CN104491207A - Cholangitis heat clearing inflammation diminish drug and preparation - Google Patents
Cholangitis heat clearing inflammation diminish drug and preparation Download PDFInfo
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- CN104491207A CN104491207A CN201510018379.3A CN201510018379A CN104491207A CN 104491207 A CN104491207 A CN 104491207A CN 201510018379 A CN201510018379 A CN 201510018379A CN 104491207 A CN104491207 A CN 104491207A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The invention discloses a cholangitis heat clearing inflammation diminish drug. The cholangitis heat clearing inflammation diminish drug is mainly prepared by the following raw material drugs, by weight part, 9 to 16 parts of small centipeda herb, 8 to 12 parts of toosendan fruits, 7 to 15 parts of white muscardine silkworms, 20 to 30 parts of milkvetch root, 10 to 15 parts of officinal magnolia barks, 7 to 14 parts of Chinese sage herb, 6 to 9 parts of aralia decaisneana hance leaves, 8 to 15 parts of spreading hedyotis, 5 to 10 parts of sedum sarmentosum, 7 to 16 parts of ginger gardenia, 6 to 9 parts of clove, 5 to 10 parts of holly barks, 6 to 12 parts of Japanese violet herb, 4 to 9 parts of Chinese eriosema root, 10 to 16 parts of epimedium herb and 6 to 12 parts of liquorice. The holangitis heat clearing inflammation diminish drug is scientific in component, collaborative in function, convenient to take and obvious in effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to cholangitis heat clearing and inflammation relieving medicament and preparation.
Background technology
Biliary tract inflammation with bile duct inflammation for main person claims cholangitis, with gallbladder inflammation for main person claims cholecystitis.Both often occur simultaneously, and its cause of disease, pathogenesis and pathological change are roughly the same, to be mostly on the basis of cholestasis caused by secondary bacterial (being mainly escherichia coli, paracolon and staphylococcus etc.) infection.Antibacterial can arrive biliary tract through lymphatic channel or blood road, and also can to drive in the wrong direction from intestinal through vater's papilla enters biliary tract.This disease often shows as middle epigastric discomfort, distending pain, or the outbreak in angor, and can increase the weight of Upper abdominal pain after feed greasy food, seldom have heating and jaundice, Abdominal Signs is not obvious, only can have the light tenderness of upper abdomen, gallbladder not enlargement.As there is acute attack, then occur stomachache, the high heat of shiver with cold and jaundice etc. three is levied.Charcot triad (stomachache, the high heat of shiver with cold, jaundice) apart from acute cholangitis outward, also has shock, the suppressed performance of central nervous system, is called that Reynolds 5-linked is levied.
Publication No. CN 103610989 A(application number 201310663260.2) Chinese patent literature disclose a kind of Chinese medicine for the treatment of acute pyogenic cholangitis, be prepared from by the medical material of following weight proportion: Radix Heraclei dissecti 17 parts, Herba passiflorae cochinchinensis 12 parts, Herba Cynanchi Thesioidis 14 parts, Radix Berberidis anhweiensis 12 parts, Radix Seu Herba Luisiae Morsei 10 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 20 parts, Bredia quadrangularis Cogn 10 parts, the grass 16 parts that knots, careless Radix Angelicae Pubescentis 14 parts, Residuum sacchari Caulis 20 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 14 parts, 15 parts, GUANGXIANG rattan, large Thalictrum thumbergii D C 15 parts, northeast Herba centaurll altaici 12 parts, dry leaf of Lignum Santali Albi 10 parts.Publication No. CN 103055288 A(application number 201210587902.0) Chinese patent literature disclose a kind of herbal composite for the treatment of acute cholangitis, the drug regimen by following ratio: Radix Bupleuri 25-30 parts; Radix Scutellariae 25-30 parts; Radix Isatidis 25-35 parts; Herba Artemisiae Scopariae 25-30 parts; Fructus Gardeniae 15-20 parts; Herba Lysimachiae 25-35 parts; Bile 2-4 parts; The capital Rhizoma Pinelliae 15-25 parts; Fructus Aurantii 25-30 parts; 10-20 parts, Rhizoma Zingiberis Recens; Radix Gentianae 15-20 parts; Fructus Jujubae 25-35 parts; Caulis Bambusae In Taenia 10-20 parts; Radix Curcumae 25-35 parts; Herba Violae 10-25 parts; Add water 1800 parts, infusion 3 filtered and recycled extracting juice, bottling high temperature sterilize, for subsequent use.Publication No. CN 101612193 A(application number 200910067324.6) Chinese patent literature disclose a kind of pharmaceutical composition being used for the treatment of cholecystitis, cholangitis, comprise the active substance of following weight fraction ratio: andrographolide part, Herba Rabdosiae Lophanthoidis water extract 20-35 part, withered tree ethanol extract 20-40 part.
In modern medicine, for the treatment of cholangitis, comprise operative treatment and Drug therapy, operation cost is large, risk is high, and Western medicine mostly is antibiotic and immunosuppressant, and side effect is obvious, and therefore both effective this disease of Chinese traditional treatment was the most applicable for safety.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the wide cholangitis heat clearing and inflammation relieving medicament of safe and applicable.
Technical scheme of the present invention is:
Cholangitis heat clearing and inflammation relieving medicament, is prepared from primarily of following bulk drugs, is weight portion: Herba Centipedae 9-16; Fructus Toosendan 8-12; Bombyx Batryticatus 7-15; Radix Astragali 20-30; Cortex Magnoliae Officinalis 10-15; Herba Salviae Chinensis 7-14; Aralia decaisneana Hance 6-9; Herba Hedyotidis Diffusae 8-15; Herba Sedi 5-10; Rhizoma Zingiberis Recens Fructus Gardeniae 7-16; Flos Caryophylli 6-9; Cortex Ilicis Rotundae 5-10; Herba violae patrinii 6-12; Radix eriosematis chinensis 4-9; Herba Epimedii 10-16; Radix Glycyrrhizae 6-12.
Preferably: Herba Centipedae 11-14; Fructus Toosendan 9-11; Bombyx Batryticatus 9-13; Radix Astragali 22-28; Cortex Magnoliae Officinalis 11-14; Herba Salviae Chinensis 9-12; Aralia decaisneana Hance 7-8; Herba Hedyotidis Diffusae 10-13; Herba Sedi 6-9; Rhizoma Zingiberis Recens Fructus Gardeniae 9-14; Flos Caryophylli 7-8; Cortex Ilicis Rotundae 6-9; Herba violae patrinii 8-10; Radix eriosematis chinensis 5-8; Herba Epimedii 12-14; Radix Glycyrrhizae 8-10.
More preferably: Herba Centipedae 12.5; Fructus Toosendan 10; Bombyx Batryticatus 11; The Radix Astragali 25; Cortex Magnoliae Officinalis 12.5; Herba Salviae Chinensis 10.5; Aralia decaisneana Hance 7.5; Herba Hedyotidis Diffusae 11.5; Herba Sedi 7.5; Rhizoma Zingiberis Recens Fructus Gardeniae 11.5; Flos Caryophylli 7.5; Cortex Ilicis Rotundae 7.5; Herba violae patrinii 9; Radix eriosematis chinensis 6.5; Herba Epimedii 23; Radix Glycyrrhizae 9.
Described cholangitis heat clearing and inflammation relieving medicament, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, adding water, it is most to boil altogether to water, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add medical material gross weight 6-9 water doubly (preferably: add medical material gross weight 7-8 water doubly; Be more preferably: the water adding medical material gross weight 7.5 times), soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts 50-70 minute (preferably: little fire decocts 55-65 minute; Be more preferably: little fire decocts 60 minutes), close fire first 20 minutes, add residue medical material, filter, collect filtrate;
(5) by step (1) (2) (3) made medical material, pulverized 120 mesh sieves, and mixed with step (4) gained filtrate, sterilizing encapsulates, and obtains decoction.
The preparation method of described cholangitis heat clearing and inflammation relieving medicament decoction, in step (3), amount of water is the 4-6 of medical material weight doubly (preferred: amount of water is 5 times of medical material weight).
Described cholangitis heat clearing and inflammation relieving medicament, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add medical material gross weight 6-9 water doubly (preferably: add medical material gross weight 7-8 water doubly; Be more preferably: the water adding medical material gross weight 7.5 times), soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts, close fire first 20 minutes, adds step (1) (2) (3) made medical material and residue medical material, filters, collect filtrate;
(5) add water step (4) gained medicinal residues continuation decoction 30 minutes, and after filtering, mixing twice gained filtrate, is evaporated to thick paste, obtains unguentum.
The preparation method of described cholangitis heat clearing and inflammation relieving medicament unguentum, the medium and small fire of step (4) decocts 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: little fire decocts 40 minutes).
Described cholangitis heat clearing and inflammation relieving medicament, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) residue medical material picked decontamination, clean, grating after drying, then pulverizes, encapsulates to obtain powder after sieving together with above-mentioned steps gained medical material.
The preparation method of described cholangitis heat clearing and inflammation relieving medicament powder, crosses 120-150 mesh sieve (preferred: to cross 130-140 mesh sieve in step (4); Be more preferably: cross 135 mesh sieves).
Described cholangitis heat clearing and inflammation relieving medicament, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add medical material gross weight 6-9 water doubly (preferably: add medical material gross weight 7-8 water doubly; Be more preferably: the water adding medical material gross weight 7.5 times), soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts 50 minutes, close fire first 20 minutes, adds step (1) (2) (3) made medical material and residue medical material, filters, collect filtrate;
(5) the above-mentioned filtrate of concentrating under reduced pressure, spraying dry, mixes with adjuvant refined honey, soft material processed, and granulation, dry, granulate, encapsulate to obtain granule.
The preparation method of described cholangitis heat clearing and inflammation relieving medicament granule, in step (5), the amount of refined honey is the 0.4-0.6 of dry thing weight doubly (preferred: the amount of refined honey is 0.5 times of dry thing weight).
Cholangitis heat clearing and inflammation relieving reagent combination science provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, gained medicament of the present invention has effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, effectively cures cholangitis;
2, preparation technology of the present invention is reasonable, and can give play to the curative effect of medicine to greatest extent, cure rate is high;
3, medical material selected by the present invention is pure natural medical material, safety and human body is had no side effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Centipedae: base is former: be the dry herb of feverfew Herba Centipedae.Nature and flavor with return through: pungent, temperature.Return lung meridian.Function with cure mainly: dispersing wind-cold, clearing the nasal passage, cough-relieving.For headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
Fructus Toosendan: base is former: be the fruit of canella Fructus Toosendan.Chemical analysis: containing Toosendanin, alkaloid, kaempferol, resin, tannin.Nature and flavor: bitter, cold, poisonous.Gui Jing: enter liver, stomach, small intestine meridian.Function cures mainly: except damp and hot, clearing away liver-fire, pain relieving, parasite killing.Control epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.
Bombyx Batryticatus: have another name called Bombyx Batryticatus, flying worm, Bombyx Batryticatus worm, the larva belonging to animal bombyx mori for Bombycidae silkworm infects muscardine and ossified Scorpio.The property of medicine: this product is slightly cylindrical, how bending shrinkage, surperficial lark, matter is hard and crisp, frangibility, acrid in the mouth, salty, and property is put down.Composition: Bombyx Batryticatus containing protein, oxamidic acid., and contains lysine, leucine, aspartic acid etc. 17 seed amino acid.According to modern pharmacological research find, this medical instrument have expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat, convulsion, hypoglycemic effect, for apoplexy, migraine and general headache, laryngopharynx swelling and pain, rubella etc.
The Radix Astragali: property is sweet, tepor.Return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be generally used for the treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Cortex Magnoliae Officinalis: base is former: be bark or the root bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils..Chemical analysis: Magnolia bark is containing magnolol, tetrahydromagnolol, iso-agnolol, honokiol, volatile oil; Another containing magnocurarine.Nature and flavor: toil, temperature.Gui Jing: enter spleen, stomach, large intestine channel.Function cures mainly: warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant.Control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.
Herba Salviae Chinensis: base is former: be the herb of labiate Herba Salviae Chinensis.Gather between the Summer Solstice to the Limit of Heat.Chemical analysis: herb is containing sterol, Triterpenoid, aminoacid.Root is containing stachyose.Nature and flavor: " Suzhou this product medical material ": " toil, flat." function cures mainly: control dysphagic, phlegm dyspnea, hepatitis, red and white leukorrhea, carbuncle, scrofula.
Aralia decaisneana Hance: base is former: be the root of Araliaceae Aralia decaisneana Hance.Nature and flavor: bitter in the mouth; Pungent; Property is put down.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Removing toxic substances and promoting subsidence of swelling.The hot headache due to common cold of main air; Cough; Rheumatic arthralgia; Waist and leg ache; Jaundice due to damp-heat; Edema; Stranguria with turbid discharge; Leukorrhagia; Amenorrhea; Puerperal exposure to wind pain; Treating swelling and pain by traumatic injury; ; Gastric abscess; Laryngopharynx swelling and pain; Gingival swelling and pain.
Herba Hedyotidis Diffusae: base is former: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae.Xia Qiu gathers, and cleans, using fresh herb or dry.Nature and flavor: sweet, light, cool.Gui Jing: enter stomach, large intestine, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.
Herba Sedi: base is former: be the herb of crassulaceae plants Herba Sedi.Chemical analysis: containing N-methylisopelletierine, dihydro-N-methyl isopelletierine, sedoheptulose, glucose, fructose, sucrose.Nature and flavor: cool in nature are sweet in the mouth, cool.Function cures mainly: eliminating damp-heat, has and reduces glutamate pyruvate transaminase effect.For the activeness of acute isocyanides inflammation, chronic persistent hepatitis, chronic hepatitis.
Rhizoma Zingiberis Recens Fructus Gardeniae: Fructus Gardeniae: bitter in the mouth, cold in nature.Have pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body, vexed for calentura, heat in blood tells nosebleed, conjunctival congestion and swelling pain.Rhizoma Zingiberis Recens Fructus Gardeniae: get Fructus Gardeniae fragment, mix thoroughly with Sucus Zingberis, run through, put in pot, heat fried dry with slow fire, taking-up cools.
Flos Caryophylli: base is former: be the alabastrum of plant clove of myrtaceae.Nature and flavor: pungent, temperature.Gui Jing: enter stomach, spleen, kidney channel.Function cures mainly: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.
Cortex Ilicis Rotundae: base is former: be bark or the root bark of holly plant Ilex rotunda Thunb..Chemical analysis: bark containing flavonoid glycoside, phenols, tannin, Triterpene Glycosides, and isolates β-Amyrin, cupreol and stearic acid.Leaf contains flavonoid glycoside, phenols, aminoacid, saccharide, triterpene.Seed is containing oleanolic acid, rotundic acid.Nature and flavor: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, dampness removing, pain relieving.Cure cold heating, tonsillitis, laryngopharynx swelling and pain, acute, chronic hepatitis, acute gastroenteritis, gastric and duodenal ulcers, rheumatic arthritis, traumatic injury, burn.
Herba violae patrinii: base is former: for Violaceae plant spends Herba Violae, the herb of viola inconspicua Blume or Nepal's common violet or whole herb with root in vain.Nature and flavor: pungent micro-hardship, cold.Function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control acute appendicitis, furuncle, red and swollen sore, jaundice, stranguria with turbid discharge, order is raw nebula also.
Radix eriosematis chinensis: base is former: be the tuber of leguminous plant Radix eriosematis chinensis.Nature and flavor: sweet are flat.Gui Jing: lung; Large intestine; Liver Channel.Function cures mainly: removing heat from the lung and dissipating phlegm.Control cough due to lung-heat, excessive thirst, dysentery.
Herba Epimedii: base is former: be the stem and leaf of Berberidaceae plant Herba Epimedii, Epimedium brevicornum or Epimedium sagittatum.Nature and flavor: acrid, sweet, warm.Gui Jing: return liver, kidney channel.Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Cure mainly: for impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Radix Glycyrrhizae: base is former: be the Root and Rootstock of pulse family glycyrrhiza genus Radix Glycyrrhizae.Nature and flavor: sweet are flat.Gui Jing: enter spleen, stomach, lung meridian.Function cures mainly: with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.
embodiment 1cholangitis heat clearing and inflammation relieving medicament, is prepared from primarily of following bulk drugs: Herba Centipedae 9g, Fructus Toosendan 8g, Bombyx Batryticatus 7g, Radix Astragali 20g, Cortex Magnoliae Officinalis 10g, Herba Salviae Chinensis 7g, Aralia decaisneana Hance 6g, Herba Hedyotidis Diffusae 8g, Herba Sedi 5g, Rhizoma Zingiberis Recens Fructus Gardeniae 7g, Flos Caryophylli 6g, Cortex Ilicis Rotundae 5g, Herba violae patrinii 6g, Radix eriosematis chinensis 4g, Herba Epimedii 10g, Radix Glycyrrhizae 6g.The preparation method of above-mentioned cholangitis heat clearing and inflammation relieving medicament decoction is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 25 minutes, little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add the water of medical material gross weight 7.5 times, soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts 60 minutes, close fire first 20 minutes, add residue medical material, filter, collect filtrate;
(5) by step (1) (2) (3) made medical material, pulverized 120 mesh sieves, and mixed with step (4) gained filtrate, sterilizing encapsulates, and obtains decoction.
embodiment 2cholangitis heat clearing and inflammation relieving medicament, is prepared from primarily of following bulk drugs: Herba Centipedae 16g, Fructus Toosendan 12g, Bombyx Batryticatus 15g, Radix Astragali 30g, Cortex Magnoliae Officinalis 15g, Herba Salviae Chinensis 14g, Aralia decaisneana Hance 9g, Herba Hedyotidis Diffusae 15g, Herba Sedi 10g, Rhizoma Zingiberis Recens Fructus Gardeniae 16g, Flos Caryophylli 9g, Cortex Ilicis Rotundae 10g, Herba violae patrinii 12g, Radix eriosematis chinensis 9g, Herba Epimedii 16g, Radix Glycyrrhizae 12g.The preparation method of above-mentioned cholangitis heat clearing and inflammation relieving medicament unguentum is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 25 minutes, little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add the water of medical material gross weight 7.5 times, soak after 20 minutes, big fire is heated to boiling, turn little fire to decoct 40 minutes, close fire first 20 minutes, add step (1) (2) (3) made medical material and residue medical material, filter, collect filtrate;
(5) add water step (4) gained medicinal residues continuation decoction 30 minutes, and after filtering, mixing twice gained filtrate, is evaporated to thick paste, obtains unguentum.
Model case: xxx, male, 61 years old.Main suit: upper right abdomen recurrent exerbation 1 year, with heating, shiver with cold and xanthochromia phenomenon; , there is upper right angina abdominis because feed is too greasy subsequently, without heating and jaundice in history of present illness: because patient's cholelithiasis carries out resection operation before 3 years, recent aggravation, stomachache outbreak is frequent, occasionally has heating, mild skin xanthochromia phenomenon, remove examination in hospital, be diagnosed as pyogenic cholangitis.
Friend is listened to introduce Chinese traditional treatment effective, so select this example gained unguentum, each 4-6g, one day three times, warm boiled water seven days is a course for the treatment of, after patient takes five days, heating paresthesia disappears, the colour of skin starts to recover normal, and take two courses for the treatment of continuously, stomachache is eliminated, remove examination in hospital, indices is all normal.
embodiment 3cholangitis heat clearing and inflammation relieving medicament, is prepared from primarily of following bulk drugs: Herba Centipedae 11g, Fructus Toosendan 9g, Bombyx Batryticatus 9g, Radix Astragali 22g, Cortex Magnoliae Officinalis 11g, Herba Salviae Chinensis 9g, Aralia decaisneana Hance 7g, Herba Hedyotidis Diffusae 10g, Herba Sedi 6g, Rhizoma Zingiberis Recens Fructus Gardeniae 9g, Flos Caryophylli 7g, Cortex Ilicis Rotundae 6g, Herba violae patrinii 8g, Radix eriosematis chinensis 5g, Herba Epimedii 12g, Radix Glycyrrhizae 8g.The preparation method of above-mentioned cholangitis heat clearing and inflammation relieving medicament powder is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 25 minutes, little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) residue medical material picked decontamination, clean, grating after drying, then pulverizes together with above-mentioned steps gained medical material, encapsulates to obtain powder after crossing 135 mesh sieves.
Model case: xxx, women, 50 years old.Medical history: before half a year without obvious inducement, patient occurs that abdominal pain is uncomfortable, in paroxysmal dull pain, without radiating pain and other uncomfortable diseases, remove hospital admission, be diagnosed as cholangitis on inspection, take antibiotic therapy, go home after sb.'s illness took a favorable turn to recuperate, after this state of an illness occurs again repeatedly, occasionally has fever phenomenon.
Recommend through people, take this example gained powder, each 4-6g, one day three times, warm boiled water, within seven days, be a course for the treatment of, after patient takes one week, colic symptoms alleviates, and attack times obviously reduces, after taking two courses for the treatment of continuously, substantially do not show effect, consolidate again a course for the treatment of, recovery from illness.
embodiment 4cholangitis heat clearing and inflammation relieving medicament, is prepared from primarily of following bulk drugs: Herba Centipedae 14g, Fructus Toosendan 11g, Bombyx Batryticatus 13g, Radix Astragali 28g, Cortex Magnoliae Officinalis 14g, Herba Salviae Chinensis 12g, Aralia decaisneana Hance 8g, Herba Hedyotidis Diffusae 13g, Herba Sedi 9g, Rhizoma Zingiberis Recens Fructus Gardeniae 14g, Flos Caryophylli 8g, Cortex Ilicis Rotundae 9g, Herba violae patrinii 10g, Radix eriosematis chinensis 8g, Herba Epimedii 14g, Radix Glycyrrhizae 10g.The preparation method of above-mentioned cholangitis heat clearing and inflammation relieving medicament granule is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 25 minutes, little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add the water of medical material gross weight 7.5 times, soak after 20 minutes, big fire is heated to boiling, turn little fire to decoct 50 minutes, close fire first 20 minutes, add step (1) (2) (3) made medical material and residue medical material, filter, collect filtrate;
(5) the above-mentioned filtrate of concentrating under reduced pressure, spraying dry, adds the adjuvant refined honey mixing of its weight 0.5 times, soft material processed, and granulation, dry, granulate, encapsulate to obtain granule.
Model case: xxx, female, 55 years old.Medical history: greasy food of taking food in a large number when patient celebrates a birthday, next day epigastrium hurt like hell, and with phenomenons such as heating, vomitings, after taking medicine, disease amelioration is not obvious, then removes hospital admission, shows through B ultrasonic, be diagnosed as acute cholangitis, because of irritated to antibiotic, turn Chinese traditional treatment.
Take this example gained granule, each 4-6g, one day three times, warm boiled water seven days is a course for the treatment of, after patient takes three days, the symptoms such as heating, vomiting are eliminated, after taking a course for the treatment of continuously, the state of an illness is obviously alleviated, and stomachache alleviates, consolidate again a course for the treatment of, patient fully recovers, and follows up a case by regular visits in half a year, does not occur repeatedly.
embodiment 5cholangitis heat clearing and inflammation relieving medicament, is prepared from primarily of following bulk drugs: Herba Centipedae 12.5g, Fructus Toosendan 10g, Bombyx Batryticatus 11g, Radix Astragali 25g, Cortex Magnoliae Officinalis 12.5g, Herba Salviae Chinensis 10.5g, Aralia decaisneana Hance 7.5g, Herba Hedyotidis Diffusae 11.5g, Herba Sedi 7.5g, Rhizoma Zingiberis Recens Fructus Gardeniae 11.5g, Flos Caryophylli 7.5g, Cortex Ilicis Rotundae 7.5g, Herba violae patrinii 9g, Radix eriosematis chinensis 6.5g, Herba Epimedii 23g, Radix Glycyrrhizae 9g.The preparation method of above-mentioned cholangitis heat clearing and inflammation relieving medicament decoction is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 25 minutes, little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add the water of medical material gross weight 7.5 times, soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts 60 minutes, close fire first 20 minutes, add residue medical material, filter, collect filtrate;
(5) by step (1) (2) (3) made medical material, pulverized 120 mesh sieves, and mixed with step (4) gained filtrate, sterilizing encapsulates, and obtains decoction.
test example 1the clinical practice of gained cholangitis heat clearing and inflammation relieving medicament (embodiment 5) of the present invention:
Choose crowd: according to hospital outpatient case history, screening cholangitis patient 446 example, wherein women 218 example, male 228 example, the range of age 35-65 year, 43.8 years old mean age.
Test method: patient is divided into two groups at random, experimental group 326 example and matched group 120 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes gained decoction of the present invention, each 60-90ml, every day three times, warmly takes, and within seven days, is a course for the treatment of; Matched group takes other conventional medicines (XIAOYAN LIDAN PIAN, JINDAN PIAN, gentamycin or other antibiotic etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) fully recovers: clinical symptoms is all eliminated, and checks that each index is normal, does not recur in three months; (2) effective: clinical symptom relief, check indices improvement or normal; (3) invalid: clinical symptoms is without being clearly better or increasing the weight of.
Clinical effectiveness: take medicine after three courses for the treatment of, the therapeutic outcome of two groups is as follows:
Experimental group: cure rate 79.5%(259/326), effective percentage 18.7%(61/326), inefficiency 1.8%(6/326) and, total effective rate 98.2%;
Matched group: cure rate 60.8%(73/120), effective percentage 24.2%(29/120), inefficiency 15.0%(18/120) and, total effective rate 85.0%.
As can be seen here, experimental group product curative effect used is obviously better than matched group, and before and after treatment, the patient body situation of experimental group is significantly increased comparatively before.
The Chinese medicine used in the present invention, the wherein dispersing wind-cold of Herba Centipedae, the liver heat removing pain relieving of Fructus Toosendan, expellingging wind and relieving convulsion of Bombyx Batryticatus, resolving toxin and disinhibiting the throat, the inducing diuresis to remove edema of the Radix Astragali, the warming the middle warmer and descending qi of Cortex Magnoliae Officinalis, the eliminating damp-heat of Herba Sedi, the clearing away heat and promoting diuresis of Rhizoma Zingiberis Recens Fructus Gardeniae, the warming middle-JIAO warming the kidney of Flos Caryophylli, the removing heat from the lung and dissipating phlegm of Radix eriosematis chinensis, the strong muscle of the kidney invigorating of Herba Epimedii, the lung moistening removing toxic substances of Radix Glycyrrhizae, add Aralia decaisneana Hance, Herba Hedyotidis Diffusae, the heat-clearing and toxic substances removing of Cortex Ilicis Rotundae and Herba violae patrinii, all medicines share, effectively can alleviate the stomachache that cholangitis brings, high heat, the uncomfortable disease such as jaundice, thus raising therapeutic effect, total effective rate is made to reach 98.2%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. cholangitis heat clearing and inflammation relieving medicament, is characterized in that, is prepared from primarily of following bulk drugs, is weight portion: Herba Centipedae 9-16; Fructus Toosendan 8-12; Bombyx Batryticatus 7-15; Radix Astragali 20-30; Cortex Magnoliae Officinalis 10-15; Herba Salviae Chinensis 7-14; Aralia decaisneana Hance 6-9; Herba Hedyotidis Diffusae 8-15; Herba Sedi 5-10; Rhizoma Zingiberis Recens Fructus Gardeniae 7-16; Flos Caryophylli 6-9; Cortex Ilicis Rotundae 5-10; Herba violae patrinii 6-12; Radix eriosematis chinensis 4-9; Herba Epimedii 10-16; Radix Glycyrrhizae 6-12.
2. cholangitis heat clearing and inflammation relieving medicament as claimed in claim 1, is characterized in that, Herba Centipedae 11-14; Fructus Toosendan 9-11; Bombyx Batryticatus 9-13; Radix Astragali 22-28; Cortex Magnoliae Officinalis 11-14; Herba Salviae Chinensis 9-12; Aralia decaisneana Hance 7-8; Herba Hedyotidis Diffusae 10-13; Herba Sedi 6-9; Rhizoma Zingiberis Recens Fructus Gardeniae 9-14; Flos Caryophylli 7-8; Cortex Ilicis Rotundae 6-9; Herba violae patrinii 8-10; Radix eriosematis chinensis 5-8; Herba Epimedii 12-14; Radix Glycyrrhizae 8-10(is preferably: Herba Centipedae 12.5; Fructus Toosendan 10; Bombyx Batryticatus 11; The Radix Astragali 25; Cortex Magnoliae Officinalis 12.5; Herba Salviae Chinensis 10.5; Aralia decaisneana Hance 7.5; Herba Hedyotidis Diffusae 11.5; Herba Sedi 7.5; Rhizoma Zingiberis Recens Fructus Gardeniae 11.5; Flos Caryophylli 7.5; Cortex Ilicis Rotundae 7.5; Herba violae patrinii 9; Radix eriosematis chinensis 6.5; Herba Epimedii 23; Radix Glycyrrhizae 9).
3. the cholangitis heat clearing and inflammation relieving medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, adding water, it is most to boil altogether to water, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add medical material gross weight 6-9 water doubly (preferably: add medical material gross weight 7-8 water doubly; Be more preferably: the water adding medical material gross weight 7.5 times), soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts 50-70 minute (preferably: little fire decocts 55-65 minute; Be more preferably: little fire decocts 60 minutes), close fire first 20 minutes, add residue medical material, filter, collect filtrate;
(5) by step (1) (2) (3) made medical material, pulverized 120 mesh sieves, and mixed with step (4) gained filtrate, sterilizing encapsulates, and obtains decoction.
4. the preparation method of cholangitis heat clearing and inflammation relieving medicament decoction as claimed in claim 3, is characterized in that, in step (3), amount of water is the 4-6 of medical material weight doubly (preferred: amount of water is 5 times of medical material weight).
5. the cholangitis heat clearing and inflammation relieving medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add medical material gross weight 6-9 water doubly (preferably: add medical material gross weight 7-8 water doubly; Be more preferably: the water adding medical material gross weight 7.5 times), soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts, close fire first 20 minutes, adds step (1) (2) (3) made medical material and residue medical material, filters, collect filtrate;
(5) add water step (4) gained medicinal residues continuation decoction 30 minutes, and after filtering, mixing twice gained filtrate, is evaporated to thick paste, obtains unguentum.
6. the preparation method of cholangitis heat clearing and inflammation relieving medicament unguentum as claimed in claim 5, is characterized in that, the medium and small fire of step (4) decocts 30-50 minute (preferably: little fire decocts 35-45 minute; Be more preferably: little fire decocts 40 minutes).
7. the cholangitis heat clearing and inflammation relieving medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) residue medical material picked decontamination, clean, grating after drying, then pulverizes, encapsulates to obtain powder after sieving together with above-mentioned steps gained medical material.
8. the preparation method of cholangitis heat clearing and inflammation relieving medicament powder as claimed in claim 7, is characterized in that, crosses 120-150 mesh sieve (preferred: to cross 130-140 mesh sieve in step (4); Be more preferably: cross 135 mesh sieves).
9. the cholangitis heat clearing and inflammation relieving medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Bombyx Batryticatus to clean, put into white vinegar and soak 20-30 minute (preferred: to soak 25 minutes), little fire heating evaporate to dryness, taking-up is dried in the air cool;
(2) Flos Caryophylli is removed impurity, sieve dedust bits, be placed in frying pan, slow fire stir-fries 5 minutes, and taking-up is smashed to pieces;
(3) Cortex Magnoliae Officinalis and Cortex Ilicis Rotundae are removed rough bark, section, add Rhizoma Zingiberis Recens, the water adding medical material weight 5 times boils to water most altogether, and removing Rhizoma Zingiberis Recens, dries medical material;
(4) Fructus Toosendan, the Radix Astragali, Aralia decaisneana Hance, Rhizoma Zingiberis Recens Fructus Gardeniae, Radix eriosematis chinensis and Herba Epimedii are cleaned, add medical material gross weight 6-9 water doubly (preferably: add medical material gross weight 7-8 water doubly; Be more preferably: the water adding medical material gross weight 7.5 times), soak after 20 minutes, big fire is heated to boiling, turns little fire and decocts 50 minutes, close fire first 20 minutes, adds step (1) (2) (3) made medical material and residue medical material, filters, collect filtrate;
(5) the above-mentioned filtrate of concentrating under reduced pressure, spraying dry, mixes with adjuvant refined honey, soft material processed, and granulation, dry, granulate, encapsulate to obtain granule.
10. the preparation method of cholangitis heat clearing and inflammation relieving medicament granule as claimed in claim 9, is characterized in that, in step (5), the amount of refined honey is the 0.4-0.6 of dry thing weight doubly (preferred: the amount of refined honey is 0.5 times of dry thing weight).
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| CN1328834A (en) * | 2000-11-15 | 2002-01-02 | 郑国芃 | Capsule for curing cholecystitis |
| CN1416862A (en) * | 2002-11-06 | 2003-05-14 | 李建中 | Gandanqing capsule |
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Address after: 716000 Yanan province Shaanxi City Baota District Road No. 61, Mei District No. 3 Building 1 unit 502 Applicant after: Wang Jinqiang Address before: Hualong Road, Licheng District 250000 Shandong city of Ji'nan province No. 999 Fairview springs District Applicant before: Wang Jinqiang |
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Application publication date: 20150408 |