CN104523576A - Polyhexamethylene guanidine cream - Google Patents
Polyhexamethylene guanidine cream Download PDFInfo
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- CN104523576A CN104523576A CN201410841827.5A CN201410841827A CN104523576A CN 104523576 A CN104523576 A CN 104523576A CN 201410841827 A CN201410841827 A CN 201410841827A CN 104523576 A CN104523576 A CN 104523576A
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- cream
- polyhexamethylene guanidine
- mixture
- guanidine
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Abstract
The invention relates to the technical field of a skin sterilization product, in particular to a polyhexamethylene guanidine cream. The polyhexamethylene guanidine cream is composed of, by mass, 0.1%-5% of polyhexamethylen guanidine hydrochloride, 1% of a synergistic agent, 2% of azone, 0.5% of vitamin E, 45%-50% of PEG300 and 45%-50% of PEG1500. The manufacturing process includes the steps that according to the proportion, the equal amounts of PEG300 and PEG1500 are mixed and stirred for 15 minutes to obtain a cream body A; according to the proportion, the polyhexamethylen guanidine hydrochloride and the synergistic agent are mixed and stirred to obtain a mixture B; according to the proportion, the azone, the vitamin E and the mixture B are sequentially added into the cream body A and stirred for 30 minutes until the mixture is even, and the polyhexamethylene guanidine cream is obtained. The polyhexamethylene guanidine cream has the advantages that the formula is scientific and reasonable, the effect is rapid, no stimulation appears, no toxic and side effect appears, no resistance to drugs appears, and the use is convenient.
Description
Technical field:
The present invention relates to skin sterilization product technical field, be specifically related to a kind of polyhexamethylene guanidine emulsifiable paste.
Background technology:
Environment-friendly type macromolecule polymer bactericide---polyhexamethylene guanidine, has broad-spectrum; Valid density is low; Speed of action is fast; Stable in properties; Premium properties soluble in water; Can use at normal temperatures; For a long time antibacterial, have no side effect; Non-corrosiveness; Colourless, odorless; Nontoxic; Do not fire, not quick-fried, use safety; Convenient transportation, can be described as best antibacterial.In fact, this product is a kind of environment-friendly multipurpose new polymers, in industrial, agriculture, medical and daily life, have purposes extremely widely.
Polyhexamethylene guanidine is used for dermatosis: the killing action of this product to antibacterial, fungus is strong, effect is lasting, therefore can easily for the various dermatosiss caused by the sex pheromones such as dermatophytosis, yeast, mycete, staphylococcus aureus, Candida albicans, escherichia coli, pathogenic bacterium.And play antipruritic, putrefaction-removing granulation-promoting, recovery skin normal function effect.
But when polyhexamethylene guanidine is applied to skin surface at present, be the form adopting liquid fungicide mostly, use inconvenience, effect is bad.
Summary of the invention:
The object of this invention is to provide a kind of polyhexamethylene guanidine emulsifiable paste, its scientific formulation is reasonable, have rapid-action, do not stimulate, have no side effect, without Drug resistance, the feature such as easy to use.
In order to solve the problem existing for background technology, the present invention is by the following technical solutions: its quality consists of than formula: Polyhaxemethylenguanidine Hydrochloride 0.1%-5%, synergist 1%, azone 2%, vitamin E 0.5%, PEG300 45%-50%, PEG1500 45%-50%.
Production technology of the present invention is:
(1). according to aforementioned proportion, PEG300 and PEG1500 of equivalent mixed and stirs 15 minutes, obtaining body of paste A;
(2). according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride and synergist mixed and stirs, obtaining mixture B;
(3). azone, vitamin E and mixture B are added in body of paste A according to aforementioned proportion successively, stirs 30 minutes until mix homogeneously, obtain polyhexamethylene guanidine emulsifiable paste.
Polyhexamethylene guanidine emulsifiable paste of the present invention is applicable to the various dermatosiss caused by the sex pheromones such as dermatophytosis, yeast, mycete, staphylococcus aureus, Candida albicans, escherichia coli, pathogenic bacterium, the scytitis caused as contact dermatitis, neurodermatitis, seborrheic dermatitis, folliculitis, eczema, psoriasis, lichen planus, chronicus, pompholyx disease etc. and the treatment of skin pruritus.
The present invention has following beneficial effect:
1. rapid-action: dermal application administration, sterilization rapidly, successful.
2. do not stimulate: multinomial toxicology shows, skin, wound are not stimulated.
3. have no side effect: multinomial pharmacology shows, has no side effect, safe and reliable.
4. without Drug resistance: unique pathogenic bacteria principle of killing makes it without Drug resistance, and permanence operation does not subtract.
5. easy to use: medicine is directly coated onto affected part, use whenever and wherever possible.
Detailed description of the invention:
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with detailed description of the invention, the present invention is further elaborated.Should be appreciated that detailed description of the invention described herein only in order to explain the present invention, be not intended to limit the present invention.
This detailed description of the invention is by the following technical solutions: its quality consists of than formula: Polyhaxemethylenguanidine Hydrochloride 0.1%-5%, synergist 1%, azone 2%, vitamin E 0.5%, PEG30045%-50%, PEG1500 45%-50%.
The production technology of this detailed description of the invention is:
(1). according to aforementioned proportion, PEG300 and PEG1500 of equivalent mixed and stirs 15 minutes, obtaining body of paste A;
(2). according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride and synergist mixed and stirs, obtaining mixture B;
(3). azone, vitamin E and mixture B are added in body of paste A according to aforementioned proportion successively, stirs 30 minutes until mix homogeneously, obtain polyhexamethylene guanidine emulsifiable paste.
Usage and the consumption of this detailed description of the invention are as follows:
External, gets this product and smears skin discomfort place in right amount, every day 2-3 time, long-term chronic or situation comparatively severe one, every day 3-4 time.Use 7 days should be continued, in case recurrence after transference cure.
The pharmacological toxicology of this detailed description of the invention:
Pharmacological action
Main Ingredients and Appearance is polyhexamethylene guanidine, has broad-spectrum bactericidal action to Grain-positive, gram-negative bacteria.To pathogenic bacterium such as comprising dermatophytosis, yeast, mycete, staphylococcus aureus, Candida albicans, escherichia coli, there is bactericidal action.Its mechanism of action is that active ingredient becomes electropositive, be easy to by electronegative each bacterioid, fungus, virus adsorb and be wound around, thus suppress the splitting function of pathogenic bacteria, make antibacterial lose fertility, add the respiration channel plugging microorganism, microorganism is choked to death rapidly
Toxicological effect
Transdermal stimulation test, Eye irritation, repeatedly intact skin stimulate and a damaged skin experiment, belong to nonirritant; All belong to nontoxic through acute oral toxicity, acute inhalation toxicity, subacute toxicity test, micronucleus test.
The above is only in order to illustrate technical scheme of the present invention and unrestricted, other amendment that those of ordinary skill in the art make technical scheme of the present invention or equivalently to replace, only otherwise depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (1)
1. polyhexamethylene guanidine emulsifiable paste, is characterized in that its quality consists of than formula: Polyhaxemethylenguanidine Hydrochloride 0.1%-5%, synergist 1%, azone 2%, vitamin E 0.5%, PEG30045%-50%, PEG1500 45%-50%.
Polyhexamethylene guanidine emulsifiable paste, is characterized in that its production technology is:
(1). according to aforementioned proportion, PEG300 and PEG1500 of equivalent mixed and stirs 15 minutes, obtaining body of paste A;
(2). according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride and synergist mixed and stirs, obtaining mixture B;
(3). azone, vitamin E and mixture B are added in body of paste A according to aforementioned proportion successively, stirs 30 minutes until mix homogeneously, obtain polyhexamethylene guanidine emulsifiable paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410841827.5A CN104523576A (en) | 2014-12-31 | 2014-12-31 | Polyhexamethylene guanidine cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410841827.5A CN104523576A (en) | 2014-12-31 | 2014-12-31 | Polyhexamethylene guanidine cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104523576A true CN104523576A (en) | 2015-04-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410841827.5A Pending CN104523576A (en) | 2014-12-31 | 2014-12-31 | Polyhexamethylene guanidine cream |
Country Status (1)
| Country | Link |
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| CN (1) | CN104523576A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213312A (en) * | 2015-10-30 | 2016-01-06 | 卫国刚 | Polyhexamethylene guanidine propionate cream for treating dexmatosis and spray |
| CN105535015A (en) * | 2016-01-05 | 2016-05-04 | 山西海博贝马生物科技有限公司 | Polyhexamethylen guanidine hydrochloride itching-relieving water spray and preparation method thereof |
| CN108096368A (en) * | 2018-01-09 | 2018-06-01 | 江苏曦肤康生物制药有限公司 | A kind of antibacterial cream of skin for treating recalcitrant dermal disease and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101628035A (en) * | 2008-07-14 | 2010-01-20 | 烟台绿叶动物保健品有限公司 | Suppository for treating livestock endometritis |
| CN103705535A (en) * | 2013-12-27 | 2014-04-09 | 王东宇 | Gynecological chitosan gel and preparation method thereof |
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2014
- 2014-12-31 CN CN201410841827.5A patent/CN104523576A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101628035A (en) * | 2008-07-14 | 2010-01-20 | 烟台绿叶动物保健品有限公司 | Suppository for treating livestock endometritis |
| CN103705535A (en) * | 2013-12-27 | 2014-04-09 | 王东宇 | Gynecological chitosan gel and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 常忆凌: "《药剂学》", 28 February 2009 * |
| 张炳盛等: "《中药药剂学》", 28 February 2013 * |
| 韩丽等: "《药剂学实验》", 31 August 2014 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213312A (en) * | 2015-10-30 | 2016-01-06 | 卫国刚 | Polyhexamethylene guanidine propionate cream for treating dexmatosis and spray |
| CN105535015A (en) * | 2016-01-05 | 2016-05-04 | 山西海博贝马生物科技有限公司 | Polyhexamethylen guanidine hydrochloride itching-relieving water spray and preparation method thereof |
| CN108096368A (en) * | 2018-01-09 | 2018-06-01 | 江苏曦肤康生物制药有限公司 | A kind of antibacterial cream of skin for treating recalcitrant dermal disease and preparation method thereof |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150422 |
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| RJ01 | Rejection of invention patent application after publication |