CN104398927A - 治疗膝关节滑膜炎的中药制剂 - Google Patents

治疗膝关节滑膜炎的中药制剂 Download PDF

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CN104398927A
CN104398927A CN201410637526.0A CN201410637526A CN104398927A CN 104398927 A CN104398927 A CN 104398927A CN 201410637526 A CN201410637526 A CN 201410637526A CN 104398927 A CN104398927 A CN 104398927A
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吴金霞
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Abstract

本发明公开了一种用于治疗膝关节滑膜炎的中药制剂，其特征在于，选择的中药原料及重量份分别是：丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份。本发明所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有增强免疫力的作用。具有祛风散寒、活血散瘀、消肿止痛的功效，是治疗膝关节滑膜炎的内服纯中草药组成制剂。

Description

治疗膝关节滑膜炎的中药制剂
技术领域
本发明涉及中药制剂领域，具体涉及一种用于治疗膝关节滑膜炎的中药制剂，具有祛风散寒、活血散瘀、消肿止痛的功效。
背景技术
膝盖滑膜炎又称膝关节滑膜炎，是一种多发性疾病。容易造成患者暂时或长期部分丧失劳动力，对患者危害都较大。膝盖滑膜炎又称膝关节滑膜炎，是一种多发性疾病。容易造成患者暂时或长期部分丧失劳动力，对患者危害都较大。主要是因软骨退变与骨质增生产生的机械性生物化学性刺激，继发膝关节滑膜水肿、渗出和积液等。急性膝盖滑膜炎：外伤包括有：膝关节扭伤、半月板损伤、侧副韧带或交叉韧带损伤，关节内积液或有时积血，表现为急性膝关节外伤性滑膜炎。有时也可因单纯膝关节滑膜损伤所致，如外伤较轻，或长期慢性膝关节劳损。加上风、寒、湿邪侵袭，可使膝关节逐渐出现肿胀和功能障碍者，则形成慢性膝关节滑膜炎。关节肿胀型主要是过度运动后肿胀为主，疼痛轻重不一。非肿胀型，以关节疼痛为主，常伴有轻度肿胀。当膝关节长时间单一动作超量运动之后，滑膜组织充血水肿，红、白细胞及纤维素渗出与关节腔内压升高及氧分压下降呈正相关系，且当渗出速度超过滑膜代偿性吸收速度时，关节积液，进而使关节腔内压继续升高，氧分压继续下降的恶性循环，久之滑膜退变脂肪化生等慢性无菌炎症形成，膝盖滑膜损伤后，滑膜呈现充血、水肿和中性粒细胞浸润。滑膜血管扩张，血浆和细胞外渗，产生大量渗出液，同时滑膜细胞活跃，产生大量粘液素。渗出液中含有红细胞、白细胞、胆红质、脂肪、粘液素和纤维素等。严重者关节积液呈血性。关节肿胀及活动受限。
发明内容：
本发明的目的在于提供一种用于治疗膝关节滑膜炎的中药制剂，具有祛风散寒、活血散瘀、消肿止痛的功效。
为实现上述目的本发明采用了如下的技术方案：本发明所述中药制剂选择的药材及重量份分别是：丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份。
本发明选择的中药原料中：丝瓜络：味甘，性凉。归肺、肝、胃经。体轻通利。通经活络，清热解毒，利尿消肿，止血。主治胸胁胀痛，风湿痹痛，筋脉拘挛，女子经闭，乳汁不通，痰热咳嗽，热毒痈肿，痔漏，水肿，小便不利，便血，崩漏。
女贞子：性味：甘，苦，平。归经：肝；肾经；功效分类：补益药。功效：补益肝肾，清虚热，强腰膝，明耳目，乌须发。主治：头昏目眩；腰膝酸软；遗精；耳鸣；须发早白，骨蒸潮热。
豨签草：性味苦寒，又有化湿热作用，故痹痛偏于湿热的病症尤为适宜。用于中风，半身不遂，腰膝无力等症：本品酒治蒸熟又能强筋骨，适用于四肢麻痹、腰膝无力、中风口眼歪斜、半身不遂等症。用于疮疡肿痛、风疹湿疹瘙痒等症：本品生用还能清热解毒，可用于疮疡肿毒，以及风疹湿疮、皮肤搔痒等症。内服外用均可。此外，本品现在又用于高血压症，有降压作用。
元参：味苦咸。性微寒。无毒。正禀北方水气。兼得春阳之和以生。可升可降。阴也。恶黄、干姜、茴香、山萸。反藜芦。勿犯铜铁。主治：主腹中寒热积聚。女子产乳余疾。补肾气。令人明目。
川牛膝：归经肝；肾经。性味甘；微苦；性平。功能主治：祛风，利湿，通经，活血。治风湿腰膝疼痛，脚痿筋挛，血淋，尿血，妇女经闭，症瘕。用于经闭症瘕，胞衣不下，关节痹痛，足痿筋挛，尿血血淋，跌扑损伤。
防己：功效：利水消肿，祛风止痛。主治：水肿脚气，小便不利，湿疹疮毒，风湿痹痛，高血压症。一般认为，汉防己利水消肿作用较强，木防己祛风止痛作用较好。
薏苡：味甘、淡，性微寒。有健脾利湿、清热排脓功能。用于脾虚泄泻水肿脚气、白带、湿、关节疼痛、肠痈、肺痿等症。尚用于胃癌、子宫颈癌、绒毛膜上皮癌等癌症以及多发性疣。【化学成分】叶含生物碱，种子含有大量淀粉及多种维生素。还含有的主要的主要成分是固醇、多种氨基酸、薏苡仁油、薏苡仁脂、碳水化合物、B族维生素等；【主治】：治胃寒疼痛、气血虚弱。【性味归经】：甘、温脾、胃经。
土茯苓：【功能】解毒，除湿，利关节。主治：治梅毒，淋浊，筋骨挛痛，脚气，疗疔疮，痈肿，瘰疬，梅毒及汞中毒所致的肢体拘挛，筋骨疼痛。
桂枝：【主治】散寒解表；温通经脉；通阳化气。主风寒表证；寒湿痹痛；四肢厥冷；经闭痛经；症瘕结块；胸痹；心悸；痰饮；小便不利。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。【功效】发汗解肌，温经通脉，助阳化气，散寒止痛。
当归：【化学成分】含基本内酯、正丁烯酰内酯、阿魏酸、烟酸、蔗糖和多种氨基酸，以及倍半萜类化合物等。【性味归经】性温，昧甘、辛。归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。
细辛：【归经】：肺经、肾经、心经、肝经、胆经、脾经。【性味】味辛；性温；小毒。【功效】：解表散寒；祛风止痛；温肺化饮；通窍。【主治】：散寒祛风；止痛；温肺化饮；通窍。风寒表证；头痛，牙痛；风湿痹痛；痰饮咳喘；鼻塞；鼻渊；口疮。用于风寒感冒，头痛，牙痛，鼻塞鼻渊，风湿痹痛，痰饮喘咳。
黄芪：具有1、表虚自汗，多用于体虚表弱所致的自汗。2、阴虚盗汗；3、急性肾炎水肿，用于阳气不足所致的虚性水肿；4、慢性肾炎水肿、脾肾虚者；5、阳气虚弱，用于疮疡久不溃破而内陷，有促进溃破及局限作用。6、疮疡久溃不愈，用于疮疡溃破后，久不收口，有生肌收口之作用；7、脾气虚证，虚弱倦怠，泄泻，中气下陷，脏器脱垂，食少纳呆诸症。8、肺气虚证。咳喘日久，气短神疲，痰雍于肺无力咯出。9、多汗而浮肿。10、用于气虚衰弱，倦怠乏力，或中气下陷、脱肛、子宫脱垂。性味：甘，微温。归经：归肺、脾、肝、肾经；有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
白术：【性味归经】苦、甘，温。归脾、胃经。功效：健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。
红花：【化学成分】含红花甙、新红花甙、红花醌甙、红花多糖、棕榈酸、肉桂酸、月桂酸。【性味】性温，味辛。【功能主治】活血通经，散淤止痛，用于闭经，痛经，恶露不行，症瘕痞块，跌扑损伤，疮疡肿痛。
泽泻：性味：甘，寒。归经：入肾、膀胱经。功效：利水，渗湿，泄热。治小便不利，水肿胀满，呕吐，泻痢，痰饮，脚气，淋病，尿血。化学成分：块茎含泻醇(alisol)A、B、C、泽泻醇A单乙酸酯(alisol A monoacetate)，泽泻醇B单乙酸酯(alisol B monoacetate)，泽泻醇C单乙酸醋(alisol Cmonoacetate)表泽泻醇(epialisol)A，泽泻薁醇(alismol)，泽泻薁醇氧化物(alismoxide)，16β-甲氧基泽泻醇B单乙酸酯(16β-methocyal-isol Bmonoacetate)，16β-羟基泽泻醇B单乙酸酯(16β-hydroxyal-isol B monoacetate)，谷甾醇-3-O-硬脂酰基-β-D-吡喃葡萄糖甙(sitosterol-3-O-steroyl-β-D-glucopyranoside)。还含胆碱(cho-line)，糖和钾、钙、镁等元素。
本发明所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有增强免疫力的作用。具有祛风散寒、活血散瘀、消肿止痛的功效，是治疗膝关节滑膜炎的内服纯中草药组成制剂。临床应用时具有良好的确切效果。
本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。例如可以将这些原料药研成粉末混合均匀散剂冲服；可以将这些原料药一起水煎，然后浓缩煎液服用，或者把浓缩煎液浓缩成膏加工成丸剂服用；为了使该药物的各原料更好地发挥药效，针对某原料药进行特殊提取，如乙醇提取，这些不能用于限制本发明的保护范围。
本发明所述药物具有祛风散寒、活血散瘀、消肿止痛的功效，用于治疗膝关节滑膜炎。本发明人经过反复研究，并通过临床试验的反复验证，终于找到了有更好疗效的内服药物，从而完成了本发明。
临床药效试验材料及典型病例：
1.杜XX，男，52岁。会诊日期2013年1月10日。
患者于2012年1、2月份，因感受寒冷之邪，发现双下肢膝关节疼痛。每遇气候变化时疼痛加重，但局部不红不肿，未做治疗。2012年12月，双膝关节肿胀酸困，屈伸不利，症状加重。在某医院接诊，确诊为关节炎、关节腔积液。口服消炎药治疗半个多月，双膝关节肿胀增剧，积液不断增加，未见明显疗效。故前来就诊。双膝关节肿胀如鹤膝，按之应手，有波动感，以右侧为重。纳呆便溏，下肢冷胀酸困。舌边有齿痕、苔白腻，脉滑数。此为患寒痹日久，加之脾肾亏损，气化不利，水液内停，寒湿凝结，阻滞经络所致。治宜温肾健脾，活血利水。服本方8剂后，肿胀感冷感大减，积液减少，苔白，脉细数。继续服用本方15剂后，双膝关节积液消失，活动自如，病已痊愈。
方法和有效量：丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份；取处方规定量中药材饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。
汤剂内服为主，每日早晚2次内服，每次150ml温服。汤剂则作用快而力峻，适应于病情较急重者。如病情较轻或缓者，宜为丸剂内服求其功。
具体实施方式
所述用于治疗膝关节滑膜炎的中药制剂，其特征在于，选择的中药原料及重量份分别是：丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份；
制备方法：取丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份；分别制成饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。

Claims (1)

1.用于治疗膝关节滑膜炎的中药制剂，其特征在于，选择的中药原料及重量份分别是：丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份；
其制备方法：取丝瓜络15份、女贞子15份、豨签草15份、元参30份、川牛膝9份、防己24份、薏苡30份、土茯苓30份、桂枝10份、当归20份、细辛3份、黄芪30份、白术12份、红花10份、泽泻12份；分别制成饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。
CN201410637526.0A 2014-10-31 2014-10-31 治疗膝关节滑膜炎的中药制剂 Pending CN104398927A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106798865A (zh) * 2017-02-16 2017-06-06 成都市飞龙水处理技术研究所青白江第分所 一种治疗急慢性滑膜炎的中药组合物及其制备方法
CN108066664A (zh) * 2018-01-19 2018-05-25 范鹏程 治疗膝关节滑膜炎的中药制剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106798865A (zh) * 2017-02-16 2017-06-06 成都市飞龙水处理技术研究所青白江第分所 一种治疗急慢性滑膜炎的中药组合物及其制备方法
CN108066664A (zh) * 2018-01-19 2018-05-25 范鹏程 治疗膝关节滑膜炎的中药制剂

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