CN104524075A - Medicine treating cancer pain and preparation method thereof - Google Patents

Medicine treating cancer pain and preparation method thereof Download PDF

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CN104524075A
CN104524075A CN201410748525.3A CN201410748525A CN104524075A CN 104524075 A CN104524075 A CN 104524075A CN 201410748525 A CN201410748525 A CN 201410748525A CN 104524075 A CN104524075 A CN 104524075A
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medicine
pain
cancer pain
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treating cancer
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任立杰
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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Abstract

The invention relates to a medicine treating cancer pain and a preparation method thereof. The medicine treating cancer pain is composed of the following traditional Chinese medicine raw materials in parts by weight: 5-15 g of livistona chinensis, 10-25 g of rhizoma polygoni cuspidati, 20-35 g of radix glycyrrhizae, 10-15 g of fimbriate orostachys, 10-20 g of fruit of fiverleaf akebia, 10-15 g of leaf of Chinese crinum, 10-20 g of all-grass of downy ground-cherry, 10-20 g of papaya, 5-10 g of root of tall monkshood, 5-15 g of kadsura longipedunculata finetet gagn., 10-15 g of root of greyblue spicebush, and 10-15 g of impatiens leptocaulon hook.f.. The medicine treating cancer pain employs the medicinal materials for compatibility and gives play to efficacy of moistening lung and resolving phlegm, activating blood and resolving stasis, regulating qi and relieving pain, and detoxifying and dispersing swelling. The medicine is capable of effectively relieving cancer pain, is substantial in curative effect and small in side effect, is used to prepare an externally-applied medicinal paste, is strong in permeability, can directly act on nidus, makes up disadvantages of orally-administrated medicines, enhances treatment effect on tumor, and helps to improve life quality of patients and prolong lifespan.

Description

Medicine for the treatment of of cancer pain and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to medicine of a kind for the treatment of of cancer pain and preparation method thereof.
Background technology
Cancer pain means oncothlipsis, invades the neural pain produced of related organization, is one of cancer clinical common sympton.Early stage in cancer, because tumor body is still little, general without transfer, thus the incidence rate of cancer pain is lower; In late period, focus is comparatively large, constantly carries out infiltrative growth to neighbouring histoorgan, and often has bone marrow etc. to shift a long way.Therefore, the incidence rate of cancer pain improves greatly.Cancerous pain mostly is rest pain, and increases thereupon focus and constantly aggravate.Pain is roughly divided into two kinds: a kind of is locality, can locate; Another kind is then diffuse type, and painful area is unclear.
Pain caused by cancer is called carcinoma pain by Chinese medicine, refers to that meridians invaded by tumor poison or tumor block blocks meridian qi and blood and causes the pain of body a part.Carcinoma pain often comes across disease, long-pending, tumor, stone, abdominal mass, breast carcinoma, indurated subcutaneous mass, regurgitation, dysentery etc. and caused QI and blood thereof and decays during all diseases wait in TCM Document.Have the description of " osteanabrosis, pork sink, fullness caused by stagnant QI, inconvenience of panting, interior pain draw shoulder item in the heart " in "Nei Jing", pole is like advanced lung cancer pain.Have again the record in " amass the cloudy gas of person also, its normal place that started, its pain is not from its portion ", illustrate that long-pending BOB(beginning of block) has fixed position when producing, its pain is positioned at long-pending block place, and pain in fixed position.
The traditional Chinese medical science thinks that being mainly in evil poison of cancer pain stores, qi depression to blood stasis, stagnation of QI and blood may bring about pain.Its clinical manifestation of cancer pain can be divided into Sheng type, blood stasis type and Qi-stagnation type in evil poison.In evil poison, Sheng type often shows as locally scorching hot, and pain is fixing does not move, and that touches exacerbates; Blood stasis type often shows as the perverse sample pain of pin of partial fixing, dark tongue quality, tongue with ecchymosis; Qi-stagnation type often shows as migratory pain, attacks and alters distending pain.
The method of Modern medical therapy cancer pain has topical therapeutic, analgesic and blocks the pathway etc. of pain.Local lump can be given radiotherapy, chemotherapy or carry out controls local tumor with operation by local symptom, removes the pain caused local compression; Half body radiotherapy causes pain curative effect better to the extensive Bone tumour of whole body; Cut off neck marrow ventrolateral tract method, nerve conduction capable of blocking, also can obtain analgesic effect.Current analgesic has aspirin, bucinnazine, dipyrone, indometacin etc., but not good enough to the curative effect of cancer pain, and often can not prolonged application because of the toxicity such as digestive tract reaction and bone marrow depression.Narcotic analgesics has codeine, dolantin, though energy respite cancerous pain, easily cause additive, and demand is more and more large, interval time is more and more short.
Summary of the invention
The object of the present invention is to provide medicine of a kind for the treatment of of cancer pain adopting pure raw material of Chinese medicine to make and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is: the medicine for the treatment of of cancer pain, is made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 5-15g, Rhizoma Polygoni Cuspidati 10-25g, Radix Glycyrrhizae 20-35g, Herba Orostachyos 10-15g, Fructus Akebiae 10-20g, Folium Crini Sinici 10-15g Herba Physalis pubescentis 10-20g, Fructus Caricae 10-20g, Radix aconiti sinomontani 5-10g, Radix Kadsurae longipedunculatae 5-15g, Radix Linderae Glaucae 10-15g, Impatiens leptocaulon Hook.f. 10-15g.
Preferably, the medicine for the treatment of of cancer pain, is made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 10g, Rhizoma Polygoni Cuspidati 15g, Radix Glycyrrhizae 25g, Herba Orostachyos 15g, Fructus Akebiae 10g, Folium Crini Sinici 15g ， Herba Physalis pubescentis 15g, Fructus Caricae 15g, Radix aconiti sinomontani 10g, Radix Kadsurae longipedunculatae 10g, Radix Linderae Glaucae 10g, Impatiens leptocaulon Hook.f. 10g.
The preparation method of said medicine is: above-mentioned raw material of Chinese medicine was pulverized 80 mesh sieves, adds Oleum sesami furnishing paste after mixing.
The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:
Semen livistonae chinensis is the leaf of babassu Semen livistonae chinensis, seed or root, anticancer.Sweet, puckery, flat, for esophageal carcinoma, chorionic epithelioma, malignant mole, leukemia.Treat various pain.
Rhizoma Polygoni Cuspidati, be the rhizome of polygonaceae plant Rhizoma Polygoni Cuspidati, micro-hardship, is slightly cold, and returns liver, gallbladder, lung meridian, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Radix Glycyrrhizae is the Root and Rootstock of pulse family glycyrrhiza genus Radix Glycyrrhizae, sweet, flat, GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Orostachyos is the herb of crassulaceae plants Herba Orostachyos or orostachys erudescens etc., acid, bitter, cool, returns liver, lung meridian, cooling blood for hemostasis; Heat-clearing and toxic substances removing; Removing dampness sword skin ulcer.Main haematemesis; Epistaxis; Have blood in stool; Dysentery; Pyretic stranguria; Menoxenia; Furuncle carbuncle; Hemorrhoid; Eczema; Scald; Pneumonia; Hepatitis; Cervical erosion; Chyluria.
Fructus Akebiae, be the fruit of BENTONG section plant Caulis Akebiae, threeleaf akebia, white BENTONG, mildly bitter flavor, property is put down, and returns liver, stomach, urinary bladder channel, dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
Folium Crini Sinici is the leaf of amrallid Bulbus et Radix Crini Sinici, pungent, bitter, cool, heat-clearing and toxic substances removing; Stasis-dispelling and pain-killing.Main herpes simplex toxic swelling; Lymphadenitis; Pharyngolaryngitis; Headache; Arthralgia pain is numb; Traumatic injury congestive edema; Fracture; Venom.
Herba Physalis pubescentis is the herb of plant of Solanaceae Herba Physalis pubescentis, bitter in the mouth, acid, cold in nature, heat clearing away; Diuresis; Removing toxic substances; Detumescence.Main flu; Cough due to lung-heat; Laryngopharynx swelling and pain; Gingival swelling and pain; Jaundice due to damp-heat; Dysentery; Edema; Pyretic stranguria; Pemphigus; Furuncle.
Fructus Caricae is the fruit of Caricaceae plant Fructus Caricae, sweet, flat, main dyspepsia; Stomach; Duodenal ulcer pain; Milk is rare; Rheumatic arthralgia; Numb limbs and tense tendons; Eczema; Rotten skin ulcer; Intestinal parasitical diseases.
Radix aconiti sinomontani is the root of ranunculaceae plant Aconitum sinomontanum Nakai, bitter, pungent, temperature, GUIXIN, liver, lung, spleen channel, expelling wind and removing dampness; Regulating QI to relieve pain; Promoting blood circulation to remove blood stasis.Main lumbago, skelalgia of rheumatism; Arthralgia; Traumatic injury; Stomachache; Distension and fullness of the chest and abdomen; Acute and chronic bacillary dysentery; Acute chronic enteritis; Scrofula; Furuncle.
Radix Kadsurae longipedunculatae is root or the root bark of Magnoliacea plant Kadsura Longepedunculata, pungent, bitter, warm in nature, returns spleen, stomach, Liver Channel, regulating QI to relieve pain; Promoting blood circulation and detumescence.Main stomachache; Stomachache; Rheumatic arthralgia; Dysmenorrhea; Menoxenia; Puerperal abdonimal pain; Laryngopharynx swelling and pain; Hemorrhoid; Innominate toxic swelling; Traumatic injury is hindered.
Radix Linderae Glaucae is the root of canella Fructus Linderae Glaucae, pungent, temperature, bitter, returns liver, stomach warp, dispelling wind and removing obstruction in the collateral; Vital energy regualting and blood circulation-promoting; Inducing diuresis and reducing edema; Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome; Traumatic injury; Gastralgia; De-power impairment caused by overstrain; Bronchitis; Edema.
Impatiens leptocaulon Hook.f. is the root and rhizome of Balsaminaceae plant Herba Impatientis leptocauli flower, pungent, bitter, tepor, vital energy regualting and blood circulation-promoting pain relieving.Main air wet arthritis; Treating swelling and pain by traumatic injury.
The present invention has following beneficial effect: all medicine compatibilities of medicine for the treatment of of cancer pain of the present invention play effect of moistening the lung and resolving phlegm, blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, removing toxic substances and promoting subsidence of swelling altogether, effective alleviating cancer pain, evident in efficacy, side effect is little, makes external application medical ointment, impregnability is strong, medicine is gone directly focus, makes up the deficiency of oral medicine, strengthen oncotherapy effect, improve patients ' life quality, extend the existence time limit.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
The medicine for the treatment of of cancer pain, is made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 5g, Rhizoma Polygoni Cuspidati 20g, Radix Glycyrrhizae 30g, Herba Orostachyos 10g, Fructus Akebiae 15g, Folium Crini Sinici 10g ， Herba Physalis pubescentis 20g, Fructus Caricae 10g, Radix aconiti sinomontani 8g, Radix Kadsurae longipedunculatae 15g, Radix Linderae Glaucae 12g, Impatiens leptocaulon Hook.f. 15g.
The preparation method of said medicine is: above-mentioned raw material of Chinese medicine was pulverized 80 mesh sieves, adds Oleum sesami furnishing paste after mixing.
Embodiment 2
The medicine for the treatment of of cancer pain, is made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 10g, Rhizoma Polygoni Cuspidati 15g, Radix Glycyrrhizae 25g, Herba Orostachyos 15g, Fructus Akebiae 10g, Folium Crini Sinici 15g ， Herba Physalis pubescentis 15g, Fructus Caricae 15g, Radix aconiti sinomontani 10g, Radix Kadsurae longipedunculatae 10g, Radix Linderae Glaucae 10g, Impatiens leptocaulon Hook.f. 10g.
The preparation method of said medicine is: above-mentioned raw material of Chinese medicine was pulverized 80 mesh sieves, adds Oleum sesami furnishing paste after mixing.
Embodiment 3
The medicine for the treatment of of cancer pain, is made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 15g, Rhizoma Polygoni Cuspidati 10g, Radix Glycyrrhizae 35g, Herba Orostachyos 13g, Fructus Akebiae 20g, Folium Crini Sinici 12g ， Herba Physalis pubescentis 10g, Fructus Caricae 20g, Radix aconiti sinomontani 5g, Radix Kadsurae longipedunculatae 5g, Radix Linderae Glaucae 14g, Impatiens leptocaulon Hook.f. 10g.
The preparation method of said medicine is: above-mentioned raw material of Chinese medicine was pulverized 80 mesh sieves, adds Oleum sesami furnishing paste after mixing.
Embodiment 4
The medicine for the treatment of of cancer pain, is made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 10g, Rhizoma Polygoni Cuspidati 25g, Radix Glycyrrhizae 20g, Herba Orostachyos 10g, Fructus Akebiae 15g, Folium Crini Sinici 14g ， Herba Physalis pubescentis 15g, Fructus Caricae 10g, Radix aconiti sinomontani 10g, Radix Kadsurae longipedunculatae 15g, Radix Linderae Glaucae 15g, Impatiens leptocaulon Hook.f. 13g.
The preparation method of said medicine is: above-mentioned raw material of Chinese medicine was pulverized 80 mesh sieves, adds Oleum sesami furnishing paste after mixing.
Clinical data
Physical data: clinical drug of the present invention is applied to 150 routine cancer patients, male 83 example, women 67 example, age 23-75 year, 54 years old mean age, wherein pulmonary carcinoma 35 example, esophageal carcinoma 13 example, gastric cancer 28 example, intestinal cancer 13 example, hepatocarcinoma 22 example, cancer of pancreas 9 example, mammary cancer 17 example, lymphatic cancer 13 example.
Therapeutic Method: spread on affected part outside after paste made by medicine of the present invention, every agent is applied two days, and five doses is a course for the treatment of.
Curative effect judging standard:
Complete incidence graph: completely painless after treatment;
Partial rcsponse: pain obviously alleviates, pain time shortens, and interval time extends;
Minor responses: pain has and to a certain degree alleviates, and pain time and interval time are without obvious change;
Invalid: to compare without alleviating with before treatment.
Therapeutic outcome: in 150 routine patients, total pain relief 48 example, partial rcsponse 91 example, there is not serious adverse reaction in therapeutic process in minor responses 11 example, treatment terminates the blood of rear patient, urine, stool routine and hepatic and renal function inspection and is showed no exception.

Claims (3)

1. the medicine for the treatment of of cancer pain, is characterized in that, is made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 5-15g, Rhizoma Polygoni Cuspidati 10-25g, Radix Glycyrrhizae 20-35g, Herba Orostachyos 10-15g, Fructus Akebiae 10-20g, Folium Crini Sinici 10-15g ， Herba Physalis pubescentis 10-20g, Fructus Caricae 10-20g, Radix aconiti sinomontani 5-10g, Radix Kadsurae longipedunculatae 5-15g, Radix Linderae Glaucae 10-15g, Impatiens leptocaulon Hook.f. 10-15g.
2. the medicine for the treatment of of cancer pain as claimed in claim 1, is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Semen livistonae chinensis 10g, Rhizoma Polygoni Cuspidati 15g, Radix Glycyrrhizae 25g, Herba Orostachyos 15g, Fructus Akebiae 10g, Folium Crini Sinici 15g ， Herba Physalis pubescentis 15g, Fructus Caricae 15g, Radix aconiti sinomontani 10g, Radix Kadsurae longipedunculatae 10g, Radix Linderae Glaucae 10g, Impatiens leptocaulon Hook.f. 10g.
3. the medicine for the treatment of of cancer pain as claimed in claim 1 or 2, it is characterized in that, the preparation method of said medicine is: above-mentioned raw material of Chinese medicine was pulverized 80 mesh sieves, adds Oleum sesami furnishing paste after mixing.
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CN106256359A (en) * 2016-08-31 2016-12-28 罗艳华 A kind of Anesthesia Department is for treating the pharmaceutical composition of cancerous pain
CN109248304A (en) * 2018-11-28 2019-01-22 李玉春 A kind of department of anesthesia is used to treat the pharmaceutical composition of cancer pain

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CN109248304A (en) * 2018-11-28 2019-01-22 李玉春 A kind of department of anesthesia is used to treat the pharmaceutical composition of cancer pain

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Application publication date: 20150422