CN108605976A - A kind of antiseptic for inhibiting and killing germ - Google Patents
A kind of antiseptic for inhibiting and killing germ Download PDFInfo
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- CN108605976A CN108605976A CN201810618316.5A CN201810618316A CN108605976A CN 108605976 A CN108605976 A CN 108605976A CN 201810618316 A CN201810618316 A CN 201810618316A CN 108605976 A CN108605976 A CN 108605976A
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- antiseptic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of applications of ammonia borine, have the feature that：The antiseptic contains ammonia borine.Germ includes Escherichia coli, staphylococcus aureus and Candida albicans.The dosage form of antiseptic is external-applied ointment, liquid preparation for external use, oral tablets, oral solution, disinfectant, detergent or improver of water quality.Further include auxiliary material, auxiliary material is one or more in water, thickener and filler.When the dosage form of antiseptic is liquid preparation for external use, the content range of ammonia borine is 1 μ g/mL 1mg/mL.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of antiseptic for inhibiting and killing germ.
Background technology
With the increase of world population, all kinds of diseases caused by bacterium and pathogenic microorganisms are also more prone to be passed
It broadcasts, for the disease of this kind of various bacterium infections or pathogenic microorganism infection class, treatment means primarily now are to use antibiosis
Element, and increasing with population, the expansion of the spread scope of disease, also result in being widely used for antibiotic, germ for
The drug resistance of antibiotic also gradually shows, or even the superbacteria of multi-drug resistant occurs, needs constantly to research and develop novel antibacterial
Agent slows down the generation of germ drug resistance, therefore finds and prepare simple, effective, wide spectrum antibacterial agent and have important meaning
Justice.
Invention content
The present invention is to carry out to solve the above-mentioned problems, and it is an object of the present invention to provide a kind of for inhibiting and killing germ
Antiseptic.
The present invention provides a kind of antiseptics for inhibiting and killing germ, have the feature that：The antiseptic contains
There is ammonia borine.
In a kind of antiseptic for inhibiting and killing germ provided by the invention, can also have the feature that：Its
In, germ includes Escherichia coli, staphylococcus aureus and Candida albicans.
In a kind of antiseptic for inhibiting and killing germ provided by the invention, can also have the feature that：Its
In, the dosage form of antiseptic is that external-applied ointment, liquid preparation for external use, oral tablets, oral solution, disinfectant, detergent or water quality change
Good dose.
In a kind of antiseptic for inhibiting and killing germ provided by the invention, can also have the feature that：Also
Including auxiliary material, which is one or more in water, thickener and filler.
In a kind of antiseptic for inhibiting and killing germ provided by the invention, can also have the feature that：Its
In, when the dosage form of antiseptic is liquid preparation for external use, the content range of ammonia borine is 1 μ g/mL-1mg/mL.
The effect of invention
According to a kind of antiseptic for inhibiting and killing germ according to the present invention, because ammonia borine has been used to prepare
Antiseptic, so the problem of not having drug resistance at this stage.Because preparing for ammonia borine is simple, production cost is low and can lead to
It crosses addition auxiliary material and a variety of antimicrobial products is made, so the antiseptic prepared is at low cost, has a wide range of application, can promote the use of.Cause
Nontoxic, pollution-free for ammonia borine, so the antiseptic effect on environment prepared is small, toxic side effect is small.Because using ammonia borine system
Standby antiseptic can be used in inhibiting and killing Escherichia coli, staphylococcus aureus and Candida albicans, so prepare
Antiseptic has broad-spectrum antibacterial property, applicability wide.Therefore, a kind of antiseptic for inhibiting and killing germ of the invention, it is raw
At low cost, good anti-bacterial effect is produced, applicability is wide.
Specific implementation mode
In order to which the technological means for making the present invention realize is easy to understand with effect, the present invention is made with reference to embodiments
It is specifically described.
A kind of antiseptic for inhibiting and killing germ has the feature that：The antiseptic contains ammonia borine.
Germ includes Escherichia coli, staphylococcus aureus and Candida albicans and other pathogenic microorganisms.
The dosage form of antiseptic is external-applied ointment, liquid preparation for external use, oral tablets, oral solution, disinfectant, detergent or water
Quality improving agent.
Further include auxiliary material, which is one or more in water, thickener and filler.
When the dosage form of antiseptic is liquid preparation for external use, the content range of ammonia borine is 1 μ g/mL-1mg/mL.
Embodiment one：
In 12 orifice plates, is diluted according to 2 times, the ammonia Borane solution of a concentration of 10mg/ml is diluted to concentration with culture solution
Respectively 5000 μ g/mL, 2500 μ g/mL, 1250 μ g/mL, 625 μ g/mL, 312.5 μ g/mL, 156.3 μ g/mL, 78.1 μ g/
ML, 39.1 μ g/mL, 19.5 μ g/mL, the solution of 9.8 μ g/mL, 4.9 μ g/mL are placed in 11 holes, and last 1 hole is only added
Culture solution is added 10 as control in all holes6The Escherichia coli bacteria liquid of cfu/mL, after being cultivated for 24 hours at 37 DEG C, according to solution
Concentration observes 12 orifice plates successively from low to high, observes to first and keeps limpid hole, the ammonia Borane solution corresponding to the hole dense
Degree is minimum inhibitory concentration, to all sequences of the hole for keeping limpid according to solution concentration from low to high that remain unchanged, is drawn per hole
100 μ L solution and spread plate, then after being cultivated for 24 hours at 37 DEG C, observe tablet successively from low to high according to solution concentration, observe
To the tablet of first not long bacterium, the ammonia Borane solution concentration corresponding to the tablet is minimum bactericidal concentration.
The experimental results showed that ammonia borine is 39.1 μ g/mL to the minimum inhibitory concentration of Escherichia coli, minimum bactericidal concentration is
156.3μg/mL。
Embodiment two：
In 12 orifice plates, is diluted according to 2 times, the ammonia Borane solution of a concentration of 10mg/ml is diluted to concentration with culture solution
Respectively 5000,5000 μ g/mL, 2500 μ g/mL, 1250 μ g/mL, 625 μ g/mL, 312.5 μ g/mL, 156.3 μ g/mL, 78.1
μ g/mL, 39.1 μ g/mL, 19.5 μ g/mL, the solution of 9.8 μ g/mL, 4.9 μ g/mL are placed in 11 holes, and last 1 hole only adds
Enter culture solution as control, 10 are added in all holes6The staphylococcus aureus bacterium solution of cfu/mL, at 37 DEG C, culture for 24 hours, is cultivated
After for 24 hours, 12 orifice plates are observed successively from low to high according to solution concentration, observes to first and keeps limpid hole, corresponding to the hole
Ammonia Borane solution concentration be minimum inhibitory concentration, to it is all still keep limpid holes according to solution concentration from low to high
Sequentially, 100 μ L solution and spread plate are drawn per hole, then after being cultivated for 24 hours at 37 DEG C, according to solution concentration from low to high according to
Secondary observation tablet is observed to the tablet of first not long bacterium, and the ammonia Borane solution concentration corresponding to the tablet is minimum bactericidal
Concentration.
The experimental results showed that ammonia borine is 9.8 μ g/mL, minimum bactericidal to the minimum inhibitory concentration of staphylococcus aureus
A concentration of 78.1 μ g/mL.
Embodiment three：
In 12 orifice plates, is diluted according to 2 times, the ammonia Borane solution of a concentration of 10mg/ml is diluted to concentration with culture solution
Respectively 5000 μ g/mL, 2500 μ g/mL, 1250 μ g/mL, 625 μ g/mL, 312.5 μ g/mL, 156.3 μ g/mL, 78.1 μ g/mL,
39.1 μ g/mL, 19.5 μ g/mL, the solution of 9.8 μ g/mL, 4.9 μ g/mL are placed in 11 holes, and culture is only added in last 1 hole
Liquid is added 10 as control in all holes5The Candida albicans bacterium solution of cfu/mL cultivates 48h at 28 DEG C, after cultivating 48h, presses
12 orifice plates are observed successively from low to high according to solution concentration, are observed to first and are kept limpid hole, the ammonia borine corresponding to the hole
Solution concentration is minimum inhibitory concentration, to all sequences of the hole for keeping limpid according to solution concentration from low to high that remain unchanged, often
100 μ L solution and spread plate are drawn in hole, then at 28 DEG C after culture 48h, and according to solution concentration, observation is flat successively from low to high
Plate is observed to the tablet of first not long bacterium, and the ammonia Borane solution concentration corresponding to the tablet is minimum bactericidal concentration.
The experimental results showed that ammonia borine is 78.1 μ g/mL, minimum bactericidal concentration to the minimum inhibitory concentration of Candida albicans
For 625 μ g/mL.
The effect of embodiment
According to embodiment one it is found that when ammonia borane concentration reaches 39.1 μ g/mL bacteriostasis can be generated to Escherichia coli,
It can reach the bactericidal effect to Escherichia coli when ammonia borane concentration reaches 156.3 μ g/mL.
According to embodiment two it is found that when ammonia borane concentration reaches 9.8 μ g/mL suppression can be generated to staphylococcus aureus
Bacterium acts on, and can reach bactericidal effect to staphylococcus aureus when ammonia borane concentration reaches 78.1 μ g/mL.
According to embodiment three it is found that can be generated to Candida albicans when ammonia borane concentration reaches 78.1 μ g/mL antibacterial
Effect, when ammonia borane concentration reaches the bactericidal effect that 625 μ g/mL can reach dialogue color candida albicans.
Therefore according to embodiment one to embodiment three it is found that ammonia borine can to Escherichia coli, staphylococcus aureus and
Candida albicans plays inhibition and killing effect, in addition, can be prepared pair according to the different antibacterial demands under different scenes
The antiseptic for answering the ammonia borine of concentration prepares material so as to save, and saves production cost, and reaching effective antibacterial effect
While fruit, additionally it is possible to reduce the negative effect to environment and the toxic side effect to human body.
Therefore, a kind of antiseptic for inhibiting and killing germ of the invention, production cost is low, good anti-bacterial effect, fits
It is wide with property.
The above embodiment is the preferred case of the present invention, is not intended to limit protection scope of the present invention.
Claims (5)
1. a kind of antiseptic for inhibiting and killing germ, it is characterised in that：
The antiseptic contains ammonia borine.
2. antiseptic according to claim 1, it is characterised in that：
Wherein, the germ includes Escherichia coli, staphylococcus aureus and Candida albicans.
3. antiseptic according to claim 1, it is characterised in that：
Wherein, the dosage form of the antiseptic is external-applied ointment, liquid preparation for external use, oral tablets, oral solution, disinfectant, cleaning
Agent or improver of water quality.
4. antiseptic according to claim 1, which is characterized in that further include：
Auxiliary material, the auxiliary material are one or more in water, thickener and filler.
5. antiseptic according to claim 1, it is characterised in that：
Wherein, when the dosage form of the antiseptic is liquid preparation for external use, the content range of the ammonia borine is 1 μ g/mL-1mg/
mL。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810618316.5A CN108605976B (en) | 2018-06-15 | 2018-06-15 | Antibacterial agent for inhibiting and killing bacteria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810618316.5A CN108605976B (en) | 2018-06-15 | 2018-06-15 | Antibacterial agent for inhibiting and killing bacteria |
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| Publication Number | Publication Date |
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| CN108605976A true CN108605976A (en) | 2018-10-02 |
| CN108605976B CN108605976B (en) | 2021-05-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810618316.5A Active CN108605976B (en) | 2018-06-15 | 2018-06-15 | Antibacterial agent for inhibiting and killing bacteria |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111153382A (en) * | 2020-01-07 | 2020-05-15 | 北京化工大学 | Hydrogen sustained release agent containing ammonia borane and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101309693A (en) * | 2005-09-13 | 2008-11-19 | 耶路撒冷希伯来大学伊森姆研究发展公司 | Use of amine-borane compounds as anti-microbial agents |
-
2018
- 2018-06-15 CN CN201810618316.5A patent/CN108605976B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101309693A (en) * | 2005-09-13 | 2008-11-19 | 耶路撒冷希伯来大学伊森姆研究发展公司 | Use of amine-borane compounds as anti-microbial agents |
Non-Patent Citations (1)
| Title |
|---|
| 桑琬璐等: "氨硼烷水解制氢催化剂载体的研究进展", 《材料导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111153382A (en) * | 2020-01-07 | 2020-05-15 | 北京化工大学 | Hydrogen sustained release agent containing ammonia borane and application thereof |
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| Publication number | Publication date |
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| CN108605976B (en) | 2021-05-11 |
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