JP6538556B2 - １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 - Google Patents

１−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 Download PDF

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JP6538556B2
JP6538556B2 JP2015523552A JP2015523552A JP6538556B2 JP 6538556 B2 JP6538556 B2 JP 6538556B2 JP 2015523552 A JP2015523552 A JP 2015523552A JP 2015523552 A JP2015523552 A JP 2015523552A JP 6538556 B2 JP6538556 B2 JP 6538556B2
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solution
benzene
glucopyranose
crystal
cyclopropyl
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JP2015522644A (ja
JP2015522644A5 (enExample
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マティアス エクハルト
マティアス エクハルト
ターニャ ブッツ
ターニャ ブッツ
ヒンメルスバッハ　フランク
フランク ヒンメルスバッハ
ハンス−ユルゲン マルティン
ハンス−ユルゲン マルティン
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Boehringer Ingelheim Vetmedica GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2015523552A 2012-07-26 2013-07-25 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用 Active JP6538556B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12177944.1 2012-07-26
EP12177944 2012-07-26
PCT/EP2013/065736 WO2014016381A1 (en) 2012-07-26 2013-07-25 CRYSTALLINE COMPLEX OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(ß- D-GLUCOPYRANOS-1-YL)-BENZENE, METHODS FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS

Related Child Applications (1)

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JP2018089968A Division JP2018135384A (ja) 2012-07-26 2018-05-08 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用

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JP2015522644A JP2015522644A (ja) 2015-08-06
JP2015522644A5 JP2015522644A5 (enExample) 2019-05-09
JP6538556B2 true JP6538556B2 (ja) 2019-07-03

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JP2018089968A Pending JP2018135384A (ja) 2012-07-26 2018-05-08 １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用

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US (1) US9145434B2 (enExample)
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EP4245765A3 (en) 2013-04-04 2024-03-20 Boehringer Ingelheim Vetmedica GmbH Treatment of metabolic disorders in equine animals
ES2969764T3 (es) 2013-12-17 2024-05-22 Boehringer Ingelheim Vetmedica Gmbh Un inhibidor de SGLT-2 para usar en el tratamiento de un trastorno metabólico en animales felinos
CN115282284A (zh) 2014-01-23 2022-11-04 勃林格殷格翰动物保健有限公司 犬科动物中代谢紊乱的治疗
ES2811261T3 (es) 2014-04-01 2021-03-11 Boehringer Ingelheim Vetmedica Gmbh Tratamiento de trastornos metabólicos en animales equinos
CN103965020B (zh) * 2014-05-06 2015-09-09 启东东岳药业有限公司 制备5-碘-2-溴苄醇的方法
HUE068152T2 (hu) 2014-09-25 2024-12-28 Boehringer Ingelheim Vetmedica Gmbh SGLT2-gátlók és dopamin agonisták kombinációs kezelése anyagcserezavarok megelõzésére lófélékben
PL3202772T3 (pl) * 2014-09-30 2021-02-22 Jiangsu Hengrui Medicine Co. Ltd. Kryształ kompleksu inhibitora l-proliny/glukozy sodowej 2
CZ2015110A3 (cs) * 2015-02-18 2016-08-31 Zentiva, K.S. Pevné formy empagliflozinu
MX389367B (es) 2015-08-27 2025-03-20 Boehringer Ingelheim Vetmedica Gmbh Composiciones farmaceuticas liquidas que comprenden inhibidores de sglt-2.
WO2017203457A1 (en) * 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Solid state forms of empagliflozin
CN109476624B (zh) 2016-05-28 2021-07-09 吉林惠升生物制药有限公司 钠-葡萄糖协同转运蛋白2抑制剂的晶型
CN111511725B (zh) 2017-12-19 2024-04-09 勃林格殷格翰维特梅迪卡有限公司 1-氰基-2-(4-环丙基-苄基)-4-(β-D-吡喃葡萄糖-1-基)-苯、L-脯氨酸和水的1:1:1共晶体的合成
CN114727624A (zh) 2019-11-28 2022-07-08 勃林格殷格翰动物保健有限公司 Sglt-2抑制剂在非人哺乳动物的停奶中的用途
KR20220143732A (ko) 2020-02-17 2022-10-25 베링거잉겔하임베트메디카게엠베하 고양이과에서 심장 질환을 예방 및/또는 치료하기 위한 sglt-2 억제제의 사용
MX2024001184A (es) 2021-07-28 2024-02-27 Boehringer Ingelheim Vetmedica Gmbh Uso de inhibidores de sglt-2 para la prevencion y/o tratamiento de cardiopatias en mamiferos no humanos, que excluye felinos, en particular, caninos.
EP4376819A1 (en) 2021-07-28 2024-06-05 Boehringer Ingelheim Vetmedica GmbH Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
MX2024001185A (es) 2021-07-28 2024-02-27 Boehringer Ingelheim Vetmedica Gmbh Uso de inhibidores de sglt-2 para la prevencion y/o tratamiento de enfermedades renales en mamiferos no humanos.
EP4531810A1 (en) 2022-05-25 2025-04-09 Boehringer Ingelheim Vetmedica GmbH Aqueous pharmaceutical compositions comprising sglt-2 inhibitors
US20240307628A1 (en) 2023-03-06 2024-09-19 Boehringer Ingelheim Vetmedica Gmbh Systems and methods for delivery of liquid pharmaceutical compositions in particular comprising one or more sglt-2 inhibitor(s)
EP4702012A1 (en) 2023-04-24 2026-03-04 Boehringer Ingelheim Vetmedica GmbH Crystalline complexes between velagliflozin and selected co-crystal forming agents, methods for their preparation and the use thereof for preparing medicaments
WO2024240632A1 (en) 2023-05-24 2024-11-28 Boehringer Ingelheim Vetmedica Gmbh Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan
KR20260019532A (ko) 2023-05-24 2026-02-10 베링거잉겔하임베트메디카게엠베하 하나 이상의 sglt-2 억제제와 텔미사르탄을 포함하는 비인간 포유류의 신장 질환 및/또는 고혈압의 병용 치료 및/또는 예방

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Also Published As

Publication number Publication date
RS63881B1 (sr) 2023-02-28
EP2877460A1 (en) 2015-06-03
ES2694675T3 (es) 2018-12-26
DK2877460T3 (en) 2019-01-07
MX357906B (es) 2018-07-30
FI3351539T3 (fi) 2023-02-19
SI2877460T1 (sl) 2018-12-31
PL3351539T3 (pl) 2023-03-06
EP4166548A1 (en) 2023-04-19
US20140031540A1 (en) 2014-01-30
JP2015522644A (ja) 2015-08-06
PL2877460T3 (pl) 2019-04-30
WO2014016381A1 (en) 2014-01-30
EA201500038A1 (ru) 2015-07-30
EA025438B1 (ru) 2016-12-30
JP2018135384A (ja) 2018-08-30
DK3351539T3 (da) 2023-01-30
MX2015000962A (es) 2015-04-16
EP3351539A1 (en) 2018-07-25
AU2013294947A1 (en) 2015-01-22
HUE061450T2 (hu) 2023-07-28
PT3351539T (pt) 2023-01-17
US9145434B2 (en) 2015-09-29
CA2878698A1 (en) 2014-01-30
AR091908A1 (es) 2015-03-11
BR112015001327B1 (pt) 2022-08-16
SI3351539T1 (sl) 2023-03-31
BR112015001327A2 (pt) 2017-07-04
EA201600506A1 (ru) 2017-03-31
CN108774200A (zh) 2018-11-09
SG11201500574QA (en) 2015-02-27
PT2877460T (pt) 2018-12-19
EP3351539B1 (en) 2022-11-09
AU2013294947B2 (en) 2017-03-30
HRP20181972T1 (hr) 2019-01-25
ES2937665T3 (es) 2023-03-30
LT3351539T (lt) 2023-02-10
EP2877460B1 (en) 2018-09-12
HRP20230081T1 (hr) 2023-03-17
TW201418275A (zh) 2014-05-16
CA2878698C (en) 2021-03-23
CN104470908A (zh) 2015-03-25

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