CN104398927A - 治疗膝关节滑膜炎的中药制剂 - Google Patents

治疗膝关节滑膜炎的中药制剂 Download PDF

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CN104398927A
CN104398927A CN201410637526.0A CN201410637526A CN104398927A CN 104398927 A CN104398927 A CN 104398927A CN 201410637526 A CN201410637526 A CN 201410637526A CN 104398927 A CN104398927 A CN 104398927A
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吴金霞
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Abstract

本发明公开了一种用于治疗膝关节滑膜炎的中药制剂,其特征在于,选择的中药原料及重量份分别是:丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份。本发明所选用的原料药材药性效互补,规避了药物之间配伍的相恶、相畏、相杀之选,使药物相须、相使作用显著,具有增强免疫力的作用。具有祛风散寒、活血散瘀、消肿止痛的功效,是治疗膝关节滑膜炎的内服纯中草药组成制剂。

Description

治疗膝关节滑膜炎的中药制剂
技术领域
[0001] 本发明涉及中药制剂领域,具体涉及一种用于治疗膝关节滑膜炎的中药制剂,具有祛风散寒、活血散瘀、消肿止痛的功效。
背景技术
[0002] 膝盖滑膜炎又称膝关节滑膜炎,是一种多发性疾病。容易造成患者暂时或长期部分丧失劳动力,对患者危害都较大。膝盖滑膜炎又称膝关节滑膜炎,是一种多发性疾病。容易造成患者暂时或长期部分丧失劳动力,对患者危害都较大。主要是因软骨退变与骨质增生产生的机械性生物化学性刺激,继发膝关节滑膜水肿、渗出和积液等。急性膝盖滑膜炎:外伤包括有:膝关节扭伤、半月板损伤、侧副韧带或交叉韧带损伤,关节内积液或有时积血,表现为急性膝关节外伤性滑膜炎。有时也可因单纯膝关节滑膜损伤所致,如外伤较轻,或长期慢性膝关节劳损。加上风、寒、湿邪侵袭,可使膝关节逐渐出现肿胀和功能障碍者,则形成慢性膝关节滑膜炎。关节肿胀型主要是过度运动后肿胀为主,疼痛轻重不一。非肿胀型,以关节疼痛为主,常伴有轻度肿胀。当膝关节长时间单一动作超量运动之后,滑膜组织充血水肿,红、白细胞及纤维素渗出与关节腔内压升高及氧分压下降呈正相关系,且当渗出速度超过滑膜代偿性吸收速度时,关节积液,进而使关节腔内压继续升高,氧分压继续下降的恶性循环,久之滑膜退变脂肪化生等慢性无菌炎症形成,膝盖滑膜损伤后,滑膜呈现充血、水肿和中性粒细胞浸润。滑膜血管扩张,血浆和细胞外渗,产生大量渗出液,同时滑膜细胞活跃,产生大量粘液素。渗出液中含有红细胞、白细胞、胆红质、脂肪、粘液素和纤维素等。严重者关节积液呈血性。关节肿胀及活动受限。
发明内容
:
[0003] 本发明的目的在于提供一种用于治疗膝关节滑膜炎的中药制剂,具有祛风散寒、活血散瘀、消肿止痛的功效。
[0004] 为实现上述目的本发明采用了如下的技术方案:本发明所述中药制剂选择的药材及重量份分别是:丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份。
[0005] 本发明选择的中药原料中:丝瓜络:味甘,性凉。归肺、肝、胃经。体轻通利。通经活络,清热解毒,利尿消肿,止血。主治胸胁胀痛,风湿痹痛,筋脉拘挛,女子经闭,乳汁不通,痰热咳嗽,热毒痈肿,痔漏,水肿,小便不利,便血,崩漏。
[0006] 女贞子:性味:甘,苦,平。归经:肝;肾经;功效分类:补益药。功效:补益肝肾,清虚热,强腰膝,明耳目,乌须发。主治:头昏目眩;腰膝酸软;遗精;耳鸣;须发早白,骨蒸潮热。
[0007] 豨签草:性味苦寒,又有化湿热作用,故痹痛偏于湿热的病症尤为适宜。用于中风,半身不遂,腰膝无力等症:本品酒治蒸熟又能强筋骨,适用于四肢麻痹、腰膝无力、中风口眼歪斜、半身不遂等症。用于疮疡肿痛、风疹湿疹瘙痒等症:本品生用还能清热解毒,可用于疮疡肿毒,以及风疹湿疮、皮肤搔痒等症。内服外用均可。此外,本品现在又用于高血压症,有降压作用。
[0008] 元参:味苦咸。性微寒。无毒。正禀北方水气。兼得春阳之和以生。可升可降。阴也。恶黄、干姜、茴香、山萸。反藜芦。勿犯铜铁。主治:主腹中寒热积聚。女子产乳余疾。补肾气。令人明目。
[0009] 川牛膝:归经肝;肾经。性味甘;微苦;性平。功能主治:祛风,利湿,通经,活血。治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,症瘕。用于经闭症瘕,胞衣不下,关节痹痛,足痿筋挛,尿血血淋,跌扑损伤。
[0010] 防己:功效:利水消肿,祛风止痛。主治:水肿脚气,小便不利,湿疹疮毒,风湿痹痛,高血压症。一般认为,汉防己利水消肿作用较强,木防己祛风止痛作用较好。
[0011] 薏苡:味甘、淡,性微寒。有健脾利湿、清热排脓功能。用于脾虚泄泻水肿脚气、白带、湿、关节疼痛、肠痈、肺痿等症。尚用于胃癌、子宫颈癌、绒毛膜上皮癌等癌症以及多发性疣。【化学成分】叶含生物碱,种子含有大量淀粉及多种维生素。还含有的主要的主要成分是固醇、多种氨基酸、薏苡仁油、薏苡仁脂、碳水化合物、B族维生素等;【主治】:治胃寒疼痛、气血虚弱。【性味归经】:甘、温脾、胃经。
[0012] 土茯苓:【功能】解毒,除湿,利关节。主治:治梅毒,淋浊,筋骨挛痛,脚气,疗疔疮,痈肿,瘰疬,梅毒及汞中毒所致的肢体拘挛,筋骨疼痛。
[0013] 桂枝:【主治】散寒解表;温通经脉;通阳化气。主风寒表证;寒湿痹痛;四肢厥冷;经闭痛经;症瘕结块;胸痹;心悸;痰饮;小便不利。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。【功效】发汗解肌,温经通脉,助阳化气,散寒止痛。
[0014] 当归:【化学成分】含基本内酯、正丁烯酰内酯、阿魏酸、烟酸、蔗糖和多种氨基酸,以及倍半萜类化合物等。【性味归经】性温,昧甘、辛。归肝、心、脾经。【功能主治】补血活血,调经止痛,润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。
[0015] 细辛:【归经】:肺经、肾经、心经、肝经、胆经、脾经。【性味】味辛;性温;小毒。【功效】:解表散寒;祛风止痛;温肺化饮;通窍。【主治】:散寒祛风;止痛;温肺化饮;通窍。风寒表证;头痛,牙痛;风湿痹痛;痰饮咳喘;鼻塞;鼻渊;口疮。用于风寒感冒,头痛,牙痛,鼻塞鼻渊,风湿痹痛,痰饮喘咳。
[0016] 黄芪:具有1、表虚自汗,多用于体虚表弱所致的自汗。2、阴虚盗汗;3、急性肾炎水肿,用于阳气不足所致的虚性水肿;4、慢性肾炎水肿、脾肾虚者;5、阳气虚弱,用于疮疡久不溃破而内陷,有促进溃破及局限作用。6、疮疡久溃不愈,用于疮疡溃破后,久不收口,有生肌收口之作用;7、脾气虚证,虚弱倦怠,泄泻,中气下陷,脏器脱垂,食少纳呆诸症。8、肺气虚证。咳喘日久,气短神疲,痰雍于肺无力咯出。9、多汗而浮肿。10、用于气虚衰弱,倦怠乏力,或中气下陷、脱肛、子宫脱垂。性味:甘,微温。归经:归肺、脾、肝、肾经;有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
[0017] 白术:【性味归经】苦、甘,温。归脾、胃经。功效:健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。
[0018] 红花:【化学成分】含红花甙、新红花甙、红花醌甙、红花多糖、棕榈酸、肉桂酸、月桂酸。【性味】性温,味辛。【功能主治】活血通经,散淤止痛,用于闭经,痛经,恶露不行,症瘕痞块,跌扑损伤,疮疡肿痛。
[0019] 泽泻:性味:甘,寒。归经:入肾、膀胱经。功效:利水,渗湿,泄热。治小便不利,水肿胀满,呕吐,泻痢,痰饮,脚气,淋病,尿血。化学成分:块茎含泻醇(alisol)A、B、C、泽泻醇 A 单乙酸酯(alisol A monoacetate),泽ί写醇 B 单乙酸酯(alisol B monoacetate),泽ί写醇 C 单乙酸醋(alisol C monoacetate)表泽ί写醇(epialisol) Α,泽湾奥醇(alismol),泽ί写奥醇氧化物(alismoxide), 16 β -甲氧基泽ί写醇B单乙酸酯(16 β -methocyal-1sol Bmonoacetate), 16 β -轻基泽ί写醇 B 单乙酸酯(16 β-hydroxyal-1sol B monoacetate),谷留醇-3-0-硬脂酸基 -D-卩比喃葡萄糖式(sitosterol-3-O-steroyl- β -D-glucopyranoside)。还含胆碱(cho-line),糖和锂、Μ、登等元素。
[0020] 本发明所选用的原料药材药性效互补,规避了药物之间配伍的相恶、相畏、相杀之选,使药物相须、相使作用显著,具有增强免疫力的作用。具有祛风散寒、活血散瘀、消肿止痛的功效,是治疗膝关节滑膜炎的内服纯中草药组成制剂。临床应用时具有良好的确切效果O
[0021 ] 本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。例如可以将这些原料药研成粉末混合均匀散剂冲服;可以将这些原料药一起水煎,然后浓缩煎液服用,或者把浓缩煎液浓缩成膏加工成丸剂服用;为了使该药物的各原料更好地发挥药效,针对某原料药进行特殊提取,如乙醇提取,这些不能用于限制本发明的保护范围。
[0022] 本发明所述药物具有祛风散寒、活血散瘀、消肿止痛的功效,用于治疗膝关节滑膜炎。本发明人经过反复研究,并通过临床试验的反复验证,终于找到了有更好疗效的内服药物,从而完成了本发明。
[0023] 临床药效试验材料及典型病例:
[0024] 1.杜XX,男,52岁。会诊日期2013年I月10日。
[0025] 患者于2012年1、2月份,因感受寒冷之邪,发现双下肢膝关节疼痛。每遇气候变化时疼痛加重,但局部不红不肿,未做治疗。2012年12月,双膝关节肿胀酸困,屈伸不利,症状加重。在某医院接诊,确诊为关节炎、关节腔积液。口服消炎药治疗半个多月,双膝关节肿胀增剧,积液不断增加,未见明显疗效。故前来就诊。双膝关节肿胀如鹤膝,按之应手,有波动感,以右侧为重。纳呆便溏,下肢冷胀酸困。舌边有齿痕、苔白腻,脉滑数。此为患寒痹日久,加之脾肾亏损,气化不利,水液内停,寒湿凝结,阻滞经络所致。治宜温肾健脾,活血利水。服本方8剂后,肿胀感冷感大减,积液减少,苔白,脉细数。继续服用本方15剂后,双膝关节积液消失,活动自如,病已痊愈。
[0026] 方法和有效量:丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份;取处方规定量中药材饮片,置适宜煎煮器中,加入清水适量,浸泡适宜时间,加热至沸,保持微沸状态一定时间(约25〜30分钟),分离煎出液,药渣再加水适量煎煮,按规定煎煮2〜3次后,合并煎出液,过滤或沉降分离煎出液供使用。
[0027] 汤剂内服为主,每日早晚2次内服,每次150ml温服。汤剂则作用快而力峻,适应于病情较急重者。如病情较轻或缓者,宜为丸剂内服求其功。
具体实施方式
[0028] 所述用于治疗膝关节滑膜炎的中药制剂,其特征在于,选择的中药原料及重量份分别是:丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份;
[0029] 制备方法:取丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份;分别制成饮片,置适宜煎煮器中,加入清水适量,浸泡适宜时间,加热至沸,保持微沸状态一定时间(约25〜30分钟),分离煎出液,药渣再加水适量煎煮,按规定煎煮2〜3次后,合并煎出液,过滤或沉降分离煎出液供使用。

Claims (1)

1.用于治疗膝关节滑膜炎的中药制剂,其特征在于,选择的中药原料及重量份分别是:丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份; 其制备方法:取丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份;分别制成饮片,置适宜煎煮器中,加入清水适量,浸泡适宜时间,加热至沸,保持微沸状态一定时间(约25〜30分钟),分离煎出液,药渣再加水适量煎煮,按规定煎煮2〜3次后,合并煎出液,过滤或沉降分离煎出液供使用。
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106798865A (zh) * 2017-02-16 2017-06-06 成都市飞龙水处理技术研究所青白江第分所 一种治疗急慢性滑膜炎的中药组合物及其制备方法
CN108066664A (zh) * 2018-01-19 2018-05-25 范鹏程 治疗膝关节滑膜炎的中药制剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106798865A (zh) * 2017-02-16 2017-06-06 成都市飞龙水处理技术研究所青白江第分所 一种治疗急慢性滑膜炎的中药组合物及其制备方法
CN108066664A (zh) * 2018-01-19 2018-05-25 范鹏程 治疗膝关节滑膜炎的中药制剂

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