CN104445142B - 用于人工气管的玻璃碳及其制备方法 - Google Patents

用于人工气管的玻璃碳及其制备方法 Download PDF

Info

Publication number
CN104445142B
CN104445142B CN201410625934.4A CN201410625934A CN104445142B CN 104445142 B CN104445142 B CN 104445142B CN 201410625934 A CN201410625934 A CN 201410625934A CN 104445142 B CN104445142 B CN 104445142B
Authority
CN
China
Prior art keywords
parts
glassy carbon
artificial trachea
polyacrylonitrile
titanium dioxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201410625934.4A
Other languages
English (en)
Other versions
CN104445142A (zh
Inventor
赵秀芳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhao Xiufang
Original Assignee
Suzhou Vivotide Biotechnologies Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201610312249.5A priority Critical patent/CN105948750B/zh
Priority to CN201610312354.9A priority patent/CN105859293B/zh
Priority to CN201610310548.5A priority patent/CN106007719B/zh
Priority to CN201410625934.4A priority patent/CN104445142B/zh
Priority to CN201610312351.5A priority patent/CN105999395B/zh
Priority to CN201610310581.8A priority patent/CN106039397B/zh
Priority to CN201610311124.0A priority patent/CN105800589B/zh
Priority to CN201610310549.XA priority patent/CN105948749B/zh
Application filed by Suzhou Vivotide Biotechnologies Co ltd filed Critical Suzhou Vivotide Biotechnologies Co ltd
Publication of CN104445142A publication Critical patent/CN104445142A/zh
Application granted granted Critical
Publication of CN104445142B publication Critical patent/CN104445142B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/515—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics
    • C04B35/52—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on carbon, e.g. graphite
    • C04B35/524—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on carbon, e.g. graphite obtained from polymer precursors, e.g. glass-like carbon material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/08—Carbon ; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/046—Tracheae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3201—Alkali metal oxides or oxide-forming salts thereof
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3208—Calcium oxide or oxide-forming salts thereof, e.g. lime
    • C04B2235/3212—Calcium phosphates, e.g. hydroxyapatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3231—Refractory metal oxides, their mixed metal oxides, or oxide-forming salts thereof
    • C04B2235/3232—Titanium oxides or titanates, e.g. rutile or anatase
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/48—Organic compounds becoming part of a ceramic after heat treatment, e.g. carbonising phenol resins
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/50—Constituents or additives of the starting mixture chosen for their shape or used because of their shape or their physical appearance
    • C04B2235/54—Particle size related information
    • C04B2235/5418—Particle size related information expressed by the size of the particles or aggregates thereof
    • C04B2235/5427—Particle size related information expressed by the size of the particles or aggregates thereof millimeter or submillimeter sized, i.e. larger than 0,1 mm
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/50—Constituents or additives of the starting mixture chosen for their shape or used because of their shape or their physical appearance
    • C04B2235/54—Particle size related information
    • C04B2235/5418—Particle size related information expressed by the size of the particles or aggregates thereof
    • C04B2235/5436—Particle size related information expressed by the size of the particles or aggregates thereof micrometer sized, i.e. from 1 to 100 micron
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/70—Aspects relating to sintered or melt-casted ceramic products
    • C04B2235/96—Properties of ceramic products, e.g. mechanical properties such as strength, toughness, wear resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Organic Chemistry (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明公开了一种用于人工气管的玻璃碳及其制备方法，用于人工气管的玻璃碳包括以下重量份计的原料：聚丙烯腈40～100份、聚硅氧烷30～40份、醋酸纤维素80～100份、聚氯乙烯20～30份、磷酸三钙10～20份、氧化钾90～100份、二氧化钛20～70份、聚二甲基硅氧烷60～90份。制备方法：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至2000～3000℃反应1～2h。本发明的玻璃碳生物稳定性较好，弹性模量为22～24GPa，疲劳强度为93～100MPa，抗压强度为680～700MPa，耐生物老化性能强。

Description

用于人工气管的玻璃碳及其制备方法
技术领域
本发明涉及生物医药材料领域，尤其涉及一种用于人工气管的玻璃碳及其制备方法。
背景技术
玻璃碳(GC)是一种新型的碳材料．玻璃碳，具有气密性和导电性好、热胀系数小、质地坚硬和易于抛光成镜面、化学惰性、具有较高的氢超电位等特点，因此适用于做电化学和电分析用的工作电极材料。因其端口形貌和结构特征类似玻璃而被称做玻璃碳，是1962年由英国的Davison和日本Yamada几乎同时发明了的。由于玻璃碳具有密度小、耐高温、抗渗透等特性，使其在化学工业、冶金工业、电子工业、生物工程等诸多领域有广泛的用途。
玻璃碳具有气密性和导电性好、热胀系数小、质地坚硬和易于抛光成镜面、化学惰性、具有较高的氢超电位等特点，因此适用于做电化学和电分析用的工作电极材料。电极的形式有棒状、圆盘、旋转圆盘、旋转环盘电极等。玻璃碳电极适用的电位范围较宽，既可以在负电位区研究无机物，也可以研究多在正电位区发生的有机物的氧化还原反应。用它作基体，还可以制备汞膜玻碳电极和化学修饰电极。电极在使用前要进行表面抛光、化学处理和电化学处理。
发明内容
本发明针对现有技术的不足，提供一种用于人工气管的玻璃碳及其制备方法，玻璃碳耐生物老化性能强。
为了解决上述技术问题，本发明采用以下技术方案：
用于人工气管的玻璃碳，包括以下重量份计的原料：聚丙烯腈40～100份、聚硅氧烷30～40份、醋酸纤维素80～100份、聚氯乙烯20～30份、磷酸三钙10～20份、氧化钾90～100份、二氧化钛20～70份、聚二甲基硅氧烷60～90份。
作为对本发明的进一步改进，用于人工气管的玻璃碳，包括以下重量份计的原料：聚丙烯腈70份、聚硅氧烷35份、醋酸纤维素90份、聚氯乙烯25份、磷酸三钙15份、氧化钾95份、二氧化钛50份、聚二甲基硅氧烷70份。
作为对本发明的进一步改进，二氧化钛的粒径为40～150μm。
作为对本发明的进一步改进，聚丙烯腈的分子量为10000～20000。
本发明还提供了一种用于人工气管的玻璃碳的制备方法。
一种用于人工气管的玻璃碳的制备方法，包括以下步骤：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至2000～3000℃反应1～2h。
作为对本发明的进一步改进，碳化处理时间为20～50min。
有益效果：现有技术的玻璃碳由于生物环境的腐蚀造成其中金属离子向周围组织扩散，本发明的玻璃碳可以作为人工气管应用，不易腐蚀扩散，是因为经碳化处理后的玻璃碳生物稳定性较好，弹性模量为22～24GPa，疲劳强度为93～100MPa，抗压强度为680～700MPa，耐生物老化性能强。
具体实施方式
下面结合具体实施例对本发明作进一步说明。
实施例1
用于人工气管的玻璃碳，包括以下重量份计的原料：聚丙烯腈70份、聚硅氧烷35份、醋酸纤维素90份、聚氯乙烯25份、磷酸三钙15份、氧化钾95份、二氧化钛50份、聚二甲基硅氧烷70份。
二氧化钛的粒径为100μm。
聚丙烯腈的分子量为15000。
一种用于人工气管的玻璃碳的制备方法，包括以下步骤：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至2500℃反应1.5h。
碳化处理时间为40min。
实施例2
用于人工气管的玻璃碳，包括以下重量份计的原料：聚丙烯腈40份、聚硅氧烷30份、醋酸纤维素80份、聚氯乙烯20份、磷酸三钙10份、氧化钾90份、二氧化钛20份、聚二甲基硅氧烷60份。
二氧化钛的粒径为40μm。
聚丙烯腈的分子量为10000。
一种用于人工气管的玻璃碳的制备方法，包括以下步骤：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至2000℃反应1h。
碳化处理时间为20min。
实施例3
用于人工气管的玻璃碳，包括以下重量份计的原料：聚丙烯腈100份、聚硅氧烷40份、醋酸纤维素100份、聚氯乙烯30份、磷酸三钙20份、氧化钾100份、二氧化钛70份、聚二甲基硅氧烷90份。
二氧化钛的粒径为150μm。
聚丙烯腈的分子量为20000。
一种用于人工气管的玻璃碳的制备方法，包括以下步骤：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至3000℃反应2h。
碳化处理时间为50min。
实施例4
用于人工气管的玻璃碳，包括以下重量份计的原料：聚丙烯腈90份、聚硅氧烷33份、醋酸纤维素85份、聚氯乙烯22份、磷酸三钙12份、氧化钾93份、二氧化钛30份、聚二甲基硅氧烷70份。
二氧化钛的粒径为60μm。
聚丙烯腈的分子量为12000。
一种用于人工气管的玻璃碳的制备方法，包括以下步骤：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至2200℃反应1.2h。
碳化处理时间为25min。
实施例5
用于人工气管的玻璃碳，包括以下重量份计的原料：聚丙烯腈80份、聚硅氧烷38份、醋酸纤维素97份、聚氯乙烯28份、磷酸三钙18份、氧化钾98份、二氧化钛60份、聚二甲基硅氧烷80份。
二氧化钛的粒径为130μm。
聚丙烯腈的分子量为18000。
一种用于人工气管的玻璃碳的制备方法，包括以下步骤：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至2800℃反应1.8h。
碳化处理时间为40min。
对比例1
与实施例1相同，不同在于：省略在无氧介质中进行碳化处理的步骤。
性能测试
测定实施例和对比例的产品性能，结果见表1。
表1
实施例1 实施例2 实施例3 实施例4 实施例5 对比例1
弹性模量GPa 24 23 22 23 22 15
疲劳强度MPa 100 97 93 94 95 67
抗压强度MPa 700 680 684 685 688 436
结论：经碳化处理后的玻璃碳生物稳定性较好，不会像现有技术的玻璃碳由于生物环境的腐蚀造成其中金属离子向周围组织扩散，本发明的玻璃碳弹性模量为22～24GPa，疲劳强度为93～100MPa，抗压强度为680～700MPa，耐生物老化性能强。

Claims (6)

1.用于人工气管的玻璃碳，其特征在于，由以下重量份计的原料组成：聚丙烯腈40～100份、聚硅氧烷30～40份、醋酸纤维素80～100份、聚氯乙烯20～30份、磷酸三钙10～20份、氧化钾90～100份、二氧化钛20～70份、聚二甲基硅氧烷60～90份。
2.根据权利要求1所述的用于人工气管的玻璃碳，其特征在于，包括以下重量份计的原料：聚丙烯腈70份、聚硅氧烷35份、醋酸纤维素90份、聚氯乙烯25份、磷酸三钙15份、氧化钾95份、二氧化钛50份、聚二甲基硅氧烷70份。
3.根据权利要求1所述的用于人工气管的玻璃碳，其特征在于，二氧化钛的粒径为40～150μm。
4.根据权利要求1所述的用于人工气管的玻璃碳，其特征在于，聚丙烯腈的分子量为10000～20000。
5.基于权利要求1所述的用于人工气管的玻璃碳的制备方法，其特征在于，包括以下步骤：聚丙烯腈、聚硅氧烷、醋酸纤维素、聚氯乙烯、磷酸三钙、氧化钾、二氧化钛、聚二甲基硅氧烷混合均匀，熔化，冷却成型；在无氧介质中进行碳化处理，然后升温至2000～3000℃反应1～2h。
6.根据权利要求5所述的用于人工气管的玻璃碳的制备方法，其特征在于，碳化处理时间为20～50min。
CN201410625934.4A 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制备方法 Expired - Fee Related CN104445142B (zh)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201610310548.5A CN106007719B (zh) 2014-11-10 2014-11-10 一种耐生物老化性能强的玻璃碳、人工气管的制备方法
CN201410625934.4A CN104445142B (zh) 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制备方法
CN201610312351.5A CN105999395B (zh) 2014-11-10 2014-11-10 一种玻璃碳、人工气管的制备方法
CN201610310581.8A CN106039397B (zh) 2014-11-10 2014-11-10 玻璃碳、人工气管的制备方法
CN201610312249.5A CN105948750B (zh) 2014-11-10 2014-11-10 玻璃碳及其制成的人工气管
CN201610310549.XA CN105948749B (zh) 2014-11-10 2014-11-10 耐生物老化性能强的玻璃碳、人工气管的制备方法
CN201610311124.0A CN105800589B (zh) 2014-11-10 2014-11-10 一种玻璃碳及其制成的人工气管
CN201610312354.9A CN105859293B (zh) 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制成的人工气管

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410625934.4A CN104445142B (zh) 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制备方法

Related Child Applications (7)

Application Number Title Priority Date Filing Date
CN201610310548.5A Division CN106007719B (zh) 2014-11-10 2014-11-10 一种耐生物老化性能强的玻璃碳、人工气管的制备方法
CN201610312351.5A Division CN105999395B (zh) 2014-11-10 2014-11-10 一种玻璃碳、人工气管的制备方法
CN201610311124.0A Division CN105800589B (zh) 2014-11-10 2014-11-10 一种玻璃碳及其制成的人工气管
CN201610312249.5A Division CN105948750B (zh) 2014-11-10 2014-11-10 玻璃碳及其制成的人工气管
CN201610310549.XA Division CN105948749B (zh) 2014-11-10 2014-11-10 耐生物老化性能强的玻璃碳、人工气管的制备方法
CN201610312354.9A Division CN105859293B (zh) 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制成的人工气管
CN201610310581.8A Division CN106039397B (zh) 2014-11-10 2014-11-10 玻璃碳、人工气管的制备方法

Publications (2)

Publication Number Publication Date
CN104445142A CN104445142A (zh) 2015-03-25
CN104445142B true CN104445142B (zh) 2016-11-23

Family

ID=52892006

Family Applications (7)

Application Number Title Priority Date Filing Date
CN201610312249.5A Active CN105948750B (zh) 2014-11-10 2014-11-10 玻璃碳及其制成的人工气管
CN201410625934.4A Expired - Fee Related CN104445142B (zh) 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制备方法
CN201610310549.XA Expired - Fee Related CN105948749B (zh) 2014-11-10 2014-11-10 耐生物老化性能强的玻璃碳、人工气管的制备方法
CN201610312351.5A Expired - Fee Related CN105999395B (zh) 2014-11-10 2014-11-10 一种玻璃碳、人工气管的制备方法
CN201610312354.9A Expired - Fee Related CN105859293B (zh) 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制成的人工气管
CN201610310581.8A Expired - Fee Related CN106039397B (zh) 2014-11-10 2014-11-10 玻璃碳、人工气管的制备方法
CN201610310548.5A Expired - Fee Related CN106007719B (zh) 2014-11-10 2014-11-10 一种耐生物老化性能强的玻璃碳、人工气管的制备方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201610312249.5A Active CN105948750B (zh) 2014-11-10 2014-11-10 玻璃碳及其制成的人工气管

Family Applications After (5)

Application Number Title Priority Date Filing Date
CN201610310549.XA Expired - Fee Related CN105948749B (zh) 2014-11-10 2014-11-10 耐生物老化性能强的玻璃碳、人工气管的制备方法
CN201610312351.5A Expired - Fee Related CN105999395B (zh) 2014-11-10 2014-11-10 一种玻璃碳、人工气管的制备方法
CN201610312354.9A Expired - Fee Related CN105859293B (zh) 2014-11-10 2014-11-10 用于人工气管的玻璃碳及其制成的人工气管
CN201610310581.8A Expired - Fee Related CN106039397B (zh) 2014-11-10 2014-11-10 玻璃碳、人工气管的制备方法
CN201610310548.5A Expired - Fee Related CN106007719B (zh) 2014-11-10 2014-11-10 一种耐生物老化性能强的玻璃碳、人工气管的制备方法

Country Status (1)

Country Link
CN (7) CN105948750B (zh)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3548649B2 (ja) * 1996-03-26 2004-07-28 東海カーボン株式会社 カーボン発熱体
KR100430460B1 (ko) * 1996-08-28 2004-07-19 닛신보세키 가부시키 가이샤 유리형상탄소및그제조방법,자기기록매체용기판및플라즈머에칭용전극판
JP2005326240A (ja) * 2004-05-13 2005-11-24 Toshiba Corp 分析用容器及び微量元素量分析方法
US20100104849A1 (en) * 2005-05-03 2010-04-29 Lashmore David S Carbon composite materials and methods of manufacturing same
US8951451B2 (en) * 2009-05-26 2015-02-10 Incubation Alliance, Inc. Carbon material and method for producing same
BR112012002233A2 (pt) * 2009-07-31 2019-09-24 Massachustts Institute Of Tech sietmas e métodos relacionados à formação de nanoestruturas a base de carbono.
CN101626075B (zh) * 2009-08-03 2011-03-30 北京化工大学 锡碳复合纳米纤维薄膜负极材料及其制备方法
CN102168324B (zh) * 2011-03-08 2012-08-22 西安工程大学 静电纺纳米丝束的碳化装置及纳米碳纤维的制备方法
CN102276280A (zh) * 2011-04-20 2011-12-14 上海交通大学 基于玻璃碳和碳添加物的复合薄板及其制备方法
CN102936763B (zh) * 2012-10-12 2015-03-18 福建师范大学 一种玻璃碳纳米纤维的制备方法
CN103508437A (zh) * 2013-08-13 2014-01-15 南京工业大学 一种酚醛树脂基玻璃碳微球的制备方法

Also Published As

Publication number Publication date
CN105859293A (zh) 2016-08-17
CN105948749B (zh) 2018-06-29
CN105999395A (zh) 2016-10-12
CN105948749A (zh) 2016-09-21
CN106007719B (zh) 2018-06-29
CN105859293B (zh) 2018-06-29
CN106039397B (zh) 2019-05-17
CN104445142A (zh) 2015-03-25
CN105999395B (zh) 2019-01-01
CN105948750B (zh) 2018-08-10
CN105948750A (zh) 2016-09-21
CN106007719A (zh) 2016-10-12
CN106039397A (zh) 2016-10-26

Similar Documents

Publication Publication Date Title
CN106693842B (zh) 一种生物质碳气凝胶及其制备方法和应用
CN106744806A (zh) 金属有机骨架为模板的氮掺杂多孔碳材料及其应用
CN104818449B (zh) 一种锆或锆合金表面离子渗氧制备二氧化锆渗层的方法
CN108314013A (zh) 一种规则多孔石墨烯厚膜及其制备方法
CN104445142B (zh) 用于人工气管的玻璃碳及其制备方法
CN103789717A (zh) 一种钛及钛合金表面渗氧方法
CN102690050A (zh) 一种化学钢化玻璃的加工方法
CN105800589B (zh) 一种玻璃碳及其制成的人工气管
CN106832371B (zh) 一种加工海藻酸钙水凝胶cah人工肌肉的热处理工艺方法
CN105293473A (zh) 一种以聚偏氟乙烯为前驱体的多孔碳材料及制备方法
CN101504385A (zh) 一种提高碳电极灵敏度、选择性和抗毒化能力的方法
CN102041535B (zh) 一种利用氯化铁同时制备的两种超疏水薄膜的方法
CN105399086B (zh) 一种氯化钠辅助制备石墨烯多孔膜的方法
CN105842289B (zh) 一种金属氧化物气敏传感基体材料及其制备方法
CN118099358B (zh) 一种硬碳复合材料的制备工艺及其制品和应用
CN103524041B (zh) 一种钠电池界面同相化封接方法
JP2020057524A (ja) 硫化物固体電解質の回復方法
CN108328606A (zh) 一种规则多孔石墨烯薄膜及其制备方法
CN104711571A (zh) 一种镁合金表面改性方法
CN103021764A (zh) 一种制备场发射阴极的处理方法
CN103985545A (zh) 一种高压钽电解电容器阳极薄膜的热处理方法
CN104124308A (zh) 光电阴极制备工艺
CN102060449B (zh) 一种地质缝隙人工物理模型的制备方法
CN103021763A (zh) 一种制备场发射阴极材料的方法
CN103028534B (zh) 一种防结露风口的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
CB03 Change of inventor or designer information

Inventor after: Zhao Xiufang

Inventor before: Pan Lingen

Inventor before: Qiu Dongcheng

Inventor before: Liu Lefeng

COR Change of bibliographic data
TA01 Transfer of patent application right

Effective date of registration: 20160909

Address after: Longju town center 257000 Shandong province Dongying city Dongying district hospital

Applicant after: Zhao Xiufang

Address before: Wuzhong District town Suzhou city Jiangsu province 215101 gold Jinchang Road No. 360

Applicant before: SUZHOU VIVOTIDE BIOTECHNOLOGIES Co.,Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20161123

CF01 Termination of patent right due to non-payment of annual fee