CN104491827A - Traditional Chinese medicine preparation for preventing postpartum hemorrhage and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for preventing postpartum hemorrhage and preparation method thereof Download PDF

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CN104491827A
CN104491827A CN201510014057.1A CN201510014057A CN104491827A CN 104491827 A CN104491827 A CN 104491827A CN 201510014057 A CN201510014057 A CN 201510014057A CN 104491827 A CN104491827 A CN 104491827A
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parts
chinese medicine
radix
medicine preparation
preparation
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刘玉娥
董秋华
刘玉荣
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention provides a traditional Chinese medicine preparation for preventing postpartum hemorrhage and a preparation method thereof. The traditional Chinese medicine preparation comprises the following raw medicinal materials: ginseng, radix aconiti carmichaeli, ginger charcoal, myrrh, dragon's blood, Chinese angelica, rhizoma chuanxiong, lentinus lepideus, sanicula chinensis, silkworm cocoon, leaf of Chinese loropetalum, triflorous ainsliaea leaf, rubia yunnanensis, root of common triplostegia, scarlet kadsura root, ground beetle, gardenia jasminoides root, eurya nitida, woodfordia fruticosa and lentinus edodes. The traditional Chinese medicine preparation provided by the invention realizes an exact curative effect and brings few toxic and side effects when used for preventing postpartum hemorrhage.

Description

A kind of Chinese medicine preparation prevented and cure the postpartum bleeding and preparation method thereof
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine preparation prevented and cure the postpartum bleeding and preparation method thereof.
Background technology
Postpartum hemorrhage refers to bleeding profusely of being difficult to puerperal to stop.This is that one is very serious, but not too common complication.If process in time would not critical life.Uterus is too lax or fail to tighten due to long-term beaten childbirth, produces wound and crosses and mostly likely bleed.Metreurysma excessive may, polyhydramnios, puerpera physical weakness individual large due to multiple birth, fetus as anemia, frightened, or overtired caused by.Placenta Hominis deformity, also can stop uterus symmetric shrinkage.
In the world, postpartum hemorrhage remains the reason the most common causing maternal death, effectively controls the death that postpartum hemorrhage can avoid a lot of pregnant and lying-in women unnecessary.Postpartum hemorrhage all can occur in the place that any one is given a birth, and the postpartum hemorrhage of 70% caused due to uterine contractions fatigue.Treatment uterine inertia, except using uterine contraction agent, carry out beyond kneading uterine, other method seems to need further increase other drug or increase surgical intervention, also a lot of complicated medical apparatus and instruments can may be needed in the past, but this is very not possible in outlying district, have impact on the carrying out of further intervening, likely becomes the reason of maternal death thus.Be first reason causing maternal death in recent years at China's postpartum hemorrhage, particularly in Far-away Backward Areas, this situation is more outstanding always.The sickness rate of postpartum hemorrhage accounts for about 2% ~ 3% of childbirth sum, and because the subjective factors measuring and collect amount of bleeding is comparatively large, actual sickness rate is higher.
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of Chinese medicine preparation prevented and cure the postpartum bleeding and preparation method thereof, Chinese medicine preparation of the present invention is to the definite curative effect that prevented and cure the postpartum bleeding, and toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation prevented and cure the postpartum bleeding, its raw medicinal material comprises: Radix Ginseng, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens charcoal, Myrrha, Sanguis Draxonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, leopard mushroom, sanicle, Bombyx bombycis, Folium Loropetali, Folium Ainslaea Triflorae, Rubiayunnanensis (Franch.) Dlels, all draw, Radix Kadsurae Coccineae, female ground beetle, Radix Fructus Gardeniae, Eurya nitida, Flos Woodfordiae Fruticosae and Lentinus Edodes.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Radix Ginseng 10 ~ 35 parts, Radix Aconiti Lateralis Preparata 5 ~ 15 parts, Rhizoma Zingiberis Recens charcoal 10 ~ 20 parts, Myrrha 15 ~ 30 parts, Sanguis Draxonis 15 ~ 25 parts, Radix Angelicae Sinensis 10 ~ 30 parts, Rhizoma Chuanxiong 10 ~ 20 parts, 15 ~ 30 parts, leopard mushroom, sanicle 15 ~ 25 parts, Bombyx bombycis 10 ~ 35 parts, Folium Loropetali 15 ~ 40 parts, Folium Ainslaea Triflorae 10 ~ 20 parts, Rubiayunnanensis (Franch.) Dlels 15 ~ 25 parts, all draw 15 ~ 25 parts, Radix Kadsurae Coccineae 15 ~ 30 Fen ， female ground beetle 5 ~ 15 parts, Radix Fructus Gardeniae 15 ~ 30 parts, Eurya nitida 15 ~ 25 parts, Flos Woodfordiae Fruticosae 10 ~ 30 parts and 15 ~ 40 parts, Lentinus Edodes.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Radix Ginseng 20 ~ 30 parts, Radix Aconiti Lateralis Preparata 5 ~ 10 parts, Rhizoma Zingiberis Recens charcoal 15 ~ 20 parts, Myrrha 15 ~ 25 parts, Sanguis Draxonis 18 ~ 25 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Rhizoma Chuanxiong 15 ~ 20 parts, 15 ~ 25 parts, leopard mushroom, sanicle 15 ~ 20 parts, Bombyx bombycis 20 ~ 30 parts, Folium Loropetali 20 ~ 30 parts, Folium Ainslaea Triflorae 15 ~ 20 parts, Rubiayunnanensis (Franch.) Dlels 15 ~ 22 parts, all draw 15 ~ 23 parts, Radix Kadsurae Coccineae 15 ~ 20 Fen ， female ground beetle 8 ~ 15 parts, Radix Fructus Gardeniae 18 ~ 30 parts, Eurya nitida 15 ~ 20 parts, Flos Woodfordiae Fruticosae 10 ~ 25 parts and 15 ~ 25 parts, Lentinus Edodes.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ginseng 20 parts, Radix Aconiti Lateralis Preparata 6 parts, Rhizoma Zingiberis Recens charcoal 28 parts, Myrrha 23 parts, Sanguis Draxonis 23 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 15 parts, 16 parts, leopard mushroom, sanicle 19 parts, Bombyx bombycis 28 parts, Folium Loropetali 27 parts, Folium Ainslaea Triflorae 19 parts, Rubiayunnanensis (Franch.) Dlels 16 parts, all draw 22 parts, Radix Kadsurae Coccineae 20 Fen ， female ground beetle 12 parts, Radix Fructus Gardeniae 28 parts, Eurya nitida 19 parts, Flos Woodfordiae Fruticosae 24 parts and 25 parts, Lentinus Edodes.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ginseng 26 parts, Radix Aconiti Lateralis Preparata 8 parts, Rhizoma Zingiberis Recens charcoal 26 parts, Myrrha 19 parts, Sanguis Draxonis 22 parts, Radix Angelicae Sinensis 24 parts, Rhizoma Chuanxiong 18 parts, 21 parts, leopard mushroom, sanicle 16 parts, Bombyx bombycis 24 parts, Folium Loropetali 22 parts, Folium Ainslaea Triflorae 17 parts, Rubiayunnanensis (Franch.) Dlels 19 parts, all draw 18 parts, Radix Kadsurae Coccineae 17 Fen ， female ground beetle 9 parts, Radix Fructus Gardeniae 24 parts, Eurya nitida 17 parts, Flos Woodfordiae Fruticosae 19 parts and 17 parts, Lentinus Edodes.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is that the ethanol of 85% ~ 95% is as solvent, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps,
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
Beneficial effect of the present invention: Chinese medicine preparation of the present invention is to the definite curative effect that prevented and cure the postpartum bleeding, and toxic and side effects is little.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation prevented and cure the postpartum bleeding, its raw medicinal material comprises: Radix Ginseng, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens charcoal, Myrrha, Sanguis Draxonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, leopard mushroom, sanicle, Bombyx bombycis, Folium Loropetali, Folium Ainslaea Triflorae, Rubiayunnanensis (Franch.) Dlels, all draw, Radix Kadsurae Coccineae, female ground beetle, Radix Fructus Gardeniae, Eurya nitida, Flos Woodfordiae Fruticosae and Lentinus Edodes.
In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:
Radix Ginseng: [another name] people rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) (" herbal classic "), Rhizoma Panacis Japonici, SHENCAO, Sphallerocarpus gracilis, Herba Wedeliae Wallichii (" WU Pu Bencao "), Herba Stellariae Saxatilis (" extensively refined "), hundred chi pestles (" Bencao Tujing "), the beautiful door screen of sea fat, golden well, Radix Ginseng (" detailed outline "), battledore (" Liaoning main Chinese medicinal materials ").For the root of Araliaceae Radix Ginseng.Warm in nature, sweet in the mouth, micro-hardship.Enter spleen, lung meridian.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.[extracts] " Chinese medicine voluminous dictionary "
Radix Aconiti Lateralis Preparata: [another name] Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata.This product is the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Late June excavated to early August, and removing parent root, fibrous root and silt, practise and claim " mud Radix Aconiti Lateralis Preparata ".Extremely hot in nature, sweet in the mouth, pungent, poisonous.GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.[extracts] " Chinese Pharmacopoeia "
Rhizoma Zingiberis Recens charcoal: the processed product that the dry rhizome for zingiber is formed through parch to black.Warm in nature, bitter in the mouth, pungent, puckery.Enter spleen, liver, kidney channel.Warming the meridian for stopping bleeding; Warming spleen and stopping diarrha.Main deficient cold type is spitted blood; Have blood in stool; Metrorrhagia; Yang deficiency is had loose bowels.[extracts] " China's book on Chinese herbal medicine "
Myrrha: the gum resin that [another name] myrrh (" detailed outline ") is olive subject plant myrrh or Alan fort myrrh.February in November to next year or 6 ~ July gather.The many cracks by bark of this product are oozed out naturally; Or bark is cut, gum resin is oozed out from wound.Liquid just in yellow-white, solidifies gradually after ingress of air and forms rufous lump.Adopt after remove bark and impurity, put dry ventilation preserve.The flat bitter in the mouth of property, enters Liver Channel.Loose blood blood stasis removing, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.[extracts] " Chinese medicine voluminous dictionary "
Sanguis Draxonis: [another name] Sanguis Draxonis.This product is that the resin that oozes out of babassu Sanguis Draxonis Daemonorops draco Blume. fruit is through being processed into.Property flat, sweet in the mouth, salty.GUIXIN, Liver Channel.Removing blood stasis and relieving pain, hemostasia and promoting granulation.Lose for falling to flutter, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.[extracts] " Chinese Pharmacopoeia "
Radix Angelicae Sinensis: [another name] dry returns, horse hair Radix Angelicae Sinensis, the Qin which, horse hair is returned, cloud is returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis.For the root of umbelliferae angelica.Warm in nature, sweet in the mouth, pungent, bitter.Return liver, the heart, spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Chuanxiong: [another name] mountain is brought up thoroughly, rhizome of chuanxiong Qiong, Oleum Linderae, recklessly Qiong, gag bit, rhizome of chuanxiong Qiong, Medulla passeris rhizome of chuanxiong, capital rhizome of chuanxiong, pass through rhizome of chuanxiong, Ligusticum slnense, platform rhizome of chuanxiong, western rhizome of chuanxiong.For the rhizome of samphire Rhizoma Chuanxiong.Acrid in the mouth warm in nature, returns liver, gallbladder, pericardium channel.Blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Main menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.[extracts] " China's book on Chinese herbal medicine "
Leopard mushroom: [another name] Scaly lentinus, white Lentinus Edodes.For the sporophore of Bai Mo section fungus leneinus lepideus Franch.The flat sweet in the mouth of property, enters the heart, spleen channel.Fill blood; Benefit conscience.Main insufficiency of vital energy and blood; Deficiency of both the heart and spleen; Fatigue and weak; Insomnia cardiopalmus.[extracts] " China's book on Chinese herbal medicine "
Sanicle: [another name] Spuropimpinella brachycarpa (Kom.) Kitag., mountain celery, the five fingers infantile malnutrition, flipper, Radix seu Herba Gei aleppici.For the herb of samphire sanicle.Cool in nature, acrid in the mouth, micro-sweet.Removing toxic substances; Hemostasis.Main pharyngalgia; Cough; Menorrhagia; Hematuria; Traumatic hemorrhage; Sore and toxic.[extracts] " China's book on Chinese herbal medicine "
Bombyx bombycis: [another name] Cocoon.This product is Insecta Lepidoptera Bombycidae silkworm Bombyx mori L., is used as medicine with the cocoon removing cocoon pupa.Clearing away heat to stop bleeding, cures mainly skin ulcer and swells without a head, stranguria with blood pain, stool hematochezia, married woman's metrorrhagia.[extracts] " national Chinese herbal medicine compilation "
Folium Loropetali: be the leaf of Hamamelidaceae Plants Loropetalum chinense (R. Br.) Oliv..[nature and flavor] bitter in the mouth; Puckery; Cool in nature.[return through] liver; Stomach; Large intestine channel.[function cures mainly] astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main spitting of blood; Spit blood; Have blood in stool; Metrorrhagia; Post partum longtime lochia; Purpura; Summer-heat dysentery; Traumatic injury; Wound hemorrhage; Liver-heat conjunctival congestion; Laryngalgia.[extracts] " China's book on Chinese herbal medicine "
Folium Ainslaea Triflorae: the sub-Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) of [another name] BAIHU, great Ye Lycoris radiata.For the leaf of feverfew three flower Ainsliaea fragrans Champ..Summer, autumn picking leaves, dry or levigation for subsequent use.Property flat, acrid in the mouth, micro-puckery.Hemostasis, granulation promoting, closes up.Control knife injury hemorrhage, grind into powder and spread injury.[extracts] " Chinese medicine voluminous dictionary "
Rubiayunnanensis (Franch.) Dlels: [another name] Herba Rubiae Yunnanensis, Yunnan Herba Salviae Chinensis.This product is Rubiaceae Rubiayunnanensis (Franch.) Dlels, with all herbal medicine.The flat sweet in the mouth of property.Enrich blood and invigorate blood circulation, expelling wind and removing dampness, softening the hard mass removing mass.Cure mainly anemia, traumatic injury, chronic gastritis, lipoma, menoxenia.[extracts] " national Chinese herbal medicine compilation "
All draw: [another name] all draws ginseng, Radix Triplostegiae Glanduliferae, native Herba Patriniae, Radix Satyrii nepalensis, Radix Raphani ginseng, Bai Doula, coelogyne flaccida cindl, Herba Achilleae, Radix Raphani Radix Triplostegiae Glanduliferae, Silene tatarinowii Regel-Melandrium tatarinwiii (Regel) Tsui., two perfume (or spice).For the root of Dipsacaceae plant southwest capsule bud flower.Slightly warm in nature, sweet in the mouth, micro-hardship.Enter lung, spleen, kidney channel.The kidney warming QI invigorating; Promoting blood circulation and hemostasis.Main body deadhead dusk; Asthenia chronic cough; Insufficiency of the spleen food stagnation; Lumbago due to renal deficiency; Leukorrhagia; Sexual impotence; Infertile; Rheumatic heart disease; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Radix Kadsurae Coccineae: [another name] enters ground Moschus, Clausena excavata Burm.f. (" register planted by Guangxi medicine "), thoroughly like a chain of pearls or a string of beads, Cortex schizophragmatis integrifolii radicis, 300 liang of silver (Guangzhou army " conventional Chinese herbal medicine handbook ").For root bark or the root of Magnoliacea plant Kadsura coccinea (Lem.) A.C. Smith.The whole year can adopt.Guangzhou army " conventional Chinese herbal medicine handbook ": " pungent micro-hardship, temperature." circulation of qi promoting, invigorates blood circulation, dissipating blood stasis, pain relieving.Control acute gastroenteritis, chronic gastritis, gastric and duodenal ulcers, rheumatic ostalgia, dysmenorrhes, puerperal, the stasis of blood was stagnant, traumatic injury, and knife injury is hemorrhage.[extracts] " Chinese medicine voluminous dictionary "
Female ground beetle: [another name] eupolyphoge sinensis (" herbal classic "), ground beetle (" not Lu "), cross street (" increase is refined "), dustpan worm (amplification on Canon of Materia Medica) Ke Bo worm (" pocket side "), ground slave girl worm (" Boydii children's side "), mountain Blatta seu periplaneta (" book on Chinese herbal medicine asks former "), DIWUGUI (" classifying herbal "), eupolyphaga (" Chinese medicine shape sex experience differential method "), Cimex bedbug is female, lid worm (" Hebei medical material "), eupolyphage sece steleophaga (" Jilin Chinese herbal medicine "), joint joint worm, Formica fusca tiger (" Jiangsu medical material will ").For the male Scorpio of Corydiidae insecticide eupolyphoge sinensis or Ji Lian section insecticide opishoplatia orientalis Brumister.Catch between 5 ~ August.Be spread on the ground to trap it with the fragrant Testa Tritici of stir-fry, or evening lamp light trapping.Catch after, scald dead with boiling water, dry or dry; Also after can cleaning with clear water, then use salt decocting in water mistake, dry or dry.Salty in the mouth cold in nature is poisonous." Thunder God concocts property of medicine solution ": " enter the heart, liver, spleen three warp." removing blood stasis, removing mass, dredging collateral, reason wound.Control lump in the abdomen, amenorrhea due to stagnation of blood, postnatal blood stasis is suffered from abdominal pain, traumatic injury, swollen and rigid tongue, congenital deformity of the tongue.[extracts] " Chinese medicine voluminous dictionary "
Radix Fructus Gardeniae: be the root of Maguireothamnus speciosus Fructus Gardeniae.Cold in nature, sweet in the mouth, hardship.Enter liver, gallbladder, stomach warp.Clearing away heat-damp and promoting diuresis; Cooling blood for hemostasis.Main icterohepatitis; Dysentery; Cholecystitis; The high heat of flu; Spit blood; Epistaxis; Urinary tract infection; Oedema due to nephritis; Mastitis; Acute toothache; Sore and toxic; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Eurya nitida: be the Herb of plant of theaceae Eurya nitida.Property flat, bitter in the mouth, puckery.Expelling wind and removing dampness; Removing toxic substances sore; Hemostasis.Main air pain of dampness syndrome; Have loose bowels; Innominate toxic swelling; Skin infection festers; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Flos Woodfordiae Fruticosae: [another name] red Mel flower, Wu Fuhua, wild Flos Carthami, stasis-breaking drug, Sha Hua, shrimp flower.Lythraceae Flos Woodfordiae Fruticosae Woodfordia fruticosa (L.) Kurz, is used as medicine with root, flower.Warm in nature, sweet in the mouth, puckery.Regulating menstruation and activating blood, cooling blood for hemostasis, dredge the meridian passage.Cure mainly metrorrhagia, menoxenia, rheumatic arthritis, lumbar muscle strain, epistaxis, hemoptysis.[extracts] " national Chinese herbal medicine compilation "
Lentinus Edodes: [another name] Lentinus Edodes, conjunction gill fungus, platform gill fungus, platform bacterium, thunder shy gill fungus, Dai Sha, stone gill fungus, vertebra gill fungus, fragrant letter, Flammulina velutipes, Flos Chrysanthemi mushroom, fragrant stricture of vagina.For the sporophore of Bai Mo section fungus Lentinus Edodes.The flat sweet in the mouth of property is nontoxic.Enter liver, stomach warp.Righting tonify deficiency; Spleen benefiting and stimulating the appetite; To dispel the wind rash; Phlegm-eliminiating and qi-regulating; Removing toxic substances; Anticancer.Main healthy energy is weak; God is tired weak; Indigestion and loss of appetite; Dyspepsia; Anemia; Rickets; Hypertension; Hyperlipemia; Chronic hepatitis; Night sweat; Incontinence of urine; Edema; Measles is sent out not smooth thoroughly; Urticaria; Poison mushroom is poisoning; Tumor.[extracts] " China's book on Chinese herbal medicine "
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Radix Ginseng 10 ~ 35 parts, Radix Aconiti Lateralis Preparata 5 ~ 15 parts, Rhizoma Zingiberis Recens charcoal 10 ~ 20 parts, Myrrha 15 ~ 30 parts, Sanguis Draxonis 15 ~ 25 parts, Radix Angelicae Sinensis 10 ~ 30 parts, Rhizoma Chuanxiong 10 ~ 20 parts, 15 ~ 30 parts, leopard mushroom, sanicle 15 ~ 25 parts, Bombyx bombycis 10 ~ 35 parts, Folium Loropetali 15 ~ 40 parts, Folium Ainslaea Triflorae 10 ~ 20 parts, Rubiayunnanensis (Franch.) Dlels 15 ~ 25 parts, all draw 15 ~ 25 parts, Radix Kadsurae Coccineae 15 ~ 30 Fen ， female ground beetle 5 ~ 15 parts, Radix Fructus Gardeniae 15 ~ 30 parts, Eurya nitida 15 ~ 25 parts, Flos Woodfordiae Fruticosae 10 ~ 30 parts and 15 ~ 40 parts, Lentinus Edodes.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: Radix Ginseng 20 ~ 30 parts, Radix Aconiti Lateralis Preparata 5 ~ 10 parts, Rhizoma Zingiberis Recens charcoal 15 ~ 20 parts, Myrrha 15 ~ 25 parts, Sanguis Draxonis 18 ~ 25 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Rhizoma Chuanxiong 15 ~ 20 parts, 15 ~ 25 parts, leopard mushroom, sanicle 15 ~ 20 parts, Bombyx bombycis 20 ~ 30 parts, Folium Loropetali 20 ~ 30 parts, Folium Ainslaea Triflorae 15 ~ 20 parts, Rubiayunnanensis (Franch.) Dlels 15 ~ 22 parts, all draw 15 ~ 23 parts, Radix Kadsurae Coccineae 15 ~ 20 Fen ， female ground beetle 8 ~ 15 parts, Radix Fructus Gardeniae 18 ~ 30 parts, Eurya nitida 15 ~ 20 parts, Flos Woodfordiae Fruticosae 10 ~ 25 parts and 15 ~ 25 parts, Lentinus Edodes.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ginseng 20 parts, Radix Aconiti Lateralis Preparata 6 parts, Rhizoma Zingiberis Recens charcoal 28 parts, Myrrha 23 parts, Sanguis Draxonis 23 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 15 parts, 16 parts, leopard mushroom, sanicle 19 parts, Bombyx bombycis 28 parts, Folium Loropetali 27 parts, Folium Ainslaea Triflorae 19 parts, Rubiayunnanensis (Franch.) Dlels 16 parts, all draw 22 parts, Radix Kadsurae Coccineae 20 Fen ， female ground beetle 12 parts, Radix Fructus Gardeniae 28 parts, Eurya nitida 19 parts, Flos Woodfordiae Fruticosae 24 parts and 25 parts, Lentinus Edodes.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Ginseng 26 parts, Radix Aconiti Lateralis Preparata 8 parts, Rhizoma Zingiberis Recens charcoal 26 parts, Myrrha 19 parts, Sanguis Draxonis 22 parts, Radix Angelicae Sinensis 24 parts, Rhizoma Chuanxiong 18 parts, 21 parts, leopard mushroom, sanicle 16 parts, Bombyx bombycis 24 parts, Folium Loropetali 22 parts, Folium Ainslaea Triflorae 17 parts, Rubiayunnanensis (Franch.) Dlels 19 parts, all draw 18 parts, Radix Kadsurae Coccineae 17 Fen ， female ground beetle 9 parts, Radix Fructus Gardeniae 24 parts, Eurya nitida 17 parts, Flos Woodfordiae Fruticosae 19 parts and 17 parts, Lentinus Edodes.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is that the ethanol of 85% ~ 95% is as solvent, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps,
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: injectable powder
Get Radix Ginseng 200g, Radix Aconiti Lateralis Preparata 60g, Rhizoma Zingiberis Recens charcoal 280g, Myrrha 230g, Sanguis Draxonis 230g, Radix Angelicae Sinensis 180g, Rhizoma Chuanxiong 150g, leopard mushroom 160g, sanicle 190g, Bombyx bombycis 280g, Folium Loropetali 270g, Folium Ainslaea Triflorae 190g, Rubiayunnanensis (Franch.) Dlels 160g, all draw 220g, Radix Kadsurae Coccineae 200g ， female ground beetle 120g, Radix Fructus Gardeniae 280g, Eurya nitida 190g, Flos Woodfordiae Fruticosae 240g and Lentinus Edodes 250g.
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is that the ethanol of 90% is as solvent, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 6 DEG C, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 55 minutes at this, the micron particles of acquisition 2 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 35g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.2g needle-use activated carbon, fully stirs 50 minutes; Decarbonization filtering; With 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 2: tablet
Get Radix Ginseng 260g, Radix Aconiti Lateralis Preparata 80g, Rhizoma Zingiberis Recens charcoal 260g, Myrrha 190g, Sanguis Draxonis 220g, Radix Angelicae Sinensis 240g, Rhizoma Chuanxiong 180g, leopard mushroom 210g, sanicle 160g, Bombyx bombycis 240g, Folium Loropetali 220g, Folium Ainslaea Triflorae 170g, Rubiayunnanensis (Franch.) Dlels 190g, all draw 180g, Radix Kadsurae Coccineae 170g ， female ground beetle 90g, Radix Fructus Gardeniae 240g, Eurya nitida 170g, Flos Woodfordiae Fruticosae 190g and Lentinus Edodes 170g.
Prepare according to the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 300 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.27 times, 0.13 times of lactose, the starch of 0.25 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.025 times of magnesium stearate, granulate, tabletting, makes.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 23 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 2, (concentration is 7.28g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>36.4 crude drug/kg, every day, maximum dosage-feeding was 72.8 crude drugs/kg/ day.Chinese medicine preparation clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine preparation of the present invention is 680 times of quantity.Therefore Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine preparation embodiment 2 tablet of the present invention presses 13.35,19.26 and 38.33g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 468 routine patients are pregnant and lying-in women's my institute in February, 2013 ~ in March, 2014.17 ~ 43 years old age, pregnant all 35 ~ 42 weeks, primipara 274 example, multipara 194 example.Wherein, Cesarean esction 306 example, vaginal delivery 162 example.Be divided into Chinese drug-treated group, matched group and blank group at random.
Chinese drug-treated group 156 example, 17 ~ 41 years old age, pregnant all 35 ~ 40 weeks, primipara 96 example, multipara 60 example.Wherein, Cesarean esction 104 example, vaginal delivery 52 example.
Matched group 156 example, 18 ~ 43 years old age, pregnant all 37 ~ 42 weeks, primipara 88 example, multipara 68 example.Wherein, Cesarean esction 100 example, vaginal delivery 56 example.
Blank group 156 example, 18 ~ 42 years old age, pregnant all 36 ~ 42 weeks, primipara 90 example, multipara 66 example.Wherein, Cesarean esction 102 example, vaginal delivery 54 example.
Three groups of ages, the course of disease, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).
Criterion: puerpera amount of bleeding >=400ml in delivery of baby 2h, in delivery of baby 24h, puerpera amount of bleeding >=500ml person is postpartum hemorrhage.Amount of bleeding adopts weight method and area-method to calculate, [dressing heavy (dry weight) before point puerperium dressing heavy (weight in wet base)-childbirth]/1.05=blood loss (blood specific gravity is pressed 1.05g/ml and calculated), area-method: blood wetted surface presses 10cm 2for 1ml calculates; Hemorrhage total amount is the blood loss of weight method acquisition and the blood loss sum of area-method acquisition.
Therapeutic Method:
Chinese drug-treated group: the injectable powder 100mg of the intramuscular injection embodiment of the present invention 1 after delivery of baby, the injectable powder 80mg of the 12 hours intramuscular injection embodiment of the present invention again 1 in interval or 4, the tablet of the oral embodiment of the present invention 2;
Matched group: intramuscular injection oxytocin 20U after delivery of baby, misoprostol 200 μ g puts into rectum 6cm place, Placenta Hominis give birth to after Given oral Misoprostol 200 μ g;
Blank group: intramuscular injection oxytocin 20U after delivery of baby.
Observation index and recording method: observe and record 2h amount of bleeding in puerperal, puerperal 24h amount of bleeding, a situation arises for postpartum hemorrhage rate and bad kickback of using medicine.
Therapeutic outcome: see the following form.
Three groups, table 1 2h amount of bleeding in puerperal and puerperal 24 internal hemorrhage amount compare
Group Example 2h average bleeding in puerperal (ml) 24h average bleeding in puerperal (ml)
Chinese drug-treated group 156 172±34.7 208±36.2
Matched group 156 216±29.5 283±32.8
Blank group 156 253±38.1 324±29.5
Known by table 1, relative to matched group and blank group, medicine of the present invention obviously can reduce the average bleeding of 2h and 24h in puerperal.
Table 2 three groups of incidence of postpartum compare
Group Number of cases Postpartum hemorrhage number Bleeding event
Chinese drug-treated group 156 1 0.64％
Matched group 156 3 1.92％
Blank group 156 7 4.49％
Known by table 2, relative to matched group and blank group, medicine of the present invention can reduce number and ratio that postpartum hemorrhage occurs.
Table 3 three groups of untoward reaction generation number of cases compare
Group Number of cases Feel sick Uterine contraction Slight breast Stomachache Shiver with cold Blood pressure Face
Vomiting Pain Vexedly to feel suffocated Raise Flushing
Chinese drug-treated group 156 0 0 1 0 0 0 1
Matched group 156 6 3 4 2 2 1 3
Blank group 156 0 1 0 0 0 0 0
Known by table 2, relative to matched group, the untoward reaction generation number of medicine of the present invention is less; Chinese drug-treated group and blank group compare zero difference.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. the Chinese medicine preparation prevented and cure the postpartum bleeding, is characterized in that comprising following prescription: Radix Ginseng, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens charcoal, Myrrha, Sanguis Draxonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, leopard mushroom, sanicle, Bombyx bombycis, Folium Loropetali, Folium Ainslaea Triflorae, Rubiayunnanensis (Franch.) Dlels, all draw, Radix Kadsurae Coccineae, female ground beetle, Radix Fructus Gardeniae, Eurya nitida, Flos Woodfordiae Fruticosae and Lentinus Edodes.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Ginseng 10 ~ 35 parts, Radix Aconiti Lateralis Preparata 5 ~ 15 parts, Rhizoma Zingiberis Recens charcoal 10 ~ 20 parts, Myrrha 15 ~ 30 parts, Sanguis Draxonis 15 ~ 25 parts, Radix Angelicae Sinensis 10 ~ 30 parts, Rhizoma Chuanxiong 10 ~ 20 parts, 15 ~ 30 parts, leopard mushroom, sanicle 15 ~ 25 parts, Bombyx bombycis 10 ~ 35 parts, Folium Loropetali 15 ~ 40 parts, Folium Ainslaea Triflorae 10 ~ 20 parts, Rubiayunnanensis (Franch.) Dlels 15 ~ 25 parts, all draw 15 ~ 25 parts, Radix Kadsurae Coccineae 15 ~ 30 parts, female ground beetle 5 ~ 15 parts, Radix Fructus Gardeniae 15 ~ 30 parts, Eurya nitida 15 ~ 25 parts, Flos Woodfordiae Fruticosae 10 ~ 30 parts and 15 ~ 40 parts, Lentinus Edodes.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Ginseng 20 ~ 30 parts, Radix Aconiti Lateralis Preparata 5 ~ 10 parts, Rhizoma Zingiberis Recens charcoal 15 ~ 20 parts, Myrrha 15 ~ 25 parts, Sanguis Draxonis 18 ~ 25 parts, Radix Angelicae Sinensis 15 ~ 30 parts, Rhizoma Chuanxiong 15 ~ 20 parts, 15 ~ 25 parts, leopard mushroom, sanicle 15 ~ 20 parts, Bombyx bombycis 20 ~ 30 parts, Folium Loropetali 20 ~ 30 parts, Folium Ainslaea Triflorae 15 ~ 20 parts, Rubiayunnanensis (Franch.) Dlels 15 ~ 22 parts, all draw 15 ~ 23 parts, Radix Kadsurae Coccineae 15 ~ 20 parts, female ground beetle 8 ~ 15 parts, Radix Fructus Gardeniae 18 ~ 30 parts, Eurya nitida 15 ~ 20 parts, Flos Woodfordiae Fruticosae 10 ~ 25 parts and 15 ~ 25 parts, Lentinus Edodes.
4. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Ginseng 20 parts, Radix Aconiti Lateralis Preparata 6 parts, Rhizoma Zingiberis Recens charcoal 28 parts, Myrrha 23 parts, Sanguis Draxonis 23 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 15 parts, 16 parts, leopard mushroom, sanicle 19 parts, Bombyx bombycis 28 parts, Folium Loropetali 27 parts, Folium Ainslaea Triflorae 19 parts, Rubiayunnanensis (Franch.) Dlels 16 parts, all draw 22 parts, Radix Kadsurae Coccineae 20 Fen ， female ground beetle 12 parts, Radix Fructus Gardeniae 28 parts, Eurya nitida 19 parts, Flos Woodfordiae Fruticosae 24 parts and 25 parts, Lentinus Edodes.
5. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Radix Ginseng 26 parts, Radix Aconiti Lateralis Preparata 8 parts, Rhizoma Zingiberis Recens charcoal 26 parts, Myrrha 19 parts, Sanguis Draxonis 22 parts, Radix Angelicae Sinensis 24 parts, Rhizoma Chuanxiong 18 parts, 21 parts, leopard mushroom, sanicle 16 parts, Bombyx bombycis 24 parts, Folium Loropetali 22 parts, Folium Ainslaea Triflorae 17 parts, Rubiayunnanensis (Franch.) Dlels 19 parts, all draw 18 parts, Radix Kadsurae Coccineae 17 Fen ， female ground beetle 9 parts, Radix Fructus Gardeniae 24 parts, Eurya nitida 17 parts, Flos Woodfordiae Fruticosae 19 parts and 17 parts, Lentinus Edodes.
6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is that the ethanol of 85% ~ 95% is as solvent, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
7. Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
8. a preparation method for the Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
9. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is that the ethanol of 85% ~ 95% is as solvent, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
CN201510014057.1A 2015-01-12 2015-01-12 Traditional Chinese medicine preparation for preventing postpartum hemorrhage and preparation method thereof Pending CN104491827A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105012731A (en) * 2015-07-17 2015-11-04 赵建方 Traditional Chinese medicine for preventing postpartum hemorrhage and preparation method of traditional Chinese medicine

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CN103520409A (en) * 2013-10-18 2014-01-22 王彩英 Chinese herba preparation for treating secretory otitis media and preparation method thereof
CN103536737A (en) * 2013-10-25 2014-01-29 张建民 Traditional Chinese medicament for treating liver-qi stagnation type thyroid adenoma and preparation method thereof
CN104173987A (en) * 2014-09-03 2014-12-03 河南科技大学第一附属医院 Traditional Chinese medicine for treating postpartum hemorrhage caused by blood stasis and qi obstruction and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1483420A (en) * 2002-09-18 2004-03-24 江苏康缘药业股份有限公司 Traditional Chinese medicine composition and preparation method
CN103520409A (en) * 2013-10-18 2014-01-22 王彩英 Chinese herba preparation for treating secretory otitis media and preparation method thereof
CN103536737A (en) * 2013-10-25 2014-01-29 张建民 Traditional Chinese medicament for treating liver-qi stagnation type thyroid adenoma and preparation method thereof
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* Cited by examiner, † Cited by third party
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CN105012731A (en) * 2015-07-17 2015-11-04 赵建方 Traditional Chinese medicine for preventing postpartum hemorrhage and preparation method of traditional Chinese medicine

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Application publication date: 20150408