CN104519975B - 用于从样本流体分离滤液的方法和分离装置 - Google Patents
用于从样本流体分离滤液的方法和分离装置 Download PDFInfo
- Publication number
- CN104519975B CN104519975B CN201380042263.2A CN201380042263A CN104519975B CN 104519975 B CN104519975 B CN 104519975B CN 201380042263 A CN201380042263 A CN 201380042263A CN 104519975 B CN104519975 B CN 104519975B
- Authority
- CN
- China
- Prior art keywords
- filter
- sample
- plunger
- filtrate
- doughnut
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000706 filtrate Substances 0.000 title claims abstract description 42
- 239000012530 fluid Substances 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims description 14
- 238000000926 separation method Methods 0.000 title abstract description 20
- 210000004369 blood Anatomy 0.000 claims abstract description 18
- 239000008280 blood Substances 0.000 claims abstract description 18
- 238000007789 sealing Methods 0.000 claims abstract description 15
- 239000012528 membrane Substances 0.000 claims description 19
- 238000001914 filtration Methods 0.000 claims description 5
- 235000012489 doughnuts Nutrition 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- 238000005204 segregation Methods 0.000 claims 7
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000000630 rising effect Effects 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 abstract description 2
- 230000037431 insertion Effects 0.000 abstract description 2
- 230000000903 blocking effect Effects 0.000 description 12
- 210000003743 erythrocyte Anatomy 0.000 description 8
- 238000009736 wetting Methods 0.000 description 7
- 238000000605 extraction Methods 0.000 description 6
- 239000011148 porous material Substances 0.000 description 5
- 210000000601 blood cell Anatomy 0.000 description 3
- 239000003365 glass fiber Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000009172 bursting Effects 0.000 description 2
- 238000005534 hematocrit Methods 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D24/00—Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof
- B01D24/28—Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof with the filter bed moving during the filtration
- B01D24/30—Translation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/24—Specific pressurizing or depressurizing means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/05—Moving the membrane in one direction, e.g. displacement, translational movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
- B01L2300/047—Additional chamber, reservoir
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179912.6 | 2012-08-09 | ||
| EP12179912.6A EP2695656A1 (de) | 2012-08-09 | 2012-08-09 | Verfahren sowie eine Separationsvorrichtung zur Abtrennung eines Filtrats von einer Probenflüssigkeit |
| PCT/EP2013/066550 WO2014023765A2 (en) | 2012-08-09 | 2013-08-07 | Method and separation device for separating a filtrate from a sample fluid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104519975A CN104519975A (zh) | 2015-04-15 |
| CN104519975B true CN104519975B (zh) | 2017-04-19 |
Family
ID=46851289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380042263.2A Expired - Fee Related CN104519975B (zh) | 2012-08-09 | 2013-08-07 | 用于从样本流体分离滤液的方法和分离装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9835531B2 (enExample) |
| EP (2) | EP2695656A1 (enExample) |
| JP (1) | JP2015531860A (enExample) |
| CN (1) | CN104519975B (enExample) |
| WO (1) | WO2014023765A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9358508B2 (en) * | 2013-04-25 | 2016-06-07 | Lockheed Martin Corporation | Dryer and water recovery/purification unit employing graphene oxide or perforated graphene monolayer membranes |
| GB201411615D0 (en) * | 2014-06-30 | 2014-08-13 | Ge Healthcare Uk Ltd | Device and method for cell nuclei preparation |
| US11033896B2 (en) * | 2014-08-08 | 2021-06-15 | Ortho-Clinical Diagnostics, Inc. | Lateral-flow assay device with filtration flow control |
| EP3248004B1 (en) | 2015-01-21 | 2020-10-07 | Agency For Science, Technology And Research | Rare cells and uses thereof |
| CN104887322A (zh) * | 2015-05-06 | 2015-09-09 | 赵甲辰 | 肺脓肿智能诊断治疗台 |
| JP2018524571A (ja) | 2015-06-08 | 2018-08-30 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 生物学的なサンプルを濾過するための濾過セルおよび方法 |
| AU2016222413B2 (en) * | 2015-10-09 | 2021-04-01 | Arockia Xavier DOSS | Plasma clot serum separation apparatus and method |
| DK3420334T3 (da) | 2016-02-24 | 2020-12-14 | Partnership For Clean Competition | Flerlaget anordning til separation af blodkomponenter og anvendelser deraf |
| EP3423827B1 (en) * | 2016-03-02 | 2025-12-17 | Becton, Dickinson and Company | Biological fluid separation device |
| CA3026549A1 (en) | 2016-06-09 | 2017-12-14 | Becton, Dickinson And Company | Biological fluid separation device |
| WO2020039677A1 (ja) * | 2018-08-23 | 2020-02-27 | 株式会社村田製作所 | 濾過装置及び濾過方法 |
| US12128334B2 (en) * | 2018-09-05 | 2024-10-29 | Kin Mun Chin | Filter press with threadably advanced filtrate receiving plunger |
| MY195849A (en) * | 2018-09-05 | 2023-02-23 | Kin Mun Chin | Device for Filtering |
| KR102807500B1 (ko) | 2018-12-27 | 2025-05-16 | 아란세오 도이치란드 게엠베하 | 예비가교된 니트릴 고무의 미분 혼합물 |
| KR102418963B1 (ko) * | 2020-11-20 | 2022-07-08 | 고려대학교 산학협력단 | 미세입자의 분석방법 및 장치 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3814079A (en) | 1972-04-28 | 1974-06-04 | Upjohn Co | Liquid collecting and filtering device |
| FR2274918A1 (fr) * | 1974-03-30 | 1976-01-09 | Sarstedt Kunststoff | Dispositif de filtrage pour la separation de fractions de sang |
| US4046145A (en) | 1976-06-29 | 1977-09-06 | American Hospital Supply Corporation | Syringe connector |
| US4131549A (en) * | 1977-05-16 | 1978-12-26 | Ferrara Louis T | Serum separation device |
| DE3610429A1 (de) | 1986-03-27 | 1987-10-01 | Boehringer Mannheim Gmbh | Gerinnungsneutrale, hydrophile glasfasern |
| US4800020A (en) * | 1987-05-21 | 1989-01-24 | Xydex Corporation | Piston filtering device |
| US4921618A (en) * | 1987-07-01 | 1990-05-01 | Basf Corporation | Inverted separation and transfer device, and process for using same |
| US4990253A (en) * | 1988-01-25 | 1991-02-05 | Abbott Laboratories | Fluid sample filtration device |
| US4891134A (en) * | 1988-01-25 | 1990-01-02 | Abbott Laboratories | Sample filtration device |
| US4962044A (en) * | 1988-04-25 | 1990-10-09 | Hoffmann-La Roche Inc. | Test tube filter/dispenser apparatus and method |
| CA2006880A1 (en) | 1989-01-03 | 1990-07-03 | William D. Huse | Push column and chromatography method |
| DE3913197A1 (de) | 1989-04-21 | 1990-10-25 | Sarstedt Walter Geraete | Blutentnahmevorrichtung |
| DE4015589A1 (de) | 1990-05-15 | 1991-11-21 | Boehringer Mannheim Gmbh | Vorrichtung und deren verwendung zur abtrennung von plasma aus vollblut |
| JPH0593721A (ja) * | 1990-12-03 | 1993-04-16 | Sanwa Kagaku Kenkyusho Co Ltd | 血清・血漿分離器具 |
| US5234608A (en) | 1990-12-11 | 1993-08-10 | Baxter International Inc. | Systems and methods for processing cellular rich suspensions |
| JPH0595721A (ja) | 1991-10-07 | 1993-04-20 | Yanmar Agricult Equip Co Ltd | コンバインにおける刈取搬送装置 |
| US5672481A (en) | 1991-10-23 | 1997-09-30 | Cellpro, Incorporated | Apparatus and method for particle separation in a closed field |
| JPH05188053A (ja) | 1992-01-10 | 1993-07-27 | Sanwa Kagaku Kenkyusho Co Ltd | 血液から血清又は血漿成分を分離する器具 |
| US5578459A (en) | 1993-11-24 | 1996-11-26 | Abbott Laboratories | Method and apparatus for collecting a cell sample from a liquid specimen |
| GB9426251D0 (en) | 1994-12-24 | 1995-02-22 | Fsm Technologies Ltd | Device |
| AU4766896A (en) | 1995-02-09 | 1996-08-27 | First Medical, Inc. | Peristaltic system and method for plasma separation |
| US5637087A (en) | 1995-03-22 | 1997-06-10 | Abbott Laboratories | Prefilled, two-constituent syringe |
| US5549816A (en) * | 1995-10-31 | 1996-08-27 | Hach Company | Re-usable piston filter system |
| US6117394A (en) | 1996-04-10 | 2000-09-12 | Smith; James C. | Membrane filtered pipette tip |
| US6241947B1 (en) | 1998-01-27 | 2001-06-05 | Fuji Photo Film Co., Ltd. | Chemical analysis system and blood filtering unit |
| US6669905B1 (en) | 1998-05-21 | 2003-12-30 | Baxter International Inc. | Systems and methods for collecting plasma that is free or virtually free of cellular blood species |
| US6817256B2 (en) | 2001-02-27 | 2004-11-16 | Alfa Wassermann, Inc. | Pipette sampling system |
| JP3815976B2 (ja) * | 2001-03-16 | 2006-08-30 | 株式会社アイ・デザイン | 血液ろ過器及び採血器 |
| US6869405B2 (en) | 2001-03-30 | 2005-03-22 | Becton, Dickinson And Company | Blunt cannula and filter assembly and method of use with point-of-care testing cartridge |
| US6761855B1 (en) | 2001-11-05 | 2004-07-13 | Biosearch Technologies, Inc. | Column for solid phase processing |
| US7682818B2 (en) | 2003-03-28 | 2010-03-23 | Fujifilm Corporation | Apparatus for separating and purifying nucleic acid and method for separating and purifying nucleic acid |
| DE102004056655B4 (de) | 2004-11-23 | 2007-03-29 | Sarstedt Ag & Co. | Probenröhrchen zur Aufnahme von Körperflüssigkeit, insbesondere Blut |
| US8563264B2 (en) * | 2007-11-20 | 2013-10-22 | 3M Innovative Properties Company | Sample preparation for environmental sampling |
| US20100093551A1 (en) | 2008-10-09 | 2010-04-15 | Decision Biomarkers, Inc. | Liquid Transfer and Filter System |
| EP2264453B1 (en) | 2009-06-17 | 2013-04-03 | Leukocare Ag | Method for filtering blood |
| JP5686810B2 (ja) | 2009-09-17 | 2015-03-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 液体サンプルを入力するためのサンプル入力デバイス(凝塊キャッチャー) |
| US9116089B2 (en) | 2010-11-10 | 2015-08-25 | Boehringer Ingelheim Microparts Gmbh | Device for filtering blood |
-
2012
- 2012-08-09 EP EP12179912.6A patent/EP2695656A1/de not_active Withdrawn
-
2013
- 2013-08-07 EP EP13750666.3A patent/EP2882512B1/en active Active
- 2013-08-07 JP JP2015525878A patent/JP2015531860A/ja active Pending
- 2013-08-07 WO PCT/EP2013/066550 patent/WO2014023765A2/en not_active Ceased
- 2013-08-07 CN CN201380042263.2A patent/CN104519975B/zh not_active Expired - Fee Related
-
2015
- 2015-02-06 US US14/615,700 patent/US9835531B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2695656A1 (de) | 2014-02-12 |
| EP2882512B1 (en) | 2019-05-01 |
| WO2014023765A2 (en) | 2014-02-13 |
| EP2882512A2 (en) | 2015-06-17 |
| HK1206302A1 (en) | 2016-01-08 |
| US20150153258A1 (en) | 2015-06-04 |
| US9835531B2 (en) | 2017-12-05 |
| CN104519975A (zh) | 2015-04-15 |
| JP2015531860A (ja) | 2015-11-05 |
| WO2014023765A3 (en) | 2014-05-01 |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170419 Termination date: 20180807 |