CN109021517A - A kind of composite anti-corrosive antimicrobial sustained-release film and preparation method thereof - Google Patents
A kind of composite anti-corrosive antimicrobial sustained-release film and preparation method thereof Download PDFInfo
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- CN109021517A CN109021517A CN201810704324.1A CN201810704324A CN109021517A CN 109021517 A CN109021517 A CN 109021517A CN 201810704324 A CN201810704324 A CN 201810704324A CN 109021517 A CN109021517 A CN 109021517A
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- corrosive
- release film
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0058—Biocides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/13—Phenols; Phenolates
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- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of composite anti-corrosive antimicrobial sustained-release films, and raw material includes following component according to parts by weight: 2-20 parts of gallic acid；5-40 parts of wormwood extract；5-40 parts of calamus extract；20-88 parts of polycaprolactone.Three kinds of anti-corrosive antibacterial active components of gallic acid, wormwood extract, calamus extract of selection are natural plant extracts, polycaprolactone has biodegradable performance, therefore composite anti-corrosive antimicrobial sustained-release film can gradually degrade in the environment after use, it can be absorbed or be decomposed by environment, there is no substance residual, there is no post-processing problems, will not pollute ambient enviroment.Method of the preparation using hot pressing, 3D printing or melt-blown forming, environmentally protective, simple and reliable process, no organic solvent and the problems such as being added into use, environmental pollution be not present of other additives.
Description
Technical field
The invention belongs to technical field of composite materials, and in particular to a kind of composite anti-corrosive antimicrobial sustained-release film and its preparation side
Method
Background technique
With the development of society and the improvement of people's living standards, people are to the quality of living environment and wanting for health level
Ask higher and higher.The antimildew and antibacterial agent that novel, efficient, non-toxic and tasteless and Durability of antimicrobial effect can be good is researched and developed, is that anti-corrosion is anti-
One of bacterium investigation of materials and the emphasis direction of development.
However, antiseptic and antibiotic agent used at present generally only has single antisepsis and sterilization ingredient, antisepsis and sterilization object compared with
Be it is single, be difficult to accomplish to kill the purpose of a variety of pathogenic microorganisms, bacterium simultaneously, and that there are stability is poor, easily decompose, use
The disadvantages of service life is shorter.In addition, many antiseptic and antibiotic agents also have the toxic side effect to people, animal and the harm of environmental pollution.
Summary of the invention
It is an object of that present invention to provide a kind of broad spectrum preservation antibacterial, application range is wide, effective time is long, is applicable in varying environment
And it can also ensure that the composite anti-corrosive antimicrobial sustained-release film of safety and validity.
In order to achieve the above objectives, as follows using technical solution:
A kind of composite anti-corrosive antimicrobial sustained-release film, raw material includes following component according to parts by weight:
According to the above scheme, the number-average molecular weight of the polycaprolactone is between 20000-2000000.
According to the above scheme, it includes leaf, root, stem, flower or seed using extraction that the wormwood extract, which is the plant of wormwood,
Or it impregnates resulting extract or uses the resulting crushed material of mechanical means.
According to the above scheme, it includes leaf, root, stem, flower or seed using solvent that the calamus extract, which is the plant of calamus,
It extracts or impregnates resulting extract or use the resulting crushed material of mechanical means.
The preparation method of above-mentioned composite anti-corrosive antimicrobial sustained-release film, comprising the following steps:
Each raw material is uniformly mixed, is shaped at 50-200 DEG C through hot pressing, 3D printing or melt-blown, is prepared into film.
The present invention has the beneficial effect that:
Wherein wormwood extract has good antibiosis and antiviral functions, mosquito dispersing, sterilization, prevention disease, disinfection
Antipruritic effect.Calamus extract has the function of good desinsection, sterilizing, anti-corrosion, antiviral.Gallic acid have it is anti-inflammatory,
The various biologicals such as anti-mutation, anti-oxidant, free radical resisting activity.The present invention mixes three kinds of active components according to a certain percentage,
Not only widen significantly antimicrobial spectrum, can complementary synergy, improve three kinds of performances, reduce in terms of all have it is obvious excellent
Point, but also the dosage of single three kinds of ingredients can be reduced, to reach optimal three kinds of effects, it is slow to expand composite anti-corrosive antibacterial
It releases the scope of application of film, enhance the function and effect of anti-corrosive antibacterial.
Polycaprolactone is the high molecular material of film forming, while playing the role of slow release to anti-corrosive antibacterial object, can be effective
The rate of release for controlling active component makes antiseptic and antibiotic agent by design dosage, by certain rate in desired time range
Slow release improves utilization rate, safety and the validity of antiseptic and antibiotic agent to achieve the purpose that extend anti-corrosive antibacterial.Experiment
The result shows that composite anti-corrosive antimicrobial sustained-release film prepared by the present invention has slow-release controlled-release effect, to Escherichia coli, mould, song
The growth and breeding of mould, Mucor etc. have very strong inhibiting effect.
Three kinds of anti-corrosive antibacterial active components of gallic acid, wormwood extract, calamus extract of selection are natural plant
Object extract, polycaprolactone has biodegradable performance, therefore composite anti-corrosive antimicrobial sustained-release film after use can be in environment
In gradually degrade, can by environment absorb or decompose, without substance remain, be not present post-processing problem, surrounding ring will not be polluted
Border.
The side that the preparation of composite anti-corrosive antimicrobial sustained-release film of the invention is shaped using hot pressing, 3D printing or melt-blown
Method, environmentally protective, simple and reliable process, no organic solvent and other additives are added into use, and it is dirty that there is no environment
The problems such as dye.
Detailed description of the invention
Fig. 1: the medicament slow release curve of composite anti-corrosive antimicrobial sustained-release film of the present invention；
Fig. 2: the anti-corrosive antibacterial performance of composite anti-corrosive antimicrobial sustained-release film of the present invention.
Specific embodiment
Following specific embodiments further illustrate technical solution of the present invention, but not as to the scope of the present invention
Limitation.
Embodiment 1
The present embodiment composite anti-corrosive antimicrobial sustained-release film, (100 parts) in parts by weight meters of raw material are as follows:
Each raw material is uniformly mixed, through hot forming at 120 DEG C, is prepared into film.
The medicament slow release curve of the present embodiment composite anti-corrosive antimicrobial sustained-release film is as shown in Figure 1, in 800 hours, wormwood
Extract and calamus extract can sustained release, and in the drug release percentage of 800h only 20% or so.
The anti-corrosive antibacterial performance of the present embodiment composite anti-corrosive antimicrobial sustained-release film as shown in Figure 2, by black mould grow up 7 days after
Photo comparison it is found that the present embodiment antibiotic property clearly.
Embodiment 2
The present embodiment composite anti-corrosive antimicrobial sustained-release film, raw material are as follows according to parts by weight:
Each raw material is uniformly mixed, through hot forming at 160 DEG C, is prepared into film.
Embodiment 3
The present embodiment composite anti-corrosive antimicrobial sustained-release film, raw material are as follows according to parts by weight:
Each raw material is uniformly mixed, through hot forming at 80 DEG C, is prepared into film.
Embodiment 4
The present embodiment composite anti-corrosive antimicrobial sustained-release film, raw material are as follows according to parts by weight:
Each raw material is uniformly mixed, through hot forming at 100 DEG C, is prepared into film.
Embodiment 5
The present embodiment composite anti-corrosive antimicrobial sustained-release film, raw material are as follows according to parts by weight:
Each raw material is uniformly mixed, through hot forming at 150 DEG C, is prepared into film.
Claims (5)
1. a kind of composite anti-corrosive antimicrobial sustained-release film, it is characterised in that raw material includes following component according to parts by weight:
2. composite anti-corrosive antimicrobial sustained-release film as described in claim 1, it is characterised in that the number-average molecular weight of the polycaprolactone
Between 20000-2000000.
3. composite anti-corrosive antimicrobial sustained-release film as described in claim 1, it is characterised in that the wormwood extract is wormwood
Plant includes leaf, root, stem, flower or seed using extraction or impregnates resulting extract or use the resulting crushing of mechanical means
Object.
4. composite anti-corrosive antimicrobial sustained-release film as described in claim 1, it is characterised in that the calamus extract is calamus
Plant includes leaf, root, stem, flower or seed using solvent extraction or impregnates resulting extract or use the resulting powder of mechanical means
It minces.
5. the preparation method of any one of the claim 1-4 composite anti-corrosive antimicrobial sustained-release film, comprising the following steps:
Each raw material is uniformly mixed, is shaped at 50-200 DEG C through hot pressing, 3D printing or melt-blown, is prepared into film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810704324.1A CN109021517A (en) | 2018-06-30 | 2018-06-30 | A kind of composite anti-corrosive antimicrobial sustained-release film and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810704324.1A CN109021517A (en) | 2018-06-30 | 2018-06-30 | A kind of composite anti-corrosive antimicrobial sustained-release film and preparation method thereof |
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| CN109021517A true CN109021517A (en) | 2018-12-18 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529561A (en) * | 2020-07-01 | 2020-08-14 | 招商局健康产业(蕲春)有限公司 | Wormwood essential oil gel sustained-release system prepared by low-temperature 3D printing method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106280332A (en) * | 2016-08-22 | 2017-01-04 | 王利萍 | A kind of preparation method of PCL antiseptic packaging films |
-
2018
- 2018-06-30 CN CN201810704324.1A patent/CN109021517A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106280332A (en) * | 2016-08-22 | 2017-01-04 | 王利萍 | A kind of preparation method of PCL antiseptic packaging films |
Non-Patent Citations (3)
| Title |
|---|
| 唐荣华等: "《抗衰老中草药的研究》", 28 February 1983, 安徽科学技术出版社 * |
| 孔令义: "《中药制药化学》", 30 April 2007, 中国医药科技出版社 * |
| 王淼: "《中华传世老偏方 治病一本通》", 28 February 2014, 天津出版传媒集团 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529561A (en) * | 2020-07-01 | 2020-08-14 | 招商局健康产业(蕲春)有限公司 | Wormwood essential oil gel sustained-release system prepared by low-temperature 3D printing method |
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Application publication date: 20181218 |
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