CN104491530A - 一种治疗由肠功能紊乱引起的便秘的颗粒剂及其制备方法 - Google Patents
一种治疗由肠功能紊乱引起的便秘的颗粒剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗由肠功能紊乱引起的便秘的颗粒剂,各原料药如下,均为重量份:芒硝3-9,枳实6-12,小米12-25,莱菔8-16,桑葚子6-12,川芎5-15,甘薯3-7,火麻仁7-15,知母10-20,天门冬3-9,菟丝子9-15,佩兰5-15,荸荠3-12,郁李仁3-8,当归10-20。本发明颗粒剂不仅能够治疗由肠功能紊乱引起的便秘症状,还能起到调节肠功能的作用,治疗由肠功能紊乱引起的便秘效果显著,无副作用,实用性广,不但可以使病情得到良好控制,而且能对损伤的机体起到修复作用。
Description
技术领域
本发明属中医中药领域,尤其是涉及一种治疗由肠功能紊乱引起的便秘的颗粒剂及其制备方法。
背景技术
肠功能紊乱,即胃肠神经官能症,又称肠道功能紊乱,是一组胃肠综合症的总称,是高级神经活动障碍导致植物神经系统功能失常。主要为胃肠的运动与分泌机能失调,无组织学器质性病理改变,不包括其他系统疾病引起的胃肠道功能紊乱。肠功能紊乱可造成便秘、便血、直肠炎、十二指肠溃疡等严重问题。
肠功能紊乱属中医“腹痛”、“泄泻”、“下利”等病症范畴,并与便秘密切相关。中医认为本病与饮食不节,过食生冷肥甘;或情志失调,肝气郁结;或劳倦太过,脾气受损;或年老体衰,久病脏虚,以致脾胃功能障碍等有关。临床可分为肝气乘脾、湿浊困脾、脾胃虚弱、脾肾阳虚等症型。药物治疗治疗肠功能紊乱的西药很多,但指标客观和疗效可靠者甚少,因该病为功能性疾病,可伴有全身诸多症状比如:梅核气、神经性呕吐、神经性嗳气、神经性厌食与肠易激综合征,常伴有失眠、焦虑、注意力涣散、健忘、神经过敏、头痛等其他功能性症状。所以治疗需要运用理肠调胃安神汤全面调理心神以及五脏,才可彻底恢复正常,切不可头痛医头,脚痛治脚,没有抓住疾病的主要矛盾去进行综合治疗,而是把片面的症状,当成了主要症状,造成顾此失彼,致使疾病反复发作,难以治愈。
肠功能紊乱几乎包括了消化道发病时的全部症状:腹痛、腹胀、便秘、便秘、便秘便秘交替出现、粘状便、水样便、黏液便等,因此在临床诊断上造成模糊概念,曾被称为黏液结肠炎、结肠病变、结肠过敏、过敏性结肠炎、易激结肠等。直到现今才被统一称为肠易激综合症,临床上简称ibs。肠功能紊乱症状虽然多样,但归结起来,全都是由于肠道功能紊乱造成的。为了便于临床治疗,有人将其分为:便秘型;便秘型;便秘、便秘交替型等三型。其特征是:各项物理检查及化验检查均未见异常肠道本身并无严重损害,但稍受刺激,活动就不正常,表现为运动过快为便秘;运动过慢为便秘、痉挛等,肠功能紊乱的症状群。轻度肠功能紊乱的临床表现可有:腹痛、腹胀、腹部不适、便秘或便秘。腹痛多为发作性,常在进食或冷饮后加重,排便排气后减轻。便秘者粪便多为糊状,可含粘液,但绝无脓血便发生。便秘多在餐前或餐后后发生,便意急。有的以便秘为主,有的为便秘与便秘交替发生。轻者可只有间歇性便秘,可伴有腹部不适,多在排便后缓解。结肠功能紊乱是功能性疾病,虽有肠功能紊乱的症状,但检查并无器质性肠道病变,所以患者的一般情况良好,并有自动缓解的表现。经过胃肠调理与治疗,可以好转或痊愈。
近年来,肠功能紊乱在世界范围内发病率较高且有日渐上升趋势,工作生活压力、情绪变化、精神紧张均易诱发肠功能紊乱,已成为职业人士高发的疾病,多见于青壮年、成
年女性、脑力劳动者、性格内向者、常处于神经过敏状态的人等,是胃肠道功能紊乱的易感人群,严重影响人们的工作和生活,降低了生活质量。肠功能紊乱患者尤其就诊患者焦虑、抑郁等多种心理异常发病率明显高于普通人群,一些患者症状发生前或症状加重前多经历各种应激事件,从而引起结肠和小肠的运动功能改变及分泌功能的失调,进而影响机体器官功能。心理、情绪、社会及环境因素在肠功能紊乱病程中起着重要的作用,是以社会心理因素刺激而触发的心身疾病,精神因素与肠功能紊乱发病关系密切。
目前,治疗肠功能紊乱的药物有很多,针对上述问题,公开号102805794A(申请号201210310522.2)的中国专利文献公开了治疗慢性肠功能紊乱的纯中药组合物及由其制备的纯中药外用粉贴剂,,其中药原料及重量份为:佛手1-15 份,细辛1-9 份,川乌1-12 份,白附子1-18 份,丁香1-12 份,香附1-15 份,冰片1-9 份,薄荷1-9 份,樟脑1-9 份,乳香1-9 份,虎杖1-15 份。还提供了上述的治疗慢性肠功能紊乱的纯中药组合物在制备治疗慢性肠功能紊乱的纯中药制剂中的应用以及制成的治疗慢性肠功能紊乱的纯中药外用粉贴剂。公开号103536638A(申请号201310504920.2)的中国专利文献公开了一种治疗消化系统功能紊乱的药物组合物,其特征在于包括以下成分:人参10-25份,白术10-25份,茯苓12-25份,以重量份数计。公开号103520428A(申请号201310516102.4)的中国专利文献公开了一种具有改善肠功能紊乱的中药组合物及其应用,它涉及具有改善肠功能紊乱的中药组合物及其应用,是由炒白术、炒白芍、合欢花、煨葛根、佛手、焦山楂、山药和五味子制成。
由此可见,中药在治疗由肠功能紊乱引起的便秘方面去得了很好的疗效,但是其制备方法都比较复杂,大多数是汤剂,众所周知,汤剂不方便携带,而且纯中药汤剂非常的苦,不容易下咽。
发明内容
针对现有治疗由肠功能紊乱引起的便秘方法的不足,本发明的目的之一在于提供一种治疗由肠功能紊乱引起的便秘的颗粒剂,在服用本药治疗过程中,见效快,且无副作用,在改善便秘、胃肠胀气症状的同时,还能够调节肠功能,是一种治疗由肠功能紊乱引起的便秘的理想颗粒剂。
本发明的另一目的就是提供上述治疗由肠功能紊乱引起的便秘的颗粒剂的制备方法。
本发明的上述目的是通过以下技术方案来实现的:
一种治疗由肠功能紊乱引起的便秘的颗粒剂,各原料药如下,均为重量份:芒硝3-9,枳实6-12,小米12-25,莱菔8-16,桑葚子6-12,川芎5-15,甘薯3-7,火麻仁7-15,知母10-20,天门冬3-9,菟丝子9-15,佩兰5-15,荸荠3-12,郁李仁3-8,当归10-20。
一种治疗由肠功能紊乱引起的便秘的颗粒剂,优选的方案,各原料药如下,均为重量份:芒硝5-7,枳实8-10,小米16-21,莱菔12-14,桑葚子8-10,川芎8-13,甘薯4-6,火麻仁10-12,知母13-18,天门冬5-7,菟丝子11-13,佩兰8-13,荸荠5-10,郁李仁4-6,当归13-18。
一种治疗由肠功能紊乱引起的便秘的颗粒剂,更佳优选的方案,各原料药如下,均为重量份:芒硝6,枳实9,小米18,莱菔13,桑葚子9,川芎10,甘薯5,火麻仁11,知母15,天门冬6,菟丝子12,佩兰11,荸荠8,郁李仁5,当归15。
一种治疗由肠功能紊乱引起的便秘的颗粒剂的制备方法,步骤如下:
①将芒硝置于80-100℃的热水中,待水温冷却至室温时,加入食盐,待食盐完全融化后,浸泡10-30分钟(优选20分钟),待用;
②取当归和川芎洗净,沥干水分,高温杀菌1-5分钟,切片,用米醋喷淋均匀,稍闷10分钟,置烧干的热锅内用微火炒3-8分钟,取出,放置室温时,研磨成细末待用;
③将枳实、桑葚子、火麻仁、知母、天门冬、菟丝子、佩兰、荸荠和郁李仁置于瓦片上,小火慢烘10-30分钟,晾凉研磨成细末,过80-120目筛(优选100目筛);
④将莱菔和甘薯洗净,切成长1-3厘米的块;
⑤将小米淘洗1-3次,加小米重量8-12倍的水,浸泡1小时后加入步骤①所得芒硝,大火煮沸后加入步骤④所得物,大火煮沸4-8分钟后,兑入冷水,转文火煎煮20-40分钟,用铁勺慢慢搅拌,待搅拌至莱菔和甘薯成为稠状物时,加入步骤②和③所得细末,充分搅拌成稠膏;
⑥将步骤⑤所得稠膏在50-70℃干燥10-18小时,制成颗粒。
上述颗粒剂的制备方法,步骤①芒硝置于85-95℃的热水中(优选芒硝置于90℃的热水中)。
上述颗粒剂的制备方法,步骤②高温杀菌2-4分钟(优选高温杀菌3分钟)。
上述颗粒剂的制备方法,步骤③小火慢烘15-25分钟(优选小火慢烘20分钟)。
上述颗粒剂的制备方法,步骤⑤加小米重量9-11倍的水(优选加小米重量10倍的水)。
上述颗粒剂的制备方法,步骤⑤大火煮沸5-7分钟后,兑入冷水,转文火煎煮25-35分钟(优选大火煮沸6分钟后,兑入冷水,转文火煎煮30分钟)。
上述颗粒剂的制备方法,步骤⑥稠膏在55-65℃干燥12-16小时,制成颗粒(优选稠膏在60℃干燥14小时,制成颗粒)。
本发明对由肠功能紊乱引起的便秘的效果显著,为使本发明达到最佳的治疗效果,每日3次,分别于三餐后半小时服用,每次2g,开水冲服,10天为一个疗程。
各原料药的药理功效分别为:
芒硝:基原:为硫酸盐类芒硝族矿物芒硝的提纯品。成分:芒硝主要含硫酸钠,尚含食盐、硫酸钙和硫酸镁等杂志。芒硝在大气中易失去水,故表面常呈百分状:此种风化的芒硝,其硫酸钠含量可超过44.1%。药性:咸、苦,寒。归胃、大肠经。功用主治:泻火通便,软坚,消肿。主治实热积滞,大便秘结,腹胀痞痛,肠痈,乳痈,丹毒,目赤翳障,咽喉肿痛,口疮。
枳实:基原:为芸香科柑橘属植物酸橙及其栽培变种或甜橙的幼果。成分:1.酸橙 果实主要含黄酮类:橙皮苷,新橙皮苷,柚皮苷等。种子含柠檬苦素类:宜昌橙苦素,闹米林,去乙酰闹米林,柠檬苦素等。 2.甜橙 果实主要含黄酮类:“柚皮芸香苷,异樱花素-7-芸香糖苷等。果皮含黄酮类:橙皮苷、柚皮苷等。
药性:苦、辛,微寒。归脾、胃、大肠经。功用主治:破气消积,化痰除痞。主治积滞内停,痞满胀痛,大便秘结,泻痢后重,结胸,胸痹,胃下垂,子宫脱垂,脱肛。
小米,原名:粟,也称作梁、狗尾草、黄粟、粟米,拉丁文名:Setaria italica (L.) Beauv. var. germanica (Mill.) Schrad. 禾本科、狗尾草属一年生草本,须根粗大,秆粗壮,属是谷子去皮后的结果,谷子是谷类植物,禾木本的一种,粟的营养价值很高,含丰富的蛋白质和脂肪和维生素,它不仅供食用,入药有清热、清渴,滋阴,补脾肾和肠胃,利小便、治水泻等功效。
莱菔:基原:为十字花科莱菔属植物莱菔的鲜根。成分:根含苷类芥子油苷,葡萄糖莱菔素,莱菔苷。酚酸类:对香豆酸,咖啡酸,阿魏酸,苯丙酮酸,龙胆酸等。药性:辛、甘,凉;熟者甘,平。归脾、胃、肺、大肠经。功用主治:消食,下气,化痰,止血。主治消化不良,食积胀满,吞酸,翻胃,吐食,肠风,泄泻,痢疾,便秘,痰热咳嗽,咽喉不利,咳血,吐血,衄血,便血,消渴,淋虫。外治疗疮肿疡,损伤瘀肿,烫伤及冻疮。
桑葚子:基原:为桑科桑属植物桑的干燥果穗。成分:果穗含维生素B1、B2和胡萝卜素;其脂类的脂肪酸主要为亚油酸,油酸,软脂酸,硬脂酸,尚有少量辛酸,壬酸,癸酸等。药性:甘、酸、寒。归甘、肾经。功用主治:滋阴养血,生津,润肠。主治肝肾不足和血虚精亏的头晕目眩,耳鸣,须发早白,失眠,消渴,腰酸,肠燥便秘,秃疮。
甘薯:别名朱薯、山芋、红山药、金薯、红苕、地瓜。性味功效 甘,平,无毒。入脾、肾经。功能补中和血,益气生津,宽肠胃,通便秘。适用于脾胃虚弱所致的消化不良、泄泻等,外用可治痈疮肿毒等。
火麻仁:基原:为桑科大麻属植物大麻的种仁。成分:种子含胡芦巴碱,L-右旋异亮氨酸三甲铵乙内酯。种子含脂肪酸及脂类:硬脂酸,花生酸,木蜡酸,棕榈酸,棕榈油酸等。药性:甘,平。归脾、胃、大肠经。功用主治:润燥滑肠,利水,活血。主治肠燥便秘,风痹,消渴,风水,脚气,热淋,痢疾,月经不调,疮癣,丹毒。
知母:基原:为百合科知母属植物知母的根茎。成分:根茎中含知母皂甙A-Ⅰ、A-Ⅱ、A-Ⅲ、A-Ⅳ, B-Ⅰ和B-Ⅱ.其中知母皂甙A-Ⅰ是萨尔萨皂甙元β-D-吡喃半乳糖甙,知母皂甙A-Ⅲ是萨尔萨皂甙元与知母双糖结合而成的双糖甙.知母根茎中的皂甙元有萨尔萨皂甙元、吗尔考皂甙元、新芰脱皂甙元等。药性:苦,寒。归肺、胃、肾经。功用主治:清热泻火,滋阴润燥。主治温热病高热烦渴,肺热咳嗽,骨蒸潮热,遗精,盗汗,虚烦不眠,消渴。
天门冬:基原:为百合科天门冬属植物天门冬的块根。成分:块根含甾体皂苷:甲基原薯蓣皂苷,为原薯蓣皂苷,另含6个甾体皂苷,苷元分别为雅姆皂苷元,薯蓣皂苷元,菝葜皂苷元,异菝葜皂苷元;糖类:葡萄糖,果糖,蔗糖等。药性:甘、苦,寒。归肺、肾经。功用主治:滋阴润燥,清肺降火。主治燥热咳嗽,阴虚劳嗽,热病伤阴,内热消渴,肠燥便秘,咽喉肿痛。
佩兰:基原:为菊科泽兰属植物佩兰的地上部分。成分:1.佩兰 全草含挥发油:对聚伞花素,乙酸橙花醇酯,百里香酚甲醚。花及叶中含蒲公英甾醇,蒲公英甾醇乙酸酯,蒲公英甾醇棕榈酸酯等。2.台湾佩兰 含倍半萜类成分:泽兰内酯,台湾泽兰内酯,4-羟基-2-羟甲基-2-丁烯酰台湾泽兰内酯。药性:辛,平。归脾、胃经。功用主治:解暑化湿,醒脾和中。主治暑湿或湿温初起,发热头重,胸闷腹胀,脘痞不饥,恶心呕吐,口中甜腻,消渴。
荸荠:别名马蹄、乌芋、地栗。性味功效:甘、寒。功能清热、化痰、消积、化疣。适用于温病消渴、黄疸、热淋、痞积、目赤、咽喉肿痛、赘疣等。预防急性传染病、清热泻火、凉血解毒、利尿通便祛痰、消食除胀,调理痔疮或痢疾便血、妇女崩漏、阴虚肺燥、痰热咳嗽、咽喉不利、痞块积聚、目赤障翳、辅助退烧等功效。此外,荸荠含有一种抗病毒物质可抑制流脑,流感病毒,能用于预防流脑及流感的传播。
郁李仁:基原:为蔷薇科郁李属植物郁李、欧李及榆叶梅属植物榆叶梅、长梗扁桃等的种仁。成分:1.郁李 种子含苦杏仁苷,郁李仁苷A、B;2种蛋白质成分:IR-A和IR-B。新鲜果实含蔷薇苷A、B,即是郁李仁苷A、B;还含熊果酸,香草酸,原儿茶酸,阿福豆苷,山奈苷,野蔷薇苷。2.欧李 种子含苦杏仁苷,郁李仁苷A、B。3.长梗郁李 种子含苦杏仁苷,郁李仁苷A、B。4.毛叶欧李 种子含苦杏仁苷,郁李仁苷A、B。 药性:辛、苦、甘,平。归脾、大肠、小肠经。功用主治:润肠通便,下气利水。主治肠燥便秘,小便不利,水肿腹满,脚气。豇豆:基原:为豆科豇豆属植物豇豆的种子。成分:含氨基酸:胱氨酸,天冬氨酸,苏氨酸,丝氨酸,谷氨酸,甘氨酸,丙氨酸,甲硫氨酸等。药性:甘、咸,平。归脾、肾经。功用主治:健脾利湿,补肾涩精。主治脾胃虚弱,吐泻痢疾,肾虚腰痛,遗精,消渴,白带白浊,小便频数。
菟丝子:基原:为旋花科菟丝子属植物菟丝子的全草。成分:菟丝子含生物碱、蒽醌、香豆素、黄酮、甙类、甾醇、鞣酸、糖类等。黄酮类有:槲皮素、紫云英甙、金丝桃甙;甾醇类有:胆甾醇、菜油甾醇、β-谷甾醇、豆甾醇、β-香树脂醇。 亦含微量元素如锶、钼、钙、镁、铁、锰、锌、铜等以及多种氨基酸(种子中的游离氨基酸和水解后的总氨基酸为5.3%,其中必需氨基酸的含量占42.8%)。药性:微辛,甘,平,无毒。功用主治:补肾益精,养肝明目。适用于肝肾不足的腰膝筋骨酸痛,腿脚软弱无力、阳痿遗精、呓语、小便频数、尿有余沥、头晕眼花、视物不清、耳鸣耳聋以及妇女带下、习惯性流产等症。
川芎:行气开郁,法风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。用于月经不调,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。
当归:甘、辛、温,补血;活血;调经止痛;润燥滑肠。主血虚诸证;月经不调;经闭;痛经;症瘕结聚;崩漏;虚寒腹痛;痿痹;肌肤麻木;肠燥便难;赤痢后重;痈疽疮疡;跌扑损伤。
本发明颗粒剂不仅能够治疗由肠功能紊乱引起的便秘症状,还能起到调节肠功能的作用,治疗由肠功能紊乱引起的便秘效果显著,无副作用,实用性广,不但可以使病情得到良好控制,而且能对损伤的机体起到修复作用。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不被此限制。
实施例1:一种治疗由肠功能紊乱引起的便秘的颗粒剂,各原料药如下,均为重量份(每份取10g):芒硝3,枳实6,小米12,莱菔8,桑葚子6,川芎5,甘薯3,火麻仁7,知母10,天门冬3,菟丝子9,佩兰5,荸荠3,郁李仁3,当归10。
一种治疗由肠功能紊乱引起的便秘的颗粒剂,制备步骤如下:
①将芒硝置于80℃的热水中,待水温冷却至室温时,加入食盐,待食盐完全融化后,浸泡10分钟,待用;
②取当归和川芎洗净,沥干水分,高温杀菌1分钟,切片,用米醋喷淋均匀,稍闷10分钟,置烧干的热锅内用微火炒3分钟,取出,放置室温时,研磨成细末待用;
③将枳实、桑葚子、火麻仁、知母、天门冬、菟丝子、佩兰、荸荠和郁李仁置于瓦片上,小火慢烘10分钟,晾凉研磨成细末,过80目筛;
④将莱菔和甘薯洗净,切成长1厘米的块;
⑤将小米淘洗1次,加小米重量8倍的水,浸泡1小时后加入步骤①所得芒硝,大火煮沸后加入步骤④所得物,大火煮沸4分钟后,兑入冷水,转文火煎煮20分钟,用铁勺慢慢搅拌,待搅拌至莱菔和甘薯成为稠状物时,加入步骤②和③所得细末,充分搅拌成稠膏;
⑥将步骤⑤所得稠膏在50℃干燥10小时,制成颗粒。
典型病例一: 王XX,女,45岁,山东省聊城市人。劳累加上饮食不规律,常常会感到腹痛,但因为实在是太忙,加上自己怕麻烦不想去医院,生活中患者遇到一些小病,就自己去药店买些药吃。直到2012年,患者开始出现腹部绞痛的症状,他认为是平时没好好吃饭导致,就自己寻医问药,刚开始的时候,确实腹痛现象有所减轻,但吃了一段时间之后,就不大见效了,甚至还出现了严重的便秘,患者对此非常烦恼。他开始认识到自己的病可能没想象中那么简单。吃了一些止泻药之后,患者的便秘现象有了一定的改善,腹部不再痛了,他就没再想治疗的事。但没想到的是,没过多久再一次出现绞痛、便秘,而且情况很严重,最后去医院进行检查,发现患者的结肠粘膜破损已经非常严重,确诊为结肠炎,这也是导致他便秘不止的原因。结肠炎如果不及时治愈,可能导致肠穿孔、结肠癌、便血、中毒性肠扩张等严重后果。在医院治疗一段时间后,症状得到缓解,可没过多久又一次出现便秘,这让患者很是绝望。
服用实施例1所得颗粒剂,服用5天,腹痛、便秘的现象得到了明显的改善;服用10天,去医院检查,发现结肠粘膜破损情况已经消失,如今已经快1年过去了,也没出现过腹痛、便秘的情况,完全恢复了健康。
实施例2:一种治疗由肠功能紊乱引起的便秘的颗粒剂,各原料药如下,均为重量份(每份取10g):芒硝9,枳实12,小米25,莱菔16,桑葚子12,川芎15,甘薯7,火麻仁15,知母20,天门冬9,菟丝子15,佩兰15,荸荠12,郁李仁8,当归20。
一种治疗由肠功能紊乱引起的便秘的颗粒剂,制备步骤如下:
①将芒硝置于100℃的热水中,待水温冷却至室温时,加入食盐,待食盐完全融化后,浸泡30分钟,待用;
②取当归和川芎洗净,沥干水分,高温杀菌5分钟,切片,用米醋喷淋均匀,稍闷10分钟,置烧干的热锅内用微火炒8分钟,取出,放置室温时,研磨成细末待用;
③将枳实、桑葚子、火麻仁、知母、天门冬、菟丝子、佩兰、荸荠和郁李仁置于瓦片上,小火慢烘30分钟,晾凉研磨成细末,过120目筛;
④将莱菔和甘薯洗净,切成长1-3厘米的块;
⑤将小米淘洗3次,加小米重量12倍的水,浸泡1小时后加入步骤①所得芒硝,大火煮沸后加入步骤④所得物,大火煮沸8分钟后,兑入冷水,转文火煎煮40分钟,用铁勺慢慢搅拌,待搅拌至莱菔和甘薯成为稠状物时,加入步骤②和③所得细末,充分搅拌成稠膏;
⑥将步骤⑤所得稠膏在70℃干燥18小时,制成颗粒。
实施例3:一种治疗由肠功能紊乱引起的便秘的颗粒剂,各原料药如下,均为重量份(每份取10g):芒硝5,枳实8,小米16,莱菔12,桑葚子8,川芎8,甘薯4,火麻仁10,知母13,天门冬5,菟丝子11,佩兰8,荸荠5,郁李仁4,当归13。
一种治疗由肠功能紊乱引起的便秘的颗粒剂,制备步骤如下:
①将芒硝置于85℃的热水中,待水温冷却至室温时,加入食盐,待食盐完全融化后,浸泡15分钟,待用;
②取当归和川芎洗净,沥干水分,高温杀菌2分钟,切片,用米醋喷淋均匀,稍闷10分钟,置烧干的热锅内用微火炒5分钟,取出,放置室温时,研磨成细末待用;
③将枳实、桑葚子、火麻仁、知母、天门冬、菟丝子、佩兰、荸荠和郁李仁置于瓦片上,小火慢烘15分钟,晾凉研磨成细末,过90目筛;
④将莱菔和甘薯洗净,切成长1.5厘米的块;
⑤将小米淘洗1次,加小米重量9倍的水,浸泡1小时后加入步骤①所得芒硝,大火煮沸后加入步骤④所得物,大火煮沸5分钟后,兑入冷水,转文火煎煮25分钟,用铁勺慢慢搅拌,待搅拌至莱菔和甘薯成为稠状物时,加入步骤②和③所得细末,充分搅拌成稠膏;
⑥将步骤⑤所得稠膏在55℃干燥12小时,制成颗粒。
实施例4:一种治疗由肠功能紊乱引起的便秘的颗粒剂,各原料药如下,均为重量份(每份取10g):芒硝7,枳实10,小米21,莱菔14,桑葚子10,川芎13,甘薯6,火麻仁12,知母18,天门冬7,菟丝子13,佩兰13,荸荠10,郁李仁6,当归18。
一种治疗由肠功能紊乱引起的便秘的颗粒剂,制备步骤如下:
①将芒硝置于95℃的热水中,待水温冷却至室温时,加入食盐,待食盐完全融化后,浸泡25分钟,待用;
②取当归和川芎洗净,沥干水分,高温杀菌4分钟,切片,用米醋喷淋均匀,稍闷10分钟,置烧干的热锅内用微火炒7分钟,取出,放置室温时,研磨成细末待用;
③将枳实、桑葚子、火麻仁、知母、天门冬、菟丝子、佩兰、荸荠和郁李仁置于瓦片上,小火慢烘25分钟,晾凉研磨成细末,过110目筛;
④将莱菔和甘薯洗净,切成长2.5厘米的块;
⑤将小米淘洗3次,加小米重量11倍的水,浸泡1小时后加入步骤①所得芒硝,大火煮沸后加入步骤④所得物,大火煮沸7分钟后,兑入冷水,转文火煎煮35分钟,用铁勺慢慢搅拌,待搅拌至莱菔和甘薯成为稠状物时,加入步骤②和③所得细末,充分搅拌成稠膏;
⑥将步骤⑤所得稠膏在65℃干燥16小时,制成颗粒。
典型病例二:杨XX,男,50岁,山东省济南市济阳县人。症状:时常出现便秘、腹痛后大便不成型、胃口很差、早饱、打嗝、肠鸣的症状。2011年5月,患者持续便秘2个月,时轻时重,最初为下腹痛后大便不成型,自己搞了点养脾胃的中成药吃,一个月后突然严重,便秘严重,胃口完全消失,肠鸣,腹胀腹隐痛,胃胀。西医检查大便,做了肠镜未见异常。后来又看了中医,病情稍微好转之后,无法进一步恢复,胃口很差,早饱,打嗝,排气,肠鸣,体重已下降20多斤。去医院诊断为胃肠功能紊乱,这是一种很常见的疾病,起病多缓慢,病程多缠绵日久,症状复杂,呈持续性或反复发作性。
服用实施例4所得颗粒剂,服用3天,腹泻腹痛、早饱、打嗝、肠鸣的症状有了缓解,见此效果;腹泻次数基本正常,上腹疼痛也基本消失,胃口也变好了。继续服用实施例4所得治疗肠功能紊乱的药剂粉剂3天作为巩固,患者的疾病就彻底治愈了,在接下来的随访中未复发,服用期间无副作用出现。
实施例5:一种治疗由肠功能紊乱引起的便秘的颗粒剂,各原料药如下,均为重量份(每份取10g):芒硝6,枳实9,小米18,莱菔13,桑葚子9,川芎10,甘薯5,火麻仁11,知母15,天门冬6,菟丝子12,佩兰11,荸荠8,郁李仁5,当归15。
一种治疗由肠功能紊乱引起的便秘的颗粒剂,制备步骤如下:
①将芒硝置于90℃的热水中,待水温冷却至室温时,加入食盐,待食盐完全融化后,浸泡20分钟,待用;
②取当归和川芎洗净,沥干水分,高温杀菌3分钟,切片,用米醋喷淋均匀,稍闷10分钟,置烧干的热锅内用微火炒6分钟,取出,放置室温时,研磨成细末待用;
③将枳实、桑葚子、火麻仁、知母、天门冬、菟丝子、佩兰、荸荠和郁李仁置于瓦片上,小火慢烘20分钟,晾凉研磨成细末,过100目筛;
④将莱菔和甘薯洗净,切成长2厘米的块;
⑤将小米淘洗2次,加小米重量10倍的水,浸泡1小时后加入步骤①所得芒硝,大火煮沸后加入步骤④所得物,大火煮沸6分钟后,兑入冷水,转文火煎煮30分钟,用铁勺慢慢搅拌,待搅拌至莱菔和甘薯成为稠状物时,加入步骤②和③所得细末,充分搅拌成稠膏;
⑥将步骤⑤所得稠膏在60℃干燥14小时,制成颗粒。
试验例1 实施例5所得治疗由肠功能紊乱引起的便秘的颗粒剂的临床应用:在4所医院筛选150例患者,其中女性75例,男性75例。试验之前1周,对该人群进行连续观察,记录症状及变化,随机分为两组,实验组及对照组,实验组服用本发明所得产品,对照组服用其他治疗由肠功能紊乱引起的便秘的药物(如颠茄片、普鲁苯辛等常规药物)。疗效情况判定标准:治愈:服用本品后,不适症状完全消失;有效:服用本品后,不适症状减轻或部分消失;无效:服用本品后,不适症状无变化或复发。总有效包括治愈和有效,结果如表1所示。
表1服用实施例5所得产品治疗效果验证
治疗效果:从表1可以明显看出,服用本发明实施例3所得治疗由肠功能紊乱引起的便秘的颗粒剂的实验组的治愈78例(78%), 有效20例(20%),无效2例(2%),总有效率98%。而对照组的治愈率仅达到24%,无效率却高达了30%,服用本发明所得治疗由肠功能紊乱引起的便秘的颗粒剂的实验组明显优于服用其他药物的对照组。本发明颗粒剂不仅能治疗由肠功能紊乱引起的便秘,还能够一并健脾养胃,减轻患者的身体负担,是一种治疗由肠功能紊乱引起的便秘的理想颗粒剂。
Claims (10)
1.一种治疗由肠功能紊乱引起的便秘的颗粒剂,其特征在于:各原料药如下,均为重量份:芒硝3-9,枳实6-12,小米12-25,莱菔8-16,桑葚子6-12,川芎5-15,甘薯3-7,火麻仁7-15,知母10-20,天门冬3-9,菟丝子9-15,佩兰5-15,荸荠3-12,郁李仁3-8,当归10-20。
2.根据权利要求1所述的治疗由肠功能紊乱引起的便秘的颗粒剂,其特征在于:各原料药如下,均为重量份:芒硝5-7,枳实8-10,小米16-21,莱菔12-14,桑葚子8-10,川芎8-13,甘薯4-6,火麻仁10-12,知母13-18,天门冬5-7,菟丝子11-13,佩兰8-13,荸荠5-10,郁李仁4-6,当归13-18。
3.根据权利要求1所述的治疗由肠功能紊乱引起的便秘的颗粒剂,其特征在于:各原料药如下,均为重量份:芒硝6,枳实9,小米18,莱菔13,桑葚子9,川芎10,甘薯5,火麻仁11,知母15,天门冬6,菟丝子12,佩兰11,荸荠8,郁李仁5,当归15。
4.根据权利要求1-3任一项所述的治疗由肠功能紊乱引起的便秘的颗粒剂的制备方法,步骤如下:
①将芒硝置于80-100℃的热水中,待水温冷却至室温时,加入食盐,待食盐完全融化后,浸泡10-30分钟(优选20分钟),待用;
②取当归和川芎洗净,沥干水分,高温杀菌1-5分钟,切片,用米醋喷淋均匀,稍闷10分钟,置烧干的热锅内用微火炒3-8分钟,取出,放置室温时,研磨成细末待用;
③将枳实、桑葚子、火麻仁、知母、天门冬、菟丝子、佩兰、荸荠和郁李仁置于瓦片上,小火慢烘10-30分钟,晾凉研磨成细末,过80-120目筛(优选100目筛);
④将莱菔和甘薯洗净,切成长1-3厘米的块;
⑤将小米淘洗1-3次,加小米重量8-12倍的水,浸泡1小时后加入步骤①所得芒硝,大火煮沸后加入步骤④所得物,大火煮沸4-8分钟后,兑入冷水,转文火煎煮20-40分钟,用铁勺慢慢搅拌,待搅拌至莱菔和甘薯成为稠状物时,加入步骤②和③所得细末,充分搅拌成稠膏;
⑥将步骤⑤所得稠膏在50-70℃干燥10-18小时,制成颗粒。
5.根据权利要求4所述的颗粒剂的制备方法,其特征在于:步骤①芒硝置于85-95℃的热水中(优选芒硝置于90℃的热水中)。
6.根据权利要求4所述的中药颗粒剂的制备方法,其特征在于:步骤②高温杀菌2-4分钟(优选高温杀菌3分钟)。
7.根据权利要求4所述的中药颗粒剂的制备方法,其特征在于:步骤③小火慢烘15-25分钟(优选小火慢烘20分钟)。
8.根据权利要求4所述的中药颗粒剂的制备方法,其特征在于:步骤⑤加糯米重量9-11倍的水(优选加糯米重量10倍的水)。
9.根据权利要求4所述的中药颗粒剂的制备方法,其特征在于:步骤⑤大火煮沸5-7分钟后,兑入冷水,转文火煎煮25-35分钟(优选大火煮沸6分钟后,兑入冷水,转文火煎煮30分钟)。
10.根据权利要求4所述的中药颗粒剂的制备方法,其特征在于:步骤⑥稠膏在55-65℃干燥12-16小时,制成颗粒(优选稠膏在60℃干燥14小时,制成颗粒)。
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