CN104470908A - 1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯的结晶复合物,其制备方法及其用于制备药物的用途 - Google Patents

1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯的结晶复合物,其制备方法及其用于制备药物的用途 Download PDF

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Publication number
CN104470908A
CN104470908A CN201380037186.1A CN201380037186A CN104470908A CN 104470908 A CN104470908 A CN 104470908A CN 201380037186 A CN201380037186 A CN 201380037186A CN 104470908 A CN104470908 A CN 104470908A
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CN
China
Prior art keywords
crystalline
crystalline composites
solution
benzene
glucopyranose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380037186.1A
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English (en)
Chinese (zh)
Inventor
M·埃克哈特
T·巴茨
F·希梅尔斯巴赫
H-J·马丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
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Boehringer Ingelheim Vetmedica GmbH
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Priority to CN201810468431.9A priority Critical patent/CN108774200A/zh
Publication of CN104470908A publication Critical patent/CN104470908A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201380037186.1A 2012-07-26 2013-07-25 1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯的结晶复合物,其制备方法及其用于制备药物的用途 Pending CN104470908A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810468431.9A CN108774200A (zh) 2012-07-26 2013-07-25 化合物的结晶复合物，其制备方法及其用于制备药物的用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12177944.1 2012-07-26
EP12177944 2012-07-26
PCT/EP2013/065736 WO2014016381A1 (en) 2012-07-26 2013-07-25 CRYSTALLINE COMPLEX OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(ß- D-GLUCOPYRANOS-1-YL)-BENZENE, METHODS FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS

Related Child Applications (1)

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CN201810468431.9A Division CN108774200A (zh) 2012-07-26 2013-07-25 化合物的结晶复合物，其制备方法及其用于制备药物的用途

Publications (1)

Publication Number Publication Date
CN104470908A true CN104470908A (zh) 2015-03-25

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CN201380037186.1A Pending CN104470908A (zh) 2012-07-26 2013-07-25 1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯的结晶复合物,其制备方法及其用于制备药物的用途
CN201810468431.9A Pending CN108774200A (zh) 2012-07-26 2013-07-25 化合物的结晶复合物，其制备方法及其用于制备药物的用途

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Country Status (23)

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US (1) US9145434B2 (enExample)
EP (3) EP4166548A1 (enExample)
JP (2) JP6538556B2 (enExample)
CN (2) CN104470908A (enExample)
AR (1) AR091908A1 (enExample)
AU (1) AU2013294947B2 (enExample)
BR (1) BR112015001327B1 (enExample)
CA (1) CA2878698C (enExample)
DK (2) DK2877460T3 (enExample)
EA (2) EA025438B1 (enExample)
ES (2) ES2937665T3 (enExample)
FI (1) FI3351539T3 (enExample)
HR (2) HRP20181972T1 (enExample)
HU (1) HUE061450T2 (enExample)
LT (1) LT3351539T (enExample)
MX (1) MX357906B (enExample)
PL (2) PL3351539T3 (enExample)
PT (2) PT3351539T (enExample)
RS (1) RS63881B1 (enExample)
SG (1) SG11201500574QA (enExample)
SI (2) SI3351539T1 (enExample)
TW (1) TW201418275A (enExample)
WO (1) WO2014016381A1 (enExample)

Cited By (1)

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CN111511725A (zh) * 2017-12-19 2020-08-07 勃林格殷格翰维特梅迪卡有限公司 1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯、L-脯氨酸和水的1:1:1共晶体的合成

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PT2981269T (pt) 2013-04-04 2023-10-10 Boehringer Ingelheim Vetmedica Gmbh Tratamento de distúrbios metabólicos em animais equinos
CN105828815B (zh) * 2013-12-17 2020-03-27 勃林格殷格翰动物保健有限公司 猫科动物中代谢紊乱的治疗
PL3485890T3 (pl) 2014-01-23 2023-08-28 Boehringer Ingelheim Vetmedica Gmbh Inhibitory SGLT2 do leczenia zaburzeń metabolicznych u zwierząt psowatych
KR102662473B1 (ko) * 2014-04-01 2024-05-03 베링거잉겔하임베트메디카게엠베하 말과 동물에서 대사 장애의 치료
CN103965020B (zh) * 2014-05-06 2015-09-09 启东东岳药业有限公司 制备5-碘-2-溴苄醇的方法
DK3197429T3 (da) * 2014-09-25 2024-08-26 Boehringer Ingelheim Vetmedica Gmbh Kombinationsbehandling med sglt2-hæmmere og dopaminagonister til forebyggelse af metaboliske lidelser af dyr i hestefamilien
BR112017005454A2 (pt) * 2014-09-30 2017-12-12 Jiangsu Hengrui Medicine Co composto de l-prolina do inibidor 2 do cotransportador de sódio-glicose, e mono-hidrato e cristal do composto de l-prolina
CZ2015110A3 (cs) * 2015-02-18 2016-08-31 Zentiva, K.S. Pevné formy empagliflozinu
WO2017032799A1 (en) 2015-08-27 2017-03-02 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising sglt-2 inhibitors
WO2017203457A1 (en) * 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Solid state forms of empagliflozin
US10793588B2 (en) 2016-05-28 2020-10-06 Ji Lin Hui Sheng Bio-Pharmaceutical Co., Ltd. Crystal form of sodium-glucose cotransporter 2 inhibitor
WO2021105152A1 (en) 2019-11-28 2021-06-03 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors in the drying-off of non-human mammals
BR112022016360A2 (pt) 2020-02-17 2022-10-04 Boehringer Ingelheim Vetmedica Gmbh Uso de inibidores de sglt-2 para a prevenção e/ou tratamento de doenças cardíacas em felinos
EP4376829A1 (en) 2021-07-28 2024-06-05 Boehringer Ingelheim Vetmedica GmbH Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in non-human mammals excluding felines, in particular canines
WO2023006747A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of renal diseases in non-human mammals
US20240269105A1 (en) 2021-07-28 2024-08-15 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
CA3256728A1 (en) 2022-05-25 2023-11-30 Boehringer Ingelheim Vetmedica Gmbh AQUEOUS PHARMACEUTICAL COMPOSITIONS CONTAINING SGLT-2 INHIBITORS
TW202500160A (zh) 2023-03-06 2025-01-01 德商百靈佳殷格翰維美迪加股份有限公司 用於遞送特別是包含一或多種ｓｇｌｔ—２抑制劑之液體醫藥組合物之系統及方法
KR20260004451A (ko) 2023-04-24 2026-01-08 베링거잉겔하임베트메디카게엠베하 벨라글리플로진과 선택된 공결정 형성제의 결정성 복합체, 이의 제조방법 및 의약의 제조에서의 이의 용도
WO2024240632A1 (en) 2023-05-24 2024-11-28 Boehringer Ingelheim Vetmedica Gmbh Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan
TW202508455A (zh) 2023-05-24 2025-03-01 德商百靈佳殷格翰維美迪加股份有限公司 包含一或多種sglt-2抑制劑及替米沙坦(telmisartan)之非人類哺乳動物之腎臟疾病及/或高血壓之組合治療及/或預防

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN111511725A (zh) * 2017-12-19 2020-08-07 勃林格殷格翰维特梅迪卡有限公司 1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯、L-脯氨酸和水的1:1:1共晶体的合成
CN111511725B (zh) * 2017-12-19 2024-04-09 勃林格殷格翰维特梅迪卡有限公司 1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯、L-脯氨酸和水的1:1:1共晶体的合成

Also Published As

Publication number Publication date
EP3351539B1 (en) 2022-11-09
JP6538556B2 (ja) 2019-07-03
JP2015522644A (ja) 2015-08-06
PT2877460T (pt) 2018-12-19
BR112015001327A2 (pt) 2017-07-04
BR112015001327B1 (pt) 2022-08-16
JP2018135384A (ja) 2018-08-30
EP2877460B1 (en) 2018-09-12
ES2937665T3 (es) 2023-03-30
PL2877460T3 (pl) 2019-04-30
HRP20230081T1 (hr) 2023-03-17
AR091908A1 (es) 2015-03-11
EA025438B1 (ru) 2016-12-30
CA2878698C (en) 2021-03-23
CN108774200A (zh) 2018-11-09
MX2015000962A (es) 2015-04-16
EA201500038A1 (ru) 2015-07-30
EA201600506A1 (ru) 2017-03-31
PL3351539T3 (pl) 2023-03-06
SI2877460T1 (sl) 2018-12-31
AU2013294947B2 (en) 2017-03-30
ES2694675T3 (es) 2018-12-26
EP2877460A1 (en) 2015-06-03
MX357906B (es) 2018-07-30
CA2878698A1 (en) 2014-01-30
SI3351539T1 (sl) 2023-03-31
EP4166548A1 (en) 2023-04-19
HRP20181972T1 (hr) 2019-01-25
SG11201500574QA (en) 2015-02-27
WO2014016381A1 (en) 2014-01-30
DK3351539T3 (da) 2023-01-30
RS63881B1 (sr) 2023-02-28
HUE061450T2 (hu) 2023-07-28
FI3351539T3 (fi) 2023-02-19
AU2013294947A1 (en) 2015-01-22
DK2877460T3 (en) 2019-01-07
EP3351539A1 (en) 2018-07-25
LT3351539T (lt) 2023-02-10
US9145434B2 (en) 2015-09-29
PT3351539T (pt) 2023-01-17
US20140031540A1 (en) 2014-01-30
TW201418275A (zh) 2014-05-16

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