JP6538556B2 - １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 - Google Patents

１−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 Download PDF

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JP6538556B2
JP6538556B2 JP2015523552A JP2015523552A JP6538556B2 JP 6538556 B2 JP6538556 B2 JP 6538556B2 JP 2015523552 A JP2015523552 A JP 2015523552A JP 2015523552 A JP2015523552 A JP 2015523552A JP 6538556 B2 JP6538556 B2 JP 6538556B2
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solution
benzene
glucopyranose
crystal
cyclopropyl
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JP2015522644A (ja
JP2015522644A5 (enExample
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マティアス エクハルト
マティアス エクハルト
ターニャ ブッツ
ターニャ ブッツ
ヒンメルスバッハ　フランク
フランク ヒンメルスバッハ
ハンス−ユルゲン マルティン
ハンス−ユルゲン マルティン
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Boehringer Ingelheim Vetmedica GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2015523552A 2012-07-26 2013-07-25 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 Active JP6538556B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12177944 2012-07-26
EP12177944.1 2012-07-26
PCT/EP2013/065736 WO2014016381A1 (en) 2012-07-26 2013-07-25 CRYSTALLINE COMPLEX OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(ß- D-GLUCOPYRANOS-1-YL)-BENZENE, METHODS FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS

Related Child Applications (1)

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JP2018089968A Division JP2018135384A (ja) 2012-07-26 2018-05-08 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用

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JP2015522644A JP2015522644A (ja) 2015-08-06
JP2015522644A5 JP2015522644A5 (enExample) 2019-05-09
JP6538556B2 true JP6538556B2 (ja) 2019-07-03

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JP2015523552A Active JP6538556B2 (ja) 2012-07-26 2013-07-25 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用
JP2018089968A Pending JP2018135384A (ja) 2012-07-26 2018-05-08 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用

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US (1) US9145434B2 (enExample)
EP (3) EP2877460B1 (enExample)
JP (2) JP6538556B2 (enExample)
CN (2) CN104470908A (enExample)
AR (1) AR091908A1 (enExample)
AU (1) AU2013294947B2 (enExample)
BR (1) BR112015001327B1 (enExample)
CA (1) CA2878698C (enExample)
DK (2) DK2877460T3 (enExample)
EA (2) EA025438B1 (enExample)
ES (2) ES2937665T3 (enExample)
FI (1) FI3351539T3 (enExample)
HR (2) HRP20230081T1 (enExample)
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SI (2) SI3351539T1 (enExample)
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WO (1) WO2014016381A1 (enExample)

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DK3721882T3 (da) * 2014-04-01 2024-10-21 Boehringer Ingelheim Vetmedica Gmbh Behandling af hypofyse pars intermedia-dysfunktion hos hestedyr
CN103965020B (zh) * 2014-05-06 2015-09-09 启东东岳药业有限公司 制备5-碘-2-溴苄醇的方法
KR102539788B1 (ko) * 2014-09-25 2023-06-07 베링거잉겔하임베트메디카게엠베하 말과 동물의 대사 장애를 예방하기 위한 sglt2 억제제와 도파민 작용제의 병용 치료
PT3202772T (pt) * 2014-09-30 2020-11-20 Jiangsu Hengrui Medicine Co Cristal de um complexo de l-prolina/inibidor do cotransportador de sódio-glicose 2
CZ2015110A3 (cs) * 2015-02-18 2016-08-31 Zentiva, K.S. Pevné formy empagliflozinu
MX389367B (es) 2015-08-27 2025-03-20 Boehringer Ingelheim Vetmedica Gmbh Composiciones farmaceuticas liquidas que comprenden inhibidores de sglt-2.
WO2017203457A1 (en) * 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Solid state forms of empagliflozin
KR102226465B1 (ko) * 2016-05-28 2021-03-11 하이난 수안주 파마 코포레이션 리미티드 나트륨-글루코스 공수송체 2에 대한 억제제의 결정형
MX2020006387A (es) * 2017-12-19 2020-09-03 Boehringer Ingelheim Vetmedica Gmbh Sintesis del cocristal 1:1:1 de 1-ciano-2-(4-ciclopropil-bencil)-4 -(beta-d-glucopiranos-1-il)-benceno, l-prolina y agua.
BR112022010385A2 (pt) 2019-11-28 2022-08-23 Boehringer Ingelheim Vetmedica Gmbh Uso de inibidores de sglt-2 na secagem de mamíferos não humanos
KR20220143732A (ko) 2020-02-17 2022-10-25 베링거잉겔하임베트메디카게엠베하 고양이과에서 심장 질환을 예방 및/또는 치료하기 위한 sglt-2 억제제의 사용
US20240398845A1 (en) 2021-07-28 2024-12-05 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in non-human mammals excluding felines, in particular canines
WO2023006745A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
EP4376830A1 (en) 2021-07-28 2024-06-05 Boehringer Ingelheim Vetmedica GmbH Use of sglt-2 inhibitors for the prevention and/or treatment of renal diseases in non-human mammals
JP2025516857A (ja) 2022-05-25 2025-05-30 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー Ｓｇｌｔ－２阻害薬を含む水性医薬組成物
US20240307628A1 (en) 2023-03-06 2024-09-19 Boehringer Ingelheim Vetmedica Gmbh Systems and methods for delivery of liquid pharmaceutical compositions in particular comprising one or more sglt-2 inhibitor(s)
KR20260004451A (ko) 2023-04-24 2026-01-08 베링거잉겔하임베트메디카게엠베하 벨라글리플로진과 선택된 공결정 형성제의 결정성 복합체, 이의 제조방법 및 의약의 제조에서의 이의 용도
AU2024276892A1 (en) 2023-05-24 2025-10-16 Boehringer Ingelheim Vetmedica Gmbh Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan
CN121175053A (zh) 2023-05-24 2025-12-19 勃林格殷格翰动物保健有限公司 包含一或多种sglt-2抑制剂及替米沙坦的非人类哺乳动物中肾脏疾病和/或高血压的组合治疗和/或预防

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Also Published As

Publication number Publication date
JP2015522644A (ja) 2015-08-06
CA2878698A1 (en) 2014-01-30
US9145434B2 (en) 2015-09-29
EP2877460B1 (en) 2018-09-12
ES2937665T3 (es) 2023-03-30
CN108774200A (zh) 2018-11-09
CN104470908A (zh) 2015-03-25
TW201418275A (zh) 2014-05-16
MX357906B (es) 2018-07-30
RS63881B1 (sr) 2023-02-28
PT2877460T (pt) 2018-12-19
MX2015000962A (es) 2015-04-16
PL3351539T3 (pl) 2023-03-06
CA2878698C (en) 2021-03-23
AU2013294947B2 (en) 2017-03-30
PL2877460T3 (pl) 2019-04-30
PT3351539T (pt) 2023-01-17
EP3351539A1 (en) 2018-07-25
WO2014016381A1 (en) 2014-01-30
ES2694675T3 (es) 2018-12-26
EA025438B1 (ru) 2016-12-30
EP4166548A1 (en) 2023-04-19
BR112015001327A2 (pt) 2017-07-04
US20140031540A1 (en) 2014-01-30
SG11201500574QA (en) 2015-02-27
EA201500038A1 (ru) 2015-07-30
FI3351539T3 (fi) 2023-02-19
SI3351539T1 (sl) 2023-03-31
HRP20181972T1 (hr) 2019-01-25
LT3351539T (lt) 2023-02-10
EP3351539B1 (en) 2022-11-09
HUE061450T2 (hu) 2023-07-28
SI2877460T1 (sl) 2018-12-31
DK2877460T3 (en) 2019-01-07
AR091908A1 (es) 2015-03-11
DK3351539T3 (da) 2023-01-30
HRP20230081T1 (hr) 2023-03-17
JP2018135384A (ja) 2018-08-30
EP2877460A1 (en) 2015-06-03
BR112015001327B1 (pt) 2022-08-16
EA201600506A1 (ru) 2017-03-31
AU2013294947A1 (en) 2015-01-22

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