CN104524104B - A kind of Sanqi Shuishu Capsule and preparation method thereof - Google Patents
A kind of Sanqi Shuishu Capsule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Sanqi Shuishu Capsule and preparation method thereof, Sanqi Shuishu Capsule is made of the raw material of following weight ratio part: 15~24 parts of Radix Notoginseng, 5~10 parts of Chinese yam, 3~8 parts of the fruit of glossy privet, 6~12 parts of eclipta, 8~14 parts of Radix Polygalae, 5~12 parts of safflower；The present invention is using valuable ingredient of traditional Chinese medicine Radix Notoginseng as primary raw material, the fruit of glossy privet, Chinese yam, safflower, eclipta, Radix Polygalae is added and carries out rational proportion, synergy is controlled from this, internal organs and its negative and positive of qi and blood are recuperated under medical treatment emphatically, by restoring normal coordination between heart and kidney, enriching yin calming heart, promoting blood circulation and removing obstruction in channels, makes qi and blood and smooth, not only make ataraxy, treatment insomnia, it is more adjustable endocrine, anti-aging has significant curative effect to chloasma, acne.
Description
Technical field
The invention belongs to Chinese medicine health-care fields, specifically, being related to a kind of Sanqi Shuishu Capsule and preparation method thereof.
Background technique
Insomnia is or after being ill and old, insufficiency of natural endowment, the causes of disease such as have a guilty consicence, to cause the mind due to feelings will, diet internal injury
Dystrophy is confused and worried, so as to cause cannot often obtain a kind of illness that ortho is characterized.
It is mainly shown as the deficiency of sleeping time depth and fatigue cannot be eliminated, regain one's strength and energy, less serious case fall asleep
Difficulty or sleep but not soundly, sometimes sleeping and sometimes waking, or cannot sleep again after waking up, it is heavy then be insomnia all night.Insomnia Chinese medicine referred to as " is insomnia ",
Chinese medicine, which controls the common parting of debate card from liver, has liver-yang hyperactivity, liver depression stasis blocking, liver depression forming fire (wind), liver depression to violate stomach (perverse and unreasonable manner), liver depression
The high kidney deficiency of the anti-heart, liver.Though insomnia is not belonging to critical illness, people's normal life, work, study and health are interfered, and can add
Weight or induction palpitaition, thoracic obstruction, dizziness, headache, apoplexy etc., are also frequently accompanied by the appearance of the illnesss such as chloasma, acne, and lose
The diseases such as dormancy, chloasma, acne are because of stagnation of liver-QI with deficiency of the spleen, caused by qi deficiency to blood stasis.
Currently, clinically commonly using the Western medicine of such as barbiturates, Benzodiazepines and other non-barbiturates calmness, hypnosis
Treatment of insomnia patients, such drug is taken for a long time there are drug resistance, dependence, additive and incoordination, amnesia occur etc. bad
Reaction, and have different degrees of damage to liver kidney, and there is no effect to some illnesss generated with insomnia.
Summary of the invention
In view of the above-mentioned problems, the present invention proposes a kind of Sanqi Shuishu Capsule and preparation method thereof, it is with valuable ingredient of traditional Chinese medicine Radix Notoginseng
Primary raw material, be added the fruit of glossy privet, Chinese yam, safflower, eclipta, Radix Polygalae carry out rational proportion, synergy, have recuperating qi-blood,
Promoting blood circulation and removing obstruction in channels, tonifying Qi intelligence development, the function of nourishing conscience, mental-tranquilization, anti-aging, can effectively improve sleep, also to insomnia
Chloasma, the acne of generation have significant curative effect.
To solve the above-mentioned problems, the technical solution adopted in the present invention: a kind of Sanqi Shuishu Capsule, by following weight ratio
Part raw material composition: 15~24 parts of Radix Notoginseng, 5~10 parts of Chinese yam, 3~8 parts of the fruit of glossy privet, 6~12 parts of eclipta, 8~14 parts of Radix Polygalae,
5~12 parts of safflower.
A kind of preferred embodiment of Sanqi Shuishu Capsule according to the present invention, Sanqi Shuishu Capsule is by following weight percent
The raw material of content forms: 20 parts of Radix Notoginseng, 8 parts of Chinese yam, 6 parts of the fruit of glossy privet, 10 parts of eclipta, 12 parts of Radix Polygalae, 8 parts of safflower.
The preparation method of above-mentioned Sanqi Shuishu Capsule, comprises the steps of:
1) to pretreatment of raw material: Radix Notoginseng: cleaning, and cleans, dries spare；Chinese yam: cleaning, and cleans, and slice dries, and fries and steams
It is spare；The fruit of glossy privet: cleaning, and cooks, and dries spare；Eclipta: cleaning, and cleans, cooks, dry spare；Radix Polygalae: cleaning, and dries
It is spare；Safflower: cleaning, and dries spare；
2) bulk pharmaceutical chemicals are crushed, formulation weight is taken to be added than the Radix Notoginseng of part, Chinese yam, the fruit of glossy privet, eclipta, Radix Polygalae, safflower
60% ethyl alcohol extracts twice, and alcohol adding amount is followed successively by 8 times, 6 times, and two hours every time, filtration, merging filtrate recycled ethyl alcohol, filtrate
Relative density 1.25 is concentrated at 65-70 DEG C；
3) the resulting concentration filtrate of step 2 is spray-dried, effective component is made；
4) by the resulting effective component spraying granulation of step 3), 14 meshes are crossed in 60 DEG C of dryings, are packed into capsule, and 0.4g/,
Packaging is examined to get finished product.
The effect of each constituent of the invention, is as follows:
Radix Notoginseng: sweet in flavor, slight bitter, temperature return liver, stomach meridian；With improvement myocardial ischemia, anoxic, reducing blood lipid, blood pressure lowering, anti-blood
Bolt, Hemorrhagic shock, anti-fibrosis activity, anti-inflammatory and antalgic, hypoglycemic, anti-aging, tranquilizing and allaying excitement, strengthen immunity and Hepatoprotective cholagogue are made
With, and do not have the side effect of habituation.
Chinese yam contains the substances such as amylase, polyphenol oxidase, is conducive to taste digestion and absorption function, is flat tonifying spleen and stomach simply
Dual-purpose of drug and food product, clinically commonly use control the illnesss such as weakness of the spleen and the stomach, the tired, diarrhea of deficiency of food body；Chinese yam contains various nutrients,
There are strong body, the effect of nourishing kidney and replenishing pneuma；Chinese yam contains saponin, lymphatic temperament, there is a lubrication, moist effect, thus can beneficial lung qi, support
Lung yin can treat deficiency syndrome of the lung phlegm and cough the disease of chronic cough；Chinese yam contains mucus protein, plays the role of reducing blood glucose, can be used for treating glycosuria
Disease；Chinese yam contains a large amount of mucus albumen, electrolytes and minerals, can effectively prevent blood lipid in the precipitating of vascular wall, prevention
Cardiovascular diseases, the effect of obtaining intelligence promoting and tranquilization, promote longevity.
The pharmacological property of the fruit of glossy privet is more gentle, has nourishing liver and kidney, improving eyesight black hair, reducing blood lipid and anti arteriosclerosis, hypoglycemic, mentions
High cellular immunity and humoral immune function adjust endocrine system, also have the function of anti-inflammatory, anticancer, antimutation.Modern times face
Optic neuritis, leukopenia, chronic hepatitis, hyperlipemia, coronary heart disease, hypertension, Chidren Poisoning hearing are also used on bed
Decline, neurasthenia, alopecia etc..
Eclipta also known as Eclipta prostrata, Herba Ecliptae are the herb of compositae plant Eclipta prostrata, annual summer, two season of autumn extract herb, remove
Silt is removed, drying or drying in the shade can be used as medicine.Eclipta has hemostasis, improves immune, liver protection, removes free radical and anti-dye body damage
Wound, antibacterial, anti-aging and anti-mutation, growing and blacking hair and other effects；It can be clinically used for menopause symptom of releiving, control the deficiency of liver-yin and kidney-yin
Disease controls the blood loss disease of YinXuXueRe, controls allergic rhinitis.
The agents area of Radix Polygalae is mainly the root of Radix Polygalae, and root contains saponin, and two kinds of sapogenin crystallizations, Radix Polygalae can be got after hydrolysis
Sapogenin A and presenegenin B separately contains polygalytol, N-acetylglucosamine, alkaloid tenuidine, fat oil, tree
Rouge etc..Clinically being mainly used for insomnia and dreamful sleep, palpitation and severe palpitation, amnesia, epilepsy, to shy mad, coughing with a lot of sputum, skin sore, breast swollen
Bitterly, sore throat.
Safflower contains carthamin yellow and carthamin, and carthamin is hydrolyzed through hydrochloric acid, obtains glucose and carthamin, separately still fatty
Oil claims safflower oil, is the glyceride type of palmitinic acid, stearic acid, arachidic acid, oleic acid, linoleic acid, linolenic acid etc..Energy blood circulation,
Stasis eliminatings analgesic, acute and chronic muscular strain, treatment injure by a crashing object, sprain caused subcutaneous congested, swelling clinically mainly used for treating,
Treat coronary heart disease, treatment callosity etc..
Beneficial effects of the present invention: the present invention using valuable ingredient of traditional Chinese medicine Radix Notoginseng as primary raw material, be added the fruit of glossy privet, Chinese yam, safflower,
Eclipta, Radix Polygalae carry out rational proportion, synergy, wherein the activating microcirculation and removing stasis medicinal of Radix Notoginseng energy, tranquilizing and allaying excitement, anti-aging, liver protection benefit
Gallbladder；Chinese yam can prevent cardiovascular diseases, nourishing kidney and replenishing pneuma, intelligence promoting and tranquilization, promote longevity；Nourishing liver and kidney, the improving eyesight black hair of fruit of glossy privet energy, resists
Scorching anticancer, moreover it is possible to adjust endocrine；Eclipta energy liver protecting improves immunity, antibacterial anti-aging；It is more that Radix Polygalae can treat insomnia
Dream, palpitation and severe palpitation；Safflower energy blood circulation, stasis eliminatings analgesic；Pharmaceutical composition of the present invention is controlled from this, recuperate under medical treatment emphatically internal organs and its
Negative and positive of qi and blood makes qi and blood and smooth, not only makes ataraxy, treatment insomnia, more by restoring normal coordination between heart and kidney, enriching yin calming heart, promoting blood circulation and removing obstruction in channels
It is adjustable endocrine, anti-aging has significant curative effect to chloasma, acne.
Specific embodiment
Embodiment 1
1, bulk pharmaceutical chemicals: Radix Notoginseng 150g, Chinese yam 50g, fruit of glossy privet 30g, eclipta 60g, Radix Polygalae 80g, safflower 50g.
2, preparation method:
1) to pretreatment of raw material: Radix Notoginseng: cleaning, and cleans, dries spare；Chinese yam: cleaning, and cleans, and slice dries, and fries and steams
It is spare；The fruit of glossy privet: cleaning, and cooks, and dries spare；Eclipta: cleaning, and cleans, cooks, dry spare；Radix Polygalae: cleaning, and dries
It is spare；Safflower: cleaning, and dries spare；
2) bulk pharmaceutical chemicals are crushed, formulation weight is taken to be added than the Radix Notoginseng of part, Chinese yam, the fruit of glossy privet, eclipta, Radix Polygalae, safflower
60% ethyl alcohol extracts twice, and alcohol adding amount is followed successively by 8 times, 6 times, and two hours every time, filtration, merging filtrate recycled ethyl alcohol, filtrate
Relative density 1.25 is concentrated at 65-70 DEG C；
3) the resulting concentration filtrate of step 2 is spray-dried, effective component is made；
4) by the resulting effective component spraying granulation of step 3), 14 meshes are crossed in 60 DEG C of dryings, are packed into capsule, and 0.4g/,
Packaging is examined to get finished product.
3, instructions of taking and dosage:
Warm water takes, 2 times a day, 4 tablets each time.
Embodiment 2
1, bulk pharmaceutical chemicals: Radix Notoginseng 240g, Chinese yam 100g, fruit of glossy privet 80g, eclipta 120g, Radix Polygalae 140g, safflower 120g.
2, preparation method:
1) to pretreatment of raw material: Radix Notoginseng: cleaning, and cleans, dries spare；Chinese yam: cleaning, and cleans, and slice dries, and fries and steams
It is spare；The fruit of glossy privet: cleaning, and cooks, and dries spare；Eclipta: cleaning, and cleans, cooks, dry spare；Radix Polygalae: cleaning, and dries
It is spare；Safflower: cleaning, and dries spare；
2) bulk pharmaceutical chemicals are crushed, formulation weight is taken to be added than the Radix Notoginseng of part, Chinese yam, the fruit of glossy privet, eclipta, Radix Polygalae, safflower
60% ethyl alcohol extracts twice, and alcohol adding amount is followed successively by 8 times, 6 times, and two hours every time, filtration, merging filtrate recycled ethyl alcohol, filtrate
Relative density 1.25 is concentrated at 65-70 DEG C；
3) the resulting concentration filtrate of step 2 is spray-dried, effective component is made；
4) by the resulting effective component spraying granulation of step 3), 14 meshes are crossed in 60 DEG C of dryings, are packed into capsule, and 0.4g/,
Packaging is examined to get finished product.
3, instructions of taking and dosage:
Warm water takes, 2 times a day, 4 tablets each time.
Embodiment 3
1, bulk pharmaceutical chemicals: Radix Notoginseng 200g, Chinese yam 80g, fruit of glossy privet 60g, eclipta 100g, Radix Polygalae 120g, safflower 80g.
2, preparation method:
1) to pretreatment of raw material: Radix Notoginseng: cleaning, and cleans, dries spare；Chinese yam: cleaning, and cleans, and slice dries, and fries and steams
It is spare；The fruit of glossy privet: cleaning, and cooks, and dries spare；Eclipta: cleaning, and cleans, cooks, dry spare；Radix Polygalae: cleaning, and dries
It is spare；Safflower: cleaning, and dries spare；
2) bulk pharmaceutical chemicals are crushed, formulation weight is taken to be added than the Radix Notoginseng of part, Chinese yam, the fruit of glossy privet, eclipta, Radix Polygalae, safflower
60% ethyl alcohol extracts twice, and alcohol adding amount is followed successively by 8 times, 6 times, and two hours every time, filtration, merging filtrate recycled ethyl alcohol, filtrate
Relative density 1.25 is concentrated at 65-70 DEG C；
3) the resulting concentration filtrate of step 2 is spray-dried, effective component is made；
4) by the resulting effective component spraying granulation of step 3), 14 meshes are crossed in 60 DEG C of dryings, are packed into capsule, and 0.4g/,
Packaging is examined to get finished product.
3, instructions of taking and dosage:
Warm water takes, 2 times a day, 4 tablets each time.
Analysis of experiments
Test 1: the present invention improves sleep Experiment on Function
1, experimental animal is grouped: choose healthy adult, similar in weight, and the male mice of same kind 240, every 60
Mouse is divided into one group, is divided into four groups, carries out direct sleep laboratory respectively, extends the test of yellow Jackets sleeping time, penta bar
Than appropriate sodium sub-threshold dose hypnosis test, barbital sodium Sleep Latency Test, each group is divided into 4 groups, and one group is control group,
Other three groups are respectively basic, normal, high three dosage groups.
2, trial drug: test drug human body recommended dose be daily 3.2g/60kg.bw capsule of the present invention, mouse etc.
Effect dosage is equivalent to 10 times of human body recommended dose, respectively using 5 times of human body recommended dose, 10 times, 30 times as low (0.27g/
Kg.bw), (0.53g/kg.bw), high dose (1.60g/kg.bw), take administration by gavage to gavage in, and control group fills distilled water, continuously
Test 30 days, each dosage group gives the trial drug of matched doses respectively.
3, process is tested:
(1), direct sleep laboratory
After observation mouse gives the test drug of various dose, control group gives same volume distilled water, if sleeps
Phenomenon is more than to be judged within 60 seconds enter sleep with righting reflex loss, and righting reflex restores to be animal awakening, righting reflex loss
It is the animal sleep time to this period is restored, records control group and various dose group sleep number of animals and sleeping time.
(2) extend the test of yellow Jackets sleeping time
After to last sample 20 minutes, groups of animals is through yellow Jackets 35mg/kg BW, injection volume is injected intraperitoneally
0.1mL/10g BW, using the righting reflex loss of mouse as index, can observation tested material extend yellow Jackets sleeping time,
Test carries out at night.
(3) yellow Jackets sub-threshold dose hypnosis test
After to last sample 20 minutes, groups of animals is through yellow Jackets 30mg/kg BW, injection volume is injected intraperitoneally
0.1mL/10g BW observes the sleep quality of mouse in 30 minutes, is to fall asleep with righting reflex loss 60 seconds or more persons, record
The sleep number of animals of each group in 30 minutes, calculate incidence of sleep animals, and test carries out at night.
(4), barbital sodium Sleep Latency Test
Through barbital sodium 200mg/kg BW is injected intraperitoneally, injection volume is each group mouse within 20 minutes after giving last sample
0.1mL/10g BW, using righting reflex loss as index, can observation trial drug shorten barbital sodium Sleep latency.
4, test result analysis:
(1), influence of the trial drug to mouse weight
Seen from table 1, the mouse weight of each dosage group in test front and back is compared with the mouse weight of control group, and difference is without aobvious
Work property (P > 0.05), shows the sample to the body weight increase of mouse without influence.
(2), direct sleep laboratory result
As seen from Table 2, the capsule of orally administration mouse various dose 30 days, each dosage group is turned over without animal
Positive reflection disappears, i.e., all animals do not enter into sleep state, and the trial drug is prompted not have direct inducing mouse sleep to make
With.
(3) influence of the trial drug to yellow Jackets sleeping time
Note: * is that there were significant differences compared with the control group (P < 0.05).
As seen from Table 3, the capsule of orally administration mouse various dose 30 days, the sleeping time of each dosage group compares
According to the extension of group, and high, middle dose group and the difference of control group have conspicuousness (P < 0.05), prompt the sample to have and extend penta
The effect of barbital sodium sleeping time.
(4) influence of the trial drug to yellow Jackets sub-threshold dose syngignoscism
Note: * is that there were significant differences compared with the control group (P < 0.05), and * * is to have extremely significant difference compared with the control group
(P < 0.01).
As seen from Table 4, the capsule of orally administration mouse various dose 30 days, the mouse sleep rate of each dosage group are higher than pair
According to group, and high dose group has extremely significant difference (P < 0.01) compared with the control group, and middle dose group has aobvious compared with the control group
It writes difference (P < 0.05), the trial drug is prompted to cooperate with syngignoscism with the yellow Jackets of sub-threshold dose.
(5) trial drug is on the preclinical influence of barbital sodium hypnosis
Note: * is that there were significant differences compared with the control group (P < 0.05), and * * is to have extremely significant difference compared with the control group
(P < 0.01).
As seen from Table 5, the capsule of orally administration mouse various dose 30 days, the Sleep latency of each dosage group compares
The shortening of control group, and the difference of each dosage group and negative control group all has conspicuousness (P < 0.01 or P < 0.05), prompts
The sample has the function of shortening barbital sodium Sleep latency.
5, result judgement:
Respectively to be equivalent to 5,10,20 times of dosage capsule of the present invention of human body recommended amounts continuously to intragastric administration on mice 30 days,
It on mouse weight without influence, is acted on without directly sleep, yellow Jackets sleeping time can be extended, cooperateed under yellow Jackets threshold
Dosage syngignoscism shortens barbital sodium Sleep latency, and the present invention is prompted to have the function of improving sleep.
Test 2: the present invention removes the human trial of chloasma function
1, subjects: selection 18-60 year old chloasma female patient 60, exclude gestation or breast feeding women, exclusion pair
Allergy sufferers of the present invention, exclude to merge intentionally, liver, the severe primaries Disease such as kidney and hemopoietic system, participating in experimenter is
Voluntarily, experimental period is 30 days, 2 times a day, 4 tablets each time.
2, process is tested:
(1), the detection of area of chloasma size: experimenter's test-meal present invention front and back is participated in same digital camera specific
Under the conditions of shoot front, left side and right side photo, it is yellowish-brown to measure full face with " skin pigment spot image quantization analysis system "
Area (the cm of spot2).
(2), shade changes: according to Institute of Geography, Academia Sinica's development and design, Mapping Press goes out for 1992
Brown colour atla in " the practical standard colour atla " of version is the judgment criteria of the chloasma color depth: I degree (15,20,5), II degree
(30,40,10), III degree (40,60,15).
(3), nti-freckle attacks effect evaluation:
Effective: chloasma color declines I degree, while area reduces >=10%, and it is (original yellowish-brown not generate new chloasma
Spot position chloasma number increases but area reduces, and is considered as and does not generate new chloasma).
Invalid: chloasma color integral and area are without significant change or exacerbation.
3, test result:
(1) variation of the chloasma color depth
The variation of the 6 chloasma color depth of table
| Number of cases | Before test | After test | Difference | |
| Colour atla (degree) | 60 | 1.75±0.32 | 1.36±0.43 | - 0.39 ± 0.38** |
Note: * * is that difference is extremely significant (P < 0.01).
As can be seen from Table 6, before and after the test, the average chloasma color of experimenter shoals, and itself difference is extremely significant
(P < 0.01).
(2) area of chloasma size measurement
Note: * * is that difference is extremely significant (P < 0.01).
As can be seen from Table 7, before and after the test, the average area of chloasma of experimenter becomes smaller, area > 10% to become smaller, and
Itself difference is extremely significant (P < 0.01).
(3) freckle effect is evaluated
As can be seen from Table 8, after using the present invention, effective percentage is 71.67%, prompts the present invention to have and preferably dispels
Chloasma attacks effect.
Test 3: the present invention removes the human trial of face acnes function
1, subjects: selection skin quality is identical, the facial patient for having acne 40, and men and women is fifty-fifty, and age bracket is 18-60 years old
Between, experimenter is voluntary participation, and experimental period is 30 days, 2 times a day, 4 tablets each time.
2, test process: each participation experimenter's test-meal present invention front and back is shot same under given conditions with same digital camera
Then the facial photo at one position measures acne number, each experimenter is average after counting, and average is adopted by the processing that rounds up
With itself cross-reference.
3, test result:
As can be seen from Table 9, before and after the experimenter test-meal present invention, acne number significantly reduces table 9, prompts present invention tool
There is the effect of removing acne.
By that can be clear that present invention tool is significantly improved sleep to each test data analyzer of the invention
Effect, while there is remarkable result to chloasma faciei and acne is dispelled, and the present invention is harmless, is preferable health care
Product.
The present invention is added the fruit of glossy privet, Chinese yam, safflower, eclipta, Radix Polygalae and is closed using valuable ingredient of traditional Chinese medicine Radix Notoginseng as primary raw material
Reason proportion, synergy, wherein the activating microcirculation and removing stasis medicinal of Radix Notoginseng energy, tranquilizing and allaying excitement, anti-aging, Hepatoprotective cholagogue；Chinese yam can prevent painstaking effort disease
Disease, intelligence promoting and tranquilization, is promoted longevity at nourishing kidney and replenishing pneuma；Fruit of glossy privet energy nourishing liver and kidney, improving eyesight black hair, anti-inflammatory anticancer, moreover it is possible to divide in adjusting
It secretes；Eclipta energy liver protecting improves immunity, antibacterial anti-aging；Radix Polygalae can treat insomnia and dreamful sleep, palpitation and severe palpitation；Safflower energy
Blood circulation, stasis eliminatings analgesic；Pharmaceutical composition of the present invention is controlled from this, is recuperated under medical treatment internal organs and its negative and positive of qi and blood emphatically, is passed through traffic
It is heart kidney, enriching yin calming heart, promoting blood circulation and removing obstruction in channels, make qi and blood and smooth, not only make ataraxy, treatment insomnia is more adjustable endocrine, anti-ageing
It is anti-old, there is significant curative effect to chloasma, acne.
Finally, it is stated that preferred embodiment above is only used to illustrate the technical scheme of the present invention and not to limit it, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (2)
1. a kind of Sanqi Shuishu Capsule, it is characterised in that: Sanqi Shuishu Capsule is made of the raw material of following weight ratio part: Radix Notoginseng 20
Part, 8 parts of Chinese yam, 6 parts of the fruit of glossy privet, 10 parts of eclipta, 12 parts of Radix Polygalae, 8 parts of safflower.
2. a kind of preparation method of Sanqi Shuishu Capsule according to claim 1, it is characterised in that: by following steps group
At:
1) to pretreatment of raw material: Radix Notoginseng: cleaning, and cleans, dries spare；Chinese yam: cleaning, and cleans, and slice dries, and it is spare to fry steaming；
The fruit of glossy privet: cleaning, and cooks, and dries spare；Eclipta: cleaning, and cleans, cooks, dry spare；Radix Polygalae: cleaning, and dries spare；
Safflower: cleaning, and dries spare；
2) bulk pharmaceutical chemicals are crushed, formulation weight is taken to be added 60% than the Radix Notoginseng of part, Chinese yam, the fruit of glossy privet, eclipta, Radix Polygalae, safflower
Ethyl alcohol extracts twice, and alcohol adding amount is followed successively by 8 times, 6 times, and two hours every time, filtration, merging filtrate recycled ethyl alcohol, and filtrate exists
Relative density 1.25 is concentrated at 65-70 DEG C；
3) the resulting concentration filtrate of step 2 is spray-dried, effective component is made；
4) by the resulting effective component spraying granulation of step 3), 14 meshes are crossed in 60 DEG C of dryings, are packed into capsule, 0.4g/, are packed,
It examines to get finished product.
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