CN101095907A - 一种治疗糖尿病性末梢神经炎的中成药 - Google Patents
一种治疗糖尿病性末梢神经炎的中成药 Download PDFInfo
- Publication number
- CN101095907A CN101095907A CNA2007101183565A CN200710118356A CN101095907A CN 101095907 A CN101095907 A CN 101095907A CN A2007101183565 A CNA2007101183565 A CN A2007101183565A CN 200710118356 A CN200710118356 A CN 200710118356A CN 101095907 A CN101095907 A CN 101095907A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- portions
- peripheral neuritis
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 54
- 201000001119 neuropathy Diseases 0.000 title claims abstract description 21
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 19
- 206010029240 Neuritis Diseases 0.000 title claims abstract description 17
- 229940079593 drug Drugs 0.000 title description 16
- 239000009636 Huang Qi Substances 0.000 claims description 9
- 241000237636 Pheretima Species 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 230000000694 effects Effects 0.000 abstract description 20
- 230000008901 benefit Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 241000241550 Cyathula Species 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 25
- 210000004369 blood Anatomy 0.000 description 23
- 210000004185 liver Anatomy 0.000 description 12
- 208000006820 Arthralgia Diseases 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 8
- 201000000736 Amenorrhea Diseases 0.000 description 7
- 206010001928 Amenorrhoea Diseases 0.000 description 7
- 231100000540 amenorrhea Toxicity 0.000 description 7
- 208000005171 Dysmenorrhea Diseases 0.000 description 6
- 206010013935 Dysmenorrhoea Diseases 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 208000011580 syndromic disease Diseases 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 208000033808 peripheral neuropathy Diseases 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 208000025747 Rheumatic disease Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 230000007823 neuropathy Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 230000000552 rheumatic effect Effects 0.000 description 4
- 208000019255 Menstrual disease Diseases 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008736 traumatic injury Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010019468 Hemiplegia Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 208000021642 Muscular disease Diseases 0.000 description 2
- 201000009623 Myopathy Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000019802 Sexually transmitted disease Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 208000002894 beriberi Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 201000005518 mononeuropathy Diseases 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010051244 Dyschezia Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010036105 Polyneuropathy Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010037714 Quadriplegia Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010041954 Starvation Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 231100000132 chronic toxicity testing Toxicity 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 235000002378 plant sterols Nutrition 0.000 description 1
- 230000007824 polyneuropathy Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 201000002327 urinary tract obstruction Diseases 0.000 description 1
- 210000001604 vasa vasorum Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种治疗糖尿病性末梢神经炎的中成药，它是以鸡血藤、川牛膝、生黄芪和当归等10多味中草药为原料。具有益气养血，温经通络的功效。本发明是在传统的中医辨证治疗的基础上结合现代最新科研成果研制而成的。本发明的目的是提供一种治疗糖尿病性末梢神经炎的中药制剂。具有疗效确切、安全方便、无毒副作用、价格低廉的特点。
Description
技术领域
本发明涉及一种治疗糖尿病性末梢神经炎的中成药，是一种治疗糖尿病性末梢神经炎以中草药为原料的中药制剂。属于中药领域。
背景技术
糖尿病周围神经病变多见于中年以上，糖尿病控制不满意或病程较长者。少数患者以神经病变为首发症状。最常见且症状较早出现的为下肢病变。糖尿病神经病变临床表现较复杂，其分类方法多种，尚未取得一致意见。为便于临床观察，故按病变部位结合病变性质分类。周围神经病变又称末梢神经性病变。按其临床表现分为对称性多发神经病变及非对称性多发单神经病变。其中对称性多发神经病变还包括：远端对称性感觉神经病变、对称性运动神经病变；非对称性多发性神经病变和单一神经病变，主要为神经干滋养血管供血不足所致。按照多发神经病变的临床表现，相当中医的“痹证”、“痛证”、“痿证”范围。本病系因糖尿病久病不愈，久病必虚，耗伤正气，引起气血不足，营卫不调，络脉空虚，气血运行不畅。《类证治裁》：“诸气血凝滞，久而成痹。”早在上古时代就认识到“大经空虚”，并认识到痿证的发生与五脏病变相关。中医在临床上分气虚血痹、肝肾两虚、脾虚痰阻、瘀阻脉络等症型辨证治疗，取得很好效果。发明一种既安全又有效的中药制剂，具有重大意义。
发明内容
本发明是在传统的中医辨证治疗的基础上结合现代最新科研成果研制而成的。本发明的目的是提供一种治疗糖尿病性末梢神经炎的中成药。具有疗效确切、安全方便、无毒副作用、价格低廉的特点。
本发明是由下述重量配比的原料制成的：
生黄芪 1.5～6份 赤芍 1.0～4份 秦艽 0.1～2份
丹参 1.5～6份 当归 1.0～4份 桑枝 0.1～2份
鸡血藤 1.5～6份 莪术 1.0～4份 木瓜 0.1～2份
川牛膝 1.0～4份 桂枝 0.1～2份 地龙 0.1～2份。
本发明的优选配方各原料的重量配比是：
生黄芪 2.5～3.5份 赤芍 1.5～2.5份 秦艽 0.5～1.5份
丹参 2.5～3.5份 当归 1.5～2.5份 桑枝 0.5～1.5份
鸡血藤 2.5～3.5份 莪术 1.5～2.5份 木瓜 0.5～1.5份
川牛膝 1.5～2.5份 桂枝 0.5～1.5份 地龙 0.5～1.5份。
本发明的最佳配方各原料的重量配比是：
生黄芪 3份 赤芍 2份 秦艽 1份
丹参 3份 当归 2份 桑枝 1份
鸡血藤 3份 莪术 2份 木瓜 1份
川牛膝 2份 桂枝 1份 地龙 1份。
本发明中的药物机理如下：
生黄芪 药性甘、温。归肺、脾经。具有益气升阳，固表止汗，利水消肿，托毒生肌的功效。可治疗一切气虚血亏之证，如脾虚泄泻，肺虚咳嗽，脱肛，子宫下垂，自汗，盗汗，水肿，血痹，痈疽难溃或久溃不敛等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第2813页)。
丹参药性苦，微寒。归心、心包、肝经。具有活血祛瘀，调经止痛，除烦安神，凉血消痈的功效。可治疗妇女月经不调，痛经，经闭，产后瘀滞腹痛，心腹疼痛，癥瘕积聚，热痹肿痛，跌打损伤，热入营血，烦燥不安，心烦失眠，痈疮肿毒等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第647页)。
鸡血藤药性苦、微甘，温。归肝、肾经。具有活血舒筋，养血调经的功效。可治疗手足麻木，肢体瘫痪，风湿痹痛，贫血，月经不调，痛经，闭经等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社第二版第1689页)。
川牛膝药性甘、微苦，平。归肝、肾经。具有活血祛瘀，祛风利湿的功效。可治疗血瘀经闭，难产，胞衣不下，产后瘀血腹痛，热淋，石淋，痛经，风湿腰膝疼痛，跌打损伤等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第301页)。
赤芍药性苦，微寒。归肝、脾经。具有清热凉血，活血祛瘀的功效。可治疗温毒发斑，吐血衄血，肠风下血，目赤肿痛，痈肿疮疡，闭经，痛经，崩带淋浊，瘀滞胁痛，疝瘕积聚，跌扑损伤等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社第二版第1440页)。
当归药性甘、辛、苦，温。归肝、心、脾经。具有补血活血，调经止痛，润燥滑肠的功效。可治疗血虚诸证，月经不调，经闭，痛经，癥瘕结聚，崩漏，虚寒腹痛，痿痹，肌肤麻木，肠燥便难，赤痢后重，痈疽疮疡，跌扑损伤等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第1210页)。
莪术性味苦、辛、温。归肝、脾经。具有行气破瘀，消积止痛，化聚消症，抗早孕的功效。可治疗心腹胀痛、症瘕积聚、宿食不消、肝脾肿大、血瘀腹痛、血滞经闭、宫颈糜烂、跌打损伤作痛等。(季宇彬主编《抗癌中药药理与应用》黑龙江科学技术出版社1999年版第995页)。
桂枝药性辛、甘，温。归膀胱、心、肺经。具有散寒解表，温经，通阳的功效。可治疗风寒表证，寒湿痹痛，四肢厥冷，经闭痛经，癥瘕结块，胸痹，心悸，痰饮，小便不利等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第2522页)。
秦艽 药性苦、辛，微寒。归胃、肝、胆经。具有祛风湿，清虚热，退黄的功效。可治疗风湿痹痛，筋骨拘挛，手足不遂，骨蒸潮热，小儿疳热，湿热黄疸等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第2469页)。
桑枝药性苦，平。归肝经。具有祛风湿，通经络，行水气的功效。可治疗风湿痹痛，中风半身不遂，水肿脚气，肌体风痒等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社第二版第2783页)。
木瓜药性酸，温。归肝、脾、胃经。具有舒筋活络，和胃化湿的功效。可治疗风湿痹痛，肢体酸重，筋脉拘挛，吐泻转筋，脚气，水肿，痢疾等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第474页)。
地龙性味咸、寒。入肝、脾、肺、膀胱经。具有清热、平肝、止喘、通络利尿的功效。主治高热狂燥、惊风抽搐、风热头痛、目赤、中风半身不遂，喘息、喉痹、关节疼痛、齿衄、小便不通、瘰疬、痄腮、疮疡、高热、支气管哮喘、高血压病、精神病、下肢溃疡、湿疹、丹毒，烧烫伤、骨折等。(季宇彬主编《抗癌中药药理与应用》黑龙江科学技术出版社1999年版第522页)。
本发明遵循中医“君臣佐使”的组方原则，用生黄芪、丹参和鸡血藤为君药；用赤芍、当归、秦艽、川牛膝、地龙和莪术为臣药；用桂枝、桑枝和木瓜为佐使药。诸药相合，共具益气养血，温经通络的功效。治疗糖尿病性末梢神经炎具有疗效确切，无毒副作用，服用方便，价格低廉的特点。
本发明药物临床使用结果表明，有如下优点：
1、本发明选用的中草药各组份符合中华人民共和国药典的规定，利用各味中药的综合作用治疗糖尿病性末梢神经炎，对人体无毒无害。经动物急、慢性毒性实验表明被实验的动物未见任何毒性反应，其主要脏器也无明显的改变，药物安全可靠。
2、本发明药中富含蛋白质，葡萄糖，葡萄糖醛酸，挥发油，果胶，果糖，有机酸，卵磷脂，维生素，氨基酸，还含皂甙，植物甾醇和钙等多种微量元素，利于人体吸收，增强体质。
3、本发明不仅可有效的治疗糖尿病性末梢神经炎，对糖尿病性末梢神经炎的预防也有很好的作用，治疗糖尿病性末梢神经炎具有疗效确切，无毒副作用，服用方便，价格低廉的特点。
为表明本发明药物对治疗糖尿病性末梢神经炎的治疗效果，经临床试验结果如下；治疗糖尿病性末梢神经炎患者20例。服用实施例汤剂，每次1袋，一日二至三次，饭前半小时服用。一个月为一个疗程，连续服用三个疗程观察疗效。痊愈9例占45％，好转8例占40％，无效3例占15％，总有效率达85％。经三个疗程治疗后，病人无任何不良反应，三大常规化验及肝肾功能检测未发现异常。
具体实施方式
实施例 汤剂 按下述重量称取原料：
生黄芪 3份 赤芍 2份 秦艽 1份
丹参 3份 当归 2份 桑枝 1份
鸡血藤 3份 莪术 2份 木瓜 1份
川牛膝 2份 桂枝 1份 地龙 1份。
制备方法是取上述原料洗净去杂，晾干，粉碎成颗粒，加水浸泡1小时，置多功能提取罐中加水煎煮二次，第一次加总药材10倍量的水，煎煮1.5～2小时，取煎液，滤过。第二次加总药材7倍量的水，煎煮1～1.2小时，取两次煎液，滤过，热封袋中，105℃高温灭菌，包装即得。本发明制成的治疗糖尿病性末梢神经炎的汤剂为塑封袋装，每袋210ml，口服，一次一袋，每日二至三次。一个月为一个疗程。
Claims (3)
1、一种治疗糖尿病性末梢神经炎的中成药，其特征在于它是由下述重量配比的原料制成的：
生黄芪 1.5～6份 赤芍 1.0～4份 秦艽 0.1～2份
丹参 1.5～6份 当归 1.0～4份 桑枝 0.1～2份
鸡血藤 1.5～6份 莪术 1.0～4份 木瓜 0.1～2份
川牛膝 1.0～4份 桂枝 0.1～2份 地龙 0.1～2份。
2、根据权利要求1所述的一种治疗糖尿病性末梢神经炎的中成药，其中各原料的重量配比是：
生黄芪 2.5～3.5份 赤芍 1.5～2.5份 秦艽 0.5～1.5份
丹参 2.5～3.5份 当归 1.5～2.5份 桑枝 0.5～1.5份
鸡血藤 2.5～3.5份 莪术 1.5～2.5份 木瓜 0.5～1.5份
川牛膝 1.5～2.5份 桂枝 0.5～1.5份 地龙 0.5～1.5份。
3、根据权利要求1所述的一种治疗糖尿病性末梢神经炎的中成药，其中各原料的重量配比是：
生黄芪 3份 赤芍 2份 秦艽 1份
丹参 3份 当归 2份 桑枝 1份
鸡血藤 3份 莪术 2份 木瓜 1份
川牛膝 2份 桂枝 1份 地龙 1份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101183565A CN101095907A (zh) | 2007-07-05 | 2007-07-05 | 一种治疗糖尿病性末梢神经炎的中成药 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101183565A CN101095907A (zh) | 2007-07-05 | 2007-07-05 | 一种治疗糖尿病性末梢神经炎的中成药 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101095907A true CN101095907A (zh) | 2008-01-02 |
Family
ID=39010130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101183565A Pending CN101095907A (zh) | 2007-07-05 | 2007-07-05 | 一种治疗糖尿病性末梢神经炎的中成药 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101095907A (zh) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099849A (zh) * | 2013-02-19 | 2013-05-15 | 青岛正大海尔制药有限公司 | 一种治疗糖尿病的药物组合物、制备方法及其新用途 |
| CN104027662A (zh) * | 2014-02-23 | 2014-09-10 | 刘静 | 治疗糖尿病足的中药及其制备方法 |
| CN104352964A (zh) * | 2014-10-27 | 2015-02-18 | 王洪强 | 一种治疗糖尿病肢体麻木的中药 |
| CN105250569A (zh) * | 2015-11-26 | 2016-01-20 | 王茂凯 | 一种用于治疗末梢神经炎的中药丸剂及制备方法 |
| CN117018148A (zh) * | 2023-09-22 | 2023-11-10 | 中国中医科学院西苑医院 | 一种治疗糖尿病下肢动脉硬化血管闭塞的中药组合物及制备方法 |
-
2007
- 2007-07-05 CN CNA2007101183565A patent/CN101095907A/zh active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099849A (zh) * | 2013-02-19 | 2013-05-15 | 青岛正大海尔制药有限公司 | 一种治疗糖尿病的药物组合物、制备方法及其新用途 |
| CN103099849B (zh) * | 2013-02-19 | 2014-03-19 | 青岛正大海尔制药有限公司 | 一种治疗糖尿病的药物组合物、制备方法及其用途 |
| CN104027662A (zh) * | 2014-02-23 | 2014-09-10 | 刘静 | 治疗糖尿病足的中药及其制备方法 |
| CN104352964A (zh) * | 2014-10-27 | 2015-02-18 | 王洪强 | 一种治疗糖尿病肢体麻木的中药 |
| CN105250569A (zh) * | 2015-11-26 | 2016-01-20 | 王茂凯 | 一种用于治疗末梢神经炎的中药丸剂及制备方法 |
| CN117018148A (zh) * | 2023-09-22 | 2023-11-10 | 中国中医科学院西苑医院 | 一种治疗糖尿病下肢动脉硬化血管闭塞的中药组合物及制备方法 |
| CN117018148B (zh) * | 2023-09-22 | 2025-03-04 | 中国中医科学院西苑医院 | 一种治疗糖尿病下肢动脉硬化血管闭塞的中药组合物及制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101095907A (zh) | 一种治疗糖尿病性末梢神经炎的中成药 | |
| CN101112518A (zh) | 一种治疗产后血虚发热的中药制剂 | |
| CN101095780A (zh) | 治疗糖尿病性脂肪肝的中药制剂 | |
| CN101249151A (zh) | 一种治疗风湿痹的中药制剂 | |
| CN101129483A (zh) | 一种治疗产后身痛的中药制剂 | |
| CN101129511A (zh) | 一种治疗肩周炎的中药制剂 | |
| CN101095872A (zh) | 治疗过敏性紫癜性肾炎的中药组合 | |
| CN101085281A (zh) | 治疗慢性肾炎的一种中药 | |
| CN101085273A (zh) | 一种治疗月经过少的中药组合物 | |
| CN101085169A (zh) | 治疗尿酸性肾炎的一种中药 | |
| CN101116691A (zh) | 一种治疗神经性皮炎的中药组合物 | |
| CN101095922A (zh) | 一种治疗糖尿病性末梢神经炎的中药组合物 | |
| CN101112517A (zh) | 一种治疗糖尿病性心脏病的中药组合 | |
| CN101085338A (zh) | 治疗尿酸性肾炎的中药制剂 | |
| CN101129505A (zh) | 一种治疗颈椎病的中药制剂 | |
| CN101129842A (zh) | 治疗更年期综合征的一种中药制剂 | |
| CN102872230A (zh) | 一种治疗肩周炎的中药制剂 | |
| CN101095817A (zh) | 一种治疗糖尿病性末梢神经炎的中药制剂 | |
| CN101095873A (zh) | 治疗糖尿病性末梢神经炎的一种中成药 | |
| CN101574492A (zh) | 一种治疗腰椎间盘突出的中药制剂 | |
| CN101112449A (zh) | 一种治疗习惯性流产的中药组合物 | |
| CN101574502A (zh) | 一种治疗腰椎间盘突出的中药 | |
| CN101112433A (zh) | 治疗糖尿病性脑中风的一种中药组合 | |
| CN101130033A (zh) | 一种治疗子宫内膜炎的中药组合 | |
| CN101085319A (zh) | 治疗慢性肾衰的一种中药 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080102 |