CN104474008A - Honeysuckle prickly heat water and preparation method thereof - Google Patents

Honeysuckle prickly heat water and preparation method thereof Download PDF

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Publication number
CN104474008A
CN104474008A CN201410756047.0A CN201410756047A CN104474008A CN 104474008 A CN104474008 A CN 104474008A CN 201410756047 A CN201410756047 A CN 201410756047A CN 104474008 A CN104474008 A CN 104474008A
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flos lonicerae
prickly heat
ethanol
mentholum
preparation
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周卿
熊伟
吴庆
杨小兰
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Zunyi Medical University
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Zunyi Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses honeysuckle prickly heat water and a preparation method thereof. The preparation method comprises the following steps: performing crushing treatment on honeysuckles, wild chrysanthemum flowers, argy wormwood leaf and liquoric root to obtain mixture powder; adding the mixture powder into 50% ethanol, soaking for 30 minutes, and then performing heating reflux for 3 hours to obtain a mixture liquid; filtering the mixture liquid to ensure that a filtrate and filter residues are separated; dissolving menthol into ethanol, and then adding poloxamer 188 to obtain a menthol mixed liquid; and mixing the filtrate with the menthol mixed liquid, and adding deionized water and stirring uniformly to obtain the honeysuckle prickly heat water. The honeysuckle prickly heat water disclosed by the invention is prepared from Chinese herbal medicine components, and has the effects of allergy prevention, quick action, bacterium resisting and inflammation diminishing, and prickly heat removal and itching relieving.

Description

A kind of Flos Lonicerae prickly heat liquid and preparation method thereof
[technical field]
The present invention relates to a kind of Flos Lonicerae prickly heat liquid, be specifically related to a kind of Flos Lonicerae prickly heat liquid and preparation method thereof.
[background technology]
Miliaria is shallow, inflammatory dermatoses common under summer or hot environment.Because temperature under the sultry environment of high temperature is high, high humidity, excessive sweating, not easily evaporate, perspiration makes horny layer of epidermis flood, sudoriferous duct mouth is caused to narrow or block, break because of intrinsic pressure increasing after perspiration retention in sudoriferous duct, excessive perspiration infiltrates and stimulates surrounding tissue and occur pimple, papulovesicle and phlysis in pore place.Occur after miliaria, the lighter have burn, prodding and itching feeling; Time serious, can cause tropical anhidrosis sexual exhaustion or heat exhaustion, can there is the General Symptomies such as unable, sleepy, dizzy, headache in patient.Generally adopt Rhizoma Coptidis face powder treatment miliaria at present on the market, because Rhizoma Coptidis face powder is powdered granule, very easily causes clogging of pores, increase the weight of the state of an illness.
[summary of the invention]
For the problems referred to above, a kind of Flos Lonicerae prickly heat liquid provided by the invention, by extracting the effective ingredient of Flos Lonicerae, Flos Chrysanthemi Indici, Folium Artemisiae Argyi, Radix Glycyrrhizae, Mentholum, is made into liquid state, can not cause clogging of pores while reaching treatment miliaria.
The invention provides a kind of Flos Lonicerae prickly heat liquid preparation method, comprise the following steps:
S10: after Flos Lonicerae, Flos Chrysanthemi Indici, Folium Artemisiae Argyi, Radix Glycyrrhizae are carried out pulverization process, crosses 20 ~ 60 mesh sieves, obtains mix powder;
S20: above-mentioned mixed-powder is added after soaking 0.5 ~ 1h in 50% alcoholic solution, reflux 3h, obtain mixture solution;
S30: filtered by said mixture solution, makes filtrate be separated with filtering residue;
S40: be dissolved in by Mentholum after in ethanol, add PLURONICS F87, obtains Mentholum mixed solution;
S50: the filtrate of above-mentioned acquisition is mixed with the Mentholum mixed solution of acquisition, and add deionized water and stirring evenly, obtain Flos Lonicerae prickly heat liquid.
Especially, described step S30 also comprises:
In the filtering residue obtained, add 50% ethanol, reflux 2 ~ 3h, obtain filtering residue mixture, the filtering residue mixture of acquisition is filtered, obtain second aqueous, by second aqueous with obtain filtrate and carry out mixing and after stirring, concentrating under reduced pressure acquisition concentrated solution.
A Flos Lonicerae prickly heat liquid obtained according to above-mentioned preparation method, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 3% ~ 5%, Flos Chrysanthemi Indici 1 ~ 3%, Folium Artemisiae Argyi 1 ~ 2%, Radix Glycyrrhizae 1 ~ 2%, Mentholum 0.2% ~ 0.6%, ethanol 4 ~ 7%, PLURONICS F87 1 ~ 3%, all the other are water.
Especially, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 4%, Flos Chrysanthemi Indici 2%, Folium Artemisiae Argyi 1%, Radix Glycyrrhizae 2%, Mentholum 0.4%, ethanol 6%, PLURONICS F87 1.5%, all the other are water.
Especially, described water is deionized water.
Compared to prior art, a kind of Flos Lonicerae prickly heat liquid provided by the invention, adopts medicinal herb components to be made, have antiallergic, effect rapidly, anti-inflammation, the effect of going miliaria antipruritic.
[detailed description of the invention]
For having further understanding to object of the present invention, function and technological means, existing as follows to the detailed description of the invention in conjunction with specific embodiments.
Embodiment 1:
A kind of Flos Lonicerae prickly heat liquid, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 4%, Flos Chrysanthemi Indici 2%, Folium Artemisiae Argyi 1%, Radix Glycyrrhizae 2%, Mentholum 0.4%, ethanol 6%, PLURONICS F87 1.5%, all the other are water.
Preparation method: S10: after Flos Lonicerae, Flos Chrysanthemi Indici, Folium Artemisiae Argyi, Radix Glycyrrhizae are carried out pulverization process, crosses 20 mesh sieves, obtains mix powder;
S20: above-mentioned mixed-powder is added after soaking 0.5 ~ 1h in 1000 milliliter of 50% alcoholic solution, reflux 2 ~ 3h, obtain mixture solution, pass through reflux, improve the extraction ratio of effective ingredient of Flos Lonicerae, Flos Chrysanthemi Indici, Folium Artemisiae Argyi, Radix Glycyrrhizae, make reaction more complete, extract the effective ingredient of Flos Lonicerae, Flos Chrysanthemi Indici, Folium Artemisiae Argyi, Radix Glycyrrhizae more fast;
S30: said mixture solution is filtered, filtrate is separated with filtering residue, in order to improve the utilization rate that the invention provides Chinese herbal medicine, in the filtering residue obtained, add 50% ethanol, reflux 2 ~ 3h, obtain filtering residue mixture, the filtering residue mixture of acquisition is filtered, obtain second aqueous, by second aqueous with obtain filtrate and carry out mixing and after stirring, concentrating under reduced pressure acquisition concentrated solution;
S40: be dissolved in by Mentholum after in ethanol, add PLURONICS F87, obtains Mentholum mixed solution;
S50: the filtrate of above-mentioned acquisition is mixed with the Mentholum mixed solution of acquisition, and add deionized water and stirring evenly, obtain Flos Lonicerae prickly heat liquid.
Using method: spray 3 every day, continuous 3 ~ 10 days.
Embodiment 2:
A kind of Flos Lonicerae prickly heat liquid, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 3%, Flos Chrysanthemi Indici 1%, Folium Artemisiae Argyi 2%, Radix Glycyrrhizae 1.2%, Mentholum 0.5%, ethanol 4%, PLURONICS F87 1%, all the other are water.
Preparation method and the using method of preparation method and using method and embodiment 1 are identical, repeat no more herein.
Embodiment 3:
A kind of Flos Lonicerae prickly heat liquid, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 3.5%, Flos Chrysanthemi Indici 1.5%, Folium Artemisiae Argyi 1.5%, Radix Glycyrrhizae 1.2%, Mentholum 0.2%, ethanol 4%, PLURONICS F87 1.8%, all the other are water.
Preparation method and the using method of preparation method and using method and embodiment 1 are identical, repeat no more herein.
Embodiment 4:
A kind of Flos Lonicerae prickly heat liquid, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 4.5%, Flos Chrysanthemi Indici 2.5%, Folium Artemisiae Argyi 1.8%, Radix Glycyrrhizae 1.5%, Mentholum 0.5%, ethanol 5%, PLURONICS F87 2%, all the other are water.
Preparation method and the using method of preparation method and using method and embodiment 1 are identical, repeat no more herein.
Embodiment 5:
A kind of Flos Lonicerae prickly heat liquid, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 5%, Flos Chrysanthemi Indici 3%, Folium Artemisiae Argyi 1.2%, Radix Glycyrrhizae 1.6%, Mentholum 0.6%, ethanol 7%, PLURONICS F87 3%, all the other are water.
Preparation method and the using method of preparation method and using method and embodiment 1 are identical, repeat no more herein.
Clinical drug effect:
Zhang, man, 3 years old,, there is scratchy, pain in long miliaria 5 days, has no improvement with after the treatment of Rhizoma Coptidis face powder, after to be admitted to hospital symptomatic treatment, continuity first quarter moon has no and is clearly better, and child scratches rear diabrosis, after rear spraying Flos Lonicerae prickly heat liquid provided by the invention 3 times, scratchy alleviation, again after continuous spray 3 times, the state of an illness is under control, again after continuous spray 10 times, miliaria does not recur thoroughly to disappear again.
Lee so-and-so, female, 36 years old, January there is miliaria in preabdomen, accompanies sharp, burn feeling, buys medicine for external use voluntarily smear in pharmacy, use and have no improvement after 3 days, in succession occur sleepy, dizziness, rear going to a doctor gives infusion treatment after the attached institute in certain school first, has no alleviation in hospital after one week, after ward mate introduces and uses Flos Lonicerae prickly heat liquid provided by the invention 3 days, scratchy alleviation, again continuous spray 2 days, all symptoms are thoroughly cured and without recurrence.
Together so-and-so, man, 75 years old, lie on a bed for a long time because of postoperative, there is vesicle and miliaria alba (one in miliaria) of syringe needle sample size in the position such as waist, trunk, blush appears in affected part, easy galling, galling place easy infection, and with sensation of pricking, after using medicine on the market, symptom obtains alleviation, but thoroughly do not effect a radical cure, after use Flos Lonicerae prickly heat liquid provided by the invention instead after 5 days, blush disappear, sensation of pricking obtains alleviation, galling place is formed a scab, after use continuously again after 8 days, all transference cures and no longer recurring.
It should be noted that, the above enforcement of the present invention all can only be thought explanation of the present invention, and the present invention can not be limited, claims indicate scope of the present invention, and embodiment does not point out scope of the present invention, therefore, any change in the implication suitable with claims of the present invention and scope, all should think to be included in the scope of claims.

Claims (5)

1. a Flos Lonicerae prickly heat liquid preparation method, is characterized in that, comprises the following steps:
S10: after Flos Lonicerae, Flos Chrysanthemi Indici, Folium Artemisiae Argyi, Radix Glycyrrhizae are carried out pulverization process, crosses 20 ~ 60 mesh sieves, obtains mix powder;
S20: above-mentioned mixed-powder is added after soaking 0.5 ~ 1h in 50% alcoholic solution, reflux 2 ~ 3h, obtain mixture solution;
S30: filtered by said mixture solution, makes filtrate be separated with filtering residue;
S40: be dissolved in by Mentholum after in ethanol, add PLURONICS F87, obtains Mentholum mixed solution;
S50: the filtrate of above-mentioned acquisition is mixed with the Mentholum mixed solution of acquisition, and add deionized water and stirring evenly, obtain Flos Lonicerae prickly heat liquid.
2. a kind of Flos Lonicerae prickly heat liquid preparation method according to claim 4, it is characterized in that, described step S30 also comprises:
In the filtering residue obtained, add 50% ethanol, reflux 2 ~ 3h, obtain filtering residue mixture, the filtering residue mixture of acquisition is filtered, obtain second aqueous, by second aqueous with obtain filtrate and carry out mixing and after stirring, concentrating under reduced pressure acquisition concentrated solution.
3. the Flos Lonicerae prickly heat liquid that preparation method is obtained according to claim 1 or 2, is characterized in that, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 3% ~ 5%, Flos Chrysanthemi Indici 1 ~ 3%, Folium Artemisiae Argyi 1 ~ 2%, Radix Glycyrrhizae 1 ~ 2%, Mentholum 0.2% ~ 0.6%, ethanol 4 ~ 7%, PLURONICS F87 1 ~ 3%, all the other are water.
4. Flos Lonicerae prickly heat liquid according to claim 3, is characterized in that, raw materials by weight calculates, and comprises following component:
Flos Lonicerae 4%, Flos Chrysanthemi Indici 2%, Folium Artemisiae Argyi 1%, Radix Glycyrrhizae 2%, Mentholum 0.4%, ethanol 6%, PLURONICS F87 1.5%, all the other are water.
5. the Flos Lonicerae prickly heat liquid according to claim 3 or 4, is characterized in that, described water is deionized water.
CN201410756047.0A 2014-12-10 2014-12-10 Honeysuckle prickly heat water and preparation method thereof Pending CN104474008A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104887743A (en) * 2015-05-06 2015-09-09 绥阳县吉帮金银花科技发展有限公司 Honeysuckle flower heat rash treatment lotion and preparation method thereof
CN105395593A (en) * 2015-12-09 2016-03-16 广州赛莱拉生物基因工程有限公司 Itching relieving ointment containing folium artemisiae argyi extract and preparation method thereof
CN106434057A (en) * 2016-08-28 2017-02-22 骆志明 Baby skincare hand rebatching soap capable of clearing heat and damp
CN106620096A (en) * 2016-12-02 2017-05-10 保定学院 Pure plant extract itching-relieving inflammation-diminishing ointment and preparation method thereof
CN110840768A (en) * 2019-11-26 2020-02-28 苏州东方之宝生物药业有限公司 Artemisia argyi essence stock solution and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102860967A (en) * 2011-07-04 2013-01-09 欧亮 Baby skin care product formula possessing functions of eliminating miliaria and relieving itching
CN102973634A (en) * 2012-11-22 2013-03-20 贵州大学 Extracting method of honeysuckle

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102860967A (en) * 2011-07-04 2013-01-09 欧亮 Baby skin care product formula possessing functions of eliminating miliaria and relieving itching
CN102973634A (en) * 2012-11-22 2013-03-20 贵州大学 Extracting method of honeysuckle

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
钟振声等: "《表面活性剂在化妆品中的应用》", 31 August 2003 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104887743A (en) * 2015-05-06 2015-09-09 绥阳县吉帮金银花科技发展有限公司 Honeysuckle flower heat rash treatment lotion and preparation method thereof
CN105395593A (en) * 2015-12-09 2016-03-16 广州赛莱拉生物基因工程有限公司 Itching relieving ointment containing folium artemisiae argyi extract and preparation method thereof
CN106434057A (en) * 2016-08-28 2017-02-22 骆志明 Baby skincare hand rebatching soap capable of clearing heat and damp
CN106620096A (en) * 2016-12-02 2017-05-10 保定学院 Pure plant extract itching-relieving inflammation-diminishing ointment and preparation method thereof
CN110840768A (en) * 2019-11-26 2020-02-28 苏州东方之宝生物药业有限公司 Artemisia argyi essence stock solution and preparation method thereof

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Application publication date: 20150401