CN105535015A - Polyhexamethylen guanidine hydrochloride itching-relieving water spray and preparation method thereof - Google Patents
Polyhexamethylen guanidine hydrochloride itching-relieving water spray and preparation method thereof Download PDFInfo
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- CN105535015A CN105535015A CN201610001654.5A CN201610001654A CN105535015A CN 105535015 A CN105535015 A CN 105535015A CN 201610001654 A CN201610001654 A CN 201610001654A CN 105535015 A CN105535015 A CN 105535015A
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- itching
- water spray
- pure water
- polyhexamethylen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
Abstract
The invention discloses a polyhexamethylen guanidine hydrochloride itching-relieving water spray. The polyhexamethylen guanidine hydrochloride itching-relieving water spray is prepared from, polyhexamethylen guanidine hydrochloride 0.3%-0.5%, synergist 1%, azone 2%, water-soluble vitamin E 0.05%-1%, polyethylene glycol 1%-10% and purified water 85.5%-95.65%. The polyhexamethylen guanidine hydrochloride itching-relieving water spray has the advantages that the principle that traditional itching-relieving water products relieve itching through nerve paralysis is changed, and the polyhexamethylen guanidine hydrochloride is adopted, so that the itching-relieving water spray is non-toxic, rapidly achieves sterilization and itching, does not cause skin and wound irritation and does not cause skin drying and the like after being used.
Description
Technical field
The present invention relates to a kind of Polyhaxemethylenguanidine Hydrochloride antipruritic water spray and preparation method thereof.
Background technology
In the most area of south China, because weather is damp and hot, people easily suffer from the dermatosis of various pruritus class, particularly in rural area, due to outdoor study, and the living environment of friend peasant and hygienic conditions poor, easily suffer from all kinds of dermatosis especially and cross infection, some dermatosiss are very itched incomparably, patient scratches unbearably, cause aggravation, patient suffering can't bear, and has had a strong impact on work, study and rest.Mostly to be paralysis neural for antipruritic water in the market, and as ethanol, diphhydramine hydrochloride, benzocaine, part is poisonous, and chafe and wound, particularly for child.
For the Related Technical Issues existed in prior art, at present effective solution is not yet proposed.
Summary of the invention
The object of this invention is to provide a kind of Polyhaxemethylenguanidine Hydrochloride antipruritic water spray and preparation method thereof, to overcome currently available technology above shortcomings.
The object of the invention is to be achieved through the following technical solutions:
A kind of Polyhaxemethylenguanidine Hydrochloride antipruritic water spray, to be made up of and the raw material of proportioning is made following: Polyhaxemethylenguanidine Hydrochloride accounts for 0.3%-0.5%, synergist accounts for 1%, azone accounts for 2%, water soluble vitamin E accounts for 0.05%-1%, Polyethylene Glycol accounts for 1%-10%, pure water accounts for 85.5%-95.65%.
Further, described Polyethylene Glycol is PEG400.
A preparation method for Polyhaxemethylenguanidine Hydrochloride antipruritic water spray, comprises the following steps:
S1, first taking-up 5%-10% pure water, be added to the Polyhaxemethylenguanidine Hydrochloride of said ratio and synergist in this pure water, and stir 15 minutes, makes it even, obtained solution A;
S2, take out 5%-10% pure water again, the Polyethylene Glycol of said ratio is joined in this pure water, fully stir 20 minutes, make it even, obtained clear solution B;
S3, according to preset ratio, stir condition under, in remaining pure water, add 2% azone, 0.05%-1% water soluble vitamin E, solution A, clear solution B successively, make it be uniformly mixed.
Beneficial effect of the present invention is: the present invention changes traditional antipruritic water product and carries out antipruritic principle by paralysis is neural, and adopt Polyhaxemethylenguanidine Hydrochloride, have nontoxic, quick sterilization is antipruritic, not chafe and wound, the feature such as use rear skin moist.
Detailed description of the invention
Be clearly and completely described the technical scheme in the embodiment of the present invention below, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain, all belongs to the scope of protection of the invention.
According to embodiments of the invention, provide a kind of Polyhaxemethylenguanidine Hydrochloride antipruritic water spray, to be made up of and the raw material of proportioning is made following: Polyhaxemethylenguanidine Hydrochloride accounts for 0.3%-0.5%, synergist accounts for 1%, azone accounts for 2%, water soluble vitamin E accounts for 0.05%-1%, Polyethylene Glycol accounts for 1%-10%, pure water accounts for 85.5%-95.65%.
Preferably, described Polyethylene Glycol is PEG400.
A preparation method for Polyhaxemethylenguanidine Hydrochloride antipruritic water spray, comprises the following steps:
S1, first taking-up 5%-10% pure water, be added to the Polyhaxemethylenguanidine Hydrochloride of said ratio and synergist in this pure water, and stir 15 minutes, makes it even, obtained solution A;
S2, take out 5%-10% pure water again, the Polyethylene Glycol of said ratio is joined in this pure water, fully stir 20 minutes, make it even, obtained clear solution B;
S3, according to preset ratio, stir condition under, in remaining pure water, add 2% azone, 0.05%-1% water soluble vitamin E, solution A, clear solution B successively, make it be uniformly mixed.
During embody rule:
Embodiment 1, provide a kind of Polyhaxemethylenguanidine Hydrochloride antipruritic water spray, to be made up of and the raw material of proportioning is made following: Polyhaxemethylenguanidine Hydrochloride accounts for 0.4%, synergist accounts for 1%, azone accounts for 2%, water soluble vitamin E accounts for 0.5%, Polyethylene Glycol accounts for 8%, pure water accounts for 88.1%.
A preparation method for Polyhaxemethylenguanidine Hydrochloride antipruritic water spray, comprises the following steps:
S1, first take out 8% pure water, the Polyhaxemethylenguanidine Hydrochloride of said ratio and synergist are added in this pure water, and stir 15 minutes, make it even, obtained solution A;
S2, take out 8% pure water again, the Polyethylene Glycol of said ratio is joined in this pure water, fully stir 20 minutes, make it even, obtained clear solution B;
S3, according to preset ratio, stir condition under, in the pure water of residue 72.1%, add 2% azone, 0.5% water soluble vitamin E, solution A, clear solution B successively, make it be uniformly mixed.
The splitting function of the effective anti-bacteria of product energy, fungus, virus, antibacterial, fungus, virus is made to lose reproductive performance, add the thin film that polymer is formed, plug the respiration channel of antibacterial, fungus, virus, antibacterial, fungus, virus are choked to death rapidly, its special sterilization mechanism, does not develop immunity to drugs to each bacterioid, fungus, virus, and bactericidal effect is not by the impact of antibacterial, fungus, virus variation.
The antipruritic water spray obtained by said method is changed traditional antipruritic water product and carries out antipruritic principle by paralysis is neural, adopt Polyhaxemethylenguanidine Hydrochloride, have nontoxic, quick sterilization is antipruritic, not chafe and wound, the feature such as use rear skin moist.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. a Polyhaxemethylenguanidine Hydrochloride antipruritic water spray, it is characterized in that, to be made up of and the raw material of proportioning is made following: Polyhaxemethylenguanidine Hydrochloride accounts for 0.3%-0.5%, synergist accounts for 1%, azone accounts for 2%, water soluble vitamin E accounts for 0.05%-1%, Polyethylene Glycol accounts for 1%-10%, pure water accounts for 85.5%-95.65%.
2. Polyhaxemethylenguanidine Hydrochloride antipruritic water spray as claimed in claim 1, it is characterized in that, described Polyethylene Glycol is PEG400.
3. the preparation method of Polyhaxemethylenguanidine Hydrochloride antipruritic water spray as claimed in claim 1, is characterized in that, comprise the following steps:
S1, first taking-up 5%-10% pure water, be added to the Polyhaxemethylenguanidine Hydrochloride of said ratio and synergist in this pure water, and stir 15 minutes, makes it even, obtained solution A;
S2, take out 5%-10% pure water again, the Polyethylene Glycol of said ratio is joined in this pure water, fully stir 20 minutes, make it even, obtained clear solution B;
S3, according to preset ratio, stir condition under, in remaining pure water, add 2% azone, 0.05%-1% water soluble vitamin E, solution A, clear solution B successively, make it be uniformly mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610001654.5A CN105535015A (en) | 2016-01-05 | 2016-01-05 | Polyhexamethylen guanidine hydrochloride itching-relieving water spray and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610001654.5A CN105535015A (en) | 2016-01-05 | 2016-01-05 | Polyhexamethylen guanidine hydrochloride itching-relieving water spray and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105535015A true CN105535015A (en) | 2016-05-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610001654.5A Pending CN105535015A (en) | 2016-01-05 | 2016-01-05 | Polyhexamethylen guanidine hydrochloride itching-relieving water spray and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN105535015A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111759805A (en) * | 2020-08-03 | 2020-10-13 | 山东莱博生物科技有限公司 | Oral and facial sterilizing and antiviral spray and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434799A (en) * | 2014-11-02 | 2015-03-25 | 卫国刚 | Polyhexamethylene guanidine spray and preparation method thereof |
| CN104523576A (en) * | 2014-12-31 | 2015-04-22 | 卫国刚 | Polyhexamethylene guanidine cream |
-
2016
- 2016-01-05 CN CN201610001654.5A patent/CN105535015A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434799A (en) * | 2014-11-02 | 2015-03-25 | 卫国刚 | Polyhexamethylene guanidine spray and preparation method thereof |
| CN104523576A (en) * | 2014-12-31 | 2015-04-22 | 卫国刚 | Polyhexamethylene guanidine cream |
Non-Patent Citations (1)
| Title |
|---|
| 李妮妮 等: "聚六亚甲基胍类消毒剂性能及应用研究进展", 《日用化学品科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111759805A (en) * | 2020-08-03 | 2020-10-13 | 山东莱博生物科技有限公司 | Oral and facial sterilizing and antiviral spray and preparation method and application thereof |
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20160504 |