CN106214760A - A kind of unguentum preventing and treating gynecological inflammation and preparation method thereof - Google Patents

A kind of unguentum preventing and treating gynecological inflammation and preparation method thereof Download PDF

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Publication number
CN106214760A
CN106214760A CN201610801828.6A CN201610801828A CN106214760A CN 106214760 A CN106214760 A CN 106214760A CN 201610801828 A CN201610801828 A CN 201610801828A CN 106214760 A CN106214760 A CN 106214760A
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unguentum
preventing
gynecological inflammation
treating gynecological
treating
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刘四军
张寿荣
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Guangdong Bian Que Valley Pharmaceutical Technology Co Ltd
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Guangdong Bian Que Valley Pharmaceutical Technology Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The present invention provides a kind of unguentum preventing and treating gynecological inflammation and preparation method thereof, and wherein, the unguentum of described preventing and treating gynecological inflammation is grouped into by the one-tenth of following mass percent: fluid extract 40 60%；Mixed-matrix 5 10%；Cosolvent 1 5%；Preservative 0.5 1.5%；Penetration enhancer 0.5 1.5%；Acid-base modifier 3 5%；Other are glycerol.Wherein, described fluid extract is by including that Herba Centellae, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, Flos Carthami, Flos Lonicerae, the Multiple components of Radix Cynanchi Atrati are prepared from.The local organization permeability that body dermatophytes is depended on for existence by described unguentum is the strongest, Stratum Corneum superficial part and deep fungal all have the most antibacterial, bactericidal action, multiple vaginal pathogenic had stronger bacteriostasis, and using described unguentum to treat gynecological inflammation, simple to operate, inflammation is difficult to recurrence, is prevented effectively from complication.

Description

A kind of unguentum preventing and treating gynecological inflammation and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of unguentum preventing and treating gynecological inflammation and preparation method thereof.
Background technology
Gynecological inflammation is the high morbidity in women population, and occurs in the women population at various age, married femle Sickness rate higher.Due to discomforts such as its special pruritus, causalgias, bring the biggest misery to patient.Existing preventing and treating woman The therapeutic effect of the medicine of section's inflammation is the best, is easily caused inflammation recurrence, and makes to control in the patient during treatment repeatedly Pathogenic bacteria gradually produces drug resistance to it, and even concurrently other antibacterial infects.
Therefore, prior art needs to improve further.
Summary of the invention
In view of the deficiencies in the prior art, the invention reside in unguentum and the system of the preventing and treating gynecological inflammation of a kind of good antimicrobial effect Preparation Method, it is intended to solve current gynecological inflammation medicine or method be difficult to radical curing of disease, inflammation recurrence relapse rate high and The problem having side effect.
Technical scheme is as follows:
A kind of unguentum preventing and treating gynecological inflammation, wherein, the described externally used paste composition by following mass percent preventing and treating hemorrhoid Composition:
Fluid extract 40-60%；
Mixed-matrix 5-10%；
Cosolvent 1-5%；
Preservative 0.5-1.5%；
Penetration enhancer 0.5-1.5%；
Acid-base modifier 3-5%；
Other are glycerol；
Wherein, described fluid extract by include the Herba Centellae of equal in quality, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, five times Son, Flos Carthami, Flos Lonicerae, the plurality of Chinese of Radix Cynanchi Atrati are prepared from.
The unguentum of described preventing and treating gynecological inflammation, wherein, described mixed-matrix is made up of carbomer and Polyethylene Glycol, described The mass ratio of carbomer and Polyethylene Glycol is 3:10.
The unguentum of described preventing and treating gynecological inflammation, wherein, described cosolvent is propylene glycol.
The unguentum of described preventing and treating gynecological inflammation, wherein, described preservative is ethylparaben.
The unguentum of described preventing and treating gynecological inflammation, wherein, described penetration enhancer is azone.
The unguentum of described preventing and treating gynecological inflammation, wherein, described acid-base modifier is triethanolamine.
The preparation method of the unguentum of a kind of preventing and treating gynecological inflammation as above, wherein, described preparation method is: weigh phase The snow grass of homogenous quantities, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, Flos Carthami, Flos Lonicerae, Radix Cynanchi Atrati mixing, To medicinal material mixture, boiling secondary, decoct 1h every time, the filtrate reduced in volume that will merge after filtration, obtain fluid extract；Will The fluid extract of respective quality percent, mixed-matrix, cosolvent, preservative, penetration enhancer, acid-base modifier mix, and are eventually adding Glycerol is allocated, and makes unguentum.
The preparation method of the described externally used paste preventing and treating hemorrhoid, wherein, in described decoction process, decoct for the first time adds The water yield is 12 times of medicinal material mixture quality, amount of water is medicinal material mixture quality 8 times of second time decoction.
Beneficial effect: the present invention provides a kind of unguentum preventing and treating gynecological inflammation and preparation method, and described unguentum is to body The local organization permeability that dermatophytes is depended on for existence is very strong, Stratum Corneum superficial part and deep fungal all have the most antibacterial, Bactericidal action, has stronger bacteriostasis, and uses described unguentum to treat gynecological inflammation, operation letter multiple vaginal pathogenic Single, inflammation is difficult to recurrence, is prevented effectively from complication.
Detailed description of the invention
The present invention provides a kind of unguentum preventing and treating gynecological inflammation and preparation method, for making the purpose of the present invention, technical side Case and effect are clearer, clear and definite, and the present invention is described in more detail below.Should be appreciated that concrete reality described herein Execute example only in order to explain the present invention, be not intended to limit the present invention.
A kind of unguentum preventing and treating gynecological inflammation, wherein, the described externally used paste of hemorrhoid of preventing and treating is by following mass percent One-tenth is grouped into:
Fluid extract 40-60%；
Mixed-matrix 5-10%；
Cosolvent 1-5%；
Preservative 0.5-1.5%；
Penetration enhancer 0.5-1.5%；
Acid-base modifier 3-5%；
Other are glycerol；
Wherein, described fluid extract includes the composition of following equal in quality: Herba Centellae, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, cnidium monnieri Son, Galla Chinensis, Flos Carthami, Flos Lonicerae, Radix Cynanchi Atrati.The fluid extract using above-mentioned formula to prepare is main active ingredient, above-mentioned joins 10 kinds of Chinese medicines of ratio make unguentum have the effect well suppressing vaginal pathogenic, and not only suppression Gram-positive bacteria growing, right Gram negative bacteria also has preferable inhibition, low concentration (1%) can well suppress the growth of Candida albicans, with Time can also suppress mycoplasma, trichomonas vaginitis and bacillus pyocyaneus at higher concentration (5%-10%), can effectively prevent gynecological inflammation multiple Send out.
In preferred embodiment, described mixed-matrix is made up of carbomer and Polyethylene Glycol, described carbomer and Polyethylene Glycol Mass ratio be 3:10.Each component mix homogeneously during so the mixed base mass-energy of composition makes the externally used paste of preparation, is uniformly dispersed.
Wherein, described cosolvent is propylene glycol.The propylene glycol of 1-5% contributes to each component in fluid extract and fully dissolves, and improves The active constituent content of fluid extract.
Wherein, described preservative is ethylparaben.This preservative is used the most effectively to extend externally used paste The effect duration used, and few side effects.Preferably, the content of ethylparaben is 1%.
Wherein, described penetration enhancer is azone.Preferably, the content of azone is 1%, the absorption of the externally used paste being configured so that Efficiency is high, makes the active ingredient of unguentum can be applied to the original site of hemorrhoid after absorbing, significantly improves curative effect.
Wherein, described acid-base modifier is triethanolamine.
The preparation method of the unguentum of a kind of preventing and treating gynecological inflammation as above, wherein, described preparation method is: weigh phase The snow grass of homogenous quantities, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, Flos Carthami, Flos Lonicerae, Radix Cynanchi Atrati mixing, To medicinal material mixture, boiling secondary, decoct 1h every time, the filtrate reduced in volume that will merge after filtration, obtain fluid extract；Will The fluid extract of respective quality percent, mixed-matrix, cosolvent, preservative, penetration enhancer, acid-base modifier mix, and are eventually adding Glycerol is allocated, and makes unguentum.
The preparation method of the described externally used paste preventing and treating hemorrhoid, wherein, in described decoction process, decoct for the first time adds The water yield is 12 times of medicinal material mixture quality, amount of water is medicinal material mixture quality 8 times of second time decoction.Use above-mentioned Amount of water and the mode of adding water can make the ingredient in medicinal material mixture fully be diffused in water, improve in the fluid extract of preparation The content of active ingredient, and then improve the drug effect of the described externally applied ointment preventing and treating hemorrhoid.
For the more detailed description present invention, it is exemplified below specific embodiment and the present invention is further detailed.
Embodiment 1
The present invention provides a kind of unguentum preventing and treating gynecological inflammation, and wherein, the unguentum of described preventing and treating gynecological inflammation is by following quality hundred The one-tenth of mark is grouped into:
Fluid extract 40%；
Mixed-matrix 10%；
Propylene glycol 5%；
Ethylparaben 1.5%；
Azone 1.5%；
Triethanolamine 5%；
Other are glycerol.
Wherein, described fluid extract by include the Herba Centellae of equal in quality, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, Flos Carthami, Flos Lonicerae, the plurality of Chinese of Radix Cynanchi Atrati are prepared from.
Wherein, mixed-matrix is made up of the carbomer (CP-940) that mass ratio is 3:10 and Polyethylene Glycol (PEG400).
The preparation method of the unguentum that the present invention also provides for a kind of described preventing and treating gynecological inflammation is:
By the Herba Centellae of equal in quality, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, Flos Carthami, Flos Lonicerae, white Common vetch mixes, and obtains medicinal material mixture, boiling secondary, amount of water is medicinal material mixture quality 12 times decocted for the first time, Amount of water is medicinal material mixture quality 8 times of second time decoction.Decocting 1h, after filtration, the filtrate decompression by merging is dense every time Contracting, obtains fluid extract；By the fluid extract of respective quality percent, mixed-matrix, cosolvent, preservative, penetration enhancer, acid-alkali accommodation Agent mixes, and is eventually adding glycerol and allocates, makes externally used paste.
Embodiment 2
The present invention provides a kind of unguentum preventing and treating gynecological inflammation, and wherein, the unguentum of described preventing and treating gynecological inflammation is by following quality hundred The one-tenth of mark is grouped into:
Fluid extract 50%；
Mixed-matrix 8%；
Propylene glycol 3%；
Ethylparaben 1%；
Azone 1%；
Triethanolamine 4%；
Other are glycerol.
Wherein, described fluid extract by include the Herba Centellae of equal in quality, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, Flos Carthami, Flos Lonicerae, the plurality of Chinese of Radix Cynanchi Atrati are prepared from.
Wherein, mixed-matrix is made up of the carbomer (CP-940) that mass ratio is 3:10 and Polyethylene Glycol (PEG400).
The preparation method of the unguentum of the preventing and treating gynecological inflammation that the present invention provides is same as in Example 1.
Embodiment 3
The present invention provides a kind of unguentum preventing and treating gynecological inflammation, and wherein, the unguentum of described preventing and treating gynecological inflammation is by following quality hundred The one-tenth of mark is grouped into:
Fluid extract 60%；
Mixed-matrix 5%；
Propylene glycol 1%；
Ethylparaben 0.5%；
Azone 0.5%；
Triethanolamine 3%；
Other are glycerol.
Wherein, described fluid extract by include the Herba Centellae of equal in quality, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, Flos Carthami, Flos Lonicerae, the plurality of Chinese of Radix Cynanchi Atrati are prepared from.
Wherein, mixed-matrix is made up of the carbomer (CP-940) that mass ratio is 3:10 and Polyethylene Glycol (PEG400).
The preparation method of the unguentum of the preventing and treating gynecological inflammation that the present invention provides is same as in Example 1.
It should be appreciated that the application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can To be improved according to the above description or to convert, all these modifications and variations all should belong to the guarantor of claims of the present invention Protect scope.

Claims (8)

1. the unguentum preventing and treating gynecological inflammation, it is characterised in that the described externally used paste of hemorrhoid of preventing and treating is by following percent mass The one-tenth of number is grouped into:
Fluid extract 40-60%；
Mixed-matrix 5-10%；
Cosolvent 1-5%；
Preservative 0.5-1.5%；
Penetration enhancer 0.5-1.5%；
Acid-base modifier 3-5%；
Other are glycerol；
Wherein, described fluid extract by include the Herba Centellae of equal in quality, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, five times Son, Flos Carthami, Flos Lonicerae, the plurality of Chinese of Radix Cynanchi Atrati are prepared from.
The unguentum of preventing and treating gynecological inflammation the most according to claim 1, it is characterised in that described mixed-matrix by carbomer and Polyethylene Glycol forms, and the mass ratio of described carbomer and Polyethylene Glycol is 3:10.
The unguentum of preventing and treating gynecological inflammation the most according to claim 1, it is characterised in that described cosolvent is propylene glycol.
The unguentum of preventing and treating gynecological inflammation the most according to claim 1, it is characterised in that described preservative is para hydroxybenzene first Acetoacetic ester.
The unguentum of preventing and treating gynecological inflammation the most according to claim 1, it is characterised in that described penetration enhancer is azone.
The unguentum of preventing and treating gynecological inflammation the most according to claim 1, it is characterised in that described acid-base modifier is three ethanol Amine.
7. the preparation method of the unguentum of the preventing and treating gynecological inflammation as according to any one of claim 1-6, it is characterised in that Described preparation method is: weigh the snow grass of equal in quality, Herba Portulacae, Flos Sophorae, Rhizoma Polygoni Cuspidati, powder Radix Stephaniae Tetrandrae, Fructus Cnidii, Galla Chinensis, river red Flower, Flos Lonicerae, Radix Cynanchi Atrati mixing, obtain medicinal material mixture, boiling secondary, decoct 1h every time, the filtrate that will merge after filtration Concentrating under reduced pressure, obtains fluid extract；By the fluid extract of respective quality percent, mixed-matrix, cosolvent, preservative, penetration enhancer, acid Alkali regulator mixes, and is eventually adding glycerol and allocates, makes unguentum.
The preparation method of the externally used paste preventing and treating hemorrhoid the most according to claim 7, it is characterised in that described decoction process In, amount of water is medicinal material mixture quality 12 times decocted for the first time, the amount of water that second time decocts is medicinal material mixture matter 8 times of amount.
CN201610801828.6A 2016-09-05 2016-09-05 A kind of unguentum preventing and treating gynecological inflammation and preparation method thereof Pending CN106214760A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106619780A (en) * 2017-02-24 2017-05-10 李忠泽 Gynecological antibacterial gel
CN108938703A (en) * 2018-08-10 2018-12-07 李燕儿 The gynecological gel of quick antibacterial

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106619780A (en) * 2017-02-24 2017-05-10 李忠泽 Gynecological antibacterial gel
CN108938703A (en) * 2018-08-10 2018-12-07 李燕儿 The gynecological gel of quick antibacterial

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