CN104306930A - 一种治疗急性重症胰腺炎的中药配方及其制备方法 - Google Patents

一种治疗急性重症胰腺炎的中药配方及其制备方法 Download PDF

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CN104306930A
CN104306930A CN201410547131.1A CN201410547131A CN104306930A CN 104306930 A CN104306930 A CN 104306930A CN 201410547131 A CN201410547131 A CN 201410547131A CN 104306930 A CN104306930 A CN 104306930A
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刘志鸿
韩先章
卢爱丽
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Abstract

本发明属于中医中药技术领域，特别涉及一种治疗急性重症胰腺炎的中药配方及其制备方法。由以下重量份数的中药原料配制而成：芦荟2～5份、泽泻3～5份、竹茹3～5份、半夏5～10份、蒲黄3～5份、紫堇1～2份、丹参4～6份、黄芩4～6份、栀子3～5份、柴胡5～10份、芍药4～6份、生姜4～6份、枳实5～10份、大枣5～10份、大黄5～10份、芒硝5～10份、甘遂3～5份。制备方法是水煎剂。本发明通过中药的理气开郁、活血化瘀、益气救阴之效，能够减少胰液腺分泌，快速调节自身炎症反应，预防内毒素移位，减轻病人痛苦，挽救病人生命。

Description

一种治疗急性重症胰腺炎的中药配方及其制备方法
技术领域
本发明属于中医中药技术领域，特别涉及一种治疗急性重症胰腺炎的中药配方及其制备方法。
背景技术
急性胰腺炎是多种病因导致胰酶在胰腺内被激活后引起胰腺组织自身消化、水肿、出血甚至坏死的炎症反应。临床以急性上腹痛、恶心、呕吐、发热和血胰酶增高等为特点。病变程度轻重不等，轻者以胰腺水肿为主，临床多见，病情常呈自限性，预后良好，又称为轻症急性胰腺炎。少数重者的胰腺出血坏死，常继发感染、腹膜炎和休克等，病死率高，称为急性重症胰腺炎。
70％～80％的急性重症胰腺炎是由于胆道疾病、酗酒和暴饮暴食所引起的,发病机制主要是胰液对胰腺及其周围组织自身消化的结果,炎性细胞因子互相关联和累积作用，导致血管渗漏、低血容量、多系统器官衰竭等危象的发生。急性胰腺炎治疗的最基本最重要的环节是减少胰腺分泌，中国专利(CN103191322A)公开了一种治疗急性重症胰腺炎的中药，通过改善重症急患者的胃肠功能、抑制消化液的分泌、抑制胰蛋白酶的活性，从而减轻胰腺组织炎症、降低病情的严重程度，但急性重症胰腺炎发病快、发展迅猛，需要快速见效、迅速遏制病情发展，能够回阳救逆的药物进行治疗。
发明内容
本发明的目的是提供一种治疗急性重症胰腺炎的中药配方，通过中药的理气开郁、活血化瘀、益气救阴之效，能够减少胰液腺分泌，快速调节自身炎症反应，预防内毒素移位，减轻病人痛苦，挽救病人生命。
本发明提供一种治疗急性重症胰腺炎的中药配方，由以下重量份数的中药原料配制而成：芦荟2～5份、泽泻3～5份、竹茹3～5份、半夏5～10份、蒲黄3～5份、紫堇1～2份、丹参4～6份、黄芩4～6份、栀子3～5份、柴胡5～10份、芍药4～6份、生姜4～6份、枳实5～10份、大枣5～10份、大黄5～10份、芒硝5～10份、甘遂3～5份。
进一步优选为由以下重量份数的中药原料配制而成：芦荟3份、泽泻4份、竹茹4份、半夏6份、蒲黄4份、紫堇1份、丹参5份、黄芩5份、栀子4份、柴胡7份、芍药5份、生姜5份、枳实8份、大枣6份、大黄7份、芒硝8份、甘遂4份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材2～5cm，浸泡1～2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20～40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
药理分析：
芦荟：味苦性寒，泻下；具有抗胃溃疡、抗肝损伤、清肝热泻实火作用。
泽泻：甘，寒；入肾、膀胱经。功效利水，渗湿，泄热；主治小便不利，水肿胀满，呕吐，泻痢，痰饮，脚气，淋病，尿血。
竹茹：性微寒，味甘；功能清热化痰，除烦止呕；用于痰热咳嗽、胆火挟痰、烦热呕吐、惊悸失眠、中风痰迷、舌强不语、胃热呕吐、妊娠恶阻、胎动不安。
半夏：气微，味微涩；功能燥湿化痰，降逆止呕，消痞散结。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛，呕吐反胃，胸脘痞闷，梅核气；生用外治痈肿痰核。
蒲黄：味甘、微辛，性平，归肝、心、脾经。功能止血，化瘀，通淋。用于吐血，衄血，咯血，崩漏，外伤出血，经闭，痛经，脘腹刺痛，跌打肿痛，血淋湿痛等。
紫堇：苦、涩，凉；有毒。主治肺结核咳血，遗精，疮毒，顽癣。
丹参：性味苦，微寒；归心、肝经。有祛瘀止痛，活血通经，清心除烦之功效。用于月经不调，经闭痛经，症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。
黄芩：味苦、性寒，入心、肺、胆、大肠经；有清热燥湿、泻火解毒、止血、安胎等功效；主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。现代药理证明，黄芩具有抗菌作用、抗真菌作用、抗病毒作用和抗炎抗变态反应等作用，而且不产生抗药性。
栀子：清热，泻火，凉血；治热病虚烦不眠，黄疸、淋病、消渴、目赤、咽痛、吐血、衄血、血痢、尿血、热毒疮疡、扭伤肿痛，具有护肝、利胆、降压、镇静、止血、消肿等作用。
柴胡：性味苦，微寒。归肝、胆经。有和解表里，疏肝，升阳之功效。用于感冒发热、寒热往来、疟疾、肝郁气滞、胸肋胀痛、脱肛、子宫脱垂、月经不调。
芍药：芍药含有芍药苷和芍药甙等多种药物成分,具有扩张血管、降压镇痛、清热解痉的作用,有较高的药用价值。
生姜：味辛，性热；归脾、胃、心、肺经。功效温中散寒，回阳通脉，燥湿消痰，温肺化饮；主治脘腹冷痛、呕吐、泄泻、亡阳厥逆、寒饮喘咳、寒湿痹痛。
大枣：味甘、辛，性温，无毒；归脾、胃经；主治心腹邪气，少津液、身体虚弱，大惊，四肢重；功能安中，养脾气平胃气，补中益气，养血安神；通九窍，助卜二经，补少气，和百药。长期服食能轻身延年。
大黄：味苦，寒；归脾、胃、大肠、肝、心包经。功效攻积滞，清湿热，泻火，凉血，祛瘀，解毒；主治实热便秘，热结胸痞，湿热泻痢，黄疸，淋病，水肿腹满，小便不利，目赤，咽喉肿痛，口舌生疮，胃热呕吐，吐血，咯血，衄血，便血，尿血，蓄血，经闭，产后瘀滞腹痛，症瘕积聚，跌打损伤，热毒痈疡，丹毒，烫伤。
芒硝：咸、苦，寒；归胃经，肺经，脾经，肾经，小肠经，三焦经，大肠经。功能泻热通便，润燥软坚，清火消肿，主治破痞，常温中，消食，逐水，缓泻。用于胃脘痞，食痞，消化不良，浮肿，水肿，乳肿，闭经，便秘。
枳实：苦，辛，寒；归脾，胃，肝，心经。功效主治积滞内停，痞满胀痛，大便秘结，泻痢后重，结胸，胃下垂，子宫脱垂，脱肛。
厚朴：苦，辛，性温；归脾经，胃经，大肠经。功能行气消积，燥湿除满，降逆平喘；主治食积气滞，腹胀便秘，湿阻中焦，脘痞吐泻，痰壅气逆，胸满喘咳。
甘遂：味苦；性寒，有毒；归脾经，肺经，肾经，膀胱经，大肠经，小肠经。功能泻水逐肿，消肿散结；主治水肿，腹水，留饮结胸，癫痫，喘咳，大小便不通。
本发明的中药，通过中药的理气开郁、活血化瘀、益气救阴之效，能够减少胰液腺分泌，快速调节自身炎症反应，预防内毒素移位，减轻病人痛苦，挽救病人生命。
疗效判断：
显效：3天内症状、体征缓解，7天内血、尿淀粉酶基本恢复正常。
有效：7天内症状、体征减轻，血、尿淀粉酶有下降趋势；
无效：7天内症状未减轻或恶化；
治疗结果：治疗103名急性重症胰腺炎患者，1日为1个疗程，1日2剂。服用本发明药物后，显效39例，占37.9％，有效61例，占59.2％，无效3例，占2.9％。
附几例病例作进一步说明：
病例1：柴某，男性，36岁，因突发上腹痛10小时入院，10小时前饱食大量肉食后突然出现上腹部疼痛，呈持续性绞痛，伴出汗、恶心，后疼痛加剧，伴全身乏力、大汗出，无排气及大便，胰腺CT显示血管渗漏、显示为急性重症胰腺炎，遂给予本发明中药治疗，3天后显效，炎症反应受到阻断，5天后血、尿淀粉酶基本恢复正常。
病例2：律某，女性，55岁，因腹痛、呕吐入院，伴有血、尿淀粉酶及血象增高、腹膜炎刺激征，全部病例均经CT检查都有胰腺肿大、坏死，伴腹腔或胰周积液或血性腹水，断症为急性重症胰腺炎，遂给予本发明中药治疗，3天后显效，炎症反应受到阻断，7天后血、尿淀粉酶基本恢复正常。
具体实施方式
实施例1：
一种治疗急性重症胰腺炎的中药配方，由以下重量份数的中药原料配制而成：芦荟3份、泽泻4份、竹茹4份、半夏6份、蒲黄4份、紫堇1份、丹参5份、黄芩5份、栀子4份、柴胡7份、芍药5份、生姜5份、枳实8份、大枣6份、大黄7份、芒硝8份、甘遂4份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材4cm，浸泡1.5个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮30min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例2：
一种治疗急性重症胰腺炎的中药配方，由以下重量份数的中药原料配制而成：芦荟2份、泽泻5份、竹茹3份、半夏10份、蒲黄3份、紫堇2份、丹参4份、黄芩6份、栀子3份、柴胡10份、芍药4份、生姜6份、枳实5份、大枣10份、大黄5份、芒硝10份、甘遂3份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材2cm，浸泡2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例3：
一种治疗急性重症胰腺炎的中药配方，由以下重量份数的中药原料配制而成：芦荟5份、泽泻3份、竹茹5份、半夏5份、蒲黄5份、紫堇1份、丹参6份、黄芩4份、栀子5份、柴胡5份、芍药6份、生姜4份、枳实10份、大枣5份、大黄10份、芒硝5份、甘遂5份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材5cm，浸泡1个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
以上已将本发明做一详细说明，以上所述，仅为本发明之较佳实施例而已，当不能限定本发明实施范围，即凡依本申请范围所作均等变化与修饰，皆应仍属本发明涵盖范围内。

Claims (3)

1.一种治疗急性重症胰腺炎的中药配方，其特征在于由以下重量份数的中药原料配制而成：芦荟2～5份、泽泻3～5份、竹茹3～5份、半夏5～10份、蒲黄3～5份、紫堇1～2份、丹参4～6份、黄芩4～6份、栀子3～5份、柴胡5～10份、芍药4～6份、生姜4～6份、枳实5～10份、大枣5～10份、大黄5～10份、芒硝5～10份、甘遂3～5份。
2.如权利要求1所述的一种治疗急性重症胰腺炎的中药配方，其特征在于由以下重量份数的中药原料配制而成：芦荟3份、泽泻4份、竹茹4份、半夏6份、蒲黄4份、紫堇1份、丹参5份、黄芩5份、栀子4份、柴胡7份、芍药5份、生姜5份、枳实8份、大枣6份、大黄7份、芒硝8份、甘遂4份。
3.制备如权利要求1所述的治疗急性重症胰腺炎的中药配方的方法，其特征在于由以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材2～5cm，浸泡1～2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20～40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
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CN106039198A (zh) * 2016-08-06 2016-10-26 甘肃鑫晟源生物科技开发有限责任公司 一种治疗胰腺炎的中药颗粒及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106039198A (zh) * 2016-08-06 2016-10-26 甘肃鑫晟源生物科技开发有限责任公司 一种治疗胰腺炎的中药颗粒及其制备方法

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