CN106692185A - Preparation method of medical disinfectant - Google Patents
Preparation method of medical disinfectant Download PDFInfo
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- CN106692185A CN106692185A CN201510796847.XA CN201510796847A CN106692185A CN 106692185 A CN106692185 A CN 106692185A CN 201510796847 A CN201510796847 A CN 201510796847A CN 106692185 A CN106692185 A CN 106692185A
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- preparation
- iodine
- pyridine
- chlorine
- nonionic surfactant
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a preparation method of a medical disinfectant. The preparation method comprises the following specific steps: adding iodine, chlorohexidine and polyhexamethylene guanidine into a nonionic surfactant; heating and mixing at the temperature of 40 to 60 DEG C for 1 to 3 hours; then, adding a penetrating agent and phosphoric acid; lastly, adding water to a sufficient amount to obtain the disinfectant.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of preparation method of medical disinfectant.
Background technology
It is white that chlorhexidine acetate is regarded as middle effect thimerosal, but chlorhexidine acetate in the world already
Or almost in white crystalline powder, its indissoluble or water is slightly soluble in, it is dissolved only in alcohol or similar to alcohol
Alcoholic solution, therefore the thimerosal containing chlorhexidine acetate generally contains alcohol or the alcohol similar to alcohol
Solution, it is well known that if the thimerosal with alcohol or similar to alcohol is sprayed directly on into the viscous of human body
On film or skin, the skin surface for especially suppurating or festering can produce stimulation to mucous membrane or skin,
The purposes of thimerosal is thus limited in varying degrees.
Chinese invention patent ZL97108543.9 discloses " a kind of antibiotic bactericide and its production technology ",
The antibiotic bactericide is made up of chlorhexidine acetate, ethanol, glycerine and OP emulsifying agents, although it is killed
Bacterium effect is obvious, but it contains ethanol and glycerine, therefore the intense stimulus having to skin.
Chinese invention patent ZL02126050.8 discloses " skin sterilizing agent before operation ", the disinfectant by
Chlorhexidine acetate, benzalkonium bromide, glycerine, NPE and distilled water are formulated,
Although substantially, it contains glycerine to its bactericidal effect, therefore has strong impulse to skin.
Goal of the invention of the invention is to overcome drawbacks described above, and provides a kind of nontoxic to human body, non-stimulated
Disinfection sanitizer, disinfection sanitizer manufacture method of property and application thereof.
The content of the invention
Goal of the invention：It is medical the invention provides one kind for technical problem present in prior art
The preparation method of disinfectant.
Technical scheme：The invention provides a kind of preparation method of medical disinfectant, specifically by iodine,
Chlorine pyridine, polyhexamethylene guanide are added in nonionic surfactant, and mixing is heated at 40~60 DEG C
1~3h, is subsequently adding bleeding agent, phosphoric acid, finally adds water to enough, obtains final product disinfectant.
Nonionic surfactant can be fatty liquor-saturated APEO, APES, fat
Fat acid polyethylene glycol ester, aliphatic amine polyoxyethylene ether, Tween 80 or sorbester p17.
Bleeding agent can be azone, propane diols or dimethyl sulfoxide (DMSO).
The pyridine of iodine and chlorine is bactericide；Polyhexamethylene guanide is antibacterial agent；Non-ionic surface active
Agent has synergy together with the pyridine of iodine, chlorine and polyhexamethylene guanide；Phosphoric acid is used to adjust ph values and makes to disappear
Ph=5~7.5 of toxic agent.
Each component proportion by weight scope is：Iodine 0.1~5, chlorine pyridine 0.1~4, polyhexamethylene guanide
0.05~1, nonionic surfactant 2~30, bleeding agent 0.1~1, phosphoric acid 0.2~0.8, water 60~95.
Beneficial effect：This product formula is constituted and preparation method is unique, and each component has synergy, disappears
Toxic agent wide sterilization spectrum, quick-acting, special efficacy sterilizing ability is up to more than 6h, and penetration is strong, is difficult to make micro-
Biology develops immunity to drugs, to bacterial propagule Escherichia coli, staphylococcus aureus, Candida albicans,
Pseudomonas aeruginosa and fungi etc. have extremely strong killing action.
This product stability is high, is valid up to 3 years, and with good dispersion on the skin and on mucous membrane,
The advantages of tending to smear out, permeate rapid, fast, not colored, easy cleaning of volatilizing, iodine need not be taken off, it is nontoxic
Side effect and excitant, it is safe and reliable.
Specific embodiment：
Embodiment 1
By in the pyridine of iodine, chlorine, polyhexamethylene guanide addition nonionic surfactant, add at 60 DEG C
Hot mixing 3h, is subsequently adding bleeding agent, phosphoric acid, finally adds water to enough, obtains final product disinfectant.
Nonionic surfactant can be fatty liquor-saturated APEO.Bleeding agent can be azone.Iodine
It is bactericide with chlorine pyridine；Polyhexamethylene guanide is antibacterial agent；Nonionic surfactant and iodine,
Chlorine pyridine and polyhexamethylene guanide have synergy together；Phosphoric acid is used to adjust ph values makes disinfectant
Ph=7.5.Each component proportion by weight scope is：Iodine 5, chlorine pyridine 4, polyhexamethylene guanide 1 is non-
Ionic surface active agent 30, bleeding agent 1, phosphoric acid 0.8, water 95.
Embodiment 2
By in the pyridine of iodine, chlorine, polyhexamethylene guanide addition nonionic surfactant, add at 60 DEG C
Hot mixing 3h, is subsequently adding bleeding agent, phosphoric acid, finally adds water to enough, obtains final product disinfectant.
Nonionic surfactant can be APES.Bleeding agent can be propane diols.
The pyridine of iodine and chlorine is bactericide；Polyhexamethylene guanide is antibacterial agent；Nonionic surfactant with
The pyridine of iodine, chlorine and polyhexamethylene guanide have synergy together；Phosphoric acid is used to adjust ph values makes disinfectant
Ph=7.5.Each component proportion by weight scope is：Iodine 5, chlorine pyridine 4, polyhexamethylene guanide 1,
Nonionic surfactant 30, bleeding agent 1, phosphoric acid 0.8, water 95.
Embodiment 3
By the pyridine of iodine, chlorine, polyhexamethylene guanide add nonionic surfactant in, at 40~60 DEG C
Heating 1~3h of mixing, is subsequently adding bleeding agent, phosphoric acid, finally adds water to enough, obtains final product disinfectant.
Nonionic surfactant can be sorbester p17.Bleeding agent can be dimethyl sulfoxide (DMSO).Iodine and chlorine
Pyridine is bactericide；Polyhexamethylene guanide is antibacterial agent；Nonionic surfactant and iodine, chlorine
Pyridine and polyhexamethylene guanide have synergy together；Phosphoric acid is used to adjust ph values makes disinfectant
Ph=5.Each component proportion by weight scope is：Iodine 0.1, chlorine pyridine 0.1, polyhexamethylene guanide 0.05,
Nonionic surfactant 30, bleeding agent 0.1, phosphoric acid 0.2, water 60.
Embodiment 4
By the pyridine of iodine, chlorine, polyhexamethylene guanide add nonionic surfactant in, at 40~60 DEG C
Heating 1~3h of mixing, is subsequently adding bleeding agent, phosphoric acid, finally adds water to enough, obtains final product disinfectant.
Nonionic surfactant can be APES.Bleeding agent can be sub- dimethyl
Sulfone.The pyridine of iodine and chlorine is bactericide；Polyhexamethylene guanide is antibacterial agent；Non-ionic surface active
Agent has synergy together with the pyridine of iodine, chlorine and polyhexamethylene guanide；Phosphoric acid is used to adjust ph values and makes to disappear
The ph=5 of toxic agent.Each component proportion by weight scope is：Iodine 0.1, chlorine pyridine 0.1, polyhexamethylene
Guanidine 0.05, nonionic surfactant 30, bleeding agent 0.1, phosphoric acid 0.2, water 60.
Claims (5)
1. a kind of preparation method of medical disinfectant, it is characterised in that by the pyridine of iodine, chlorine, poly- six methylene
Base guanidine is added in nonionic surfactant, and 1~3h of mixing is heated at 40~60 DEG C, is subsequently adding and is oozed
Saturating agent, phosphoric acid, finally add water to enough, obtain final product disinfectant.
2. the preparation method of medical disinfectant according to claim 1, it is characterised in that nonionic
Surfactant can be fatty liquor-saturated APEO, APES, fatty acid polyglycol second two
Alcohol ester, aliphatic amine polyoxyethylene ether, Tween 80 or sorbester p17.
3. the preparation method of medical disinfectant according to claim 1, it is characterised in that bleeding agent
Can be azone, propane diols or dimethyl sulfoxide (DMSO).
4. the preparation method of medical disinfectant according to claim 1, it is characterised in that iodine and chlorine
Pyridine is bactericide；Polyhexamethylene guanide is antibacterial agent；Nonionic surfactant and iodine, chlorine
Pyridine and polyhexamethylene guanide have synergy together；Phosphoric acid is used to adjust ph values makes disinfectant
Ph=5~7.5.
5. the preparation method of medical disinfectant according to claim 1, it is characterised in that each component
Proportion by weight scope is：Iodine 0.1~5, chlorine pyridine 0.1~4, polyhexamethylene guanide 0.05~1, it is non-from
Sub- surfactant 2~30, bleeding agent 0.1~1, phosphoric acid 0.2~0.8, water 60~95.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510796847.XA CN106692185A (en) | 2015-11-18 | 2015-11-18 | Preparation method of medical disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510796847.XA CN106692185A (en) | 2015-11-18 | 2015-11-18 | Preparation method of medical disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106692185A true CN106692185A (en) | 2017-05-24 |
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ID=58933577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510796847.XA Pending CN106692185A (en) | 2015-11-18 | 2015-11-18 | Preparation method of medical disinfectant |
Country Status (1)
| Country | Link |
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| CN (1) | CN106692185A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908170A (en) * | 2019-04-16 | 2019-06-21 | 山东名德医疗科技有限公司 | Your novel happy iodine skin mucosa disinfectant of one kind and preparation method thereof |
| CN114831130A (en) * | 2022-06-02 | 2022-08-02 | 山东志存科技有限公司 | Synthesis and preparation method of special sanitizer for underwear |
-
2015
- 2015-11-18 CN CN201510796847.XA patent/CN106692185A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908170A (en) * | 2019-04-16 | 2019-06-21 | 山东名德医疗科技有限公司 | Your novel happy iodine skin mucosa disinfectant of one kind and preparation method thereof |
| CN114831130A (en) * | 2022-06-02 | 2022-08-02 | 山东志存科技有限公司 | Synthesis and preparation method of special sanitizer for underwear |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170524 |
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| WD01 | Invention patent application deemed withdrawn after publication |