CN107412213B

CN107412213B - Multifunctional external antibacterial and sterilizing agent and preparation method thereof

Info

Publication number: CN107412213B
Application number: CN201710527810.6A
Authority: CN
Inventors: 符李凯
Original assignee: Shenzhen Haiwen Deep Biological Technology Co Ltd
Current assignee: Shenzhen Haiwen Deep Biological Technology Co Ltd
Priority date: 2017-06-30
Filing date: 2017-06-30
Publication date: 2020-03-17
Anticipated expiration: 2037-06-30
Also published as: CN107412213A

Abstract

A multifunctional external antibacterial sterilizing medicament and a preparation method thereof, wherein the medicament comprises the following components in parts by weight; benzalkonium chloride 0.05-0.2%; 0.05-2% of organosilicon quaternary ammonium salt ([3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride); 97.8 to 99.9 percent of water. The bactericide provided by the invention has the characteristics of physical sterilization and long-acting bacteriostasis, can kill bacteria and fungi such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and the like in a broad spectrum manner, and has a good sterilization effect; can prevent diseases caused by bacterial infection; can not cause the drug resistance of the bacteria. The bactericide adopts deionized water, does not contain alcohol, and increases the safety of the product; the preparation method of the bactericide has the advantages of simple operation, low consumption cost, high preparation speed and the like.

Description

Multifunctional external antibacterial and sterilizing agent and preparation method thereof

Technical Field

The invention relates to the field of external antibacterial and bacteriostatic sanitary articles, in particular to a multifunctional external antibacterial sterilizing agent adopting a physical sterilization technology and a preparation method thereof.

Background

Pathogenic microorganisms can threaten or damage human skin or articles at all times. Therefore, research on high-quality sterilization and antibacterial products is needed to kill germs and protect human health; meanwhile, the excellent antibacterial product can also protect other animals or articles from being damaged by germs.

However, the existing antibacterial and bactericidal products have the following defects:

(1) poor antibacterial and bactericidal effects, long effective antibacterial and bactericidal time, slow sterilization speed and the like;

(2) the existing external antibacterial sterilization products may cause antibiotic-resistant bacteria to appear.

Disclosure of Invention

In order to overcome the defects of the prior art, one of the purposes of the invention is to provide a multifunctional external antibacterial sterilization medicament, which is prepared by reasonably proportioning benzalkonium chloride, organosilicon quaternary ammonium salt and water, has the advantages of physical sterilization property, good sterilization effect, long bacteriostasis time, capability of killing bacteria and fungi such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and the like in a broad spectrum manner, and good sterilization effect; can prevent diseases caused by bacterial infection; can not cause the drug resistance of the bacteria. The bactericide adopts deionized water, does not contain alcohol, and increases the safety of the product.

The second object of the present invention is to provide a process for producing the above-mentioned pharmaceutical preparation.

One of the purposes of the invention is realized by adopting the following technical scheme:

a multifunctional external antibacterial sterilizing agent comprises the following components in parts by weight; benzalkonium chloride 0.05-0.2%; 0.05-2% of organosilicon quaternary ammonium salt ([3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride); 97.8 to 99.9 percent of water. The [3- (trihydroxysilyl) Propyl ] dimethyloctadecyl ammonium chloride is also 3- (trihydroxysilyl) Propyl dimethyloctadececyl ammonium chloride.

Further, the water is deionized water.

Furthermore, the organosilicon quaternary ammonium salt ([3- (trihydroxysilyl) propyl ] dimethyl octadecyl ammonium chloride) can be dissolved in deionized water after precision processing.

Further, the composition comprises the following components in parts by weight; benzalkonium chloride 0.05%; 0.05 percent of organosilicon quaternary ammonium salt ([3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride); 99.9 percent of water.

Further, the composition comprises the following components in parts by weight; 0.2% of benzalkonium chloride; 2% of organosilicon quaternary ammonium salt ([3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride); and (7) water.

Further, the composition comprises the following components in parts by weight; 0.1% of benzalkonium chloride; 0.2 percent of organosilicon quaternary ammonium salt ([3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride); 99.7 percent of water.

The invention also provides a preparation method of the multifunctional external antibacterial sterilizing medicament, which comprises the steps of simultaneously adding benzalkonium chloride and organosilicon quaternary ammonium salt into water with the temperature of 40-60 ℃, keeping the temperature of the water and uniformly stirring for 60-120 minutes; obtain the functional external antibacterial sterilizing agent.

Further, the water is deionized water.

Further, the temperature of the water is 50 ℃.

Further, the stirring time period is 90 minutes.

Compared with the prior art, the invention has the beneficial effects that:

the invention provides a multifunctional external antibacterial bactericide, which is a solvent type liquid consisting of benzalkonium chloride, organosilicon quaternary ammonium salt ([3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride) and deionized water. The medicament can be taken in the forms of spraying, foaming and the like, and can quickly kill bacteria and fungi such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and the like; preventing diseases caused by bacterial infection. More importantly, after the product is sprayed on various articles contacted with the skin once, the antibacterial deodorant can keep the functions of antibiosis, bacteriostasis and deodorization for a long time.

The preparation has the advantages of safety, no toxicity, no alcohol, etc. The invention also provides a preparation method of the medicament, and the method has the advantages of simple operation, low consumption cost, high preparation speed and the like.

The product can effectively avoid cross infection and can not generate drug resistance. The preparation has the advantages of safety, no toxicity, no alcohol, etc. The product provided by the invention does not affect the physiological function, metabolic function and immune function of the skin of human body and animals.

Detailed Description

The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.

Example 1

A multifunctional external antibacterial sterilizing agent comprises the following components in parts by weight; benzalkonium chloride, 0.05%; 0.05 percent of organosilicon quaternary ammonium salt; deionized water, 99%. As a preferred embodiment, the silicone quaternary ammonium salt is [3- (trihydroxysilyl) propyl ] dimethyloctadecyl ammonium chloride.

The functional external antibacterial disinfectant of the present example was prepared as follows: adding benzalkonium chloride and organosilicon quaternary ammonium salt into water of 40 ℃ at the same time, keeping the temperature of the water and stirring uniformly for 60 minutes; obtain the functional external antibacterial sterilizing agent.

Example 2

A multifunctional external antibacterial sterilizing agent comprises the following components in parts by weight; benzalkonium chloride, 0.2%; 2% of organosilicon quaternary ammonium salt; deionized water, 97.8%. As a preferred embodiment, the silicone quaternary ammonium salt is [3- (trihydroxysilyl) propyl ] dimethyloctadecyl ammonium chloride.

The functional external antibacterial disinfectant of the present example was prepared as follows: adding benzalkonium chloride and organosilicon quaternary ammonium salt into water of 60 ℃ at the same time, keeping the temperature of the water and stirring uniformly for 90 minutes; obtain the functional external antibacterial sterilizing agent.

Example 3

A multifunctional external antibacterial sterilizing agent further comprises the following components in parts by weight; benzalkonium chloride, 0.1%; 0.2 percent of organosilicon quaternary ammonium salt; deionized water, 99.7%; the organic silicon quaternary ammonium salt is [3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride.

The functional external antibacterial disinfectant of the present example was prepared as follows: adding the benzalkonium chloride and the organosilicon quaternary ammonium salt into water of 50 ℃ at the same time, keeping the temperature of the water and stirring uniformly for 120 minutes; obtain the functional external antibacterial sterilizing agent.

Verification examples

The agents described in examples 1 to 3 were used for the bactericidal effect test. The specific operation is as follows: diluting Escherichia coli with OD value of 1.5 to OD value of 0.1; spreading 20 microliters of the diluted bacterial liquid on a solid culture medium, and culturing for 3 hours at 37 ℃; the plate was removed, labeled, and 20. mu.l of physiological saline was applied to the plate as a control group, and the agents of examples 1 to 3 were applied to the plate as an experimental group; after plating, the culture was continued overnight and bacterial colonies were counted, and the results are shown in Table 1 below (in the table, "-" indicates no data). The results show that the invention has significant bactericidal effect compared with the control group, and secondly, the technical effect of the embodiment 3 is optimal in the scheme of the three embodiments.

TABLE 1 data of bactericidal effect

Group of	Number of colonies	Killing logarithm value
			Control group	8.50*10⁵	-
Example 1	110	3.87
			Example 2	89	3.98
Example 3	54	4.00

The product passes the inspection of national sanitation treatment safety and applicability inspection key laboratories of Guangzhou entry and exit inspection and quarantine bureau comprehensive inspection center, and the inspection report has the inspection number of 21201600859. In this test, the test items are as follows: appearance; the pH value; detecting the content of lead, arsenic and mercury; detecting microbiological indexes; coli, staphylococcus aureus and pseudomonas aeruginosa killing tests; candida albicans killing test; simulating a field disinfection test (stock table); multiple skin irritation tests; acute oral toxicity test; acute eye irritation test; a primary damaged skin irritation test; vaginal mucosa irritation test. The above project detection meets the relevant standard regulation of the country. Therefore, the invention provides an antibacterial and sterilizing agent which has an obvious sterilizing effect and is non-toxic and harmless to human bodies.

The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.

Claims

1. The multifunctional external antibacterial sterilizing agent is characterized by comprising the following components in parts by weight: benzalkonium chloride 0.05-0.2%; 0.05 to 2 percent of organosilicon quaternary ammonium salt; 97.8 to 99.9 percent of deionized water; the organic silicon quaternary ammonium salt is [3- (trihydroxy silicon base) propyl ] dimethyl octadecyl ammonium chloride;

the preparation method of the multifunctional external antibacterial sterilizing agent comprises the following steps: adding benzalkonium chloride and organosilicon quaternary ammonium salt in a formula amount into deionized water at the temperature of 40-60 ℃, and uniformly stirring for 60-120 minutes while keeping the temperature of the deionized water; obtaining the multifunctional external antibacterial sterilizing agent.

2. The multifunctional external antibacterial disinfectant as claimed in claim 1, which comprises the following components in parts by weight: benzalkonium chloride 0.05%; 0.05 percent of organosilicon quaternary ammonium salt; and 99.9 percent of deionized water.

3. The multifunctional external antibacterial disinfectant as claimed in claim 1, which comprises the following components in parts by weight: 0.2% of benzalkonium chloride; 2% of organosilicon quaternary ammonium salt; 97.8 percent of deionized water.

4. The multifunctional external antibacterial disinfectant as claimed in claim 1, which comprises the following components in parts by weight: 0.1% of benzalkonium chloride; 0.2 percent of organosilicon quaternary ammonium salt; and 99.7% of deionized water.

5. The multifunctional topical antimicrobial and antiseptic agent of claim 1 wherein the deionized water has a temperature of 50 ℃.

6. The multifunctional topical antibacterial agent according to claim 1, wherein the stirring time is 90 minutes in length.