JP6538556B2 - １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 - Google Patents

１−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 Download PDF

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JP6538556B2
JP6538556B2 JP2015523552A JP2015523552A JP6538556B2 JP 6538556 B2 JP6538556 B2 JP 6538556B2 JP 2015523552 A JP2015523552 A JP 2015523552A JP 2015523552 A JP2015523552 A JP 2015523552A JP 6538556 B2 JP6538556 B2 JP 6538556B2
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solution
benzene
glucopyranose
crystal
cyclopropyl
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JP2015522644A (ja
JP2015522644A5 (enExample
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マティアス エクハルト
マティアス エクハルト
ターニャ ブッツ
ターニャ ブッツ
ヒンメルスバッハ　フランク
フランク ヒンメルスバッハ
ハンス−ユルゲン マルティン
ハンス−ユルゲン マルティン
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Boehringer Ingelheim Vetmedica GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2015523552A 2012-07-26 2013-07-25 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 Active JP6538556B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12177944 2012-07-26
EP12177944.1 2012-07-26
PCT/EP2013/065736 WO2014016381A1 (en) 2012-07-26 2013-07-25 CRYSTALLINE COMPLEX OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(ß- D-GLUCOPYRANOS-1-YL)-BENZENE, METHODS FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS

Related Child Applications (1)

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JP2018089968A Division JP2018135384A (ja) 2012-07-26 2018-05-08 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用

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JP2015522644A JP2015522644A (ja) 2015-08-06
JP2015522644A5 JP2015522644A5 (enExample) 2019-05-09
JP6538556B2 true JP6538556B2 (ja) 2019-07-03

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JP2018089968A Pending JP2018135384A (ja) 2012-07-26 2018-05-08 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用

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US (1) US9145434B2 (enExample)
EP (3) EP3351539B1 (enExample)
JP (2) JP6538556B2 (enExample)
CN (2) CN108774200A (enExample)
AR (1) AR091908A1 (enExample)
AU (1) AU2013294947B2 (enExample)
BR (1) BR112015001327B1 (enExample)
CA (1) CA2878698C (enExample)
DK (2) DK2877460T3 (enExample)
EA (2) EA025438B1 (enExample)
ES (2) ES2937665T3 (enExample)
FI (1) FI3351539T3 (enExample)
HR (2) HRP20181972T1 (enExample)
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WO (1) WO2014016381A1 (enExample)

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ES2811261T3 (es) 2014-04-01 2021-03-11 Boehringer Ingelheim Vetmedica Gmbh Tratamiento de trastornos metabólicos en animales equinos
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WO2016046150A1 (en) 2014-09-25 2016-03-31 Boehringer Ingelheim Vetmedica Gmbh Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals
WO2016050134A1 (zh) * 2014-09-30 2016-04-07 江苏恒瑞医药股份有限公司 一种钠-葡萄糖协同转运蛋白2抑制剂的l-脯氨酸复合物、其一水合物及晶体
CZ2015110A3 (cs) * 2015-02-18 2016-08-31 Zentiva, K.S. Pevné formy empagliflozinu
BR112018003749B1 (pt) 2015-08-27 2023-10-31 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas líquidas compreendendo inibidores sglt-2, kit de peças e processo para a produção da composição farmacêutica líquida
WO2017203457A1 (en) * 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Solid state forms of empagliflozin
CN109476624B (zh) 2016-05-28 2021-07-09 吉林惠升生物制药有限公司 钠-葡萄糖协同转运蛋白2抑制剂的晶型
MX2023004791A (es) * 2017-12-19 2023-12-07 Boehringer Ingelheim Vetmedica Gmbh Sintesis del cocristal 1:1:1 de 1-ciano-2-(4-ciclopropil-bencil)-4 -(beta-d-glucopiranos-1-il)-benceno, l-prolina y agua.
BR112022010385A2 (pt) 2019-11-28 2022-08-23 Boehringer Ingelheim Vetmedica Gmbh Uso de inibidores de sglt-2 na secagem de mamíferos não humanos
JP7423800B2 (ja) 2020-02-17 2024-01-29 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー ネコにおける心臓疾患の予防および／または治療のためのｓｇｌｔ－２阻害剤の使用
US20240269105A1 (en) 2021-07-28 2024-08-15 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
JP2024525981A (ja) 2021-07-28 2024-07-12 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー ヒト以外の哺乳動物における腎疾患の予防及び／又は治療のためのｓｇｌｔ－２阻害剤の使用
KR20240041966A (ko) 2021-07-28 2024-04-01 베링거잉겔하임베트메디카게엠베하 고양이를 제외한 비인간 포유류, 특히 개에서 심장 질환의 예방 및/또는 치료를 위한 sglt-2 억제제의 용도
CA3256728A1 (en) 2022-05-25 2023-11-30 Boehringer Ingelheim Vetmedica Gmbh AQUEOUS PHARMACEUTICAL COMPOSITIONS CONTAINING SGLT-2 INHIBITORS
AR132054A1 (es) 2023-03-06 2025-05-21 Boehringer Ingelheim Vetmedica Gmbh Sistemas y métodos para la administración de composiciones farmacéuticas líquidas, en particular que comprenden uno o más inhibidores de sglt-2
CN121039113A (zh) 2023-04-24 2025-11-28 勃林格殷格翰动物保健有限公司 维格列净与所选共晶形成剂的结晶复合物、其制备方法及其在制备药物中的用途
CN121175053A (zh) 2023-05-24 2025-12-19 勃林格殷格翰动物保健有限公司 包含一或多种sglt-2抑制剂及替米沙坦的非人类哺乳动物中肾脏疾病和/或高血压的组合治疗和/或预防
CN121218995A (zh) 2023-05-24 2025-12-26 勃林格殷格翰动物保健有限公司 包含一或多种sglt-2抑制剂及匹莫苯丹和/或替米沙坦的非人类哺乳动物中心脏疾病的组合治疗和/或预防

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Also Published As

Publication number Publication date
ES2694675T3 (es) 2018-12-26
DK2877460T3 (en) 2019-01-07
AU2013294947A1 (en) 2015-01-22
DK3351539T3 (da) 2023-01-30
PL3351539T3 (pl) 2023-03-06
EA201500038A1 (ru) 2015-07-30
EP2877460A1 (en) 2015-06-03
US9145434B2 (en) 2015-09-29
RS63881B1 (sr) 2023-02-28
PT3351539T (pt) 2023-01-17
PT2877460T (pt) 2018-12-19
PL2877460T3 (pl) 2019-04-30
BR112015001327A2 (pt) 2017-07-04
CN108774200A (zh) 2018-11-09
CA2878698C (en) 2021-03-23
US20140031540A1 (en) 2014-01-30
CA2878698A1 (en) 2014-01-30
ES2937665T3 (es) 2023-03-30
HUE061450T2 (hu) 2023-07-28
MX2015000962A (es) 2015-04-16
AU2013294947B2 (en) 2017-03-30
EP3351539B1 (en) 2022-11-09
CN104470908A (zh) 2015-03-25
WO2014016381A1 (en) 2014-01-30
EP3351539A1 (en) 2018-07-25
SG11201500574QA (en) 2015-02-27
MX357906B (es) 2018-07-30
SI3351539T1 (sl) 2023-03-31
EP4166548A1 (en) 2023-04-19
JP2018135384A (ja) 2018-08-30
AR091908A1 (es) 2015-03-11
EA025438B1 (ru) 2016-12-30
HRP20181972T1 (hr) 2019-01-25
FI3351539T3 (fi) 2023-02-19
LT3351539T (lt) 2023-02-10
BR112015001327B1 (pt) 2022-08-16
TW201418275A (zh) 2014-05-16
EP2877460B1 (en) 2018-09-12
SI2877460T1 (sl) 2018-12-31
JP2015522644A (ja) 2015-08-06
EA201600506A1 (ru) 2017-03-31
HRP20230081T1 (hr) 2023-03-17

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