subcutaneous hyperemia, swelling, treatment coronary heart disease, treatment callus etc.
Beneficial effect of the present invention: the present invention for primary raw material, adds Fructus Ligustri Lucidi with valuable ingredient of Chinese medicine Radix Notoginseng, Rhizoma Dioscoreae, Flos Carthami, Herba Ecliptae, Radix Polygalae carry out rational proportion, synergy, wherein, Radix Notoginseng energy blood circulation promoting and blood stasis dispelling, tranquillizing and allaying excitement, defying age, hepatic cholagogic; Rhizoma Dioscoreae can prevent cardiovascular diseases, kidney nourishing and replenishing vital essence, intelligent promoting and the mind tranquilizing, life lengthening; Fructus Ligustri Lucidi energy nourishing the liver and kidney, improving eyesight black hair, antiinflammatory is anticancer, can also endocrine regulation; Herba Ecliptae energy hepatoprotective, raising immunity, antibacterial defying age; The dreaminess of Radix Polygalae energy Cure for insomnia, severe palpitation; Flos Carthami energy promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving; Pharmaceutical composition of the present invention is controlled from this, emphatically medical treatment internal organs and negative and positive of qi and blood thereof, by restoring normal coordination between the heart and kidney, YIN nourishing mind calming, promoting blood circulation to remove obstruction in the collateral, make QI and blood with smooth, not only make ataraxy, Cure for insomnia, more can endocrine regulation, anti-ageing anti-old, there is significant curative effect to chloasma, acne.
Detailed description of the invention
embodiment 1
1, crude drug: Radix Notoginseng 150g, Rhizoma Dioscoreae 50g, Fructus Ligustri Lucidi 30g, Herba Ecliptae 60g, Radix Polygalae 80g, Flos Carthami 50g.
2, preparation method:
1) to pretreatment of raw material: Radix Notoginseng: clean, clean, dry for subsequent use; Rhizoma Dioscoreae: clean, cleans, and section, dries, and stir-fry is steamed for subsequent use; Fructus Ligustri Lucidi: clean, cooks, and dries for subsequent use; Herba Ecliptae: clean, cleans, cooks, dry for subsequent use; Radix Polygalae: clean, dries for subsequent use; Flos Carthami: clean, dries for subsequent use;
2) crude drug is pulverized, get formulation weight adds 60% ethanol than the Radix Notoginseng of part, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Polygalae, Flos Carthami, extract twice, alcohol adding amount is followed successively by 8 times, 6 times, each two hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into relative density 1.25 at 65-70 DEG C;
3) by step 2) concentrated filtrate of gained carries out spraying dry, obtained effective ingredient;
4) by the effective ingredient spray granulation of step 3) gained, 60 DEG C of dryings, cross 14 mesh sieves, incapsulate, 0.4g/ grain, packaging, and inspection, gets product.
3, instructions of taking and dosage:
Warm water takes, every day 2 times, each 4.
embodiment 2
1, crude drug: Radix Notoginseng 240g, Rhizoma Dioscoreae 100g, Fructus Ligustri Lucidi 80g, Herba Ecliptae 120g, Radix Polygalae 140g, Flos Carthami 120g.
2, preparation method:
1) to pretreatment of raw material: Radix Notoginseng: clean, clean, dry for subsequent use; Rhizoma Dioscoreae: clean, cleans, and section, dries, and stir-fry is steamed for subsequent use; Fructus Ligustri Lucidi: clean, cooks, and dries for subsequent use; Herba Ecliptae: clean, cleans, cooks, dry for subsequent use; Radix Polygalae: clean, dries for subsequent use; Flos Carthami: clean, dries for subsequent use;
2) crude drug is pulverized, get formulation weight adds 60% ethanol than the Radix Notoginseng of part, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Polygalae, Flos Carthami, extract twice, alcohol adding amount is followed successively by 8 times, 6 times, each two hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into relative density 1.25 at 65-70 DEG C;
3) by step 2) concentrated filtrate of gained carries out spraying dry, obtained effective ingredient;
4) by the effective ingredient spray granulation of step 3) gained, 60 DEG C of dryings, cross 14 mesh sieves, incapsulate, 0.4g/ grain, packaging, and inspection, gets product.
3, instructions of taking and dosage:
Warm water takes, every day 2 times, each 4.
embodiment 3
1, crude drug: Radix Notoginseng 200g, Rhizoma Dioscoreae 80g, Fructus Ligustri Lucidi 60g, Herba Ecliptae 100g, Radix Polygalae 120g, Flos Carthami 80g.
2, preparation method:
1) to pretreatment of raw material: Radix Notoginseng: clean, clean, dry for subsequent use; Rhizoma Dioscoreae: clean, cleans, and section, dries, and stir-fry is steamed for subsequent use; Fructus Ligustri Lucidi: clean, cooks, and dries for subsequent use; Herba Ecliptae: clean, cleans, cooks, dry for subsequent use; Radix Polygalae: clean, dries for subsequent use; Flos Carthami: clean, dries for subsequent use;
2) crude drug is pulverized, get formulation weight adds 60% ethanol than the Radix Notoginseng of part, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Polygalae, Flos Carthami, extract twice, alcohol adding amount is followed successively by 8 times, 6 times, each two hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into relative density 1.25 at 65-70 DEG C;
3) by step 2) concentrated filtrate of gained carries out spraying dry, obtained effective ingredient;
4) by the effective ingredient spray granulation of step 3) gained, 60 DEG C of dryings, cross 14 mesh sieves, incapsulate, 0.4g/ grain, packaging, and inspection, gets product.
3, instructions of taking and dosage:
Warm water takes, every day 2 times, each 4.
analysis of experiments
test 1:improving water flood Experiment on Function of the present invention
1, experimental animal grouping: choose healthy adult, body weight is close, the male mice of same kind 240, every 60 mices are divided into one group, be divided into four groups, carry out direct sleep laboratory respectively, extend the pentobarbital sodium test length of one's sleep, pentobarbital sodium sub-threshold dose hypnosis test, barbital sodium Sleep Latency Test, each component is 4 groups, one group is matched group, and other three components Wei basic, normal, high three dosage groups.
2, trial drug: the capsule of the present invention by reagent human body recommended dose being 3.2g/60kg.bw every day, the dose,equivalent of mice is equivalent to 10 times of human body recommended dose, respectively using 5 of human body recommended dose times, 10 times, 30 times as low (0.27g/kg.bw), in (0.53g/kg.bw), high dose (1.60g/kg.bw), administration by gavage is taked to gavage, matched group fills with distilled water, long run test 30 days, each dosage component does not give the trial drug of matched doses.
3, process of the test:
(1), direct sleep laboratory
After observation mice gives the test drug of various dose, matched group gives same volume distilled water, whether appearance sleep phenomenon, to be judged to more than 60 seconds with righting reflex loss and to enter sleep, righting reflex recovers to be animal awakening, righting reflex loss be the animal sleep time to recovering during this period of time, records matched group and various dose group sleep number of animals and the length of one's sleep.
(2) the pentobarbital sodium test length of one's sleep is extended
Giving last sample after 20 minutes, each treated animal is through lumbar injection pentobarbital sodium 35mg/kg BW, and injection volume is 0.1mL/10g BW, with the righting reflex loss of mice for index, observe tested material and can extend pentobarbital sodium length of one's sleep, test and carry out at night.
(3) pentobarbital sodium sub-threshold dose hypnosis test
Giving last sample after 20 minutes, each treated animal is through lumbar injection pentobarbital sodium 30mg/kg BW, injection volume is 0.1mL/10g BW, observe the sleep quality of mice in 30 minutes, with righting reflex loss more than 60 seconds persons for falling asleep, record the sleep number of animals of each group in 30 minutes, calculate sleep animal incidence rate, test and carry out at night.
(4), barbital sodium Sleep Latency Test
Within 20 minutes after giving last sample, through lumbar injection barbital sodium 200mg/kg BW, injection volume is 0.1mL/10g BW to each group of mice, and take righting reflex loss as index, can viewing test medicine shorten barbital sodium Sleep latency.
4, test result analysis:
(1), trial drug is on the impact of Mouse Weight
From table 1, before and after test, each Mouse Weight of dosage group compares with the Mouse Weight of matched group, and there are no significant for difference (P>0.05), shows that this sample increases without influence the body weight of mice.
(2), direct sleep laboratory result
As seen from Table 2, per os gives the capsule 30 days of mice various dose, and each dosage group does not all have animal to occur righting reflex loss, and namely all animals does not all enter sleep state, points out this trial drug not have direct inducing mouse sleep effect.
(3) trial drug is on the impact of the pentobarbital sodium length of one's sleep
There were significant differences (P<0.05) in order to compare with matched group for note: *.
As seen from Table 3, per os gives the capsule 30 days of mice various dose, the length of one's sleep of each dosage group is all than the prolongation of matched group, and the difference of height, middle dosage group and matched group has significance (P<0.05), this sample is pointed out to have the effect extending the pentobarbital sodium length of one's sleep.
(4) trial drug is on the impact of pentobarbital sodium sub-threshold dose syngignoscism
There were significant differences (P<0.05) in order to compare with matched group for note: *, and * * has pole significant difference (P<0.01) for comparing with matched group.
As seen from Table 4, per os gives the capsule 30 days of mice various dose, the mice sleep rate of each dosage group is higher than matched group, and high dose group compares with matched group and has pole significant difference (P<0.01), middle dosage group compares with matched group and has significant difference (P<0.05), points out the pentobarbital sodium of this trial drug and sub-threshold dose to have collaborative syngignoscism.
(5) trial drug is on the preclinical impact of barbital sodium hypnosis
There were significant differences (P<0.05) in order to compare with matched group for note: *, and * * has pole significant difference (P<0.01) for comparing with matched group.
As seen from Table 5, per os gives the capsule 30 days of mice various dose, the Sleep latency of each dosage group is all than the shortening of matched group, and the difference of each dosage group and negative control group all has significance (P<0.01 or P<0.05), this sample is pointed out to have the effect shortening barbital sodium Sleep latency.
5, result judges:
Mouse stomach 30 days are given continuously respectively with the dosage capsule of the present invention of 5,10,20 times being equivalent to human body recommended amounts, on Mouse Weight without impact, not directly sleep effect, pentobarbital sodium length of one's sleep can be extended, collaborative pentobarbital sodium sub-threshold dose syngignoscism, shorten barbital sodium Sleep latency, prompting the present invention has the function of improving water flood.
test 2:the present invention removes the human trial of chloasma function
1, subjects: select 18-60 year chloasma female patient 60 example, get rid of gestation or women breast-feeding their children, get rid of allergy sufferers of the present invention, get rid of merge intentionally, liver, the severe primary Disease such as kidney and hemopoietic system, participating in experimenter is voluntarily, experimental period is 30 days, every day 2 times, each 4.
2, process of the test:
(1), the detection of area of chloasma size: participate in taking front, left surface and right flank photo under given conditions with same digital camera before and after experimenter's test-meal the present invention, measure the area (cm of full face chloasma with " skin pigment spot image quantization analytical system "
2).
(2), shade change: according to Institute of Geography, Academia Sinica's development and design, brown colour atla in " practical standard colour atla " that Mapping Press publishes for 1992 is the criterion of chloasma shade: I degree (15,20,5), II degree (30,40,10), III degree (40,60,15).
(3), speckle dispelling attacks effect evaluation:
Effective: chloasma color declines I degree, area reduces >=10% simultaneously, and does not produce new chloasma (original chloasma position chloasma number increases but area reduces, and is considered as not producing new chloasma).
Invalid: chloasma color anomalous integral area is without significant change or increase the weight of.
3, result of the test:
(1) change of chloasma shade
Table 6 chloasma shade changes
| Number of cases | Before test | After test | Difference | |
| Colour atla (degree) | 60 | 1.75±0.32 | 1.36±0.43 | -0.39±0.38＊＊ |
Note: * * is difference extremely significantly (P<0.01).
As can be seen from Table 6, before the test, the average chloasma lighter of experimenter, and self difference is extremely significantly (P<0.01).
(2) area of chloasma size measurement
Note: * * is difference extremely significantly (P<0.01).
As can be seen from Table 7, before the test, the average area of chloasma of experimenter diminishes, the area >10% diminished, and self difference extremely significantly (P<0.01).
(3) freckle effect evaluation
As can be seen from Table 8, after using the present invention, effective percentage is 71.67%, points out the present invention to have and dispels preferably
Chloasma attack effect.
test 3:the present invention removes the human trial of facial acne function
1, subjects: select that skin quality is identical, patient 40 that face has acne, men and women half and half, age bracket be 18-60 year between, experimenter is voluntary participation, and experimental period is 30 days, every day 2 times, each 4.
2, process of the test: the facial photo of taking same position before and after each participation experimenter test-meal the present invention with same digital camera under given conditions, then acne number is measured, each experimenter counts on average rear, and average, through rounding up process, adopts self cross-reference.
3, result of the test:
as can be seen from Table 9, before and after experimenter's test-meal the present invention, acne number obviously reduces table 9, points out tool of the present invention
There is the effect of removing acne.
By to each test data analyzer of the present invention, clearly can find out that the present invention has the effect of significant improving water flood, simultaneously to dispelling chloasma faciei and acne has remarkable result, and the present invention is harmless, is good health product.
The present invention for primary raw material, adds Fructus Ligustri Lucidi with valuable ingredient of Chinese medicine Radix Notoginseng, Rhizoma Dioscoreae, Flos Carthami, Herba Ecliptae, Radix Polygalae carry out rational proportion, synergy, wherein, and Radix Notoginseng energy blood circulation promoting and blood stasis dispelling, tranquillizing and allaying excitement, defying age, hepatic cholagogic; Rhizoma Dioscoreae can prevent cardiovascular diseases, kidney nourishing and replenishing vital essence, intelligent promoting and the mind tranquilizing, life lengthening; Fructus Ligustri Lucidi energy nourishing the liver and kidney, improving eyesight black hair, antiinflammatory are anticancer, can also endocrine regulation; Herba Ecliptae energy hepatoprotective, improves immunity, antibacterial defying age; The dreaminess of Radix Polygalae energy Cure for insomnia, severe palpitation; Flos Carthami energy promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving; Pharmaceutical composition of the present invention is controlled from this, emphatically medical treatment internal organs and negative and positive of qi and blood thereof, by restoring normal coordination between the heart and kidney, YIN nourishing mind calming, promoting blood circulation to remove obstruction in the collateral, make QI and blood with smooth, not only make ataraxy, Cure for insomnia, more can endocrine regulation, anti-ageing anti-old, there is significant curative effect to chloasma, acne.
What finally illustrate is, above preferred embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although by above preferred embodiment to invention has been detailed description, but those skilled in the art are to be understood that, various change can be made to it in the form and details, and not depart from claims of the present invention limited range.
Claims (3)
1. a Sanqi Shuishu Capsule, is characterized in that: Sanqi Shuishu Capsule is made up of the raw material of following weight ratio part: Radix Notoginseng 15 ~ 24 parts, Rhizoma Dioscoreae 5 ~ 10 parts, Fructus Ligustri Lucidi 3 ~ 8 parts, Herba Ecliptae 6 ~ 12 parts, Radix Polygalae 8 ~ 14 parts, 5 ~ 12 parts, Flos Carthami.
2. a kind of Sanqi Shuishu Capsule according to claim 1, is characterized in that: Sanqi Shuishu Capsule is made up of the raw material of following weight ratio part: Radix Notoginseng 20 parts, Rhizoma Dioscoreae 8 parts, Fructus Ligustri Lucidi 6 parts, Herba Ecliptae 10 parts, Radix Polygalae 12 parts, 8 parts, Flos Carthami.
3. the preparation method of a kind of Sanqi Shuishu Capsule according to claim 1 and 2, is characterized in that: be made up of following steps:
1) to pretreatment of raw material: Radix Notoginseng: clean, clean, dry for subsequent use; Rhizoma Dioscoreae: clean, cleans, and section, dries, and stir-fry is steamed for subsequent use; Fructus Ligustri Lucidi: clean, cooks, and dries for subsequent use; Herba Ecliptae: clean, cleans, cooks, dry for subsequent use; Radix Polygalae: clean, dries for subsequent use; Flos Carthami: clean, dries for subsequent use;
2) crude drug is pulverized, get formulation weight adds 60% ethanol than the Radix Notoginseng of part, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Polygalae, Flos Carthami, extract twice, alcohol adding amount is followed successively by 8 times, 6 times, each two hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into relative density 1.25 at 65-70 DEG C;
3) by step 2) concentrated filtrate of gained carries out spraying dry, obtained effective ingredient;
4) by the effective ingredient spray granulation of step 3) gained, 60 DEG C of dryings, cross 14 mesh sieves, incapsulate, 0.4g/ grain, packaging, and inspection, gets product.
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| CN107019755A (en) * | 2017-02-24 | 2017-08-08 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine for treating climacteric women endocrinopathy |
| CN109170697A (en) * | 2018-09-10 | 2019-01-11 | 漳州何氏农业开发有限公司 | A kind of food and preparation method thereof adjusting inferior health |
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