CN101244147A - Composition for external use for treating sexual disorder and preparing method - Google Patents
Composition for external use for treating sexual disorder and preparing method Download PDFInfo
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- CN101244147A CN101244147A CNA200710037464XA CN200710037464A CN101244147A CN 101244147 A CN101244147 A CN 101244147A CN A200710037464X A CNA200710037464X A CN A200710037464XA CN 200710037464 A CN200710037464 A CN 200710037464A CN 101244147 A CN101244147 A CN 101244147A
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Abstract
The invention discloses a topical composition for curing sexual dysfunction, the preparation method and application in the treatment of sexual dysfunction, which comprises (a) an acceptable carrier in pharmacy, and (b) effective dose of water extract of raw herbal materials or extract of waterborne organic solution; wherein, the raw herbal materials comprises earth golden cow, morinda officinalis how, astragali semen, hindu datura, uncaria and red raspberry.
Description
Technical field
The present invention relates to the plant extract field.Relate more specifically to the handicapped topical composition of therapeutic and method for making and the purposes that contain the Chinese crude drug extract from a kind of.
Background technology
Sexual dysfunction refers to one or several link generation obstacle in the sexual intercourse process, so that can not produce necessary physiological reaction of satisfied sexual intercourse and anhedonia.The normal sexual function of male comprises some links such as libido, erection, sexual intercourse, orgasm and ejaculation, and arbitrary link generation obstacle wherein all can influence sexual life, is called male sexual disorder.Male sexual disorder is broadly divided into functional and organic two classes, and common have dysaphrodisia, sexual impotence, erection problem, sexual intercourse obstacle, orgasm disorder, a defective ejaculation etc.Medical information shows, about 50% erection problem be simple organic diseases because of, 30% is the simple psychological cause of disease, 20% exists simultaneously for the organic and psychological cause of disease.
With regard to the male, male's sexual function mainly comprises processes such as sexual excitation, erection, sexual intercourse, ejaculation and orgasm.Also be the several stages of male's property reaction, this is a complex physical activity, and the participation of genitals, hormonal system, nervous system and ergasia is arranged.Wherein any one link breaks down, and all can cause sexual dysfunction.
Sexual dysfunction can be divided into four big classes by clinical manifestation:
(1) dysaphrodisia: hyposexuality, property detest, hypersexuality.
(2) erection problem: sexual impotence, priapism.
(3) defective ejaculation: premature ejaculation, anejaculation, retrograde ejaculation, seminal emission.
(4) sensory disturbance: dyspareunia, painful ejaculation.
With regard to the women, at present academia is also thought the existence dysfunction.
For sexual dysfunction, though medicinal preparation for oral administration such as viagra is arranged at present, the side effect of these oral formulations is bigger.
In sum, still lack therapeutic dysfunction and the less external used medicine of side effect effectively at present.Therefore, this area presses for provides a kind of dysfunction of therapeutic effectively and the less compositions of side effect.
Summary of the invention
The present invention aims to provide a kind of effectively handicapped topical composition of therapeutic and preparation method thereof.
In a first aspect of the present invention, a kind of compositions is provided, it contains (a) pharmaceutically acceptable carrier and (b) water extract of the raw medicinal material of effective dose or the extract of aqueous organic solvent, and described raw medicinal material comprises Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi;
And the extract of described medical material accounts for the 0.02-99% of composition total weight, preferably 0.1-90%, more preferably 0.2-50%.
In another preference, described raw medicinal material also comprises one or more complementary raw medicinal materials that are selected from down group: Fructus Corni, Rhizoma Curculiginis, Fructus Cnidii, Herba Epimedii, Herba Cynomorii and Herba Cistanches.
In another preference, described medical material comprises:
0.2-4 weight portion Radix Zanthoxyli;
0.3-6 weight portion Radix Morindae Officinalis;
0.3-6 weight portion Semen Astragali Complanati;
0.5-8 weight portion Flos Daturae;
0.1-2 weight portion Ramulus Uncariae Cum Uncis; With
0.3-6 weight portion Fructus Rubi.
In another preference, described compositions also comprises one or more medical materials that are selected from down group:
0.3-6 weight portion Fructus Corni;
0.3-6 weight portion Rhizoma Curculiginis;
0.3-6 weight portion Fructus Cnidii;
0.3-6 weight portion Herba Epimedii;
0.3-6 weight portion Herba Cynomorii;
0.2-4 weight portion Herba Cistanches.
In another preference, described crude drug contains:
0.5-3 weight portion Radix Zanthoxyli;
0.5-5 weight portion Radix Morindae Officinalis;
0.5-5 weight portion Semen Astragali Complanati;
1-6 weight portion Flos Daturae;
0.2-1.8 weight portion Ramulus Uncariae Cum Uncis; With
0.5-5 weight portion Fructus Rubi.
In another preference, described crude drug contains:
1-3 weight portion Radix Zanthoxyli;
1-4.5 weight portion Radix Morindae Officinalis;
1-4.5 weight portion Semen Astragali Complanati;
2-5 weight portion Flos Daturae;
0.5-1.5 the weight portion Ramulus Uncariae Cum Uncis and
1-4.5 weight portion Fructus Rubi.
In another preference, the content of complementary raw medicinal material is as follows:
0.5-5 weight portion Fructus Corni;
0.5-5 weight portion Rhizoma Curculiginis;
0.5-5 weight portion Fructus Cnidii;
0.5-5 weight portion Herba Epimedii;
0.5-5 weight portion Herba Cynomorii;
0.5-3 weight portion Herba Cistanches.
In another preference, described compositions is spray, ointment, ointment, liniment, lotion or gel.
In another preference, by the gross dry weight amount of described medical material, every gram or every milliliter of described compositions contain corresponding to 0.01-10 and restrain dried medical material, more preferably restrain dried medical material corresponding to 0.05-2.
In a second aspect of the present invention, a kind of method for preparing above-mentioned composition is provided, described method comprises step:
(i) described medical material was mixed 0.5-50 days with water or aqueous organic solvent, form mixed liquor;
(ii) filter mixed liquor, obtain filtrate, thereby obtain extract;
(iii) extract is mixed with pharmaceutically acceptable carrier, form compositions;
Perhaps
Described method comprises step:
The aqueous extract of each medical material is mixed, form and extract mixture, will extract mixture again and mix, form compositions with pharmaceutically acceptable carrier.
In another preference, described aqueous organic solvent is the mixed solution of water and alcohol (as ethanol), and wherein Chun percent by volume is 5-85% (v/v), more preferably is 10-50%.
In another preference, described alcohol comprises methanol, ethanol, propanol or its combination.
In another preference, comprise that also the extract to obtaining carries out drying in (ii) in step.
In another preference, described raw medicinal material also contains one or more complementary raw medicinal materials that are selected from down group: Fructus Corni, Rhizoma Curculiginis, Fructus Cnidii, Herba Epimedii, Herba Cynomorii and Herba Cistanches.
In a third aspect of the present invention, the purposes of a kind of Chinese medicine medicinal material composition or its aqueous extract is provided, wherein, described Chinese medicine medicinal material composition comprises: Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi, wherein said Chinese medicine medicinal material composition or its aqueous extract are used to prepare the handicapped topical composition of therapeutic.
In another preference, described Chinese medicine medicinal material composition comprises:
0.2-4 weight portion Radix Zanthoxyli;
0.3-6 weight portion Radix Morindae Officinalis;
0.3-6 weight portion Semen Astragali Complanati;
0.5-8 weight portion Flos Daturae;
0.1-2 weight portion Ramulus Uncariae Cum Uncis; With
0.3-6 weight portion Fructus Rubi.
In another preference, described Chinese medicine composition can also contain one or more complementary raw medicinal materials that are selected from down group: Fructus Corni, Rhizoma Curculiginis, Fructus Cnidii, Herba Epimedii, Herba Cynomorii and Herba Cistanches.
In another preference, the handicapped topical composition of described therapeutic is used for the treatment of sexual dysfunction.
In a fourth aspect of the present invention, a kind of aqueous extract or water extract of Chinese medicine medicinal material composition is provided, described Chinese medicine medicinal material composition contains Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi.
The specific embodiment
The inventor according to the principle of Chinese medicine " monarch ", has prepared the medical material mixture that contains Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi through extensively and in depth research first.Test shows that the water extract of described medical material mixture or the extract of aqueous organic solvent can be used for treating sexual dysfunctions such as premature ejaculation.
As used in this description and claims, " raw medicinal material " of the present invention is defined as follows:
Radix Zanthoxyli (Radix seu Ranulus et Folium Zanthoxyli Nitidi): root or the branch and leaf of Rutaceae xanthoxylum Radix Zanthoxyli.Have and dispel the wind, collateral dredging, detumescence, analgesic effect.
Fructus Corni ((Fructus Corni): Cornaceae Macrocarpium plant Fructus Corni pulp.Can control sexual impotence.
Radix Morindae Officinalis (Radix Morindae Officinalis): the root of Rubiaceae Radix Morindae Officinalis platymiscium Radix Morindae Officinalis.Can control sexual impotence.
Rhizoma Curculiginis (Rhizoma Curculiginis): Hypoxidaceae Rhizoma Curculiginis platymiscium Rhizoma Curculiginis rhizome.Can control the sexual impotence cold sperm.
Herba Cistanches (Herba Cistanches): the chylocaulous of Orobanchaceae Cistanche Hoffmgg. et Link plants Herba Cistanches and Cistanche Tubulosa.Has the smart effect of benefit.Can control sexual impotence.
Semen Astragali Complanati (Semen Astragali Complanati): the seed of leguminous plant astragatus complanatus Astragaluscomplanatus R.Br..Effect with controlling nocturnal emission with astringent drugs.
Fructus Cnidii (Fructus Cnidii): the fruit of Umbelliferae Cnidium Cusson plant cnidium monnieri.Have supporing yang, the effect of dispeling the wind.Can control impotence in male, the scrotum pruritus due to damp pathogen.
Flos Daturae (Fols Daturae): the flower of Solanaceae Datura plant datura metel, datura innoxia.Has the effect of dispeling the wind.
Herba Epimedii (Herba Epimedii): stem, the leaf of Berberidaceae barrenwort Herba Epimedii, arrow leaf Herba Epimedii, Epimedium wushanense, Herba Epimedii, pubescence Herba Epimedii etc.The tonifying YANG of arrow leaf, the effect of expelling wind and removing dampness.Can control the sexual impotence erectile problem.
Ramulus Uncariae Cum Uncis (Ramulus Uncariae Cum Uncis): be the stem and branch with belt hook of Rubiaceae wild gambier plant Ramulus Uncariae Cum Uncis, Uncaria sinensis (Oliv.) Havil., Ramulus Uncariae macrophyllae.Have light and the saturating effect of sending out.
Herba Cynomorii (Herba Cynomorii): the chylocaulous of Cynomoriaceae Herba Cynomorii platymiscium Herba Cynomorii.Can control sexual impotence.
Fructus Rubi (Fructus Rubi): the fruit of Rosaceae rubus Fructus Rubi.Have supporing yang, the effect of controlling nocturnal emission with astringent drugs.Can control sexual impotence.
In above-mentioned medical material, Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi are necessary medical material, and all the other are complementary medical material.As used herein, " auxiliary medical material ", " complementary raw medicinal material " " extra medical material " or " optional medical material " are meant in the present composition and can add the medical material that also can not add.Usually, can make effect better after adding complementary medical material.
Compositions
The inventor provides a kind of extract according to the medication principle of Chinese medicine monarch, and it contains the water extract or the aqueous organic solvent extract of the raw medicinal material (crude preparation) of Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi formation.
Usually, the parts by weight of each raw medicinal material are as follows in the described mixture:
The content of the necessary medical material of table 1
| Medical material | Content | Preferred content | Optimum content |
| Radix Zanthoxyli | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Morindae Officinalis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Semen Astragali Complanati | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Flos Daturae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Ramulus Uncariae Cum Uncis | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Fructus Rubi | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
In a preference, also can contain the water extract or the aqueous organic solvent extract of the extra handicapped medical material of adjunctive therapeutic in the compositions of the present invention.The handicapped medical material example of suitable adjunctive therapeutic comprises, but is not limited to: Fructus Corni, Rhizoma Curculiginis, Fructus Cnidii, Herba Epimedii, Herba Cynomorii and Herba Cistanches or its combination.
Usually, the consumption of these extra handicapped medical materials of adjunctive therapeutic is as follows:
The content of the complementary medical material of table 2
| Medical material | Content | Preferred content | Optimum content |
| Fructus Corni | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Rhizoma Curculiginis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Fructus Cnidii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Epimedii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Cynomorii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Cistanches | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
A kind of preferred extract of the present invention is in order to medical material mixture preparation down, and this mixture contains:
The preferred medical material proportioning of table 3
| Medical material | Content | Preferred content | Optimum content |
| Radix Zanthoxyli | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Morindae Officinalis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Semen Astragali Complanati | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Flos Daturae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Ramulus Uncariae Cum Uncis | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Fructus Rubi | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Fructus Corni | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Rhizoma Curculiginis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Fructus Cnidii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Epimedii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Cynomorii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Cistanches | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
Preparation method
The available following method preparation of active component of the present invention (being the extract of medical material): with required medical material (or medical material mixture) water or contain the suitable mixable organic solvent of water of 30-85% (v/v) as alcohol (preferred alcohol) extracting, filter the extract that obtains so then, can randomly filtrate be carried out drying with conventional method (as spray drying, lyophilizing or concentrate drying) then.Active component of the present invention can mix the extract of extractive each raw medicinal material respectively and prepare, and also can obtain by the mixture of extracting medical material.
Extracting can be carried out under room temperature or heating condition, but preferably at 4-35 ℃, more preferably carries out under 5-30 ℃.
The extractive time is not particularly limited, and is generally more than 1 hour, and for example 0.5-50 days more preferably is 1-30 days.
In another preference, can in the liquid extract that makes, add solubilizing agent (as polyoxyethylene groups), antioxidant (as sodium thiosulfate), surfactant (as sodium laurylsulfate) and/or antiseptic (as sodium benzoate), make the compositions of liquid state of the present invention, as spray.
In another preference, can in the liquid extract that makes, add greasing base (as vaseline), water-soluble base (as Polyethylene Glycol), emulsion-type substrate (as Polysorbate), antioxidant (as sodium thiosulfate) and/or antiseptic (as sodium benzoate), make the compositions of liquid state of the present invention, as ointment, ointment.
In another preference, can in the liquid extract that makes, add solvent (as water, ethanol, vegetable oil), plasticizer (as glycerol) and/or filmogen (as polyvinyl alcohol), make the compositions of liquid state of the present invention, as liniment, lotion, liniment.
In another preference, can in the liquid extract that makes, add gel-type vehicle (as carbomer, liquid paraffin), make the compositions of liquid state of the present invention, as gel.
Usually, extract of the present invention is mixed with suitable carriers can obtain compositions of the present invention.The method that can be used for preparing the present composition is not particularly limited, and the various conventional methods of available this area are as mixing method etc.
In preparation of the present invention, the extract that contains the above-mentioned raw materials medical material is as active component and pharmaceutically acceptable carrier or additives.
As used herein, term " compositions of the present invention " comprises pharmaceutical composition and the handicapped topical composition of therapeutic (as shampoo or hair products), as long as they contain the extract of the water extract of Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi or aqueous organic solvent or are made of the extract of raw medicinal materials such as Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi basically.In compositions, the extract of Radix Zanthoxyli of the present invention, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi or Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi and other auxiliary medical materials accounts for the 0.1-99% of composition total weight, preferably account for 1-90%, account for 5-80% best.
In addition, press the dry weight of medical material and calculate, every milliliter of fluid composition should restrain corresponding to 0.01-10, more preferably restrains total dried medical material corresponding to 0.05-5, restrains total dried medical material corresponding to 0.1-2.5 best.
As used herein, term " pharmaceutically acceptable carrier " refers to be used to can be used for the carrier of medicine.This term refers to some carriers like this: they itself are not necessary active component, and do not have undue toxicity after using.Suitable carriers is well known to those of ordinary skill in the art.Acceptable carrier can contain liquid on combination of Chinese medicine is learned, as water, saline, glycerol and ethanol.In addition, also may there be complementary material in these carriers, as wetting agent or emulsifying agent, pH buffer substance etc.
Compositions of the present invention also can contain at least a pharmaceutically acceptable additive, for example correctives, spice, pigment etc.These additives all are to know in this area.
Purposes and using method
Extract of the present invention or compositions can be used for treating sexual dysfunction such as premature ejaculation, erection hardness be not enough.When using, can use, comprising (but being not limited to): be sprayed on, be applied to, smear on male's sexual organ and surrounding skin thereof by conventional route.
When using compositions provided by the invention, be that the water extract of Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and the Fructus Rubi (or mixture of Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi and other auxiliary medical materials) of safe and effective amount or the extract of aqueous organic solvent are applied to the people.Wherein this safe and effective amount is generally everyone 0.01-100 gram, preferably be the 0.05-50 gram, be pressed into the dried medical material amount meter of ground Taurus, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi (or mixture of Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi and other auxiliary medical materials).Certainly, concrete dosage also should be considered the factors such as health of method of application, subject, and these all are within the skill of this area.
Major advantage of the present invention is:
1, sexual dysfunctions such as treatment premature ejaculation there is the obvious treatment effect;
2, pure natural components, safer, side effect is little.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example is usually according to the normal condition or the condition of advising according to manufacturer.Unless otherwise indicated, otherwise all percentage ratio and umber by weight.
Unless otherwise defined, the same meaning that employed all specialties and scientific words and one skilled in the art are familiar with in the literary composition.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The usefulness that preferable implementation method described in the literary composition and material only present a demonstration.
Preparation embodiment 1-4
Take by weighing the raw medicinal material of following quantity,
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) | |
| Radix Zanthoxyli | 0.2 | 3 | 3 | 2 |
| Radix Morindae Officinalis | 0.3 | 5 | 4.5 | 3 |
| Semen Astragali Complanati | 0.3 | 5 | 4.5 | 3 |
| Flos Daturae | 0.5 | 2 | 3 | 4 |
| Ramulus Uncariae Cum Uncis | 0.1 | 0.5 | 0.5 | 1 |
| Fructus Rubi | 0.3 | 5 | 4.5 | 2 |
Clean, dry, be crushed to Powdered (mean diameter is about 250-500 μ m).Placing the bottom that the column shape container (solvent flows through the medicated powder on the dividing plate from top to bottom) of dividing plate is arranged in powder, is that 40% (v/v) ethanol water is solvent (consumption is 10 times of each medical material gross dry weight) with concentration.Medical material flooded 48 hours with solvent, filtered then, collected filtrate and obtained liquid extract.
In liquid extract, add polyoxyethylene groups, sodium thiosulfate, sodium laurylsulfate and sodium benzoate to 0.5wt%.Make spray a, b, c and d respectively, each 1000 milliliters, close 1 gram medical material/1ml.
Preparation embodiment 5-8
Repeat to prepare the method for embodiment 1-4, difference is: also additionally contain in the medical material mixture
| Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | |
| Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) | Consumption (kilogram) | |
| Fructus Corni | 0.3 | 5 | 4.5 | 3 |
| Rhizoma Curculiginis | 0.3 | 5 | 0 | 0 |
| Fructus Cnidii | 0.3 | 5 | 4.5 | 3 |
| Herba Epimedii | 1 | 5 | 4.5 | 3 |
| Herba Cynomorii | 0 | 5 | 4.5 | 3 |
| Herba Cistanches | 0 | 0 | 3 | 2 |
Make spray e, f, g and h respectively.
Test implementation example 1
Treatment premature ejaculation and erection hardness are not enough
The spray b that uses embodiment 2 to make for 1 premature ejaculation patient (man, 35 years old) was sprayed directly on to before sexual intercourse on male's the sexual organ in 5-15 minute, at every turn with drip degree of being not.Use the back erection hardness and be significantly improved, and sex time has no adverse reaction from prolongation in about 1 minute 10-15 minute.
The result shows that compositions provided by the invention has treatment premature ejaculation and the not enough effect of erection hardness.
Test implementation example 2
Treatment premature ejaculation and erection hardness are not enough
The spray d that uses embodiment 4 to make for 1 premature ejaculation patient (man, 42 years old) was sprayed directly on to before sexual intercourse on male's the sexual organ in 5-15 minute, at every turn with drip degree of being not.Use the back erection hardness and be significantly improved, and sex time has no adverse reaction from prolongation in about 1.5 minutes 10-15 minute.
The result shows that compositions provided by the invention has treatment premature ejaculation and the not enough effect of erection hardness.
Test implementation example 3
The treatment premature ejaculation
Spray e, the f, g and the h that use embodiment 5-8 to make respectively for 1 premature ejaculation patient (man, 50 years old) were sprayed directly on to before sexual intercourse on male's the sexual organ in 5-15 minute, at every turn with drip degree of being not.Use the back erection hardness and be significantly improved, and sex time is average from about 1 minute prolongs 10-15 minute, have no adverse reaction.
The result shows that compositions provided by the invention has the effect of treatment premature ejaculation.
The above only is preferred embodiment of the present invention, be not in order to limit essence technology contents scope of the present invention, essence technology contents of the present invention is broadly to be defined in the claim scope of application, any technology entity or method that other people finish, if it is defined identical with the claim scope of application, also or a kind of change of equivalence, all will be regarded as being covered by among this claim scope.
Claims (10)
1. compositions, it is characterized in that, it contains (a) pharmaceutically acceptable carrier and (b) water extract of the raw medicinal material of effective dose or the extract of aqueous organic solvent, and described raw medicinal material comprises Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi;
And the extract of described medical material accounts for the 0.02-99% of composition total weight.
2. compositions as claimed in claim 1 is characterized in that, described raw medicinal material also comprises one or more complementary raw medicinal materials that are selected from down group: Fructus Corni, Rhizoma Curculiginis, Fructus Cnidii, Herba Epimedii, Herba Cynomorii and Herba Cistanches.
3. compositions as claimed in claim 1 is characterized in that, described medical material comprises:
0.2-4 weight portion Radix Zanthoxyli;
0.3-6 weight portion Radix Morindae Officinalis;
0.3-6 weight portion Semen Astragali Complanati;
0.5-8 weight portion Flos Daturae;
0.1-2 weight portion Ramulus Uncariae Cum Uncis; With
0.3-6 weight portion Fructus Rubi.
4. compositions as claimed in claim 3 is characterized in that, described compositions also comprises one or more medical materials that are selected from down group:
0.3-6 weight portion Fructus Corni;
0.3-6 weight portion Rhizoma Curculiginis;
0.3-6 weight portion Fructus Cnidii;
0.3-6 weight portion Herba Epimedii;
0.3-6 weight portion Herba Cynomorii;
0.2-4 weight portion Herba Cistanches.
5. compositions as claimed in claim 4 is characterized in that, described crude drug contains:
0.5-3 weight portion Radix Zanthoxyli;
0.5-5 weight portion Radix Morindae Officinalis;
0.5-5 weight portion Semen Astragali Complanati;
1-6 weight portion Flos Daturae;
0.2-1.8 weight portion Ramulus Uncariae Cum Uncis; With
0.5-5 weight portion Fructus Rubi.
6. as the arbitrary described compositions of claim 1-5, it is characterized in that described compositions is spray, ointment, ointment, liniment, lotion or gel.
7. one kind prepares method for compositions as claimed in claim 1, it is characterized in that,
Described method comprises step:
(i) described medical material was mixed 0.5-50 days with water or aqueous organic solvent, form mixed liquor;
(ii) filter mixed liquor, obtain filtrate, thereby obtain extract;
(iii) extract is mixed with pharmaceutically acceptable carrier, form compositions;
Perhaps
Described method comprises step:
The aqueous extract of each medical material is mixed, form and extract mixture, will extract mixture again and mix, form compositions with pharmaceutically acceptable carrier.
8. method as claimed in claim 7 is characterized in that, described raw medicinal material also contains one or more complementary raw medicinal materials that are selected from down group: Fructus Corni, Rhizoma Curculiginis, Fructus Cnidii, Herba Epimedii, Herba Cynomorii and Herba Cistanches.
9. the purposes of a Chinese medicine medicinal material composition or its aqueous extract, wherein, described Chinese medicine medicinal material composition comprises: Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi;
It is characterized in that described Chinese medicine medicinal material composition or its aqueous extract are used to prepare the handicapped topical composition of therapeutic.
10. the aqueous extract of a Chinese medicine medicinal material composition or water extract is characterized in that, described Chinese medicine medicinal material composition contains Radix Zanthoxyli, Radix Morindae Officinalis, Semen Astragali Complanati, Flos Daturae, Ramulus Uncariae Cum Uncis and Fructus Rubi.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710037464XA CN101244147A (en) | 2007-02-13 | 2007-02-13 | Composition for external use for treating sexual disorder and preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA200710037464XA CN101244147A (en) | 2007-02-13 | 2007-02-13 | Composition for external use for treating sexual disorder and preparing method |
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| CN101244147A true CN101244147A (en) | 2008-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA200710037464XA Pending CN101244147A (en) | 2007-02-13 | 2007-02-13 | Composition for external use for treating sexual disorder and preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198184A (en) * | 2010-03-24 | 2011-09-28 | 成都一平医药科技发展有限公司 | Effect of morinda officinalis extract on improving or treating sexual disorder, and application thereof |
| CN102199515A (en) * | 2011-03-29 | 2011-09-28 | 朱万财 | Health-care wine and preparation method thereof |
| CN106138425A (en) * | 2016-08-31 | 2016-11-23 | 张阳 | A kind of pharmaceutical composition treating premature ejaculation and preparation, preparation method, purposes |
-
2007
- 2007-02-13 CN CNA200710037464XA patent/CN101244147A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198184A (en) * | 2010-03-24 | 2011-09-28 | 成都一平医药科技发展有限公司 | Effect of morinda officinalis extract on improving or treating sexual disorder, and application thereof |
| CN102199515A (en) * | 2011-03-29 | 2011-09-28 | 朱万财 | Health-care wine and preparation method thereof |
| CN106138425A (en) * | 2016-08-31 | 2016-11-23 | 张阳 | A kind of pharmaceutical composition treating premature ejaculation and preparation, preparation method, purposes |
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Open date: 20080820 |