CN104306929A - 一种治疗重症急性胰腺炎的中药配方及其制备方法 - Google Patents

一种治疗重症急性胰腺炎的中药配方及其制备方法 Download PDF

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CN104306929A
CN104306929A CN201410546914.8A CN201410546914A CN104306929A CN 104306929 A CN104306929 A CN 104306929A CN 201410546914 A CN201410546914 A CN 201410546914A CN 104306929 A CN104306929 A CN 104306929A
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刘志鸿
韩先章
卢爱丽
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Abstract

本发明属于中医中药技术领域，特别涉及一种治疗重症急性胰腺炎的中药配方及其制备方法。由以下重量份数的中药原料配制而成：茵陈4～6份、白茅根4～6份、肿节风3～5份、亚麻子3～5份、延胡索3～5份、柴胡5～10份、黄芩4～6份、芍药4～6份、半夏5～10份、生姜4～6份、大枣5～10份、大黄5～10份、芒硝5～10份、枳实5～10份、厚朴5～10份、甘草3～5份。制备方法是水煎剂。本发明通过中药的理气开郁、活血化瘀、益气救阴之效，能够减少胰液腺分泌，快速调节自身炎症反应，预防内毒素移位，减轻病人痛苦，挽救病人生命。

Description

一种治疗重症急性胰腺炎的中药配方及其制备方法
技术领域
本发明属于中医中药技术领域，特别涉及一种治疗重症急性胰腺炎的中药配方及其制备方法。
背景技术
急性胰腺炎是多种病因导致胰酶在胰腺内被激活后引起胰腺组织自身消化、水肿、出血甚至坏死的炎症反应。临床以急性上腹痛、恶心、呕吐、发热和血胰酶增高等为特点。病变程度轻重不等，轻者以胰腺水肿为主，临床多见，病情常呈自限性，预后良好，又称为轻症急性胰腺炎。少数重者的胰腺出血坏死，常继发感染、腹膜炎和休克等，病死率高，称为重症急性胰腺炎。
70％～80％的重症急性胰腺炎是由于胆道疾病、酗酒和暴饮暴食所引起的,发病机制主要是胰液对胰腺及其周围组织自身消化的结果,炎性细胞因子互相关联和累积作用，导致血管渗漏、低血容量、多系统器官衰竭等危象的发生。急性胰腺炎治疗的最基本最重要的环节是减少胰腺分泌，中国专利(CN103191322A)公开了一种治疗重症急性胰腺炎的中药，通过改善重症急患者的胃肠功能、抑制消化液的分泌、抑制胰蛋白酶的活性，从而减轻胰腺组织炎症、降低病情的严重程度，但重症急性胰腺炎发病快、发展迅猛，需要快速见效、迅速遏制病情发展，能够回阳救逆的药物进行治疗。
发明内容
本发明的目的是提供一种治疗重症急性胰腺炎的中药配方，通过中药的理气开郁、活血化瘀、益气救阴之效，能够减少胰液腺分泌，快速调节自身炎症反应，预防内毒素移位，减轻病人痛苦，挽救病人生命。
本发明提供一种治疗重症急性胰腺炎的中药配方，由以下重量份数的中药原料配制而成：茵陈4～6份、白茅根4～6份、肿节风3～5份、亚麻子3～5份、延胡索3～5份、柴胡5～10份、黄芩4～6份、芍药4～6份、半夏5～10份、生姜4～6份、大枣5～10份、大黄5～10份、芒硝5～10份、枳实5～10份、厚朴5～10份、甘草3～5份。
进一步优选为由以下重量份数的中药原料配制而成：茵陈5份、白茅根5份、肿节风4份、亚麻子4份、延胡索4份、柴胡7份、黄芩5份、芍药5份、半夏6份、生姜5份、大枣7份、大黄6份、芒硝7份、枳实6份、厚朴7份、甘草4份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材2～5cm，浸泡1～2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20～40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
药理分析：
茵陈：苦、辛，微寒。归脾、胃、肝、胆经。清热利湿；退黄。主治黄疸、小便不利、湿疮瘙痒、传染性黄疸型肝炎等。药理学研究有利胆,保护肝功能,解热，抗炎,降血脂，降压,扩冠等作用。
白茅根：主治凉血止血，清热解毒。治热病烦渴，吐血，衄血，肺热喘急，胃热哕逆，淋病，小便不利，水肿，黄疸。
肿节风：苦、辛、平；归心、肝经。功能抗菌、消炎、凉血、清热解毒，祛风通络，活血散结；用于血热紫斑、紫癜，风湿痹痛，跌打损伤；肢体麻木，骨折，妇女痛经，产后瘀滞腹痛，肺炎，急性阑尾炎，急性胃肠炎，菌痢，胆囊炎，脓肿，口腔炎，风湿痹痛。
亚麻子：味甘，微温，无毒；归肺、肝、大肠经。有润滑、缓和刺激的作用，可用于治疗局部炎症。
延胡索：性味辛，苦，温，无毒；归肝，胃，心，肺，脾经。功能活血，散瘀，理气，止痛；主治心腹腰膝诸痛，月经不调，症瘕，崩中，产后血晕，恶露不尽，跌打损伤。
柴胡：性味苦，微寒。归肝、胆经。有和解表里，疏肝，升阳之功效。用于感冒发热、寒热往来、疟疾、肝郁气滞、胸肋胀痛、脱肛、子宫脱垂、月经不调。
黄芩：味苦、性寒，入心、肺、胆、大肠经；有清热燥湿、泻火解毒、止血、安胎等功效；主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。现代药理证明，黄芩具有抗菌作用、抗真菌作用、抗病毒作用和抗炎抗变态反应等作用，而且不产生抗药性。
芍药：芍药含有芍药苷和芍药甙等多种药物成分,具有扩张血管、降压镇痛、清热解痉的作用,有较高的药用价值。
半夏：气微，味微涩；功能燥湿化痰，降逆止呕，消痞散结。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛，呕吐反胃，胸脘痞闷，梅核气；生用外治痈肿痰核。
生姜：味辛，性热；归脾、胃、心、肺经。功效温中散寒，回阳通脉，燥湿消痰，温肺化饮；主治脘腹冷痛、呕吐、泄泻、亡阳厥逆、寒饮喘咳、寒湿痹痛。
大枣：味甘、辛，性温，无毒；归脾、胃经；主治心腹邪气，少津液、身体虚弱，大惊，四肢重；功能安中，养脾气平胃气，补中益气，养血安神；通九窍，助卜二经，补少气，和百药。长期服食能轻身延年。
大黄：味苦，寒；归脾、胃、大肠、肝、心包经。功效攻积滞，清湿热，泻火，凉血，祛瘀，解毒；主治实热便秘，热结胸痞，湿热泻痢，黄疸，淋病，水肿腹满，小便不利，目赤，咽喉肿痛，口舌生疮，胃热呕吐，吐血，咯血，衄血，便血，尿血，蓄血，经闭，产后瘀滞腹痛，症瘕积聚，跌打损伤，热毒痈疡，丹毒，烫伤。
芒硝：咸、苦，寒；归胃经，肺经，脾经，肾经，小肠经，三焦经，大肠经。功能泻热通便，润燥软坚，清火消肿，主治破痞，常温中，消食，逐水，缓泻。用于胃脘痞，食痞，消化不良，浮肿，水肿，乳肿，闭经，便秘。
枳实：苦，辛，寒；归脾，胃，肝，心经。功效主治积滞内停，痞满胀痛，大便秘结，泻痢后重，结胸，胃下垂，子宫脱垂，脱肛。
厚朴：苦，辛，性温；归脾经，胃经，大肠经。功能行气消积，燥湿除满，降逆平喘；主治食积气滞，腹胀便秘，湿阻中焦，脘痞吐泻，痰壅气逆，胸满喘咳。
甘草：味甘，性平；入脾、胃、肺经；功能补脾益气，清热解毒，祛痰止咳，清咽利嗓，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
本发明的中药，通过中药的理气开郁、活血化瘀、益气救阴之效，能够减少胰液腺分泌，快速调节自身炎症反应，预防内毒素移位，减轻病人痛苦，挽救病人生命。
疗效判断：
显效：3天内症状、体征缓解，7天内血、尿淀粉酶基本恢复正常。
有效：7天内症状、体征减轻，血、尿淀粉酶有下降趋势；
无效：7天内症状未减轻或恶化；
治疗结果：治疗75名重症急性胰腺炎患者，1日为1个疗程，1日2剂。服用本发明药物后，显效37例，占49.3％，有效35例，占46.7％，无效3例，占4％。
附几例病例作进一步说明：
病例1：米某，女，69岁，因腹痛5h就院，之后出现神志不清，呼之不应，急诊查MRI+DWI示右侧额叶大片状脑梗死。夜间出现高热，呼吸急促，SPO295％左右，经加大氧流量有所好转。次日晨SPO2再次下降转入ICU科。体检显示神志呈模糊状，右侧肢体活动明显，左侧肢体偏瘫，双侧瞳孔等大等圆，直径3mm，光反应存在，口唇轻度发绀，双肺呼吸音粗，双下肺呼吸音低，右侧为甚，心率130次/min，律齐，心音正常，腹膨隆，压痛(+)，肠鸣音未及，移动性浊音不明显，双下肢无明显浮肿，病理反射未引出。断症为重症急性胰腺炎，遂给予本发明中药治疗，3天后显效，炎症反应受到阻断，7天后血、尿淀粉酶基本恢复正常。
病例2：马某某，男性，73岁，因上腹部疼痛剧烈，放射至腰部，伴有呕吐现象，检查血糖为28.4mmol/l，血淀粉酶为865U，断症为重症急性胰腺炎，遂给予本发明中药治疗，3天后显效，炎症反应受到阻断，5天后血、尿淀粉酶基本恢复正常。
具体实施方式
实施例1：
一种治疗重症急性胰腺炎的中药配方，由以下重量份数的中药原料配制而成：茵陈5份、白茅根5份、肿节风4份、亚麻子4份、延胡索4份、柴胡7份、黄芩5份、芍药5份、半夏6份、生姜5份、大枣7份、大黄6份、芒硝7份、枳实6份、厚朴7份、甘草4份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材4cm，浸泡1.5个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮30min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例2：
一种治疗重症急性胰腺炎的中药配方，由以下重量份数的中药原料配制而成：茵陈4份、白茅根6份、肿节风3份、亚麻子5份、延胡索3份、柴胡10份、黄芩4份、芍药6份、半夏5份、生姜6份、大枣5份、大黄10份、芒硝5份、枳实10份、厚朴5份、甘草5份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材2cm，浸泡2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例3：
一种治疗重症急性胰腺炎的中药配方，由以下重量份数的中药原料配制而成：茵陈6份、白茅根4份、肿节风5份、亚麻子3份、延胡索5份、柴胡5份、黄芩6份、芍药4份、半夏10份、生姜4份、大枣10份、大黄5份、芒硝10份、枳实5份、厚朴10份、甘草3份。
制备方法以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材5cm，浸泡1个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
以上已将本发明做一详细说明，以上所述，仅为本发明之较佳实施例而已，当不能限定本发明实施范围，即凡依本申请范围所作均等变化与修饰，皆应仍属本发明涵盖范围内。

Claims (3)

1.一种治疗重症急性胰腺炎的中药配方，其特征在于由以下重量份数的中药原料配制而成：茵陈4～6份、白茅根4～6份、肿节风3～5份、亚麻子3～5份、延胡索3～5份、柴胡5～10份、黄芩4～6份、芍药4～6份、半夏5～10份、生姜4～6份、大枣5～10份、大黄5～10份、芒硝5～10份、枳实5～10份、厚朴5～10份、甘草3～5份。
2.如权利要求1所述的一种治疗重症急性胰腺炎的中药配方，其特征在于由以下重量份数的中药原料配制而成：茵陈5份、白茅根5份、肿节风4份、亚麻子4份、延胡索4份、柴胡7份、黄芩5份、芍药5份、半夏6份、生姜5份、大枣7份、大黄6份、芒硝7份、枳实6份、厚朴7份、甘草4份。
3.制备如权利要求1所述的治疗重症急性胰腺炎的中药配方的方法，其特征在于由以下步骤组成：按上述重量份称取中药原料，加入冷水，没过药材2～5cm，浸泡1～2个小时；然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20～40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587017A (zh) * 2015-01-21 2015-05-06 泸州医学院附属中医医院 一种清热通腑,行气活血的药物组合物及其制备方法和用途
CN105031232A (zh) * 2015-06-30 2015-11-11 卞永兴 一种用于治疗重症急性胰腺炎的中药汤剂
CN106729102A (zh) * 2017-01-23 2017-05-31 郑州市美居艺术制品有限公司 行气止痛解毒汤

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587017A (zh) * 2015-01-21 2015-05-06 泸州医学院附属中医医院 一种清热通腑,行气活血的药物组合物及其制备方法和用途
CN105031232A (zh) * 2015-06-30 2015-11-11 卞永兴 一种用于治疗重症急性胰腺炎的中药汤剂
CN106729102A (zh) * 2017-01-23 2017-05-31 郑州市美居艺术制品有限公司 行气止痛解毒汤

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