CN104520323B - 用于治疗b细胞介导的炎性疾病的方法 - Google Patents

用于治疗b细胞介导的炎性疾病的方法 Download PDF

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Publication number
CN104520323B
CN104520323B CN201380022683.4A CN201380022683A CN104520323B CN 104520323 B CN104520323 B CN 104520323B CN 201380022683 A CN201380022683 A CN 201380022683A CN 104520323 B CN104520323 B CN 104520323B
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cxcl13
antibody
binding
cxcr5
domain
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Chinese (zh)
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CN104520323A (zh
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E·S·史密斯
M·左德勒
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Vaccinex Inc
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Vaccinex Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380022683.4A 2012-03-02 2013-03-01 用于治疗b细胞介导的炎性疾病的方法 Active CN104520323B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261606049P 2012-03-02 2012-03-02
US61/606,049 2012-03-02
PCT/US2013/028602 WO2013130959A1 (en) 2012-03-02 2013-03-01 Methods for the treatment of b cell-mediated inflammatory diseases

Publications (2)

Publication Number Publication Date
CN104520323A CN104520323A (zh) 2015-04-15
CN104520323B true CN104520323B (zh) 2018-05-04

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CN201380022683.4A Active CN104520323B (zh) 2012-03-02 2013-03-01 用于治疗b细胞介导的炎性疾病的方法

Country Status (10)

Country Link
US (1) US9890213B2 (https=)
EP (1) EP2820045B1 (https=)
JP (1) JP6193275B2 (https=)
KR (1) KR102090969B1 (https=)
CN (1) CN104520323B (https=)
AU (1) AU2013225812B2 (https=)
CA (1) CA2865928C (https=)
IN (1) IN2014DN08199A (https=)
NZ (1) NZ629828A (https=)
WO (1) WO2013130959A1 (https=)

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BR112014008885B1 (pt) 2011-10-11 2021-02-17 Vaccinex, Inc uso de um anticorpo isolado ou fragmento de ligação ao antígeno do mesmo que se liga especificamente à semaforina-4d para diminuir permeabilidade da barreira hematoencefálica (bbb) em um indivíduo com permeabilidade da bbb aumentada e um transtorno neuroinflamatório
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
EP2951204B1 (en) * 2013-01-31 2019-05-22 Vaccinex, Inc. Methods for increasing immunoglobulin a levels
MX377858B (es) 2013-06-25 2025-03-11 Vaccinex Inc Combinación de moleculas inhibidoras de semaforina-4d con agentes inmunomoduladores y usos de los mismos.
IL262232B2 (en) 2016-04-22 2024-06-01 Vaccinex Inc Integral membrane protein display on poxvirus extracellular enveloped virions
KR102449406B1 (ko) 2016-08-02 2022-09-29 백시넥스 인코포레이티드 백시니아 바이러스/진핵 세포에서 폴리뉴클레오티드 라이브러리를 생산하기 위한 개선된 방법
MX2019003019A (es) * 2016-09-19 2019-09-19 I Mab Anticuerpos anti-gm-csf y usos de los mismos.
BR112020022892A2 (pt) * 2018-05-31 2021-02-23 Glycom A/S mistura de hmos para tratamento de doenças autoi-munes
CN112469735B (zh) * 2018-09-18 2022-11-08 天境生物科技(上海)有限公司 用于治疗自发性疾病和癌症的抗cxcl13抗体

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Also Published As

Publication number Publication date
KR20140138830A (ko) 2014-12-04
EP2820045A1 (en) 2015-01-07
JP6193275B2 (ja) 2017-09-06
IN2014DN08199A (https=) 2015-05-01
US20150125467A1 (en) 2015-05-07
NZ629828A (en) 2017-05-26
AU2013225812B2 (en) 2017-11-30
JP2015509960A (ja) 2015-04-02
AU2013225812A1 (en) 2014-09-25
WO2013130959A1 (en) 2013-09-06
US9890213B2 (en) 2018-02-13
EP2820045B1 (en) 2018-08-22
KR102090969B1 (ko) 2020-03-19
CA2865928C (en) 2021-02-16
CA2865928A1 (en) 2013-09-06
CN104520323A (zh) 2015-04-15

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