CN104491519A - Yin-nourishing and qi-tonifying preparation for aplastic anemia due to dual depletion of qi and blood and preparation method - Google Patents

Yin-nourishing and qi-tonifying preparation for aplastic anemia due to dual depletion of qi and blood and preparation method Download PDF

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CN104491519A
CN104491519A CN201410738677.5A CN201410738677A CN104491519A CN 104491519 A CN104491519 A CN 104491519A CN 201410738677 A CN201410738677 A CN 201410738677A CN 104491519 A CN104491519 A CN 104491519A
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aplastic anemia
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petiolus trachycarpi
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吕凤荣
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Abstract

The invention discloses a yin-nourishing and qi-tonifying preparation for aplastic anemia due to dual depletion of qi and blood and a preparation method of the preparation. The preparation is prepared from the following main raw materials in parts by weight: 9-18 parts of codonopsis pilosula, 6-12 parts of sweet clover, 2-5 parts of artemisia anomala, 10-15 parts of caulis spatholobi, 12-22 parts of caulis bambusae in taeniam, 10-20 parts of atractylodes macrocephala koidz, 6-12 parts of solidago, 6-9 parts of stellaria yunnanensis, 3-6 parts of raw iron scale, 6-12 parts of platycodon grandiflorum and 3-6 parts of crinis trachycarpi. The yin-nourishing and qi-tonifying preparation has the advantages of high effective rate, significant curative effect, good safety, low treatment cost, and no toxic or side effect, and is capable of treating both symptoms and root causes.

Description

Both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation and preparation method thereof.
Background technology
Aplastic anemia (abbreviation aplastic anemia) is one group and causes bone marrow stem cell and hematopoieticmicroenviron-ment to damage by chemistry, biology, physical factor and unknown cause, so that red pulp is replaced by fatty marrow, the disease of pancytopenia.Aplastic anemia is generally divided into acute aplastic anemia and chronic aplastic anemia, clinical main manifestations for dizzy, have palpitation, breathe hard, weak, yellowish complexion, lip, fingernail are pale, dermatorrhagia point, ecchymosis, gums oozing of blood, menorrhagia, low grade fever, can occur high heat during concurrent infection.The morbidity of aplastic anemia may be relevant with following factors: (1) medicine.Medicine is modal pathogenic factors.Drug aplastic anemia has two types: 1. relevant with dosage, is dealed with medicine went, and reaching doses will cause bone marrow depression, is generally reversible, as various antineoplastic agent.2. little with dose relationship, only there is hematopoietic disorders in few patients, the anaphylaxis of polyphyly medicine, often causes persistence aplastic anemia.This kind of medicament categories is various, common are chlorine (conjunction) mycin, organo-arsenic, atabrine, trimethadione, Phenylbutazone etc.Drug aplastic anemia is the most common to be caused by chloromycetin.(2) chemical toxicant.Benzene and derivative thereof and aplastic anemia relation are by many experimentatioies are affirmed.Since reform and opening-up, township enterprise rises, and owing to not noting labor protection, caused by benzene aplastic anemia sickness rate rises to some extent.(3) ionizing radiation.Exceed lonizing radiation allowance irradiation (as radioactive source accident) for a long time and can cause aplastic anemia.(4) viral infection.The relation of viral hepatitis and aplastic anemia is comparatively affirmed, is called Viral Hepatitis aplastic anemia.(5) immune factor.Aplastic anemia secondary can do the immunologic derangement diseases such as thymoma systemic lupus erythematosus (sle) and rheumatoid arthritis.From traditional Chinese medical science angle, aplastic anemia be because body deficiency of kidney-essence, experience external evil poison, healthy energy is deficient, can not resist heresy, and evil poison caves in, induced renal damage, and consumption is impairment of the kidney essence.Deficiency of kidney-essence, can not supplement nutrition bone marrow, bone marrow is hollow, can not biochemical blood, accumulate in evil poison, not only can consume essence of being impairment of the kidney, blood vessels can also be blocked and run, cause congestion, congestion is not dispelled, fresh blood not life, forms vicious cycle, so the basic pathology of aplastic anemia is to accumulate in deficiency of kidney-essence, pyretic toxicity, congestion resistance network.
Common treatment of aplastic anemia comprises: (one) supporting treatment.All materials of bone marrow damage that likely causes all should manage to remove, and forbidding all has inhibiting medicine to bone marrow.Actively carry out Personal hygiene and nursery work.To the suitable Protective isolation of agranulocytosis person, active prevention infects.Blood transfusion GPRS indication, goes to bone marrow transplantation person, and before transplanting, blood transfusion can directly affect its success rate, especially can not the blood of defeated family member.General is appropriate to input Red Blood Cells Concentrate.Severe haemorrhage person should input Platelet Concentrate, and the platelet transfusion adopting per unit area yield or HLA to be harmonious can improve curative effect.Transfusion person should apply the treatment of deferoxamine row ferrum.(2) androgen is treatment chronic aplastic anemia choice drug.Conventional androgen has four classes: 1. 17 alpha-alkyl androgens; 2. Testosterone esters; 3. non-17 alpha-alkyl androgens; 4. intermediate active metabolite etc.(3) bone marrow transplantation is the best approach that treatment stem cell defect causes aplastic anemia, and can reach the object of radical cure.Once make a definite diagnosis Severe or pole Severe aplastic anemia, age < 20 years old, HLA distribution type is had to conform to donor, first-selected allogeneic bone marrow transplantation is answered in hospital with good conditionsi, after transplanting, Long-term disease-free survival rate can reach 60% ~ 80%, but transplanting need be carried out, as early as possible because of the normal red cells transfusion of first visit person and platelet, easily like this make receptor to blood donor minor histocompatibility antigen sensitization, cause transplant rejection incidence rate to raise.(4) immunosuppressant is applicable to the age and is greater than 40 years old or without the suitable Severe aplastic anemia for marrow person.The most frequently used is anti-thymus globulin (ATG) and antilymphocyte globulin (ALG).(5) Chinese medicine is controlled should the kidney invigorating be this, benefiting QI for activating blood circulation of holding concurrently.Conventional Chinese medicine is Colla cornus cervi, Rhizoma Curculiginis, Herba Epimedii, the Radix Astragali, raw Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, Radix Angelicae Sinensis, Herba Cistanches, Ba Ji, Fructus Psoraleae, Semen Cuscutae, Fructus Lycii, Colla Corii Asini etc.State's internal therapy chronic aplastic anemia is commonly used androgen and is merged the treatment of traditional Chinese medical science Kidney-Nourishing.(6) hematopoietic cytokine and therapeutic alliance aplastic anemia are the anemias that hematopoietic stem cell disorder causes, endogenous plasma EPO level is all at more than 500u/L, effectively, general dosage to obtain any effect to adopt recombinant human epo to treat the required heavy dose of just possibility of aplastic anemia.Recombinant Human Colony Stimulating Factors comprises G-CSF, GM-CSF or IL-3 and treats aplastic anemia to raising neutrophilic granulocyte, and reducing infection may have certain effect, but to improving anemia and thrombocytopenia poor effect, unless heavy dose of application.But hematopoietic cytokine is expensive, be therefore only limitted to adjuvant drug during Severe aplastic anemia immunosuppressant treatment at present, as application ALG/ATG treats Severe aplastic anemia, often the accompanying infection because there is serious agranulocytosis, causes Deaths.If now merging application rHG-CSF can improve early stage grain and lack, reduce case fatality rate.Therapeutic alliance can improve Severe aplastic anemia therapeutic effect, comprise ALG/ATG and CSA therapeutic alliance, CSA and androgen therapeutic alliance etc., European blood and bone marrow transplantation group adopt ALG, CSA, methyl meticortelone and rhG-CSF therapeutic alliance, bring up to 82% to Severe aplastic anemia effective percentage.
Application publication number CN 102727707 A(application number 201110093191.7) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of leukemia and aplastic anemia, said composition is made up of Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Fructus Forsythiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Flos Lonicerae, Carapax et Plastrum Testudinis, the Radix Paeoniae Alba, Colla Corii Asini, Radix Glycyrrhizae, Radix Codonopsis, Rhizoma Dioscoreae, Fructus Lycii, Fructus Schisandrae Chinensis, Cornu Bubali, Lignum Sappan, Rhizoma Chuanxiong, Radix Platycodonis and Radix Cyathulae.Application publication number CN 103784583 A(application number 201210423876.8) Chinese patent literature disclose a kind of medicine for the treatment of anemia, the crude drug making effective ingredient forms by following weight: Herba Agrimoniae 25-35 gram, Caulis Spatholobi 15-25 gram, Radix Astragali 15-25 gram, Fructus Ligustri Lucidi 10-20 gram, Fructus Rubi 10-20 gram, Radix Angelicae Sinensis 10-18 gram, Radix Rehmanniae Preparata 10-18 gram, Herba Epimedii 10-18 gram, Fructus Psoraleae 10-18 gram, Radix Morindae Officinalis 5-15 gram, Colla Corii Asini 5-15 gram.Application publication number CN 104147341 A(application number 201410439407.4) Chinese patent literature disclose a kind of Chinese medicine for the treatment of anemia, pressed certain weight ratio synthesized by Semen Sesami Nigrum, Caulis Spatholobi, Fructus Jujubae, dried Fructus Litchi, Fructus Lycii, Bulbus Lilii, Endothelium Corneum Gigeriae Galli, Radix Gossypii, Flos Carthami, Rhizoma Cannae Indicae (Radix Cannae Indicae), Radix Glycyrrhizae.
The Drug therapy of current aplastic anemia there is no specially good effect, doctor trained in Western medicine is androgen, immune formulation and the Supporting Therapys such as blood transfusion, infection of suiting the medicine to the illness mainly, after drug withdrawal, symptom there will be again, than being easier to repeatedly, it is the method for curing the symptoms, not the disease, and side effect is large, effective percentage is relatively low, and medical expense is higher.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation and preparation method thereof.Effective percentage of the present invention is high, evident in efficacy, treating both the principal and secondary aspects of a disease, safety, medical expense are low, have no side effect.
Technical scheme of the present invention is:
Both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, take off the primary raw material medicine stating weight proportion to be prepared from: Radix Codonopsis 9-18, melilotus 6-12, Herba Artemisiae Anomalae 2-5, Caulis Spatholobi 10-15, Caulis Bambusae In Taenia 12-22, Rhizoma Atractylodis Macrocephalae 10-20, Herba Solidaginis 6-12, Radix Stellariae Yunnanensis 6-9, the pig iron falls 3-6, Radix Platycodonis 6-12, charred Petiolus Trachycarpi 3-6.
Both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Codonopsis 12-16, melilotus 8-10, Herba Artemisiae Anomalae 3-4.3, Caulis Spatholobi 12-14, Caulis Bambusae In Taenia 15-18, Rhizoma Atractylodis Macrocephalae 13-17, Herba Solidaginis 7-9, Radix Stellariae Yunnanensis 7-8.5, the pig iron falls 4-5, Radix Platycodonis 8-11, charred Petiolus Trachycarpi 4-5.
Both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Codonopsis 14, melilotus 8.5, Herba Artemisiae Anomalae 3.8, Caulis Spatholobi 13, Caulis Bambusae In Taenia 16, the Rhizoma Atractylodis Macrocephalae 15, Herba Solidaginis 8, Radix Stellariae Yunnanensis 7.5, the pig iron falls 4.3, Radix Platycodonis 9, charred Petiolus Trachycarpi 4.5.
Present invention also offers the preparation method aforementioned both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation being made pharmaceutically acceptable decoction, powder and pill.
The preparation method of described decoction is:
(1) enamel tray is put in electrothermostat and is reached 140-200 DEG C after (preferred, after enamel tray is put in electrothermostat and is reached 150-190 DEG C; Be more preferably, enamel tray put in electrothermostat and reaches after 180 DEG C), put into Petiolus Trachycarpi rapidly, baking 5-15 min(is preferred, baking 8-12 min; Be more preferably, toast 10 min), taking-up cools, and is ground into fine powder, crosses 150-190 mesh sieve and (preferably, crosses 160-180 mesh sieve; Be more preferably, cross 170 mesh sieves), obtain charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is placed in marmite, adds water, amount of water is that doubly (preferred, amount of water is 3.5-4.5 times of the medicine gross weight added to the 3-5 of the medicine gross weight added; Be more preferably, amount of water is 4 times of the medicine gross weight added), first boil to boiling with big fire, to decoct with little fire afterwards, when to decoct to medicinal liquid be the 1/4-1/2 of amount of water (preferred, when to decoct to medicinal liquid be the 2/7-2/5 of amount of water; Be more preferably, when to decoct to medicinal liquid be 1/3 of amount of water), leach medicinal liquid;
(3) step (1) gained charred Petiolus Trachycarpi fine powder is joined in step (2) gained medicinal liquid, to obtain final product.
The preparation method of described powder is:
(1) enamel tray is put in electrothermostat and is reached 130-190 DEG C after (preferred, after enamel tray is put in electrothermostat and is reached 150-180 DEG C; Be more preferably, enamel tray put in electrothermostat and reaches after 165 DEG C), put into Petiolus Trachycarpi rapidly, baking 10-20 min(is preferred, baking 12-17min; Be more preferably, baking 15min), taking-up cools, and is ground into fine powder, crosses 130-170 mesh sieve (preferably, 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves), obtain charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 130-170 mesh sieve and (preferably, cross 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves);
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 4 grams.
The preparation method of described pill is:
(1) enamel tray is put in electrothermostat and is reached 140-180 DEG C after (preferred, after enamel tray is put in electrothermostat and is reached 150-170 DEG C; Be more preferably, enamel tray put in electrothermostat and reaches after 160 DEG C), put into Petiolus Trachycarpi rapidly, baking 8-25 min(is preferred, baking 14-20min; Be more preferably, baking 17min), taking-up cools, and is ground into fine powder, crosses 140-180 mesh sieve and (preferably, crosses 150-170 mesh sieve; Be more preferably, cross 160 mesh sieves), obtain charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 140-180 mesh sieve and (preferably, cross 150-170 mesh sieve; Be more preferably, cross 160 mesh sieves);
(3) step (1) and step (2) gained fine powder are fully mixed, add water, make little pill, the particle diameter of the little pill made is that 2-6mm(is preferred, and the particle diameter of the little pill made is 3-5mm; Be more preferably, the particle diameter of the little pill made is 4mm), dry and can obtain pill finished product of the present invention.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Codonopsis: base is former: be the dry root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis or radix codonpsis tangshen etc.Radix Codonopsis has containing sterols: hitodesterol, stigmasterol, hitodesterol-β-D-Glucose glycoside, stigmasterol-β-D-Glucose glycoside, α-Herba Spinaciae sterone, stigmasterone etc.Sugar and glycoside have: inulin, fructose, four kinds of heteropolysaccharide containing fructose.Syringin, β-D-Glucopyranose. hexanol glycoside, α-D-fructofuranose ethanol glycoside.Alkaloid and nitrogen containing component have: choline, normal-butyl allophanate, codopiloic acid, 5-hydroxy-2-hydroxymethylpyridine, nicotine.Volatile ingredient has: caproic acid, enanthic acid, sad, n-nonanoic acid, dodecoic acid, Azelaic Acid, tetradecylic acid, pentadecanoic acid, hexadecylic acid, stearic acid, octadecadienoic acid, 2,4-nonadienoic acids, Pentadecane, α-curcumene, n-heptadecane, n-octadecane, AI3-36122, positive 21 alkane, positive docosane, methyl myristate, pentadecanoic acid methyl ester, methyl palmitate, methyl stearate, octadecadienoic methyl, pinene, ethyl palmitate, methyl caprylate.Still containing triterpenes and other compositions: alnulin, Taraxeryl acetate, suberone; Atractyloide II, III; Syringic aldehyde, vanillic acid, 2-furan carboxylic esters, codonolactone, 5 hydroxymethyl furfural, 5-methoxyl group furfural.In addition, the also 17 seed amino acid property of medicine such as 14 kinds of inorganic elementss such as iron content, zinc, copper, manganese and aspartic acid, threonine, serine, glutamic acid: sweet, flat.Return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Melilotus: base is former: be the herb of pulse family melilot serration melilotus.Composition: herb, containing volatile oil, includes coumarin.The property of medicine: " Inner Mongol Chinese herbal medicine ": " acrid in the mouth, property is put down." function cures mainly: " Inner Mongol Chinese herbal medicine ": " with middle stomach invigorating, clearing away heat and eliminating dampness, diuresis.Cure mainly heat-damp in summer uncomfortable in chest, greasy taste in the mouth, halitosis, dysentery with red and white feces, gonorrhea, furuncle.
Herba Artemisiae Anomalae: have another name called Herba Artemisiae Anomalae grass, Herba Senecionis Scandentis is the wounded in the battle herb of Compositae sagebruss artemisia anomalas.The property of medicine: stem is cylindrical, surperficial brown color or brown-green, matter is hard and crisp, frangibility, the integrated spike panicle of head inflorescence, withered yellow, gas fragrance, bitter in the mouth, pungent, warm in nature.GUIXIN, liver, spleen channel.Composition: mainly containing arteanoflavone, tricin, apigenin, Palmic acid etc.Find according to modern pharmacological research, this medical instrument has effect of anti-hypoxia, blood circulation promoting and blood stasis dispelling, removing food stagnancy, hemostasia and detumescence, for amenorrhea due to stagnation of blood, and abdominal pain due to retention of food, hematuria, the diseases such as scald.
Caulis Spatholobi: base is former: be the rattan of leguminous plant spatholobus suberectus, Mucuna birdwoodiana, fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan or bright leaf Moghania fluminalis(C. B. Clarke) Li rattan etc.Chemical analysis: fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan is containing milletol.The property of medicine: bitter sweet, temperature." book on Chinese herbal medicine is new again ": " enter the heart, spleen two warp." function cures mainly: to invigorate blood circulation, relaxing muscles and tendons.Control soreness of waist and knee joint, paralysis and numbness, menoxenia.
Caulis Bambusae In Taenia: base is former: the intermediate layer that the stem stalk for grass family Phyllostachys plant phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, the blue or green pole bamboo of Thorny Sinobambusa plant, Sinocalamus plant major part allusion quotation bamboo etc. goes crust to scrape.Composition: the Caulis Bambusae In Taenia of phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle is containing phenolic constituent: 2,5-dimethoxy-1,4-benzoquinone, hydroxy benzaldehyde, syringic aldehyde, coniferyl aldehyde.Another containing p-phthalic acid 2 '-hydroxyethyl methyl ester.The property of medicine: sweet, is slightly cold.Return spleen, stomach, gallbladder meridian.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting, antiabortive removing heat from blood.Cure mainly cough due to lung-heat, dysphoria with smothery sensation is palpitated with fear, and gastric heat is vomitted oh, pregnancy reactions, frequent fetal movement, spits blood, epistaxis, hematuria, metrorrhagia.
The Rhizoma Atractylodis Macrocephalae: base is former: be the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.The property of medicine: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Herba Solidaginis: base is former: be herb or the root of Compositae Herba Solidaginis platymiscium Herba Solidaginis.Composition: aerial parts is containing saponin component: Herba Solidaginis glycosides, activities of Solidago virgaurea L saponin 3 that is 3, Solidago saponin, solidago canadesis saponin, huge Herba Solidaginis saponin, the triterpene glycosides etc. of Polygalacic acid.The property of medicine: pungent, bitter, cool.Function cures mainly: wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.Cure mainly anemopyretic cold, laryngopharynx swelling and pain, cough due to lung-heat, jaundice, pyretic stranguria, carbuncle furuncle, venom, traumatic injury.
Radix Stellariae Yunnanensis: base is former: be the root of Caryophyllaceae Stellaria plant Yunnan Herba stellariae mediae.Composition: containing peptide class: Herba stellariae mediae cyclic peptide A, B, C, D, E, F, G, false Herba stellariae mediae cyclic peptide A-H, Yunnan Herba stellariae mediae cyclic peptide A, B, D, C, E, F.The property of medicine: sweet, flat.Function cures mainly: strengthening spleen and nourishing blood, invigorating the liver and kidney, detumescence.Cure mainly anemia, dizzy nervous, tinnitus hectic fever, the soreness of waist, seminal emission, menoxenia, leukorrhagia, fracture, mastitis.The pig iron falls: base is former: for being hammered into shape the iron filings fallen when the pig iron is calcined to red red, outer oxide.Composition: main containing ferroso-ferric oxide, or name magnetic oxide.The property of medicine: pungent, cool.GUIXIN, Liver Channel.Function cures mainly: checking hyperfunction of the liver for relieving convulsion, and removing toxic substances sore, enriches blood.Cure mainly demented, febrile delirium, palpitation and being susceptible to fright, rheumatic arthralgia, skin infection swells and ache, anemia.Compatibility and incompatibility of drugs: deficiency of the liver and the middle deficiency of vital energy person of trembling with fear prohibit clothes.
Radix Platycodonis: base is former: be the root of Campanulaceae Radix Platycodonis.The property of medicine: bitter, pungent, flat.Return lung meridian.Function cures mainly: have lung qi dispersing, and sore-throat relieving eliminates the phlegm, effect of evacuation of pus.For cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Petiolus Trachycarpi: this product is the dry petiole of babassu Petiolus Trachycarpi.The property of medicine: bitter, puckery, flat.Return lung, liver, large intestine channel.Function cures mainly: hemostasis with astringents.For spitting blood, epistaxis, hematuria, has blood in stool, metrostaxis.Charred Petiolus Trachycarpi: after enamel tray is put in electrothermostat and reached temperature, put into Petiolus Trachycarpi rapidly, baking, taking-up cools.
Both Qi and blood deficiency provided by the invention " aplastic anemia " enriching yin boost qi preparation compatibility is scientific and reasonable, and preparation method is simple.In addition, excellent results of the present invention also shows:
1, there is enriching yin boost qi, spleen invigorating lung benefiting, blood circulation promoting and blood stasis dispelling, hemostasia and detumescence, heat-clearing and toxic substances removing, invigorating the liver and kidney, blood-supplementing blood-nourishing
Etc. effect;
2, evident in efficacy, treating both the principal and secondary aspects of a disease;
, have no side effect 3, safely;
4, medical expense is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 20g): Radix Codonopsis 9 parts, melilotus 6 parts, Herba Artemisiae Anomalae 2 parts, Caulis Spatholobi 10 parts, Caulis Bambusae In Taenia 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Solidaginis 6 parts, Radix Stellariae Yunnanensis 6 parts, the pig iron falls 3 parts, Radix Platycodonis 6 parts, charred Petiolus Trachycarpi 3 parts.
The preparation method of above-mentioned both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation decoction is:
(1) enamel tray is put in electrothermostat reach after 140 DEG C, put into Petiolus Trachycarpi rapidly, baking 5min, taking-up cools, and is ground into fine powder, crosses 150 mesh sieves, obtains charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is placed in marmite, adds water, amount of water is 3 times of the medicine gross weight added, and first boils to boiling with big fire, decocts with little fire afterwards, when to decoct to medicinal liquid be 1/4 of amount of water, leaches medicinal liquid;
(3) step (1) gained charred Petiolus Trachycarpi fine powder is joined in step (2) gained medicinal liquid, to obtain final product.
Decoction instructions of taking of the present invention: oral, every day twice, each 300mL(is warm).
embodiment 2both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 20g): Radix Codonopsis 18 parts, melilotus 12 parts, Herba Artemisiae Anomalae 5 parts, Caulis Spatholobi 15 parts, Caulis Bambusae In Taenia 22 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Herba Solidaginis 12 parts, Radix Stellariae Yunnanensis 9 parts, the pig iron falls 6 parts, Radix Platycodonis 12 parts, charred Petiolus Trachycarpi 6 parts.
The preparation method of above-mentioned both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation decoction is:
(1) enamel tray is put in electrothermostat reach after 200 DEG C, put into Petiolus Trachycarpi rapidly, toast 15 min, taking-up cools, and is ground into fine powder, crosses 190 mesh sieves, obtains charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is placed in marmite, adds water, amount of water is 5 times of the medicine gross weight added, and first boils to boiling with big fire, decocts with little fire afterwards, when to decoct to medicinal liquid be 1/2 of amount of water, leaches medicinal liquid;
(3) step (1) gained charred Petiolus Trachycarpi fine powder is joined in step (2) gained medicinal liquid, to obtain final product.
model case one:king XX, female, 18 years old.She or the student of senior middle school one grade of 18 years old, should she of happy health, is but diagnosed as aplastic anemia.One time, dark clouds shroud she and her family.Through the treatment of 11 months, disease was not fully recovered, and medical cost of hospitalization has but spent more than 30 ten thousand yuan, allow her back heavy debt, unable continuation be in hospital she, can only rely on blood transfusion and platelet to maintain stable disease.She one be stymied by, it is pretty good that well-wisher introduces effect of the present invention, says and allow her have a try.She starts to receive treatment of the present invention like this.Take both Qi and blood deficiency of the present invention " aplastic anemia " enriching yin boost qi preparation decoction, oral, every day twice, each 300mL(is warm).Take after two months, her state of an illness just stabilizes, the mental status, also have strength with it, lip also obviously has color.This makes the mood of she one family quite a lot of slightly.
After taking 3 months, her hemoglobin and leukocyte rise obviously, to have a blood test routine: WBC 3.8 × 10 to hospital 9/ L, Hb 85g/L, PLT 30 × 10 9/ L, her state of an illness gets better every day.After taking four months, her routine blood test reaches WBC 4.6 × 10 9/ L, Hb 118g/L, PLT 82 × 10 9/ L.This allows she and her household feel incomparable happy and gratified.The adolescent girl of 18 years old, the struggle of process and the serious illness, has gone on the road of health finally!
embodiment 3both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 20g): Radix Codonopsis 12 parts, melilotus 8 parts, Herba Artemisiae Anomalae 3 parts, Caulis Spatholobi 12 parts, Caulis Bambusae In Taenia 15 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Herba Solidaginis 7 parts, Radix Stellariae Yunnanensis 7 parts, the pig iron falls 4 parts, Radix Platycodonis 8 parts, charred Petiolus Trachycarpi 4 parts.
The preparation method of above-mentioned both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation powder is:
(1) enamel tray is put in electrothermostat reach after 165 DEG C, put into Petiolus Trachycarpi rapidly, toast 15 min, taking-up cools, and is ground into fine powder, crosses 150 mesh sieves, obtains charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 150 mesh sieves;
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 4 grams.
model case two: yellow XX, female, 50 years old.Main suit: suddenly felt uncomfortable before 3 years, walk dizzy, breathe hard, the heart throbs and not to stop.Often with having a fever, feeling sick, and menstrual blood volume is very large, cannot normally go to work.Under the accompanying of layman, go to a doctor to local hospital.After three days, bone wears report finally out, is diagnosed as the poisoning aplastic anemia caused of unknown cause, routine blood test display pancytopenia, at that time hemoglobin only 3.6 grams.Under the bimestrial western medicine of hospital, not only the state of an illness does not take a turn for the better, and is degrading on the contrary, has unexpectedly occurred hematuria, had blood in stool.The even section of having time stomatitis, even speak, having a meal also has become problem, have also appeared the ecchymosis of many places, petechia with it.Introduce the present invention through friend and treat aplastic anemia effect very well, have a sense of hope in arms, she determines to make a try.Take both Qi and blood deficiency of the present invention " aplastic anemia " enriching yin boost qi preparation powder, every day twice, each 4 grams, warm water delivery service.After taking 30 days, she reverts to the same with normal person substantially.Continue to take two months, her gingiva, nasal cavity are spontaneous hemorrhagely to be stopped substantially, and subcutaneous fleckiness is also absorbed completely.Also outdoor can be arrived to do simple motion.After one week, make individual bone in locality again and worn.Bone wears report display " red system hypertrophy, disease amelioration ".Continue to take 1 month, her state of an illness is continual and steady.
embodiment 4both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 20g): Radix Codonopsis 16 parts, melilotus 10 parts, Herba Artemisiae Anomalae 4.3 parts, Caulis Spatholobi 14 parts, Caulis Bambusae In Taenia 18 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Herba Solidaginis 9 parts, Radix Stellariae Yunnanensis 8.5 parts, the pig iron falls 5 parts, Radix Platycodonis 11 parts, charred Petiolus Trachycarpi 5 parts.
The preparation method of above-mentioned both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation pill is:
(1) enamel tray is put in electrothermostat reach after 160 DEG C, put into Petiolus Trachycarpi rapidly, baking 17min, taking-up cools, and is ground into fine powder, crosses 160 mesh sieves, obtains charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 160 mesh sieves;
(3) step (1) and step (2) gained fine powder are fully mixed, add water, make little pill, the particle diameter of the little pill made is 4mm, dries and can obtain pill finished product of the present invention.
model case three:lee XX, man, 19 years old.One day, he found that petechia appears in the many places such as the arm skin of oneself, removes hospital admission, checks in: leukocyte 0.92 × 10 after ten days 9/ L, hemoglobin 92g/L, platelet 13 × 10 9/ L, breast, ilium hypertrophy severe lower, and percentage of lymphocyte 90%, last diagnosis is " acute aplastic anemia ".Give antithymocyte globulin (ATG) commissural arch p0-357 A(CSA) treatment, be aided with infection, the process of blood product infusion.The state of an illness has no improvement.Take both Qi and blood deficiency of the present invention " aplastic anemia " enriching yin boost qi preparation pill, every day three times, each 10 balls.After taking 30 days, neutrophilic granulocyte > 1.0 × 10 9/ L, after this hemogram continues to rise.Treat hemogram after 4 months and recover normally (leukocyte 8.34 × 10 completely 9/ L, hemoglobin 125g/L, platelet 127 × 10 9/ L), without any clinical symptoms.Follow up a case by regular visits to so far, patient body in order, has recovered orthobiosis and study.
embodiment 5both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 20g): Radix Codonopsis 14 parts, melilotus 8.5 parts, Herba Artemisiae Anomalae 3.8 parts, Caulis Spatholobi 13 parts, Caulis Bambusae In Taenia 16 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Herba Solidaginis 8 parts, Radix Stellariae Yunnanensis 7.5 parts, the pig iron falls 4.3 parts, Radix Platycodonis 9 parts, charred Petiolus Trachycarpi 4.5 parts.
The preparation method of above-mentioned both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation decoction is:
(1) enamel tray is put in electrothermostat reach after 180 DEG C, put into Petiolus Trachycarpi rapidly, toast 10 min, taking-up cools, and is ground into fine powder, crosses 170 mesh sieves, obtains charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is placed in marmite, adds water, amount of water is 4 times of the medicine gross weight added, and first boils to boiling with big fire, decocts with little fire afterwards, when to decoct to medicinal liquid be 1/3 of amount of water, leaches medicinal liquid;
(3) step (1) gained charred Petiolus Trachycarpi fine powder is joined in step (2) gained medicinal liquid, to obtain final product.
the diagnosis of aplastic anemia
Granulocytopenia and aplastic anemia international research group (1987) propose to diagnose aplastic anemia must meet at least 2 points in following 3: (1) hemoglobin < 100g/L; (2) platelet < 50 × 10 9/ L; (3) neutrophilic granulocyte < 1.5 × 10 9/ L.If though patient's peripheral blood two is or three be cytopenia, and reduces degree and do not reach above-mentioned standard, then should not be diagnosed as aplastic anemia, need monitoring cytometry change closely.
test example 1the clinical practice of embodiment 5 gained both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation decoction: in August, 2009 in December ,-2012, screen 272 routine aplastic anemia patients in 7 hospitals, wherein male 142 example, women 130 example, age 18-75 year, 35 years old mean age, course of disease 1-5, average course of disease 3 years.Be divided into two groups at random, experimental group and matched group (often organizing 136 examples), experimental group takes embodiment 5 products obtained therefrom, and using method is: take every day twice (warm), each 300mL.Matched group takes the medicine (as ciclosporin, androgen, antilymphocyte globulin/antithymocyte globulin (ALG/ATG), methyl meticortelone (MP), hematopoietic cell growth factor etc.) of other treatment aplastic anemia.Curative effect situation criterion: for the criterion of therapeutical effect of aplastic anemia, still adopts the standard that the 4th aplastic anemia academic conference in 1987 is formulated, and is divided into basic healing, alleviation, obviously progressive and invalid according to the recovery situation of patient.Basic healing: when not transfusing blood, anemia and bleeding disappear, and hemoglobin reaches male 120g/L, women 100g/L, and leukocyte reaches 4.0 × 10 9/ L, platelet reaches 80 × 10 9/ more than L, follows up a case by regular visits to and does not recur for more than 1 year; Alleviate: hemoglobin reaches male 120g/L, women 100g/L, follow up a case by regular visits to 3 months stable disease or continue progressive; Obvious progress: anemia and bleeding are clearly better, hemoglobin is comparatively treated first 1 month institute's measured value and is increased more than 30g/L, and can maintain more than 3 months.Invalid: through treatment, hemogram does not still have made marked progress.Total effectively comprising substantially cures and alleviates.Treat after four months, result is as shown in table 1.
Table 1: take embodiment 5 product 18-75 year aplastic anemia patient treatment outcome
As can be seen from Table 1, the experimental group total effective rate of embodiment 5 gained both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation decoction is used to reach 99.26%.And the total effective rate of matched group is only 69.85%.Experiment shows, experimental group and matched group have significant difference, and the successful of experimental group is better than matched group.
Radix Codonopsis, melilotus, Herba Artemisiae Anomalae and Caulis Spatholobi etc. suitably coordinate by the present invention, produce synergism after making these drug regimens, improve curative effect, safe and reliable, have good therapeutic effect to aplastic anemia.Radix Codonopsis invigorating the spleen and replenishing QI in side, spleen invigorating lung benefiting.Melilotus and middle stomach invigorating, clearing away heat and eliminating dampness, diuresis.Herba Artemisiae Anomalae has effect of anti-hypoxia, blood circulation promoting and blood stasis dispelling, removing food stagnancy, hemostasia and detumescence.Caulis Spatholobi is invigorated blood circulation, relaxing muscles and tendons.Caulis Bambusae In Taenia removing heat-phlegm, relieves restlessness and prevents vomiting, antiabortive removing heat from blood.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Herba Solidaginis wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.Radix Stellariae Yunnanensis strengthening spleen and nourishing blood, invigorating the liver and kidney, detumescence.The pig iron falls checking hyperfunction of the liver for relieving convulsion, and removing toxic substances sore, enriches blood.Radix Platycodonis has lung qi dispersing, sore-throat relieving, eliminates the phlegm, effect of evacuation of pus.Charred Petiolus Trachycarpi hemostasis with astringents.In formula, all medicine compatibilities, bring out the best in each other, and have the effects such as enriching yin boost qi, spleen invigorating lung benefiting, blood circulation promoting and blood stasis dispelling, hemostasia and detumescence, heat-clearing and toxic substances removing, invigorating the liver and kidney, blood-supplementing blood-nourishing, reach the object for the treatment of both the principal and secondary aspects of a disease, have no side effect.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Codonopsis 9-18, melilotus 6-12, Herba Artemisiae Anomalae 2-5, Caulis Spatholobi 10-15, Caulis Bambusae In Taenia 12-22, Rhizoma Atractylodis Macrocephalae 10-20, Herba Solidaginis 6-12, Radix Stellariae Yunnanensis 6-9, the pig iron falls 3-6, Radix Platycodonis 6-12, charred Petiolus Trachycarpi 3-6.
2. both Qi and blood deficiency according to claim 1 " aplastic anemia " enriching yin boost qi preparation, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Codonopsis 12-16, melilotus 8-10, Herba Artemisiae Anomalae 3-4.3, Caulis Spatholobi 12-14, Caulis Bambusae In Taenia 15-18, Rhizoma Atractylodis Macrocephalae 13-17, Herba Solidaginis 7-9, Radix Stellariae Yunnanensis 7-8.5, the pig iron falls 4-5, Radix Platycodonis 8-11, charred Petiolus Trachycarpi 4-5.
3. both Qi and blood deficiency according to claim 1 " aplastic anemia " enriching yin boost qi preparation, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Codonopsis 14, melilotus 8.5, Herba Artemisiae Anomalae 3.8, Caulis Spatholobi 13, Caulis Bambusae In Taenia 16, the Rhizoma Atractylodis Macrocephalae 15, Herba Solidaginis 8, Radix Stellariae Yunnanensis 7.5, the pig iron falls 4.3, Radix Platycodonis 9, charred Petiolus Trachycarpi 4.5.
4., according to arbitrary described both Qi and blood deficiency " aplastic anemia " the enriching yin boost qi preparation of claim 1-3, it is characterized in that, this both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation is made decoction, and the preparation method of described decoction is:
(1) after enamel tray is put in electrothermostat and reached 140-200 DEG C, put into Petiolus Trachycarpi rapidly, baking 5-15 min, taking-up cools, and is ground into fine powder, cross 150-190 mesh sieve (preferred, cross 160-180 mesh sieve; Be more preferably, cross 170 mesh sieves), obtain charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is placed in marmite, adds water, amount of water be the 3-5 of the medicine gross weight added doubly, first boil to boiling with big fire, to decoct with little fire afterwards, when to decoct to medicinal liquid be the 1/4-1/2 of amount of water, leach medicinal liquid;
(3) step (1) gained charred Petiolus Trachycarpi fine powder is joined in step (2) gained medicinal liquid, to obtain final product.
5. the preparation method of both Qi and blood deficiency according to claim 4 " aplastic anemia " enriching yin boost qi preparation decoction, it is characterized in that, in step (1) enamel tray put in electrothermostat reach 150-190 DEG C after (preferably enamel tray is put in electrothermostat and reaches after 180 DEG C).
6. the preparation method of both Qi and blood deficiency according to claim 4 " aplastic anemia " enriching yin boost qi preparation decoction, is characterized in that, in step (1), baking 8-12 min(preferably toasts 10 min).
7. the preparation method of both Qi and blood deficiency according to claim 4 " aplastic anemia " enriching yin boost qi preparation decoction, it is characterized in that, in step (2), amount of water is 3.5-4.5 times (preferred amount of water is 4 times of the medicine gross weight added) of the medicine gross weight added.
8. the preparation method of both Qi and blood deficiency according to claim 4 " aplastic anemia " enriching yin boost qi preparation decoction, is characterized in that, when to decoct to medicinal liquid in step (2) be the 2/7-2/5 of amount of water while being 1/3 of amount of water (preferably decoct to medicinal liquid).
9., according to arbitrary described both Qi and blood deficiency " aplastic anemia " the enriching yin boost qi preparation of claim 1-3, it is characterized in that, this both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation is made powder, and the preparation method of described powder is:
(1) enamel tray is put in electrothermostat and is reached 130-190 DEG C after (preferred, after enamel tray is put in electrothermostat and is reached 150-180 DEG C; Be more preferably, enamel tray put in electrothermostat and reaches after 165 DEG C), put into Petiolus Trachycarpi rapidly, baking 10-20 min(is preferred, baking 12-17min; Be more preferably, baking 15min), taking-up cools, and is ground into fine powder, crosses 130-170 mesh sieve and (preferably, crosses 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves), obtain charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 130-170 mesh sieve and (preferably, cross 140-160 mesh sieve; Be more preferably, cross 150 mesh sieves);
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 4 grams.
10., according to arbitrary described both Qi and blood deficiency " aplastic anemia " the enriching yin boost qi preparation of claim 1-3, it is characterized in that, this both Qi and blood deficiency " aplastic anemia " enriching yin boost qi preparation is made pill, and the preparation method of described pill is:
(1) enamel tray is put in electrothermostat and is reached 140-180 DEG C after (preferred, after enamel tray is put in electrothermostat and is reached 150-170 DEG C; Be more preferably, enamel tray put in electrothermostat and reaches after 160 DEG C), put into Petiolus Trachycarpi rapidly, baking 8-25 min(is preferred, baking 14-20min; Be more preferably, baking 17min), taking-up cools, and is ground into fine powder, crosses 140-180 mesh sieve and (preferably, crosses 150-170 mesh sieve; Be more preferably, cross 160 mesh sieves), obtain charred Petiolus Trachycarpi fine powder, for subsequent use;
(2) all the other except charred Petiolus Trachycarpi 10 taste Chinese crude drug is removed impurity, pulverize respectively and grind to form fine powder, cross 140-180 mesh sieve and (preferably, cross 150-170 mesh sieve; Be more preferably, cross 160 mesh sieves);
(3) step (1) and step (2) gained fine powder are fully mixed, add water, make little pill, the particle diameter of the little pill made is that 2-6mm(is preferred, and the particle diameter of the little pill made is 3-5mm; Be more preferably, the particle diameter of the little pill made is 4mm), dry and can obtain pill finished product of the present invention.
CN201410738677.5A 2014-12-08 2014-12-08 Yin-nourishing and qi-tonifying preparation for aplastic anemia due to dual depletion of qi and blood and preparation method Pending CN104491519A (en)

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